EE200000614A - Polyol-IFN-β Conjugate, Method for its Preparation, Pharmaceutical Composition and Use, and Methods for Attaching Polyethylene Glycol Residues to a Polypeptide and Use of a PEG Polypeptide Conjugate - Google Patents

Polyol-IFN-β Conjugate, Method for its Preparation, Pharmaceutical Composition and Use, and Methods for Attaching Polyethylene Glycol Residues to a Polypeptide and Use of a PEG Polypeptide Conjugate

Info

Publication number
EE200000614A
EE200000614A EEP200000614A EEP200000614A EE200000614A EE 200000614 A EE200000614 A EE 200000614A EE P200000614 A EEP200000614 A EE P200000614A EE P200000614 A EEP200000614 A EE P200000614A EE 200000614 A EE200000614 A EE 200000614A
Authority
EE
Estonia
Prior art keywords
conjugate
polypeptide
ifn
polyol
preparation
Prior art date
Application number
EEP200000614A
Other languages
Estonian (et)
Inventor
El Tayar Nabil
J. Roberts Michael
Harris Milton
Sawlivich Wayne
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200000614A publication Critical patent/EE200000614A/en
Publication of EE05214B1 publication Critical patent/EE05214B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
EEP200000614A 1998-04-28 1999-04-28 Polyol-IFN-β conjugate, process for its preparation and pharmaceutical composition EE05214B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8333998P 1998-04-28 1998-04-28
PCT/US1999/009161 WO1999055377A2 (en) 1998-04-28 1999-04-28 Polyol-ifn-beta conjugates

Publications (2)

Publication Number Publication Date
EE200000614A true EE200000614A (en) 2002-04-15
EE05214B1 EE05214B1 (en) 2009-10-15

Family

ID=22177687

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000614A EE05214B1 (en) 1998-04-28 1999-04-28 Polyol-IFN-β conjugate, process for its preparation and pharmaceutical composition

Country Status (31)

