EA013367B1 - Соли и полиморфные формы эффективного антидиабетического соединения - Google Patents
Соли и полиморфные формы эффективного антидиабетического соединения Download PDFInfo
- Publication number
- EA013367B1 EA013367B1 EA200600701A EA200600701A EA013367B1 EA 013367 B1 EA013367 B1 EA 013367B1 EA 200600701 A EA200600701 A EA 200600701A EA 200600701 A EA200600701 A EA 200600701A EA 013367 B1 EA013367 B1 EA 013367B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- polymorphic form
- receptor
- ρρακ
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50847003P | 2003-10-03 | 2003-10-03 | |
PCT/US2004/032552 WO2005033074A2 (en) | 2003-10-03 | 2004-10-04 | Salts and polymorphs of a potent antidiabetic compound |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600701A1 EA200600701A1 (ru) | 2006-10-27 |
EA013367B1 true EA013367B1 (ru) | 2010-04-30 |
Family
ID=34421741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600701A EA013367B1 (ru) | 2003-10-03 | 2004-10-04 | Соли и полиморфные формы эффективного антидиабетического соединения |
Country Status (19)
Country | Link |
---|---|
US (2) | US7223761B2 (ja) |
EP (1) | EP1677797B1 (ja) |
JP (2) | JP5426813B2 (ja) |
KR (1) | KR101156277B1 (ja) |
CN (1) | CN1886134A (ja) |
AT (1) | ATE546142T1 (ja) |
AU (1) | AU2004278416B2 (ja) |
BR (1) | BRPI0414957A (ja) |
CA (1) | CA2540536C (ja) |
DK (1) | DK1677797T3 (ja) |
EA (1) | EA013367B1 (ja) |
ES (1) | ES2386670T3 (ja) |
IL (1) | IL174728A (ja) |
IS (1) | IS8378A (ja) |
MX (1) | MXPA06003313A (ja) |
NO (1) | NO333002B1 (ja) |
NZ (1) | NZ546783A (ja) |
WO (1) | WO2005033074A2 (ja) |
ZA (1) | ZA200602669B (ja) |
Families Citing this family (34)
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US7041691B1 (en) * | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
US6653332B2 (en) | 2000-05-03 | 2003-11-25 | Tularik Inc. | Combination therapeutic compositions and method of use |
US20030171399A1 (en) * | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
BRPI0620268B8 (pt) * | 2005-12-22 | 2021-05-25 | Oakwood Laboratories LLC | composição eficaz como sistema de fornecimento para liberação controlada, seu uso, seu método de fabricação, e método para proteger um agente biologicamente ativo |
DE602007012299D1 (de) * | 2006-09-21 | 2011-03-10 | Piramal Live Science Ltd | Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen |
WO2009111078A2 (en) * | 2008-03-06 | 2009-09-11 | Intekrin Therapeutics, Inc. | Combination of a ppary agonist and a dipeptidyl peptidase-inhibitor for the treatment of diabetes and obesity |
US20100087481A1 (en) * | 2008-10-03 | 2010-04-08 | Lee Kathleen M | Oral pharmaceutical formulations for antidiabetic compounds |
WO2011017488A2 (en) * | 2009-08-05 | 2011-02-10 | Intekrin Therapeutics, Inc. | Combination of a selective ppar-gamma modulator and an incretin for the treatment of diabetes and obesity |
BR112013007469B1 (pt) * | 2010-09-21 | 2020-03-31 | Intekrin Therapeutics, Inc. | Composições farmacêuticas antidiabéticas sólidas, seu uso e método de preparação, método para preparar um produto de granulação e composição precursora farmacêutica |
US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
SG11201505944QA (en) * | 2013-01-30 | 2015-08-28 | Intekrin Therapeutics Inc | PPARγ AGONISTS FOR TREATMENT OF MULTIPLE SCLEROSIS |
EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
WO2017178408A1 (en) | 2016-04-15 | 2017-10-19 | Syngenta Participations Ag | Microbiocidal silicon containing aryl derivatives |
WO2018035446A1 (en) * | 2016-08-18 | 2018-02-22 | Intekrin Therapeutics, Inc. | PPARγ AGONIST FOR TREATMENT OF BLOOD CANCERS |
CN109843292A (zh) * | 2016-08-18 | 2019-06-04 | 因特克林治疗股份有限公司 | 治疗骨疾病的PPARγ激动剂 |
WO2018053040A1 (en) * | 2016-09-13 | 2018-03-22 | Intekrin Therapeutics, Inc. | Treatment of multiple sclerosis with chs-131 |
WO2018136635A1 (en) * | 2017-01-18 | 2018-07-26 | Coherus Biosciences, Inc. | Pparϒ agonist for the treatment of huntington's disease |
CA3058806A1 (en) | 2017-04-03 | 2018-10-11 | Coherus Biosciences Inc. | Ppar.gamma. agonist for treatment of progressive supranuclear palsy |
CN109651208B (zh) * | 2017-10-10 | 2022-01-04 | 中国科学院上海药物研究所 | N-芳基磺酰胺类化合物,其药物组合物及其用途 |
JP2022516509A (ja) | 2018-12-31 | 2022-02-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 非アルコール性脂肪性肝疾患(nafld)を治療するための組成物および方法 |
EP3946336A1 (en) | 2019-04-02 | 2022-02-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
