EA201290481A1 - Способ получения гидрохлорида прасугреля в полиморфной форме в - Google Patents
Способ получения гидрохлорида прасугреля в полиморфной форме вInfo
- Publication number
- EA201290481A1 EA201290481A1 EA201290481A EA201290481A EA201290481A1 EA 201290481 A1 EA201290481 A1 EA 201290481A1 EA 201290481 A EA201290481 A EA 201290481A EA 201290481 A EA201290481 A EA 201290481A EA 201290481 A1 EA201290481 A1 EA 201290481A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pension
- polymorphic form
- hydrochloride
- obtaining hydrochloride
- formula
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000005465 B01AC22 - Prasugrel Substances 0.000 abstract 1
- JALHGCPDPSNJNY-UHFFFAOYSA-N [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4h-thieno[3,2-c]pyridin-2-yl] acetate;hydron;chloride Chemical compound Cl.C1CC=2SC(OC(=O)C)=CC=2CN1C(C=1C(=CC=CC=1)F)C(=O)C1CC1 JALHGCPDPSNJNY-UHFFFAOYSA-N 0.000 abstract 1
- XAKPQERCYXQTOT-UHFFFAOYSA-N acetic acid 2-chloropyridine Chemical compound ClC1=NC=CC=C1.C(C)(=O)O XAKPQERCYXQTOT-UHFFFAOYSA-N 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960004197 prasugrel Drugs 0.000 abstract 1
- DTGLZDAWLRGWQN-UHFFFAOYSA-N prasugrel Chemical compound C1CC=2SC(OC(=O)C)=CC=2CN1C(C=1C(=CC=CC=1)F)C(=O)C1CC1 DTGLZDAWLRGWQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004947 prasugrel hydrochloride Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20090828A CZ2009828A3 (cs) | 2009-12-09 | 2009-12-09 | Zpusob prípravy hydrochloridu 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu hydrochloridu) v polymorfní forme B |
| PCT/CZ2010/000126 WO2011069473A1 (en) | 2009-12-09 | 2010-12-09 | A method for the preparation of prasugrel hydrochloride in polymorphous form b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201290481A1 true EA201290481A1 (ru) | 2013-01-30 |
Family
ID=43769289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290481A EA201290481A1 (ru) | 2009-12-09 | 2010-12-09 | Способ получения гидрохлорида прасугреля в полиморфной форме в |
Country Status (3)
| Country | Link |
|---|---|
| CZ (1) | CZ2009828A3 (cs) |
| EA (1) | EA201290481A1 (cs) |
| WO (1) | WO2011069473A1 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103012427B (zh) * | 2012-11-26 | 2015-07-08 | 天津大学 | 一种普拉格雷盐酸盐乙醇溶剂化物及其制备方法 |
| PL402028A1 (pl) | 2012-12-12 | 2014-06-23 | Instytut Farmaceutyczny | Sposób wytwarzania postaci polimorficznej B chlorowodorku prasugrelu o czystości farmaceutycznej |
| CN105669696B (zh) * | 2014-11-21 | 2019-03-26 | 四川海思科制药有限公司 | 一种盐酸普拉格雷化合物 |
| CN105601643A (zh) * | 2015-12-23 | 2016-05-25 | 山东鲁抗医药股份有限公司 | 高纯度盐酸普拉格雷的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI101150B (fi) | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| DK1298132T3 (da) | 2000-07-06 | 2007-03-12 | Sankyo Co | Hydropyridinderivatsyreadditionssalte |
| TWI392681B (zh) | 2006-04-06 | 2013-04-11 | Daiichi Sankyo Co Ltd | 高純度普拉格雷及其酸加成鹽之製法 |
| US20100204470A1 (en) | 2006-06-27 | 2010-08-12 | Sandoz Ag | method for salt preparation |
| EP2205611A4 (en) | 2007-11-09 | 2012-02-22 | Reddys Lab Ltd Dr | PROCESS FOR THE PRODUCTION OF PRASUGREL AND SALTS AND POLYMERS THEREOF |
| WO2009066326A2 (en) | 2007-11-19 | 2009-05-28 | Msn Laboratories Limited | Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts |
| US20110003847A1 (en) | 2008-02-06 | 2011-01-06 | Helm Ag | Prasugrel Salts with Improved Properties |
-
2009
- 2009-12-09 CZ CZ20090828A patent/CZ2009828A3/cs unknown
-
2010
- 2010-12-09 EA EA201290481A patent/EA201290481A1/ru unknown
- 2010-12-09 WO PCT/CZ2010/000126 patent/WO2011069473A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2009828A3 (cs) | 2011-06-22 |
| WO2011069473A1 (en) | 2011-06-16 |
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