Country Link
US (3) US6638500B1 (en)
EP (2) EP1421956B1 (en)
JP (2) JP4574007B2 (en)
KR (1) KR100622796B1 (en)
CN (2) CN100335503C (en)
AR (1) AR020070A1 (en)
AT (2) ATE275422T1 (en)
AU (1) AU762621B2 (en)
BG (2) BG64694B1 (en)
BR (1) BR9910023A (en)
CA (2) CA2330451A1 (en)
CY (1) CY1108022T1 (en)
CZ (2) CZ298597B6 (en)
DE (2) DE69920002T2 (en)
DK (2) DK1421956T3 (en)
EA (2) EA003789B1 (en)
EE (1) EE05214B1 (en)
ES (2) ES2285286T3 (en)
HK (2) HK1038194A1 (en)
HU (1) HUP0300548A3 (en)
IL (1) IL139286A (en)
NO (2) NO329749B1 (en)
NZ (1) NZ507456A (en)
PL (2) PL196533B1 (en)
PT (2) PT1075281E (en)
SI (2) SI1075281T1 (en)
SK (2) SK286217B6 (en)
TR (2) TR200003161T2 (en)
TW (2) TWI266800B (en)
UA (2) UA79430C2 (en)
WO (1) WO1999055377A2 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US7704944B2 (en) 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
US7220717B2 (en) 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
PT1121156E (en) * 1998-10-16 2006-05-31 Biogen Idec Inc CONJUGATES OF INTERFERRO-BETA-1A POLYMERS AND THEIR USES
PT1121382E (en) * 1998-10-16 2006-10-31 Biogen Idec Inc BETA INTERFERENCE FUSE PROTEINS AND THEIR RESPECTIVE USES
CA2369595C (en) * 1999-04-23 2010-10-05 Alza Corporation Conjugate having a cleavable linkage for use in a liposome
US7303760B2 (en) * 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
US7238368B2 (en) * 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
TR200101086A3 (en) * 1999-10-15 2001-08-21
US7691367B2 (en) 1999-12-24 2010-04-06 Kyowa Hakko Kirin Co., Ltd. Branched polyalkylene glycols
DE60139110D1 (en) 2000-01-10 2009-08-13 Maxygen Holdings Ltd G-CSF CONJUGATES
DK1257295T3 (en) 2000-02-11 2009-08-10 Bayer Healthcare Llc Factor VII or VIIA-like molecules
CA2436623C (en) 2001-01-30 2011-08-02 Kyowa Hakko Kogyo Co., Ltd. Branched polyalkylene glycols
EP1234583A1 (en) 2001-02-23 2002-08-28 F. Hoffmann-La Roche Ag PEG-conjugates of HGF-NK4
DE60232434D1 (en) 2001-02-27 2009-07-09 Maxygen Aps NEW INTERFERON-BETA-LIKE MOLECULES
AU2002325819B2 (en) 2001-07-11 2008-06-19 Maxygen, Inc. G-CSF Conjugates
RS55578B1 (en) 2002-01-18 2017-06-30 Biogen Ma Inc Polyalkylene polymer compounds and uses thereof
TWI334785B (en) 2002-06-03 2010-12-21 Serono Lab Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race
WO2004020468A2 (en) * 2002-08-28 2004-03-11 Maxygen Aps Interferon beta-like molecules for treatment of cancer
US8129330B2 (en) * 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
NZ541124A (en) 2002-12-26 2008-08-29 Mountain View Pharmaceuticals Polymer conjugates of interferon-beta with enhanced biological potency
CA2511815A1 (en) * 2002-12-26 2004-07-22 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
JP4847856B2 (en) 2003-03-20 2011-12-28 バイエル ヘルスケア エルエルシー Variants of FVII and FVIIa
TWI272948B (en) 2003-05-01 2007-02-11 Ares Trading Sa HSA-free stabilized interferon liquid formulations
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
ES2428358T3 (en) 2003-10-17 2013-11-07 Novo Nordisk A/S Combination therapy
WO2005074524A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human interferon polypeptides and their uses
AU2005319099B2 (en) 2004-02-02 2010-09-16 Ambrx, Inc. Modified human growth hormone
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
EP1586334A1 (en) * 2004-04-15 2005-10-19 TRASTEC scpa G-CSF conjugates with peg
NZ550926A (en) 2004-05-17 2010-01-29 Ares Trading Sa Hydrogel interferon formulations
EA012281B1 (en) 2004-06-01 2009-08-28 Арес Трейдинг С.А. Method of stabilizing proteins
UA92146C2 (en) 2004-06-01 2010-10-11 Эйрэс Трейдинг С.А. Stabilized interferon liquid formulations
TW200633718A (en) * 2004-12-16 2006-10-01 Applied Research Systems Treatment of hepatitis c in the asian population
CN101111267B (en) 2004-12-21 2012-12-05 尼克塔治疗公司 Stabilized polymeric thiol reagents
MX2007007587A (en) * 2004-12-22 2007-12-11 Ambrx Inc Formulations of human growth hormone comprising a non-naturally encoded amino acid.
CN103290084A (en) 2004-12-22 2013-09-11 Ambrx公司 Method for expression and purification of recombinant human growth hormone
ES2553160T3 (en) 2005-06-17 2015-12-04 Novo Nordisk Health Care Ag Selective reduction and derivatization of engineered Factor VII proteins comprising at least one non-native cysteine
WO2007019331A2 (en) * 2005-08-04 2007-02-15 Nektar Therapeutics Al, Corporation Conjugates of a g-csf moiety and a polymer
WO2007022799A1 (en) 2005-08-26 2007-03-01 Ares Trading S.A. Process for the preparation of glycosylated interferon beta
BRPI0616118A2 (en) 2005-09-01 2011-06-07 Ares Trading Sa treatment of optic neuritis
