EA201992188A1 - METHODS AND COMPOSITIONS FOR TREATMENT OF AGING ASSOCIATED DISORDERS USING CCR3 INHIBITORS - Google Patents

METHODS AND COMPOSITIONS FOR TREATMENT OF AGING ASSOCIATED DISORDERS USING CCR3 INHIBITORS

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Publication number
EA201992188A1
EA201992188A1 EA201992188A EA201992188A EA201992188A1 EA 201992188 A1 EA201992188 A1 EA 201992188A1 EA 201992188 A EA201992188 A EA 201992188A EA 201992188 A EA201992188 A EA 201992188A EA 201992188 A1 EA201992188 A1 EA 201992188A1
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EA
Eurasian Patent Office
Prior art keywords
methods
disease
function
compositions
treatment
Prior art date
Application number
EA201992188A
Other languages
Russian (ru)
Inventor
Стивен П. Брайтуэйт
С. Сакура Минами
Кароли Николич
Original Assignee
Алкахест, Инк.
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Publication date
Application filed by Алкахест, Инк. filed Critical Алкахест, Инк.
Priority claimed from PCT/US2018/026131 external-priority patent/WO2018187503A1/en
Publication of EA201992188A1 publication Critical patent/EA201992188A1/en

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

Предложены способы облегчения нейродегенеративного заболевания с применением CCR3-модулирующих агентов. Предложенные способы включают введение субъекту терапевтически эффективного количества CCR3-модулирующего агента с сопутствующим улучшением познавательной функции, двигательной функции или другой функции, нарушенной вследствие нейродегенеративного заболевания. Когнитивные и двигательные заболевания, при которых когнитивная функция может быть улучшена способами по данному изобретению, включают болезнь Альцгеймера, болезнь Паркинсона, лобно-височную деменцию, болезнь Хантингтона, амиотрофический боковой склероз, рассеянный склероз, глаукому, миотоническую дистрофию, сосудистую деменцию, прогрессирующий надъядерный паралич.Methods for alleviating a neurodegenerative disease using CCR3 modulating agents are proposed. The proposed methods include administering to the subject a therapeutically effective amount of a CCR3 modulating agent, with a concomitant improvement in cognitive function, motor function, or other function impaired due to a neurodegenerative disease. Cognitive and motor diseases in which cognitive function can be improved by the methods of this invention include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, glaucoma, myotonic dystrophy, vascular dementia, progressive supranuclear palsy .

EA201992188A 2018-01-23 2018-04-04 METHODS AND COMPOSITIONS FOR TREATMENT OF AGING ASSOCIATED DISORDERS USING CCR3 INHIBITORS EA201992188A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862620921P 2018-01-23 2018-01-23
PCT/US2018/026131 WO2018187503A1 (en) 2017-04-05 2018-04-04 Methods and compositions for treating aging-associated impairments using ccr3-inhibitors

Publications (1)

Publication Number Publication Date
EA201992188A1 true EA201992188A1 (en) 2020-03-23

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Application Number Title Priority Date Filing Date
EA201992188A EA201992188A1 (en) 2018-01-23 2018-04-04 METHODS AND COMPOSITIONS FOR TREATMENT OF AGING ASSOCIATED DISORDERS USING CCR3 INHIBITORS

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EA (1) EA201992188A1 (en)

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