ECSP11011437A - COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS OF THE SAME - Google Patents

COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS OF THE SAME

Info

Publication number
ECSP11011437A
ECSP11011437A EC2011011437A ECSP11011437A ECSP11011437A EC SP11011437 A ECSP11011437 A EC SP11011437A EC 2011011437 A EC2011011437 A EC 2011011437A EC SP11011437 A ECSP11011437 A EC SP11011437A EC SP11011437 A ECSP11011437 A EC SP11011437A
Authority
EC
Ecuador
Prior art keywords
compounds
methods
kinases
indications
modulation
Prior art date
Application number
EC2011011437A
Other languages
Spanish (es)
Inventor
Prabha N Ibrahim
Guoxian Wu
Wayne Spevak
Hanna Cho
Songyuan Shi
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011437(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of ECSP11011437A publication Critical patent/ECSP11011437A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen compuestos y sales de los mismos, formulaciones de los mismos, conjugados de los mismos, derivados de los mismos, formas de los mismos y usos de los mismos. En algunos aspectos y formas de realización, los compuestos descriptos o sales de los mismos, formulaciones de los mismos, conjugados de los mismos, derivados de los mismos y formas de los mismos son activos en cada una de las proteína quinasas BRaf y c-Raf-1, y también pueden ser activos en cualquiera, o ambas, de las proteínas quinasas A-Raf y B-Raf V600E. También se describen métodos de uso de los mismos para tratar enfermedades y condiciones, incluyendo melanoma, cáncer colorrectal, cáncer de tiroides, cáncer ovárico y cáncer del tracto biliar.Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In some aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof and forms thereof are active in each of the BRaf and c-Raf protein kinases. -1, and can also be active in either, or both, of the protein kinases A-Raf and B-Raf V600E. Methods of using them to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer and biliary tract cancer, are also described.

EC2011011437A 2009-05-06 2011-11-01 COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS OF THE SAME ECSP11011437A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17605409P 2009-05-06 2009-05-06

Publications (1)

Publication Number Publication Date
ECSP11011437A true ECSP11011437A (en) 2011-12-30

Family

ID=42236712

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011437A ECSP11011437A (en) 2009-05-06 2011-11-01 COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS OF THE SAME

Country Status (23)

