EA201291115A1 - Производные бициклических соединений и их применение в качестве ингибиторов acc - Google Patents

Производные бициклических соединений и их применение в качестве ингибиторов acc

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EA201291115A1
EA201291115A1 EA201291115A EA201291115A EA201291115A1 EA 201291115 A1 EA201291115 A1 EA 201291115A1 EA 201291115 A EA201291115 A EA 201291115A EA 201291115 A EA201291115 A EA 201291115A EA 201291115 A1 EA201291115 A1 EA 201291115A1
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Prior art keywords
derivatives
application
bicyclic compounds
acc inhibitors
diabetes
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EA201291115A
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English (en)
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EA021698B1 (ru
Inventor
Тохру Ямасита
Макото Камата
Хидеки Хиросе
Масатака Мураками
Такуя Фудзимото
Зенити Икеда
Цунео Ясума
Икуо Фудзимори
Рио Мизодзири
Томоя Юкава
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Такеда Фармасьютикал Компани Лимитед
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Publication of EA201291115A1 publication Critical patent/EA201291115A1/ru
Publication of EA021698B1 publication Critical patent/EA021698B1/ru

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Abstract

Изобретение относится к соединению, оказывающему ингибирующее действие на АСС, которое применимо в качестве средства для профилактики или лечения ожирения, диабета, гипертензии, гиперлипидемии, сердечной недостаточности, осложнений диабета, метаболического синдрома, саркопении, рака и т.п. и имеющему превосходную эффективность. Изобретение относится к соединению, представленному формулой (I), где каждый символ соответствует определению, данному в описании.
EA201291115A 2010-04-27 2011-04-26 Производные бициклических соединений и их применение в качестве ингибиторов acc EA021698B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010102718 2010-04-27
PCT/JP2011/060616 WO2011136385A1 (en) 2010-04-27 2011-04-26 Bicyclic compound derivatives and their use as acc inhibitors.

Publications (2)

Publication Number Publication Date
EA201291115A1 true EA201291115A1 (ru) 2013-04-30
EA021698B1 EA021698B1 (ru) 2015-08-31

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US (1) US8703758B2 (ru)
EP (1) EP2563765B1 (ru)
JP (1) JP5693611B2 (ru)
KR (1) KR20130094211A (ru)
CN (1) CN103025716B (ru)
AR (1) AR080969A1 (ru)
AU (1) AU2011246004A1 (ru)
BR (1) BR112012027648A2 (ru)
CA (1) CA2797767A1 (ru)
CO (1) CO6640253A2 (ru)
CR (1) CR20120598A (ru)
EA (1) EA021698B1 (ru)
EC (1) ECSP12012311A (ru)
ES (1) ES2546130T3 (ru)
GE (1) GEP20146178B (ru)
MA (1) MA34245B1 (ru)
NZ (1) NZ603777A (ru)
SG (1) SG185759A1 (ru)
TW (1) TW201206911A (ru)
UA (1) UA108102C2 (ru)
UY (1) UY33354A (ru)
WO (1) WO2011136385A1 (ru)
ZA (1) ZA201208895B (ru)

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JP5693611B2 (ja) 2015-04-01
CO6640253A2 (es) 2013-03-22
MA34245B1 (fr) 2013-05-02
EP2563765B1 (en) 2015-05-27
KR20130094211A (ko) 2013-08-23
EA021698B1 (ru) 2015-08-31
ES2546130T3 (es) 2015-09-18
UA108102C2 (uk) 2015-03-25
CR20120598A (es) 2013-02-19
ZA201208895B (en) 2014-01-29
GEP20146178B (en) 2014-10-10
AU2011246004A1 (en) 2012-11-29
CA2797767A1 (en) 2011-11-03
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UY33354A (es) 2011-12-01
WO2011136385A1 (en) 2011-11-03
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AR080969A1 (es) 2012-05-23
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EP2563765A1 (en) 2013-03-06
NZ603777A (en) 2013-08-30
US20110263562A1 (en) 2011-10-27
US8703758B2 (en) 2014-04-22
CN103025716A (zh) 2013-04-03

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