US20070238656A1 (en) * 2006-04-10 2007-10-11 Eastman Kodak Company Functionalized poly(ethylene glycol)
CA2653748A1 (en) * 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CN101484576A (en) 2006-05-24 2009-07-15 诺沃-诺迪斯克保健股份有限公司 Factor IX analogues having prolonged in vivo half life
EA020805B1 (en) 2006-05-24 2015-01-30 Мерк Сероно С.А. Use of combination of cladribine and beta interferon for treating multiple sclerosis
AU2008247815B2 (en) * 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
WO2009080699A2 (en) * 2007-12-20 2009-07-02 Merck Serono S.A. Peg-interferon-beta formulations
NZ620606A (en) 2008-02-08 2015-08-28 Ambrx Inc Modified leptin polypeptides and their uses
CN101525381B (en) * 2008-03-04 2012-04-18 北京百川飞虹生物科技有限公司 Novel recombinant consensus interferon and construction of a high-efficiency expression vector thereof
WO2009155102A2 (en) * 2008-05-30 2009-12-23 Barofold, Inc. Method for derivatization of proteins using hydrostatic pressure
US20110124614A1 (en) * 2008-10-25 2011-05-26 Halina Offner Methods And Compositions For The Treatment of Autoimmune Disorders
DE102009032179A1 (en) * 2009-07-07 2011-01-13 Biogenerix Ag Process for purifying interferon beta
ES2365343B1 (en) 2009-11-19 2012-07-10 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii USE OF CD98 AS AN ENDOMETRIAL RECEPTIVITY MARKER.
US20130040888A1 (en) 2010-02-16 2013-02-14 Novo Nordisk A/S Factor VIII Molecules With Reduced VWF Binding
AR080993A1 (en) 2010-04-02 2012-05-30 Hanmi Holdings Co Ltd FORMULATION OF PROLONGED BETA INTERFERTION ACTION WHERE AN IMMUNOGLOBULIN FRAGMENT IS USED
JP2013528374A (en) 2010-05-10 2013-07-11 パーシード セラピューティクス リミテッド ライアビリティ カンパニー Polypeptide inhibitors of VLA4
WO2012007324A2 (en) 2010-07-15 2012-01-19 Novo Nordisk A/S Stabilized factor viii variants
JP6042335B2 (en) 2010-09-15 2016-12-14 ノヴォ ノルディスク アー／エス Factor VIII mutant with reduced cellular uptake
EP3395356B1 (en) * 2011-02-18 2021-05-19 Stemdr Inc. Composition containing inducer of sirt1 expression for preventing or treating sepsis or septic shock
AU2012280474A1 (en) 2011-07-01 2014-01-16 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
CN104080803B (en) * 2011-10-01 2020-08-04 株式会社糖锁工学研究所 Sugar chain-added polypeptide and pharmaceutical composition containing the same
PE20142451A1 (en) 2012-02-27 2015-02-04 Amunix Operating Inc COMPOSITIONS OF CONJUGATES OF XTEN AND METHODS TO MAKE THEM
JP6112009B2 (en) 2012-02-29 2017-04-12 東レ株式会社 Body fluid retention inhibitor
MY171183A (en) 2013-03-29 2019-09-30 Glytech Inc Polypeptide glycosylated with sialylated sugar chain
WO2016013697A1 (en) * 2014-07-24 2016-01-28 에이비온 주식회사 Polyethylene glycol complex of interferon-beta variant
KR101671501B1 (en) * 2014-07-24 2016-11-03 에이비온 주식회사 PEGylated Interferon-beta Variants
LT3183264T (en) 2014-08-19 2021-01-11 Biogen Ma Inc. Pegylation method
AU2016257724B2 (en) 2015-05-01 2021-02-25 Allysta Pharmaceuticals, Inc. Adiponectin peptidomimetics for treating ocular disorders
WO2016205618A1 (en) * 2015-06-19 2016-12-22 Morphotek, Inc. Cys80 conjugated immunoglobulins
AU2018254410A1 (en) * 2017-04-17 2019-10-10 The Regents Of The University Of Colorado, A Body Corporate Optimization of enzyme replacement therapy for treatment of homocystinuria
CN113382775A (en) 2019-01-28 2021-09-10 东丽株式会社 Polyethylene glycol modifier of hepatocyte growth factor or active fragment thereof
WO2020158691A1 (en) 2019-01-28 2020-08-06 東レ株式会社 Polyethylene glycol modified body for hepatocyte growth factor or active fragment thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
WO1987000056A1 (en) * 1985-06-26 1987-01-15 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5208344A (en) * 1987-07-31 1993-05-04 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5711944A (en) 1993-11-10 1998-01-27 Enzon, Inc. Interferon polymer conjugates
KR100203824B1 (en) * 1994-03-31 1999-06-15 스티븐 엠. 오드리 Compositions and methods for stimulating megakaryocyte growth and differentiation
ATE299892T1 (en) * 1994-05-18 2005-08-15 Nektar Therapeutics METHODS AND COMPOSITIONS FOR DRY POWDER MEDICATION FROM INTERFERONS
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
SE9503380D0 (en) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US5851984A (en) * 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
KR0176625B1 (en) 1996-11-05 1999-04-01 삼성전자주식회사 Infrared object detector
JP2001508783A (en) * 1997-01-29 2001-07-03 ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー PEGylation method
IL133974A0 (en) * 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
US6307024B1 (en) * 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates

