EA028595B1 - Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака - Google Patents

Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака Download PDF

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EA028595B1
EA028595B1 EA201491399A EA201491399A EA028595B1 EA 028595 B1 EA028595 B1 EA 028595B1 EA 201491399 A EA201491399 A EA 201491399A EA 201491399 A EA201491399 A EA 201491399A EA 028595 B1 EA028595 B1 EA 028595B1
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molecular weight
low molecular
patient
cancer
weight compound
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EA201491399A
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English (en)
Russian (ru)
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EA201491399A1 (ru
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Игорь Ронинсон
Дональд Си. Портер
Марк Пи. Уэнтланд
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Сенекс Биотекнолоджи Инк.
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Publication of EA201491399A1 publication Critical patent/EA201491399A1/ru
Publication of EA028595B1 publication Critical patent/EA028595B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
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    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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EA201491399A 2012-02-02 2013-02-01 Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака EA028595B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US61/594,023 2012-02-02
US201261673419P 2012-07-19 2012-07-19
US61/673,419 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

Publications (2)

Publication Number Publication Date
EA201491399A1 EA201491399A1 (ru) 2015-04-30
EA028595B1 true EA028595B1 (ru) 2017-12-29

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Application Number Title Priority Date Filing Date
EA201491399A EA028595B1 (ru) 2012-02-02 2013-02-01 Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака
EA201791284A EA032429B1 (ru) 2012-02-02 2013-02-01 Селективные низкомолекулярные ингибиторы cdk8/cdk19 и их применение в качестве агентов для лечения рака

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EA201791284A EA032429B1 (ru) 2012-02-02 2013-02-01 Селективные низкомолекулярные ингибиторы cdk8/cdk19 и их применение в качестве агентов для лечения рака

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US (2) US9321737B2 (enrdf_load_stackoverflow)
EP (2) EP2809324B1 (enrdf_load_stackoverflow)
JP (1) JP6193268B2 (enrdf_load_stackoverflow)
KR (1) KR20150023223A (enrdf_load_stackoverflow)
CN (1) CN104363913B (enrdf_load_stackoverflow)
AU (1) AU2013214783B2 (enrdf_load_stackoverflow)
BR (1) BR112014019052A8 (enrdf_load_stackoverflow)
CL (1) CL2014002062A1 (enrdf_load_stackoverflow)
CO (1) CO7151516A2 (enrdf_load_stackoverflow)
EA (2) EA028595B1 (enrdf_load_stackoverflow)
GE (1) GEP201706688B (enrdf_load_stackoverflow)
MY (1) MY165446A (enrdf_load_stackoverflow)
PH (1) PH12014501862A1 (enrdf_load_stackoverflow)
SG (1) SG11201404596UA (enrdf_load_stackoverflow)
UA (1) UA117342C2 (enrdf_load_stackoverflow)
WO (1) WO2013116786A1 (enrdf_load_stackoverflow)

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