DK2847228T3 - Antistoffer, som kan binde til koagulationsfaktor xi og/eller dens aktiverede form faktor xia, og anvendelser deraf - Google Patents
Antistoffer, som kan binde til koagulationsfaktor xi og/eller dens aktiverede form faktor xia, og anvendelser deraf Download PDFInfo
- Publication number
- DK2847228T3 DK2847228T3 DK13721746.9T DK13721746T DK2847228T3 DK 2847228 T3 DK2847228 T3 DK 2847228T3 DK 13721746 T DK13721746 T DK 13721746T DK 2847228 T3 DK2847228 T3 DK 2847228T3
- Authority
- DK
- Denmark
- Prior art keywords
- ser
- gly
- thr
- leu
- gin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Claims (11)
1. Humant monoklonalt antistof, som kan binde til faktor Xla (FXIa) , og antigenbindende fragmenter deraf, der omfatter SEQ ID NO: 19 for aminosyresekvensen for det variable lette kædedomæne, og SEQ ID NO: 20 for aminosyresekvensen for den variable tunge kæde.
2. Humant monoklonalt antistof, som kan binde til faktor Xla, og antigenbindende fragmenter deraf, der som CDRH1 omfatter SEQ ID NO: 21, som CDRH2 SEQ ID NO: 22 og som CDRH3 SEQ ID NO: 23 og som CDRL1 SEQ ID NO: 24, som CDRL2 SEQ ID NO: 25 og som CDRL3 SEQ ID NO: 26.
3. Humant monoklonalt antistof, som kan binde til FXIa, og antigenbindende fragmenter deraf, der omfatter SEQ ID NO: 27 for aminosyresekvensen for det variable lette kæde-domæne, og SEQ ID NO: 20 for aminosyresekvensen for det variable tunge kæde-domæne.
4. Humant monoklonalt antistof, som kan binde til FXIa, og antigenbindende fragmenter deraf, der som CDRH1 omfatter SEQ ID NO: 21, som CDRH2 SEQ ID NO: 22 og som CDRH3 SEQ ID NO: 23 og som CDRL1 SEQ ID NO: 24, som CDRL2 SEQ ID NO: 25 og som CDRL3 SEQ ID NO: 28.
5. Farmaceutisk præparat, der omfatter et antistof ifølge et af kravene 1 til 4.
6. Lægemiddel, der omfatter et antistof ifølge et af kravene 1 til 4.
7. Nukleinsyre, der koder for et antistof ifølge krav 1 til 4 .
8. Vektor, der omfatter en nukleinsyre ifølge krav 7.
9. Værtscelle, der omfatter en vektor ifølge krav 8.
10. Fremgangsmåde til anvendelse af en værtscelle ifølge krav 8 til fremstilling af et antistof ifølge et hvilket som helst af kravene 1 til 4, hvilken fremgangsmåde omfatter dyrkning af værtscellen under egnede betingelser og udvinding af antistoffet.
11. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 4 til anvendelse ved behandling og/eller profylakse af en koagulationsrelateret sygdom hos mennesker eller dyr.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167438 | 2012-05-10 | ||
| EP12181697 | 2012-08-24 | ||
| EP13150361 | 2013-01-07 | ||
| US201361817675P | 2013-04-30 | 2013-04-30 | |
| PCT/EP2013/059618 WO2013167669A1 (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2847228T3 true DK2847228T3 (da) | 2018-11-19 |
Family
ID=49550177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13721746.9T DK2847228T3 (da) | 2012-05-10 | 2013-05-08 | Antistoffer, som kan binde til koagulationsfaktor xi og/eller dens aktiverede form faktor xia, og anvendelser deraf |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US9783614B2 (da) |
| EP (2) | EP2847228B1 (da) |
| JP (2) | JP6348900B2 (da) |
| KR (1) | KR102060376B1 (da) |
| CN (1) | CN104684932B (da) |
| AR (1) | AR091024A1 (da) |
| AU (2) | AU2013258043B2 (da) |
| BR (1) | BR112014027952B1 (da) |
| CA (1) | CA2872926C (da) |
| DK (1) | DK2847228T3 (da) |
| ES (1) | ES2698950T3 (da) |
| HK (1) | HK1207091A1 (da) |
| HR (1) | HRP20181680T1 (da) |
| HU (1) | HUE040580T2 (da) |
| IL (1) | IL235238B (da) |
| LT (1) | LT2847228T (da) |
| MX (1) | MX362454B (da) |
| NZ (1) | NZ701121A (da) |
| PL (1) | PL2847228T3 (da) |
| RS (1) | RS57889B1 (da) |
| SG (2) | SG11201406719UA (da) |
| SI (1) | SI2847228T1 (da) |
| TW (2) | TWI631140B (da) |
| WO (1) | WO2013167669A1 (da) |
| ZA (1) | ZA201407784B (da) |
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| HUE042940T2 (hu) | 2008-12-18 | 2019-07-29 | Univ Oregon Health & Science | Anti-FXI antitestek és alkalmazási eljárások |
| EP2766347B1 (en) | 2011-10-14 | 2016-05-04 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9108951B2 (en) | 2011-10-14 | 2015-08-18 | Bristol-Myers Squibb Company | Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors |
| PE20141825A1 (es) | 2011-10-14 | 2014-11-29 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor xia |
| CN104684932B (zh) | 2012-05-10 | 2019-03-12 | 拜耳药业股份公司 | 能够结合凝血因子XI和/或其活化形式因子XIa的抗体及其用途 |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| WO2014059203A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Crystalline forms of a factor xia inhibitor |
| ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
| CN116987080A (zh) | 2014-01-31 | 2023-11-03 | 百时美施贵宝公司 | 作为因子xia抑制剂的具有杂环p2′基团的大环化合物 |
| NO2760821T3 (da) | 2014-01-31 | 2018-03-10 | ||
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| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
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| CN103649093B (zh) | 2011-05-06 | 2017-07-07 | 拜耳知识产权有限责任公司 | 取代的咪唑并吡啶和咪唑并哒嗪及其用途 |
| WO2013030138A1 (en) | 2011-09-01 | 2013-03-07 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| WO2013030288A1 (de) | 2011-09-02 | 2013-03-07 | Bayer Intellectual Property Gmbh | Substituierte annellierte pyrimidine und ihre verwendung |
| CN104684932B (zh) * | 2012-05-10 | 2019-03-12 | 拜耳药业股份公司 | 能够结合凝血因子XI和/或其活化形式因子XIa的抗体及其用途 |
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