Country Link
US (3) US8198273B2 (en)
EP (2) EP2427433A1 (en)
JP (2) JP2012526127A (en)
KR (1) KR20140014386A (en)
CN (1) CN102459262A (en)
AR (1) AR076749A1 (en)
AU (1) AU2010246005A1 (en)
BR (1) BRPI1013843A2 (en)
CA (1) CA2759997A1 (en)
CL (1) CL2011002739A1 (en)
CR (1) CR20110562A (en)
EC (1) ECSP11011437A (en)
IL (1) IL215908A0 (en)
MA (1) MA34042B1 (en)
MX (1) MX2011011737A (en)
NI (1) NI201100189A (en)
NO (1) NO20111508A1 (en)
PE (1) PE20120518A1 (en)
RU (1) RU2011149485A (en)
SG (1) SG175810A1 (en)
TW (1) TW201041888A (en)
WO (2) WO2010129567A1 (en)
ZA (1) ZA201108124B (en)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1893612B1 (en) * 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2009143018A2 (en) 2008-05-19 2009-11-26 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PL2414356T3 (en) 2009-04-03 2016-02-29 Hoffmann La Roche Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
RU2012125070A (en) * 2009-11-18 2013-12-27 Плексксикон, Инк. COMPOUNDS AND METHODS OF KINASE MODULATION AND INDICATIONS FOR THEIR APPLICATION
MX2012007429A (en) * 2009-12-23 2012-07-23 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor.
TWI619713B (en) 2010-04-21 2018-04-01 普雷辛肯公司 Compounds and methods for kinase modulation, and indications therefor
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
US20140005160A1 (en) * 2010-12-01 2014-01-02 Hooshmand SHESHBARADARAN Method for Treating Refractory Cancer
WO2012106559A1 (en) * 2011-02-02 2012-08-09 Translational Genomics Research Institute Biomarkers and methods of use thereof
US8889684B2 (en) * 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
MA34948B1 (en) * 2011-02-07 2014-03-01 Plexxikon Inc COMPOUNDS AND METHODS FOR MODULATING KINASE, AND INDICATIONS THEREOF
TWI558702B (en) * 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
CA2828940C (en) 2011-03-10 2024-04-16 Provectus Pharmaceuticals, Inc. Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer
WO2012138809A1 (en) * 2011-04-05 2012-10-11 Dawei Zhang Heterocyclic compounds as kinase inhibitors
WO2012158957A2 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
CN107245056A (en) 2011-08-26 2017-10-13 润新生物公司 Chemical entities, composition and method
CN102993199A (en) * 2011-09-09 2013-03-27 山东轩竹医药科技有限公司 Heterocycle substituted pyrido-pyrrole kinase inhibitor
EP3332785B1 (en) 2011-09-14 2020-05-06 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP2757885B1 (en) 2011-09-21 2017-03-15 Neupharma, Inc. Certain chemical entites, compositions, and methods
WO2013049701A1 (en) 2011-09-30 2013-04-04 Neupharma, Inc. Certain chemical entities, compositions, and methods
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
US9670180B2 (en) 2012-01-25 2017-06-06 Neupharma, Inc. Certain chemical entities, compositions, and methods
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
JP6013029B2 (en) * 2012-05-25 2016-10-25 千葉県 Anticancer drug
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9150570B2 (en) * 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JO3407B1 (en) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd Tetrahydropyrazolopyrimidine Compounds
CN104470920A (en) * 2012-07-03 2015-03-25 通益制药有限公司 Solid state form of vemurafenib choline salt
DE102012016908A1 (en) * 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris (hetero) aryl-pyrazoles and their use
TWI601725B (en) 2012-08-27 2017-10-11 加拓科學公司 Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use
MX2015002887A (en) 2012-09-06 2015-07-06 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor.
WO2014047648A1 (en) 2012-09-24 2014-03-27 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN103613591B (en) * 2012-09-29 2016-04-13 上海科州药物研发有限公司 As the compound and its production and use of cMet inhibitor
US9725421B2 (en) 2012-11-12 2017-08-08 Neupharma, Inc. Substituted quinoxalines as B-raf kinase inhibitors
SG11201503977PA (en) * 2012-11-20 2015-06-29 Principia Biopharma Inc Azaindole derivatives as jak3 inhibitors
CA2895239C (en) 2012-12-21 2020-10-27 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2014111496A1 (en) * 2013-01-18 2014-07-24 F. Hoffmann-La Roche Ag 3-substituted pyrazoles and use as dlk inhibitors
CA2900951A1 (en) 2013-03-14 2014-10-02 Ratiopharm Gmbh Solid state forms of vemurafenib hydrochloride
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
MX2015012456A (en) 2013-03-15 2016-02-03 Plexxikon Inc Heterocyclic compounds and uses thereof.
