DK3017827T3 - Pneumokok-polysaccharidkonjugat-vaccine - Google Patents
Pneumokok-polysaccharidkonjugat-vaccine Download PDFInfo
- Publication number
- DK3017827T3 DK3017827T3 DK15195398.1T DK15195398T DK3017827T3 DK 3017827 T3 DK3017827 T3 DK 3017827T3 DK 15195398 T DK15195398 T DK 15195398T DK 3017827 T3 DK3017827 T3 DK 3017827T3
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- DK
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- Prior art keywords
- saccharide
- protein
- immunogenic composition
- paragraph
- vaccine
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- A—HUMAN NECESSITIES
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- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A61K2039/6068—Other bacterial proteins, e.g. OMP
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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- A61K2039/70—Multivalent vaccine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (13)
1. Immunogen sammensætning omfattende S. pneumoniae-kapselsaccharidkonjugater fra serotyper 19A og 19F, hvor 19A er konjugeret til et første bakterielt toxoid, som er pneumolysin, difteritoxoid eller CRM197, og 19F er konjugeret til et andet bakterielt toxoid, der er difteritoxoid eller CRM197, og yderligere omfattende kon-jugater af S. pneamon/'ae-kapselsaccharider 4, 6B, 9V, 14, 18C, 23F, 1, 5 og 7F, hvor gennemsnitsstørrelsen af 19A-saccharidet er mellem 110 og 700 kDa.
2. Immunogen sammensætning ifølge krav 1, der yderligere omfatter et konjugat af S. pneamon/'ae-kapselsaccharid 22F.
3. Immunogen sammensætning ifølge et hvilket som helst af de foregående krav, hvor gennemsnitsstørrelsen af 19A-saccharidet er mellem 110-300, 120-200, 130-180 eller 140-160 kDa.
4. Immunogen sammensætning ifølge et hvilket som helst af de foregående krav, hvor 19A-saccharidet er blevet dimensioneret med en faktor på ikke mere end x5.
5. Immunogen sammensætning ifølge et hvilket som helst af de foregående krav, hvor 19A-saccharidet er blevet dimensioneret ved mikrofluidisering.
6. Immunogen sammensætning ifølge et hvilket som helst af de foregående krav, hvor gennemsnitsstørrelsen af sacchariderne er over 50 kDa.
7. Immunogen sammensætning ifølge krav 6, som omfatter serotype 1 med en gennemsnitlig saccharidstørrelse på mellem 300 og 400 kDa.
8. Immunogen sammensætning ifølge krav 6 og 7, som omfatter serotype 5 med en gennemsnitlig saccharidstørrelse på mellem 350 og 450 kDa.
9. Immunogen sammensætning ifølge et hvilket som helst af kravene 6 til 8, som omfatter serotype 7F med en gennemsnitlig saccharidstørrelse på mellem 200 og 300 kDa.
10. Vaccine omfattende den immunogene sammensætning ifølge et hvilket som helst af kravene 1 til 9 og et farmaceutisk acceptabelt excipiens.
11. Fremgangsmåde til fremstilling af vaccinen ifølge krav 10, omfattende trinnet at blande den immunogene sammensætning ifølge et hvilket som helst af kravene 1 til 9 med en farmaceutisk acceptabel excipiens.
12. Immunogen sammensætning ifølge krav 1-9 eller vaccinen ifølge krav 10 til anvendelse i behandling eller forebyggelse af sygdom forårsaget af Streptococcus pneumo-n/'ae-infektion.