Also Published As

Publication number Publication date
EP1075281A2 (en) 2001-02-14
PT1075281E (en) 2004-11-30
EP1421956B1 (en) 2007-06-27
CZ298597B6 (en) 2007-11-21
KR20010071158A (en) 2001-07-28
SK286217B6 (en) 2008-05-06
DK1421956T3 (en) 2007-10-01
US7700314B2 (en) 2010-04-20
CN1302209A (en) 2001-07-04
PL344490A1 (en) 2001-11-05
NO20100324L (en) 2000-12-28
JP2002512983A (en) 2002-05-08
CY1108022T1 (en) 2013-09-04
NO332224B1 (en) 2012-07-30
DE69936409T2 (en) 2008-04-17
SK16222000A3 (en) 2001-04-09
DE69920002T2 (en) 2005-09-22
HK1076115A1 (en) 2006-01-06
JP4574007B2 (en) 2010-11-04
CN1187094C (en) 2005-02-02
TWI266800B (en) 2006-11-21
ATE365563T1 (en) 2007-07-15
UA66857C2 (en) 2004-06-15
PL193352B1 (en) 2007-02-28
US20070141620A1 (en) 2007-06-21
US20040043002A1 (en) 2004-03-04
CZ298579B6 (en) 2007-11-14
KR100622796B1 (en) 2006-09-13
IL139286A0 (en) 2001-11-25
HUP0300548A3 (en) 2005-07-28
EA200001111A1 (en) 2001-04-23
WO1999055377A2 (en) 1999-11-04
BG65046B1 (en) 2007-01-31
AR020070A1 (en) 2002-04-10
TR200101751T2 (en) 2002-05-21
EA200300382A1 (en) 2005-02-24
BG64694B1 (en) 2005-12-30
US7357925B2 (en) 2008-04-15
WO1999055377A9 (en) 2000-03-02
NO20005337L (en) 2000-12-28
US6638500B1 (en) 2003-10-28
ATE275422T1 (en) 2004-09-15
TWI232882B (en) 2005-05-21
NZ507456A (en) 2003-10-31
EP1421956A1 (en) 2004-05-26
NO20005337D0 (en) 2000-10-23
ES2285286T3 (en) 2007-11-16
CN100335503C (en) 2007-09-05
SI1421956T1 (en) 2007-10-31
NO329749B1 (en) 2010-12-13
EE05214B1 (en) 2009-10-15
EP1075281B1 (en) 2004-09-08
TR200003161T2 (en) 2001-01-22
BG109291A (en) 2006-04-28
HK1038194A1 (en) 2002-03-08
BG104871A (en) 2001-07-31
CA2330451A1 (en) 1999-11-04
DE69936409D1 (en) 2007-08-09
UA79430C2 (en) 2007-06-25
DK1075281T3 (en) 2005-01-03
BR9910023A (en) 2000-12-26
SI1075281T1 (en) 2005-02-28
EA005495B1 (en) 2005-02-24
PT1421956E (en) 2007-07-13
IL139286A (en) 2005-12-18
AU3767499A (en) 1999-11-16
SK286654B6 (en) 2009-03-05
WO1999055377A3 (en) 1999-12-29
JP2010184929A (en) 2010-08-26
ES2224649T3 (en) 2005-03-01
CN1637020A (en) 2005-07-13
AU762621B2 (en) 2003-07-03
CA2565375A1 (en) 1999-11-04
EA003789B1 (en) 2003-10-30
HUP0300548A2 (en) 2003-06-28
DE69920002D1 (en) 2004-10-14
CZ20003995A3 (en) 2001-06-13
PL196533B1 (en) 2008-01-31

