EA200701743A1 - Адъювантная композиция, содержащая фосфат алюминия и 3d-mpl - Google Patents

Адъювантная композиция, содержащая фосфат алюминия и 3d-mpl

Info

Publication number
EA200701743A1
EA200701743A1 EA200701743A EA200701743A EA200701743A1 EA 200701743 A1 EA200701743 A1 EA 200701743A1 EA 200701743 A EA200701743 A EA 200701743A EA 200701743 A EA200701743 A EA 200701743A EA 200701743 A1 EA200701743 A1 EA 200701743A1
Authority
EA
Eurasian Patent Office
Prior art keywords
adjuvant
aluminum phosphate
adjustent
mpl
3d
Prior art date
Application number
EA200701743A
Other languages
English (en)
Other versions
EA012212B1 (ru
Inventor
Дерек О`Хейган
Original Assignee
Новартис Вэксинес Энд Дайэгностикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US65374105P priority Critical
Application filed by Новартис Вэксинес Энд Дайэгностикс, Инк. filed Critical Новартис Вэксинес Энд Дайэгностикс, Инк.
Priority to PCT/GB2006/000557 priority patent/WO2006087563A2/en
Publication of EA200701743A1 publication Critical patent/EA200701743A1/ru
Publication of EA012212B1 publication Critical patent/EA012212B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/38Medical treatment of vector-borne diseases characterised by the agent
    • Y02A50/408Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa
    • Y02A50/411Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria
    • Y02A50/412Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria the medicinal preparation containing antigens or antibodies, e.g. vaccines, antisera

Abstract

Иммуногенная композиция, включающая: (i) антиген; (ii) фосфат алюминия в виде адъюванта и (iii) 3-O-деацилированный монофосфорилированный липид А в виде адъюванта. Компоненты (ii) и (iii) могут также использоваться как адъювантная система. Раскрыты различные признаки композиций, включая то, что по меньшей мере 50% 3-O-деацилированного монофосфорилированного липида А в виде адъюванта должно быть адсорбировано на фосфате алюминия в виде адъюванта. Адъювантная смесь является особенно применимой в случае поверхностного антигена вируса гепатита В.
EA200701743A 2005-02-16 2006-02-16 Адъювантная композиция, содержащая фосфат алюминия и 3d-mpl EA012212B1 (ru)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US65374105P true 2005-02-16 2005-02-16
PCT/GB2006/000557 WO2006087563A2 (en) 2005-02-16 2006-02-16 Adjuvant composition comprising aluminium phosphate and 3d-mpl

Publications (2)

Publication Number Publication Date
EA200701743A1 true EA200701743A1 (ru) 2008-02-28
EA012212B1 EA012212B1 (ru) 2009-08-28

Family

ID=36916823

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701743A EA012212B1 (ru) 2005-02-16 2006-02-16 Адъювантная композиция, содержащая фосфат алюминия и 3d-mpl

Country Status (18)