WO2020205024A1 (en) | 2019-04-04 | 2020-10-08 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
US20220193065A1 (en) | 2019-04-04 | 2022-06-23 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
WO2020205023A1 (en) | 2019-04-04 | 2020-10-08 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
EP3946335A1 (en) | 2019-04-04 | 2022-02-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
US20220202804A1 (en) | 2019-05-30 | 2022-06-30 | Coherus Biosciences, Inc. | Compositions and methods to treat cancer |
US20240066020A1 (en) | 2019-10-15 | 2024-02-29 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
WO2022051318A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a thyroid receptor beta agonist |
WO2022051316A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
WO2022051319A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a dpp-4 inhibitor |
WO2022051323A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a ppar agonist |
WO2022051321A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
JP2022104747A (ja) * | 2020-12-29 | 2022-07-11 | 国立研究開発法人国立がん研究センター | 抗ウイルス剤 |
Citations (5)
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US6653332B2 (en) * | 2000-05-03 | 2003-11-25 | Tularik Inc. | Combination therapeutic compositions and method of use |
US6770648B2 (en) * | 1999-06-30 | 2004-08-03 | Tularik Inc. | Compounds for the modulation of PPARγ activity |
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2004
- 2004-10-01 US US10/956,251 patent/US7223761B2/en active Active
- 2004-10-04 EP EP04794053A patent/EP1677797B1/en active Active
- 2004-10-04 DK DK04794053.1T patent/DK1677797T3/da active
- 2004-10-04 ZA ZA200602669A patent/ZA200602669B/en unknown
- 2004-10-04 AU AU2004278416A patent/AU2004278416B2/en not_active Ceased
- 2004-10-04 BR BRPI0414957-2A patent/BRPI0414957A/pt not_active IP Right Cessation
- 2004-10-04 MX MXPA06003313A patent/MXPA06003313A/es active IP Right Grant
- 2004-10-04 JP JP2006534205A patent/JP5426813B2/ja not_active Expired - Fee Related
- 2004-10-04 CN CNA2004800346697A patent/CN1886134A/zh active Pending
- 2004-10-04 ES ES04794053T patent/ES2386670T3/es active Active
- 2004-10-04 KR KR1020067008440A patent/KR101156277B1/ko not_active IP Right Cessation
- 2004-10-04 CA CA2540536A patent/CA2540536C/en active Active
- 2004-10-04 EA EA200600701A patent/EA013367B1/ru not_active IP Right Cessation
- 2004-10-04 NZ NZ546783A patent/NZ546783A/en not_active IP Right Cessation
- 2004-10-04 WO PCT/US2004/032552 patent/WO2005033074A2/en active Application Filing
- 2004-10-04 AT AT04794053T patent/ATE546142T1/de active
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2006
- 2006-03-27 IS IS8378A patent/IS8378A/is unknown
- 2006-04-02 IL IL174728A patent/IL174728A/en active IP Right Review Request
- 2006-05-03 NO NO20061974A patent/NO333002B1/no not_active IP Right Cessation
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2007
- 2007-05-24 US US11/807,208 patent/US8003665B2/en active Active
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2011
- 2011-12-02 JP JP2011264219A patent/JP2012097090A/ja active Pending
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Also Published As
Publication number | Publication date |
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KR101156277B1 (ko) | 2012-07-05 |
CA2540536C (en) | 2013-07-02 |
ATE546142T1 (de) | 2012-03-15 |
JP2007507537A (ja) | 2007-03-29 |
US20050143416A1 (en) | 2005-06-30 |
BRPI0414957A (pt) | 2006-11-07 |
US20070293536A1 (en) | 2007-12-20 |
ZA200602669B (en) | 2007-07-25 |
WO2005033074A3 (en) | 2005-06-16 |
CN1886134A (zh) | 2006-12-27 |
IL174728A0 (en) | 2006-08-20 |
DK1677797T3 (da) | 2012-06-04 |
EA200600701A1 (ru) | 2006-10-27 |
NZ546783A (en) | 2008-11-28 |
KR20060097121A (ko) | 2006-09-13 |
WO2005033074A2 (en) | 2005-04-14 |
EP1677797A4 (en) | 2009-03-25 |
ES2386670T3 (es) | 2012-08-24 |
US8003665B2 (en) | 2011-08-23 |
JP5426813B2 (ja) | 2014-02-26 |
AU2004278416B2 (en) | 2010-04-15 |
IS8378A (is) | 2006-03-27 |
NO333002B1 (no) | 2013-02-11 |
US7223761B2 (en) | 2007-05-29 |
EP1677797B1 (en) | 2012-02-22 |
JP2012097090A (ja) | 2012-05-24 |
EP1677797A2 (en) | 2006-07-12 |
AU2004278416A1 (en) | 2005-04-14 |
CA2540536A1 (en) | 2005-04-14 |
MXPA06003313A (es) | 2006-06-08 |
IL174728A (en) | 2011-06-30 |
NO20061974L (no) | 2006-07-03 |
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