DK3585808T3 - Modificerede serpiner til behandlingen af bradykinin formidlet sygdom - Google Patents

Modificerede serpiner til behandlingen af bradykinin formidlet sygdom Download PDF

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Publication number
DK3585808T3
DK3585808T3 DK18711233.9T DK18711233T DK3585808T3 DK 3585808 T3 DK3585808 T3 DK 3585808T3 DK 18711233 T DK18711233 T DK 18711233T DK 3585808 T3 DK3585808 T3 DK 3585808T3
Authority
DK
Denmark
Prior art keywords
serpines
bradykinine
modified
treatment
mediated disease
Prior art date
Application number
DK18711233.9T
Other languages
English (en)
Inventor
Coen Maas
Maat Steven De
Original Assignee
Preclinics Ges Fuer Praeklinische Forschung Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Preclinics Ges Fuer Praeklinische Forschung Mbh filed Critical Preclinics Ges Fuer Praeklinische Forschung Mbh
Application granted granted Critical
Publication of DK3585808T3 publication Critical patent/DK3585808T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK18711233.9T 2017-02-23 2018-02-23 Modificerede serpiner til behandlingen af bradykinin formidlet sygdom DK3585808T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17157527 2017-02-23
PCT/EP2018/054490 WO2018154044A1 (en) 2017-02-23 2018-02-23 Modified serpins for the treatment of bradykinin-mediated disease

Publications (1)

Publication Number Publication Date
DK3585808T3 true DK3585808T3 (da) 2022-01-31

Family

ID=58162468

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18711233.9T DK3585808T3 (da) 2017-02-23 2018-02-23 Modificerede serpiner til behandlingen af bradykinin formidlet sygdom

Country Status (4)

Country Link
US (2) US11851474B2 (da)
EP (1) EP3585808B1 (da)
DK (1) DK3585808T3 (da)
WO (1) WO2018154044A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201322091D0 (en) * 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
CN112315897A (zh) * 2020-11-04 2021-02-05 深圳前海鹰岗生物科技有限公司 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法
EP4052723A1 (en) * 2021-03-02 2022-09-07 Grifols Worldwide Operations Limited Alpha-1 antitrypsin dosing regimen
CN113917154B (zh) * 2021-09-22 2023-11-24 北京松果天目健康管理有限公司 尿蛋白标志物在制备糖尿病肾病临床早期检测的试剂盒中的应用
CN116549599A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 激肽及其衍生物在治疗vci、psci或csvd中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
FR2599752B1 (fr) 1986-06-10 1989-11-03 Transgene Sa Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
WO2001035965A1 (en) * 1999-11-18 2001-05-25 Bolla John D Treatment of rosacea
AU2005206806A1 (en) * 2004-01-09 2005-08-04 University Of Utah Research Foundation Methods of using high affinity ATIII variants
WO2006090282A2 (en) 2005-02-28 2006-08-31 Universite De Lausanne Recombinant inhibitor proteins of an hk14 protease and use thereof
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
EP2238984A1 (en) * 2009-04-08 2010-10-13 Institut National De La Recherche Agronomique (Inra) Caspasin inhibitor peptides
US8557961B2 (en) * 2010-04-02 2013-10-15 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
GB201322091D0 (en) * 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders

Also Published As

Publication number Publication date
WO2018154044A1 (en) 2018-08-30
US20200010533A1 (en) 2020-01-09
EP3585808B1 (en) 2021-11-10
US11851474B2 (en) 2023-12-26
US20240132573A1 (en) 2024-04-25
EP3585808A1 (en) 2020-01-01

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