Country Link
US (1) US20090214592A1 (ru)
EP (1) EP1850871A2 (ru)
JP (1) JP2008530195A (ru)
KR (1) KR20070110513A (ru)
CN (1) CN101146551A (ru)
AP (1) AP200704151A0 (ru)
AU (1) AU2006215419B2 (ru)
BE (1) BE1016991A6 (ru)
BR (1) BRPI0608430A2 (ru)
CA (1) CA2598079A1 (ru)
EA (1) EA012212B1 (ru)
IL (1) IL185346D0 (ru)
MX (1) MX2007009961A (ru)
NO (1) NO20074679L (ru)
NZ (1) NZ560930A (ru)
SG (1) SG160328A1 (ru)
WO (1) WO2006087563A2 (ru)
ZA (1) ZA200707089B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103690945A (zh) * 2005-08-02 2014-04-02 诺华疫苗和诊断有限公司 降低含油佐剂和含表面活性剂抗原之间的干扰
EP1862176A1 (de) * 2006-05-31 2007-12-05 Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH Ein Verfahren zur Herstellung einer Impfzusammensetzung
EP1862177A1 (de) * 2006-06-01 2007-12-05 Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH Ein Verfahren zur Herstellung einer Impfzusammensetzung
SI2097102T1 (sl) * 2006-09-07 2012-09-28 Glaxosmithkline Biolog Sa Kombinirano cepivo, ki ima zmanjšane količine antigena za poliovirus
WO2010099580A1 (en) * 2009-03-05 2010-09-10 Jenny Colleen Mccloskey Treatment of infection
CN102526724B (zh) * 2011-01-14 2015-07-22 四川大学 氢氧化铝凝胶-多糖复合免疫佐剂及其制备方法和用途
CA2843854A1 (en) * 2011-07-01 2013-01-10 The Regents Of The University Of California Herpes virus vaccine and methods of use
CN103330936B (zh) * 2013-07-18 2016-01-27 北京民海生物科技有限公司 一种磷酸铝佐剂原位法制备乙肝疫苗的方法
SG11201607404PA (en) * 2014-03-25 2016-10-28 Government Of The Us Secretary Of The Army Methods for enhancing the immunostimulation potency of aluminum salt-adsorbed vaccines

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707542A (en) * 1983-08-22 1987-11-17 Merck & Co., Inc. Immunogenic HbsAg derived from transformed yeast
GB8508685D0 (en) * 1985-04-03 1985-05-09 Minor P D Peptides
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5084282A (en) * 1990-08-16 1992-01-28 J.C. Steele & Sons Apparatus for forming bricks having a textured edge
DE59100033D1 (de) * 1991-04-26 1993-03-04 Lingl Anlagenbau Verfahren und vorrichtung zum kerben eines tonstrangstueckes.
US6620414B2 (en) * 1992-03-27 2003-09-16 Smithkline Beecham Biologicals (S.A.) Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
CN1087176C (zh) * 1993-03-23 2002-07-10 史密斯克莱·比奇曼生物公司 含有3-o脱酰基单磷酰脂a的疫苗制剂
US6488934B1 (en) * 1995-02-25 2002-12-03 Smithkline Beecham Biologicals S.A. Hepatitis B vaccine
GB9503863D0 (en) * 1995-02-25 1995-04-19 Smithkline Beecham Biolog Vaccine compositions
US20010053365A1 (en) * 1995-04-25 2001-12-20 Smithkline Beecham Biologicals S.A. Vaccines
GB9718901D0 (en) * 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
GB9822714D0 (en) * 1998-10-16 1998-12-09 Smithkline Beecham Sa Vaccines
CN101926993B (zh) * 1998-10-16 2013-12-04 史密丝克莱恩比彻姆生物有限公司 佐剂系统及疫苗
GB9921146D0 (en) * 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
US7030094B2 (en) * 2002-02-04 2006-04-18 Corixa Corporation Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21

Also Published As

Publication number Publication date
JP2008530195A (ja) 2008-08-07
EP1850871A2 (en) 2007-11-07
AU2006215419A1 (en) 2006-08-24
NO20074679L (no) 2007-09-13
US20090214592A1 (en) 2009-08-27
NZ560930A (en) 2011-06-30
WO2006087563A2 (en) 2006-08-24
BRPI0608430A2 (pt) 2009-12-29
AP200704151A0 (en) 2007-10-31
MX2007009961A (es) 2008-01-29
CA2598079A1 (en) 2006-08-24
IL185346D0 (en) 2008-02-09
WO2006087563A3 (en) 2007-03-15
ZA200707089B (en) 2008-11-26
AU2006215419B2 (en) 2012-03-08
EA012212B1 (ru) 2009-08-28
KR20070110513A (ko) 2007-11-19
BE1016991A6 (fr) 2007-11-06
CN101146551A (zh) 2008-03-19
SG160328A1 (en) 2010-04-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU