DK2755963T3 - New dihydroquinolin-2-one derivatives - Google Patents

New dihydroquinolin-2-one derivatives Download PDF

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Publication number
DK2755963T3
DK2755963T3 DK12756741.0T DK12756741T DK2755963T3 DK 2755963 T3 DK2755963 T3 DK 2755963T3 DK 12756741 T DK12756741 T DK 12756741T DK 2755963 T3 DK2755963 T3 DK 2755963T3
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DK
Denmark
Prior art keywords
dihydroquinolin
derivatives
new
Prior art date
Application number
DK12756741.0T
Other languages
Danish (da)
Inventor
Johannes Aebi
Kurt Amrein
Benoit Hornsperger
Henner Knust
Bernd Kuhn
Yongfu Liu
Hans P Maerki
Peter Mohr
Xuefei Tan
Mingwei Zhou
Alexander V Mayweg
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN2011079673 priority Critical
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to PCT/EP2012/067744 priority patent/WO2013037779A1/en
Application granted granted Critical
Publication of DK2755963T3 publication Critical patent/DK2755963T3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
DK12756741.0T 2011-09-15 2012-09-12 New dihydroquinolin-2-one derivatives DK2755963T3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2011079673 2011-09-15
PCT/EP2012/067744 WO2013037779A1 (en) 2011-09-15 2012-09-12 New dihydroquinoline-2-one derivatives

Publications (1)

Publication Number Publication Date
DK2755963T3 true DK2755963T3 (en) 2020-01-13

Family

ID=46829775

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12756741.0T DK2755963T3 (en) 2011-09-15 2012-09-12 New dihydroquinolin-2-one derivatives

Country Status (32)

Country Link
US (1) US9260408B2 (en)
EP (2) EP3653618A1 (en)
JP (1) JP6012735B2 (en)
KR (1) KR101785143B1 (en)
CN (1) CN103814021B (en)
AR (1) AR087901A1 (en)
AU (1) AU2012307509B2 (en)
BR (1) BR112014006283A2 (en)
CA (1) CA2846785A1 (en)
CL (1) CL2014000604A1 (en)
CO (1) CO6890099A2 (en)
CR (1) CR20140091A (en)
DK (1) DK2755963T3 (en)
EA (1) EA035757B1 (en)
EC (1) ECSP14013245A (en)
ES (1) ES2763332T3 (en)
HR (1) HRP20192323T1 (en)
HU (1) HUE047771T2 (en)
IL (1) IL231229D0 (en)
LT (1) LT2755963T (en)
MX (1) MX358376B (en)
NZ (1) NZ621599A (en)
PE (1) PE20141372A1 (en)
PL (1) PL2755963T3 (en)
PT (1) PT2755963T (en)
RS (1) RS59737B1 (en)
SG (1) SG11201400679WA (en)
SI (1) SI2755963T1 (en)
TW (1) TWI462914B (en)
UA (1) UA111626C2 (en)
WO (1) WO2013037779A1 (en)
ZA (1) ZA201401884B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015020834A2 (en) * 2013-03-08 2017-07-18 Hoffmann La Roche new hydroquinoline-2-one derivatives as aldosterone synthetase inhibitors (cyp1 1 b2 or cyp1 1 b1)
RU2015138961A (en) 2013-03-14 2017-04-18 Ф. Хоффманн-Ля Рош Аг Dihydrochinolin-2-one derivatives for use as aldosterosynthase inhibitors
US9682983B2 (en) 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
CN105073732B (en) * 2013-03-14 2017-07-21 豪夫迈·罗氏有限公司 The ketone derivatives of EEDQ 2 as aldosterone synthase inhibitors
US9181272B2 (en) 2013-04-30 2015-11-10 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors
BR112015029696A2 (en) * 2013-05-27 2017-07-25 Hoffmann La Roche new compounds of 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one
JP6416230B2 (en) 2013-05-27 2018-10-31 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Novel 3,4-dihydro-2H-isoquinolin-1-one and 2,3-dihydro-isoindol-1-one compounds
AR096424A1 (en) * 2013-05-27 2015-12-30 F Hoffmann-La Roche Ag Compounds of 3,4-dihydro-2H-isoquinolin-1-one and 2,3-dihydro-isoindol-1-one
WO2015125858A1 (en) * 2014-02-24 2015-08-27 日本曹達株式会社 Heteroaryl compound and application thereof
EP3122355A4 (en) * 2014-03-26 2017-08-09 The Brigham and Women's Hospital, Inc. Compositions and methods for inhibiting bmp
ES2774430T3 (en) 2014-04-24 2020-07-21 Mitsubishi Tanabe Pharma Corp Novel Disubstituted 1,2,4-Triazine Compound
WO2016011019A1 (en) 2014-07-15 2016-01-21 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting bmp
WO2016066663A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors
CN106604917A (en) * 2014-10-31 2017-04-26 豪夫迈·罗氏有限公司 New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors
RU2723480C2 (en) 2015-08-31 2020-06-11 Тон-А Сосио Холдингз Ко., Лтд. Heteroaryl compounds and use thereof as therapeutic drugs
JP6314196B2 (en) * 2015-10-22 2018-04-18 田辺三菱製薬株式会社 Pharmaceutical composition
US20180312503A1 (en) * 2015-10-23 2018-11-01 Mitsubishi Tanabe Pharma Corporation Novel nitrogen-containing aromatic heterocyclic compound
WO2018071343A1 (en) * 2016-10-10 2018-04-19 Dong-A Socio Holdings Co., Ltd. Heteroaryl compounds and their use as mer inhibitors