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
EP3004060B1 (en) 2013-05-30 2019-11-27 Plexxikon Inc. Compounds for kinase modulation, and indications therefor
WO2015075749A1 (en) * 2013-11-22 2015-05-28 Laurus Labs Private Limited Novel processes for the preparation of vemurafenib
CZ2013943A3 (en) 2013-11-27 2015-06-03 Zentiva, K.S. Vemurafenib crystalline forms
WO2015134536A1 (en) 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JO3512B1 (en) 2014-03-26 2020-07-05 Astex Therapeutics Ltd Quinoxaline derivatives useful as fgfr kinase modulators
AU2015238301B2 (en) 2014-03-26 2020-06-25 Astex Therapeutics Ltd Combinations
KR102479696B1 (en) 2014-03-26 2022-12-22 아스텍스 테라퓨틱스 리미티드 Combinations of an fgfr inhibitor and an igf1r inhibitor
NO2714752T3 (en) * 2014-05-08 2018-04-21
US9856259B2 (en) 2014-09-15 2018-01-02 Plexxikon Inc. Heterocyclic compounds and uses thereof
JOP20200201A1 (en) 2015-02-10 2017-06-16 Astex Therapeutics Ltd Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CZ2015250A3 (en) 2015-04-14 2016-10-26 Zentiva, K.S. Vemurafenib amorphous forms
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
AU2016328619B2 (en) 2015-09-21 2020-07-16 Opna Bio SA Heterocyclic compounds and uses thereof
JP6898919B2 (en) 2015-09-23 2021-07-07 ヤンセン ファーマシューティカ エヌ．ベー． New compound
HUE057090T2 (en) 2015-09-23 2022-04-28 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
WO2017100201A1 (en) 2015-12-07 2017-06-15 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2017161045A1 (en) 2016-03-16 2017-09-21 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
US10195188B2 (en) 2016-06-13 2019-02-05 Chemocentryx, Inc. Method of treating pancreatic cancer
KR20240110902A (en) * 2016-06-13 2024-07-16 케모센트릭스, 인크. Methods of treating pancreatic cancer
CN107722013B (en) * 2016-08-11 2021-01-12 中国科学院上海药物研究所 Deazapurine compounds, pharmaceutical compositions, preparation method and uses thereof
TW201815766A (en) 2016-09-22 2018-05-01 美商普雷辛肯公司 Compounds and methods for IDO and TDO modulation, and indications therefor
EP4134080A1 (en) 2016-11-23 2023-02-15 ChemoCentryx, Inc. Ccr2 inhibitors for use in treating renal diseases
CA3047580A1 (en) 2016-12-23 2018-07-26 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
BR112019014593A2 (en) 2017-01-17 2020-02-18 Heparegenix Gmbh MKK4 INHIBITOR AND THE PHARMACEUTICALLY ACCEPTABLE OPTICAL SALES, SOLVATES AND ISOMERS OF THE SAME, COMPOUND AND THE PHARMACEUTICALLY ACCEPTABLE PHARMACEUTICALLY ACCEPTABLE INITIATIVE KNOWLEDGE PROTECTION IN THE PROTEIN OF THE KNOWLEDGE
JP2020511467A (en) 2017-03-20 2020-04-16 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． 4- (1- (1,1-di (pyridin-2-yl) ethyl) -6- (3,5-dimethylisoxazol-4-yl) -1H-pyrrolo [3,2- that inhibits the bromodomain b] Pyridin-3-yl) benzoic acid crystalline form
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
WO2019023198A1 (en) 2017-07-25 2019-01-31 Plexxikon Inc. Formulations of a compound modulating kinases
CA3078809A1 (en) 2017-10-11 2019-04-18 Chemocentryx, Inc. Treatment of focal segmental glomerulosclerosis with ccr2 antagonists
CA3079029A1 (en) 2017-10-13 2019-04-18 Plexxikon Inc. Solid forms of a compound for modulating kinases
AU2018354423A1 (en) 2017-10-27 2020-05-14 Plexxikon Inc. Formulations of a compound modulating kinases
AU2019207491A1 (en) 2018-01-10 2020-07-30 Cura Therapeutics, Llc Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
EP3746437B1 (en) 2018-01-31 2024-08-21 HepaRegeniX GmbH Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
EP3768666A1 (en) 2018-03-20 2021-01-27 Plexxikon Inc. Compounds and methods for ido and tdo modulation, and indications therefor
EP3810139A1 (en) 2018-06-21 2021-04-28 HepaRegeniX GmbH Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US11912701B2 (en) 2018-07-16 2024-02-27 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2277551E (en) * 2002-09-06 2013-08-22 Cerulean Pharma Inc Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
EP1893612B1 (en) 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
DE102005034406A1 (en) 2005-07-22 2007-02-01 Ratiopharm Gmbh New salts of rosiglitazone
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
GB0624084D0 (en) 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
PE20121126A1 (en) * 2006-12-21 2012-08-24 Plexxikon Inc PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
SG183036A1 (en) * 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor

