EA200401484A1 - OLIGO AND POLYSACCHARIDES FOR HEMOSPATIBLE COATING, METHOD FOR THEIR RECEIVING, COATED MEDICAL DEVICE (OPTIONS) AND METHOD FOR DRAWING A HEMOSPATIBLE COVERING ON MEDICAL TYPE - Google Patents

OLIGO AND POLYSACCHARIDES FOR HEMOSPATIBLE COATING, METHOD FOR THEIR RECEIVING, COATED MEDICAL DEVICE (OPTIONS) AND METHOD FOR DRAWING A HEMOSPATIBLE COVERING ON MEDICAL TYPE

Info

Publication number
EA200401484A1
EA200401484A1 EA200401484A EA200401484A EA200401484A1 EA 200401484 A1 EA200401484 A1 EA 200401484A1 EA 200401484 A EA200401484 A EA 200401484A EA 200401484 A EA200401484 A EA 200401484A EA 200401484 A1 EA200401484 A1 EA 200401484A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polysaccharides
hemospatible
oligosaccharides
coating
stents
Prior art date
Application number
EA200401484A
Other languages
Russian (ru)
Other versions
EA016285B1 (en
Inventor
Донато Ди Биаз
Марита Катарина Линсен
Волкер Фауст
Роланд Хоррес
Михель Хофман
Эрика Хофман
Original Assignee
Хемотек Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хемотек Гмбх filed Critical Хемотек Гмбх
Priority claimed from PCT/DE2003/001253 external-priority patent/WO2003094990A1/en
Publication of EA200401484A1 publication Critical patent/EA200401484A1/en
Publication of EA016285B1 publication Critical patent/EA016285B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/18—Use of ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к олигосахаридам и полисахаридам, а также к использованию олигосахаридов и/или полисахаридов, которые содержат сахарное звено N-ацилглюкозамина или N-ацилгалактозамина, для получения гемосовместимых поверхностей, и к способам нанесения на поверхности гемосовместимого покрытия с данными олигосахаридам и и/или полисахаридами, которые имитируют субстанцию обычного биосинтетического предшественника гепарина, гепарансульфатов и хитозана. Кроме того, в изобретении описаны способы получения указанных олигосахаридов и/или полисахаридов и раскрыты различные возможности применения поверхностей с гемосовместимым покрытием. В частности, изобретение относится к применению указанных олигосахаридов и/или полисахаридов на стентах по меньшей мере с одним нанесенным согласно данному изобретению гемосовместимым покрытием, которое содержит антипролиферативный, противовоспалительный и/или антитромботический активный агент, способам изготовления указанных стентов, а также применению данных стентов для предупреждения рестеноза.Международная заявка была опубликована вместе с отчетом о международном поиске.The invention relates to oligosaccharides and polysaccharides, as well as to the use of oligosaccharides and / or polysaccharides that contain the sugar unit N-acylglucosamine or N-atsilgalaktozamina to obtain hemocompatible surfaces, and to methods of applying on the surface of the hemocompatible coating with data oligosaccharides and and / or polysaccharides that mimic the substance of the usual biosynthetic precursor heparin, heparan sulfates and chitosan. In addition, the invention describes methods for producing these oligosaccharides and / or polysaccharides and discloses various possibilities for using surfaces with a hemocompatible coating. In particular, the invention relates to the use of said oligosaccharides and / or polysaccharides on stents with at least one hemocompatible coating applied according to the invention, which contains an antiproliferative, anti-inflammatory and / or antithrombotic active agent, methods of making these stents, as well as the use of these stents for warnings restenosis. The international application was published along with an international search report.