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
GB8334282D0 (en) * 1983-12-22 1984-02-01 Pfizer Ltd Quinolone inotropic agents
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
CN85100796A (en) * 1985-04-01 1986-10-01 辉瑞公司 The preparation method of qualone derivative
FR2580646A1 (en) * 1985-04-19 1986-10-24 Synthelabo 2(1H)-Quinolinone derivatives, their preparation and their application in therapeutics
EP1874753A2 (en) 2005-04-14 2008-01-09 Smithkline Beecham Corporation Compounds, compositions and methods
DE102008022221A1 (en) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitors of human aldosterone synthase CYP11B2
MX2011012199A (en) 2009-05-15 2011-12-08 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors.
PE20120403A1 (en) 2009-05-15 2012-05-03 Novartis Ag Aryl pyridines as inhibitors of aldosterone synthase
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2

Also Published As

Publication number Publication date
MX2014002770A (en) 2014-06-05
PT2755963T (en) 2020-01-10
IL231229D0 (en) 2014-04-30
KR20140067121A (en) 2014-06-03
RS59737B1 (en) 2020-02-28
PE20141372A1 (en) 2014-10-13
CL2014000604A1 (en) 2014-10-17
CN103814021B (en) 2016-12-21
US20130072679A1 (en) 2013-03-21
BR112014006283A2 (en) 2017-04-11
EA201490596A1 (en) 2014-07-30
US9260408B2 (en) 2016-02-16
CO6890099A2 (en) 2014-03-10
SI2755963T1 (en) 2020-01-31
JP6012735B2 (en) 2016-10-25
WO2013037779A1 (en) 2013-03-21
JP2014527077A (en) 2014-10-09
EP2755963A1 (en) 2014-07-23
NZ621599A (en) 2016-07-29
AU2012307509A1 (en) 2014-03-13
UA111626C2 (en) 2016-05-25
AU2012307509B2 (en) 2017-06-29
CA2846785A1 (en) 2013-03-21
HUE047771T2 (en) 2020-05-28
SG11201400679WA (en) 2014-04-28
EP3653618A1 (en) 2020-05-20
MX358376B (en) 2018-08-16
PL2755963T3 (en) 2020-07-27
CN103814021A (en) 2014-05-21
EP2755963B1 (en) 2019-10-30
LT2755963T (en) 2020-01-27
CR20140091A (en) 2014-06-03
KR101785143B1 (en) 2017-10-12
TWI462914B (en) 2014-12-01
HRP20192323T1 (en) 2020-03-20
TW201315724A (en) 2013-04-16
AR087901A1 (en) 2014-04-23
ES2763332T3 (en) 2020-05-28
ECSP14013245A (en) 2014-07-31
ZA201401884B (en) 2019-11-27
EA035757B1 (en) 2020-08-05

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