Also Published As

Publication number Publication date
WO2010129570A1 (en) 2010-11-11
EP2427462A1 (en) 2012-03-14
WO2010129567A1 (en) 2010-11-11
MA34042B1 (en) 2013-03-05
IL215908A0 (en) 2012-01-31
US20120245174A1 (en) 2012-09-27
KR20140014386A (en) 2014-02-06
SG175810A1 (en) 2011-12-29
AU2010246005A1 (en) 2011-12-01
US8198273B2 (en) 2012-06-12
US20100286142A1 (en) 2010-11-11
NO20111508A1 (en) 2011-12-02
CA2759997A1 (en) 2010-11-11
CN102459262A (en) 2012-05-16
EP2427433A1 (en) 2012-03-14
BRPI1013843A2 (en) 2016-04-12
JP2012526127A (en) 2012-10-25
NI201100189A (en) 2012-01-11
JP2012526128A (en) 2012-10-25
CL2011002739A1 (en) 2012-04-09
US20120122860A1 (en) 2012-05-17
TW201041888A (en) 2010-12-01
AR076749A1 (en) 2011-07-06
RU2011149485A (en) 2013-06-20
PE20120518A1 (en) 2012-05-24
ZA201108124B (en) 2014-04-30
MX2011011737A (en) 2011-12-08
CR20110562A (en) 2012-02-09

Similar Documents

Publication Publication Date Title
ECSP11011437A (en) COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES AND INDICATIONS OF THE SAME
UY31829A (en) COMPOUNDS AND METHODS FOR MODULATION OF KINASES, AND INDICATIONS FOR IT
NI201100168A (en) PYRROLO [2,3-B] PYRIDINE DERIVATIVES FOR THE INHIBITION OF RAF KINASES
CO6551689A2 (en) COMPOUNDS AND METHODS FOR THE MODULATION OF KINASES, AND INDICATORS FOR IT
CR10734A (en) ANTIBODIES AND IMMUNOCATE PLAYERS AND THEIR USES
CL2019000334A1 (en) New antibody conjugates and uses thereof (divisional application 201502357)
CR20120536A (en) COMPOUNDS AND METHODS FOR THE MODULATION OF KINASE AND INDICATIONS OF THE SAME
ECSP088924A (en) ANTIBODIES AND IMMUNOCATE PLAYERS AND THEIR USES
CL2012003075A1 (en) Pharmaceutical composition in pazopanib solution, stable and for ophthalmic use; method for the preparation of said solution.
AR076105A1 (en) PIRROL DERIVATIVES [2,3-B] PIRIDINE TO INHIBIT THE RAF QUINASA
TR201909582T4 (en) Pyrimido [4,5-b] indole derivatives and their use in the expression of hematopoietic stem cells.
HN2005029978A (en) FORMULATIONS
BRPI0912292A2 (en) compositions and methods for the use of cells in the treatment of cardiac tissue.
BRPI1013771A2 (en) "Designed mesenchymal stem cells and method of using them to treat tumors."
TR201907783T4 (en) Benzosulfonamide derivatives, compositions and their use in the prevention of cancer cell metastasis.
RS54525B1 (en) Means and methods for treating dlbcl
EA201590855A1 (en) COMPOUNDS OF PYRROPOLYMIDININE AS KINAZ INHIBITORS
SV2007002813A (en) COMPOUNDS FOR THE MODULATION OF THE ACTIVITY OF THE C-FMS AND / OR THE C-KIT AND ITS APPLICABLE USES
ECSP10010548A (en) COMPOSITIONS AND METHODS OF PREPARATION AND USE OF THE SAME
EA201101522A1 (en) METHODS OF TREATMENT OF DISEASES WITH THE USE OF EPIMETABOLIC SWITCH (COENZIM Q10)
CO6751287A2 (en) Mycobacterial antigenic composition
BRPI0821489A2 (en) Treatment of intervetebral disc degeneration using cells derived from human umbilical cord tissue
MX2009009117A (en) Pyrimidine-2,4-diamine derivatives and their use as jak2 kinase inhibitors.
EA201001695A1 (en) APPLICATION OF EPOTHILON D FOR THE TREATMENT OF DISEASES ASSOCIATED WITH TAU-PROTEIN
DK2252322T3 (en) vaccine Compositions