Similar Documents

Publication Publication Date Title
EE200000614A (en) Polyol-IFN-β Conjugate, Method for its Preparation, Pharmaceutical Composition and Use, and Methods for Attaching Polyethylene Glycol Residues to a Polypeptide and Use of a PEG Polypeptide Conjugate
EE9800136A (en) Pharmaceutical composition suitable for depot medicine, its preparation method and use
EE9800180A (en) Gonadotropin-releasing hormone antagonist, its use, pharmaceutical composition and method of preparation
EE9800181A (en) Gonadotropin-releasing hormone antagonist, its use, pharmaceutical composition and method of preparation
EE04042B1 (en) Pharmaceutical composition of fenofibrates with high bioavailability and process for its preparation
NO20004741L (en) Pharmaceutical compositions for extended peptide release and method of preparation
EE200000319A (en) Site-Specific Method for the Preparation of hGRF-PEG Conjugates, hGRF-PEG Conjugates, Intermediates, Use, and Pharmaceutical Composition
EE05021B1 (en) Enteric-coated pharmaceutical composition and method for its preparation
EE200000680A (en) Enteric-coated pharmaceutical composition and method for its preparation
BR9709267A (en) Preparation of monoclonal antibody for administration to a human pharmaceutical formulation use of a monoclonal antibody preparation and process for the manufacture of a monoclonal antibody preparation
EE04417B1 (en) Oral pharmaceutical pulsatile dosage form, method of preparation and use
EE200100684A (en) Indalyl-substituted benzenecarboxamides, process for their preparation, use and pharmaceutical compositions
ITMI950529A0 (en) PHARMACEUTICAL COMPOSITIONS AND PROCEDURE FOR THEIR PREPARATION
EE9500064A (en) Substituted 1H-imidazoles, methods for their preparation, and pharmaceutical compositions
EE200000225A (en) Aryloxyalkyl dialkylamines, methods for their preparation and pharmaceutical composition
HK1061841A1 (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
EE9900112A (en) 2-Cyanoiminoimidazole derivatives, process for their preparation, use and pharmaceutical compositions
EE04119B1 (en) A pharmaceutical composition suitable for freeze-drying and a process for its preparation
EE9800200A (en) Benzoylguanidine derivatives, process for their preparation, use and pharmaceutical composition
EE04681B1 (en) 3,6-Half-Ketals of the 9a-Azalides, Method of Preparation and Pharmaceutical Composition
IT1287174B1 (en) PHARMACOLOGICALLY ACTIVE DIARYL-CYCLOMETHYLENPYRAZOLES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
EE03554B1 (en) Microporous crystalline material, method of its preparation and use in detergent compositions
EE04683B1 (en) Derivatives of group A streptogramins, process for their preparation and pharmaceutical composition
EE9900034A (en) Arylcycloalkanecarboxylic esters, their use, pharmaceutical compositions and their preparation
EE03996B1 (en) Pharmaceutical compositions, process for their preparation and use

Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20101231

HC1A Change of owner name
MM4A Lapsed by not paying the annual fees

Effective date: 20130428