DK3719021T3 - Inhibitors of adapter-associated kinase 1, compositions comprising them and methods of using the same - Google Patents

Inhibitors of adapter-associated kinase 1, compositions comprising them and methods of using the same Download PDF

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Publication number
DK3719021T3
DK3719021T3 DK20177604.4T DK20177604T DK3719021T3 DK 3719021 T3 DK3719021 T3 DK 3719021T3 DK 20177604 T DK20177604 T DK 20177604T DK 3719021 T3 DK3719021 T3 DK 3719021T3
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DK
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Prior art keywords
inhibitors
adapter
compositions
methods
same
Prior art date
Application number
DK20177604.4T
Other languages
Danish (da)
Inventor
Yingzhi Bi
Godwin Kumi
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3719021T3 publication Critical patent/DK3719021T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK20177604.4T 2014-03-17 2015-03-16 Inhibitors of adapter-associated kinase 1, compositions comprising them and methods of using the same DK3719021T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461953976P 2014-03-17 2014-03-17
EP15712026.2A EP3119783B1 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

Publications (1)

Publication Number Publication Date
DK3719021T3 true DK3719021T3 (en) 2022-06-13

Family

ID=52727478

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15712026.2T DK3119783T3 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them and method of their use
DK20177604.4T DK3719021T3 (en) 2014-03-17 2015-03-16 Inhibitors of adapter-associated kinase 1, compositions comprising them and methods of using the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15712026.2T DK3119783T3 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them and method of their use

Country Status (15)

Country Link
US (1) US9682982B2 (en)
EP (2) EP3119783B1 (en)
JP (1) JP6553081B2 (en)
CN (1) CN106103447B (en)
AR (1) AR099766A1 (en)
AU (1) AU2015231672B2 (en)
CA (1) CA2941870C (en)
DK (2) DK3119783T3 (en)
ES (2) ES2821441T3 (en)
HK (1) HK1226065A1 (en)
HU (1) HUE050975T2 (en)
PL (2) PL3119783T3 (en)
PT (2) PT3119783T (en)
TW (1) TW201620911A (en)
WO (1) WO2015142714A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038786T2 (en) * 2012-03-09 2018-11-28 Lexicon Pharmaceuticals Inc PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
ES2678877T3 (en) 2013-10-11 2018-08-20 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CN109369576B (en) * 2018-09-19 2020-11-27 上海凌凯医药科技有限公司 Method for synthesizing 3-methyloxetane-3- (4-nitrophenyl) carbonate
WO2021216441A1 (en) 2020-04-21 2021-10-28 Lexicon Pharmaceuticals, Inc. Aak1 inhibitors for use in treating viral infections
WO2021216454A1 (en) * 2020-04-21 2021-10-28 Lexicon Pharmaceuticals, Inc. 4-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine for use in the the treatment of cov-229e or cov-oc43 coronaviruses infections
WO2023196584A2 (en) * 2022-04-08 2023-10-12 New York University Endocytosis inhibitors and their use for pain treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US8591943B2 (en) * 2009-04-09 2013-11-26 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
WO2011087999A1 (en) * 2010-01-14 2011-07-21 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
MX347917B (en) * 2012-03-09 2017-05-17 Lexicon Pharmaceuticals Inc Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof.
HUE038786T2 (en) * 2012-03-09 2018-11-28 Lexicon Pharmaceuticals Inc PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
AU2013230066A1 (en) * 2012-03-09 2014-09-25 Lexicon Pharmaceuticals, Inc. Inhibition of adaptor associated kinase 1 for the treatment of pain

Also Published As

Publication number Publication date
WO2015142714A1 (en) 2015-09-24
CA2941870C (en) 2022-07-19
ES2821441T3 (en) 2021-04-26
PT3119783T (en) 2020-09-24
AR099766A1 (en) 2016-08-17
HK1226065A1 (en) 2017-09-22
AU2015231672B2 (en) 2019-06-20
CN106103447B (en) 2019-07-16
ES2911388T3 (en) 2022-05-19
AU2015231672A1 (en) 2016-09-15
TW201620911A (en) 2016-06-16
EP3119783B1 (en) 2020-06-24
JP2017507980A (en) 2017-03-23
PL3119783T3 (en) 2021-01-11
EP3119783A1 (en) 2017-01-25
PT3719021T (en) 2022-04-08
US9682982B2 (en) 2017-06-20
CN106103447A (en) 2016-11-09
JP6553081B2 (en) 2019-07-31
HUE050975T2 (en) 2021-01-28
US20160039824A1 (en) 2016-02-11
DK3119783T3 (en) 2020-09-28
CA2941870A1 (en) 2015-09-24
EP3719021A1 (en) 2020-10-07
PL3719021T3 (en) 2022-06-20
EP3719021B1 (en) 2022-03-09

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