13. Immunogen sammensætning ifølge krav 1-9 eller vaccinen ifølge krav 10 til anvendelse i behandling eller forebyggelse af sygdom forårsaget af Streptococcus pneumo-n/'ae-infektion ifølge krav 12, hvor sygdommen er enten eller både lungebetændelse og invasiv pneumokok-sygdom (IPS) hos ældre mennesker, eksacerbationer af kronisk ob-struktiv lungesygdom (KOL) hos ældre mennesker, otitis media hos spædbørn, meningitis og/eller bakteriæmi hos spædbørn, eller lungebetændelse og/eller konjunktivitis hos spædbørn.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0526232A GB0526232D0 (en) | 2005-12-22 | 2005-12-22 | Vaccine |
GBGB0607088.2A GB0607088D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0607087A GB0607087D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0609902A GB0609902D0 (en) | 2006-05-18 | 2006-05-18 | Novel composition |
GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620815A GB0620815D0 (en) | 2006-10-19 | 2006-10-19 | Vaccine |
GB0620816A GB0620816D0 (en) | 2006-10-19 | 2006-10-19 | vaccine |
PCT/GB2006/004634 WO2007068907A2 (en) | 2005-12-13 | 2006-12-12 | Vaccine compositions comprising a saponin adjuvant |
EP06830744.6A EP1973564B1 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
Publications (1)
Publication Number | Publication Date |
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DK3017827T3 true DK3017827T3 (da) | 2019-02-18 |
Family
ID=39133667
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10192663.2T DK2384765T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine mod Streptococcus pneumoniae. |
DK06830744.6T DK1973564T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine omfattende streptococcus pneumoniae-kapselpolysaccharidkonjugat |
DK15195398.1T DK3017827T3 (da) | 2005-12-22 | 2006-12-20 | Pneumokok-polysaccharidkonjugat-vaccine |
DK06830743.8T DK1962899T3 (da) | 2005-12-22 | 2006-12-20 | Pneumococcus-polysaccharid-konjugat-vaccine |
DK06841492.9T DK1968631T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10192663.2T DK2384765T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine mod Streptococcus pneumoniae. |
DK06830744.6T DK1973564T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine omfattende streptococcus pneumoniae-kapselpolysaccharidkonjugat |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06830743.8T DK1962899T3 (da) | 2005-12-22 | 2006-12-20 | Pneumococcus-polysaccharid-konjugat-vaccine |
DK06841492.9T DK1968631T3 (da) | 2005-12-22 | 2006-12-20 | Vaccine |
Country Status (37)
Country | Link |
---|---|
US (10) | US20090010959A1 (da) |
EP (10) | EP3130348A1 (da) |
JP (7) | JP5461838B2 (da) |
KR (5) | KR101418240B1 (da) |
CN (6) | CN110179974B (da) |
AR (3) | AR058592A1 (da) |
AT (1) | ATE520415T1 (da) |
AU (4) | AU2006327036B2 (da) |
BR (3) | BRPI0620460B8 (da) |
CA (5) | CA2634885C (da) |
CL (1) | CL2013002106A1 (da) |
CR (2) | CR10119A (da) |
CY (5) | CY1112677T1 (da) |
DK (5) | DK2384765T3 (da) |
EA (3) | EA014649B1 (da) |
ES (4) | ES2707499T3 (da) |
HK (1) | HK1120230A1 (da) |
HR (4) | HRP20110685T1 (da) |
HU (3) | HUE041979T2 (da) |
IL (5) | IL191913A (da) |
JO (1) | JO2813B1 (da) |
LT (3) | LT1973564T (da) |
MA (3) | MA30066B1 (da) |
MX (2) | MX2008008140A (da) |
MY (4) | MY148141A (da) |
NO (4) | NO346529B1 (da) |
NZ (4) | NZ569076A (da) |
PE (2) | PE20071305A1 (da) |
PH (1) | PH12014502544A1 (da) |
PL (5) | PL1968631T3 (da) |
PT (5) | PT1968631E (da) |
SG (1) | SG168517A1 (da) |
SI (5) | SI1962899T1 (da) |
TR (1) | TR201900418T4 (da) |
TW (4) | TW201350129A (da) |
UA (2) | UA96583C2 (da) |
WO (3) | WO2007071707A2 (da) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA011480B1 (ru) * | 2000-06-29 | 2009-04-28 | Глаксосмитклайн Байолоджикалс С.А. | Поливалентная вакцинная композиция |
JP4164361B2 (ja) * | 2000-11-07 | 2008-10-15 | イムノワクチン テクノロジーズ インコーポレーテッド | 増強した免疫応答を有するワクチン、およびその調製方法 |
US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
ES2382048T3 (es) | 2005-04-08 | 2012-06-04 | Wyeth Llc | Composición conjugada de proteína-polisacárido neumococico multivante |
ES2898451T3 (es) | 2005-06-27 | 2022-03-07 | Pfizer Ireland Pharmaceuticals | Composición inmunogénica |
MX2008008140A (es) | 2005-12-22 | 2008-09-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacarido capsular de streptococcus pneumonia. |
WO2008022298A2 (en) * | 2006-08-17 | 2008-02-21 | The Uab Research Foundation | Immunogenic pcpa polypeptides and uses thereof |
US8398985B2 (en) * | 2007-04-23 | 2013-03-19 | Serum Institute Of India Ltd. | Antigenic polysaccharides and process for their preparation |
EP2142211A1 (en) | 2007-05-02 | 2010-01-13 | GlaxoSmithKline Biologicals S.A. | Vaccine |
CN101784282B (zh) * | 2007-06-26 | 2015-07-08 | 葛兰素史密丝克莱恩生物有限公司 | 包含肺炎链球菌荚膜多糖缀合物的疫苗 |
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