EA200401484A 2002-05-09 2003-04-15 Oligo- and polysaccharides for haemocompatible coating, method for producing thereof, medical device with coating (embodiments) and method for applying haemocompatible coating on a surface of a medical device EA016285B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37867602P 2002-05-09 2002-05-09
DE10221055A DE10221055B4 (en) 2002-05-10 2002-05-10 Compounds for hemocompatible coating of surfaces, process for their preparation and their use
PCT/DE2003/001253 WO2003094990A1 (en) 2002-05-09 2003-04-15 Compounds and method for coating surfaces in a haemocompatible manner

Publications (2)

Publication Number Publication Date
EA200401484A1 true EA200401484A1 (en) 2005-06-30
EA016285B1 EA016285B1 (en) 2012-03-30

Family

ID=29285308

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401484A EA016285B1 (en) 2002-05-09 2003-04-15 Oligo- and polysaccharides for haemocompatible coating, method for producing thereof, medical device with coating (embodiments) and method for applying haemocompatible coating on a surface of a medical device

Country Status (3)

Country Link
KR (2) KR100859995B1 (en)
DE (2) DE10261986B4 (en)
EA (1) EA016285B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2541753C2 (en) * 2009-01-30 2015-02-20 Кордис Корпорейшн Eluting stent with containers

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DE10328815A1 (en) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Coating system for implants to increase tissue compatibility
DE102005040211B4 (en) 2005-08-16 2010-02-11 Maquet Cardiopulmonary Ag Use of nonionic esters in a coating for blood contacting surfaces and medical device
DE102008027133A1 (en) * 2008-05-30 2009-12-03 Ls Medcap Gmbh Fully synthetic albumin analog
DE102008059857A1 (en) * 2008-12-01 2010-06-02 Forschungsinstitut für Leder und Kunststoffbahnen gGmbH Composition, useful e.g. in molded body, medical technology and packaging for industrial purposes, and as cell growth promoting material and matrix material for cell culture, comprises gelatin, and polysaccharide derivatives, as additives
DE102009032119A1 (en) 2009-06-26 2010-12-30 Koslar, Björn H. Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure
DE102010010483B4 (en) * 2010-02-28 2017-02-09 Björn H. Koslar Medical implant
KR101302703B1 (en) 2011-02-28 2013-09-03 부산대학교 산학협력단 Drug eluting stent of graft copolymers composed of poly(3-hydroxyoctanoate) and biodegradable polymer
KR101302698B1 (en) * 2011-02-28 2013-09-03 부산대학교 산학협력단 Drug-eluting stent using block copolymers composed of poly(hydroxyoctanoate) and biodegradable polymer
RU2540468C2 (en) * 2012-11-06 2015-02-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородский государственный университет им. Н.И. Лобачевского"Российская Федерация Method of producing composite biodegradable materials based on chitosan and polylactide
RU2679887C2 (en) * 2015-12-14 2019-02-14 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации Method for obtaining materials for high-hydrophilic coating of hemocompatible membranes
KR102082390B1 (en) 2018-04-04 2020-02-27 울산과학기술원 Bio-sensing apparatus implanted inside the wall of prosthetic vascular
RU2694342C1 (en) * 2018-05-30 2019-07-11 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Aminoalkildeoxy derivative of cellulose, method of its production and agent possessing antiplatelet activity
KR102428696B1 (en) * 2020-10-28 2022-08-03 연세대학교 원주산학협력단 Hemodialysis membrane with improved phosphate adsorption ability and method for manufacturing same

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US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
FI974321A0 (en) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multiple heparinglycosaminoglycans and proteoglycans are used
IT1296581B1 (en) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B NON THROMBOGENIC POLYMERIC MATERIALS AND EXCELLENT COMPATIBILITY WITH ORGANIC FLUIDS AND TISSUES
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WO2000043120A1 (en) * 1999-01-22 2000-07-27 The Dow Chemical Company Surface modified divinylbenzene resin having a hemocompatible coating

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Publication number Priority date Publication date Assignee Title
RU2541753C2 (en) * 2009-01-30 2015-02-20 Кордис Корпорейшн Eluting stent with containers

Also Published As

Publication number Publication date
KR100854985B1 (en) 2008-08-28
DE10221055B4 (en) 2007-10-25
DE10261986A1 (en) 2004-03-18
DE10221055A1 (en) 2003-11-27
KR100859995B1 (en) 2008-09-25
DE10261986B4 (en) 2008-01-31
EA016285B1 (en) 2012-03-30
KR20050012239A (en) 2005-01-31
KR20050012237A (en) 2005-01-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU