DK2624815T3 - Oral vaccine i hurtigt opløsende doseringsform under anvendelse af stivelse - Google Patents
Oral vaccine i hurtigt opløsende doseringsform under anvendelse af stivelse Download PDFInfo
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- DK2624815T3 DK2624815T3 DK11779263.0T DK11779263T DK2624815T3 DK 2624815 T3 DK2624815 T3 DK 2624815T3 DK 11779263 T DK11779263 T DK 11779263T DK 2624815 T3 DK2624815 T3 DK 2624815T3
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Claims (15)
1. Hurtigt opløsende oral fast vaccinedoseringsform omfattende: (a) en immunogen mængde af et antigenpræparat; og (b) i det mindste ét immunreaktionsforstærkende matrixdannende middel, hvor det i det mindste ene immunreaktionsforstærkende matrixdannende middel er en stivelse, og hvor doseringsformen fremmer mundhuleoptagelse af et antigen i antigenpræparatet.
2. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, hvor stivelsen foreligger i en mængde på 2 til 90 vægt%.
3. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, hvor doseringsformen desintegrerer indenfor 10 sekunder efter anbringelse i mundhulen.
4. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, fremstillet ved frysetørring.
5. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, som yderligere omfatter i det mindste ét yderligere matrixdannende middel.
6. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 5, hvor det i det mindste ene yderligere matrixdannende middel er mannitol.
7. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 6, hvor det i det mindste ene yderligere matrixdannende middel yderligere omfatter gelatine.
8. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 7, hvor gelatinen foreligger i en mængde på 2,5 til 65 vægt%; mannitolet foreligger i en mængde på 5 til 80 vægt%; og stivelsen foreligger i en mængde på 5 til 80 vægt%.
9. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 8, hvor gelatinen foreligger i en mængde på 3 til 55 vægt%, mannitolet foreligger i en mængde på 7 til 65 vægt% og stivelsen foreligger i en mængde på 7 til 75 vægt%.
10. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, som yderligere omfatter i det mindste ét yderligere matrixdannende middel valgt fra gruppen bestående af gummier.
11. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, som yderligere omfatter et overfladeaktivt stof.
12. Hurtigt opløsende oral fast vaccinedoseringsform ifølge krav 1, som er konfigureret til at udløse en immunreaktion ved indgivelse til en patient ved placering i mundhulen.
13. Fremgangsmåde til inducering afen immunreaktion i en patient, hvilken fremgangsmåde omfatter følgende trin: anbringelse af den hurtigt opløsende orale faste vaccinedoseringsform ifølge ethvert af kravene 1-12 i mundhulen på en person, som har behov for immunreaktionen.
14. Fremgangsmåde til inducering af en immunreaktion i en patient ifølge krav 13, hvor fremgangsmåden inducerer en influenzaspecifik antistofreaktion.
15. Fremgangsmåde til inducering af en influenzaspecifik antistofreaktion i en patient ifølge krav 14, hvor anbringelsen i mundhulen er anbringelse på eller under tungen eller i kind- eller svælgområdet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39123810P | 2010-10-08 | 2010-10-08 | |
| PCT/US2011/055689 WO2012048333A1 (en) | 2010-10-08 | 2011-10-11 | Oral vaccine fast-dissolving dosage form using starch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2624815T3 true DK2624815T3 (da) | 2016-11-07 |
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Family Applications (2)
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| DK16178493.9T DK3095441T3 (da) | 2010-10-08 | 2011-10-11 | Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse |
| DK11779263.0T DK2624815T3 (da) | 2010-10-08 | 2011-10-11 | Oral vaccine i hurtigt opløsende doseringsform under anvendelse af stivelse |
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| Application Number | Title | Priority Date | Filing Date |
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| DK16178493.9T DK3095441T3 (da) | 2010-10-08 | 2011-10-11 | Hurtigt opløsende doseringsform af en oral vaccine under anvendelse af stivelse |
Country Status (18)
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| US (1) | US9956169B2 (da) |
| EP (2) | EP2624815B8 (da) |
| JP (2) | JP6061859B2 (da) |
| KR (1) | KR101751964B1 (da) |
| CN (2) | CN103347494A (da) |
| AR (1) | AR083361A1 (da) |
| AU (1) | AU2011312107B2 (da) |
| BR (1) | BR112013009255B1 (da) |
| CA (1) | CA2813146C (da) |
| DK (2) | DK3095441T3 (da) |
| ES (2) | ES2602506T3 (da) |
| HK (1) | HK1253541A1 (da) |
| HU (1) | HUE052853T2 (da) |
| MX (1) | MX347101B (da) |
| PL (1) | PL3095441T3 (da) |
| PT (1) | PT3095441T (da) |
| RU (2) | RU2639447C2 (da) |
| WO (1) | WO2012048333A1 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2602506T3 (es) * | 2010-10-08 | 2017-02-21 | R.P. Scherer Technologies, Llc | Forma de dosificación de disolución rápida de una vacuna oral usando almidón |
| US11033493B2 (en) | 2013-12-02 | 2021-06-15 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| US9668970B2 (en) * | 2013-12-02 | 2017-06-06 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| US10272038B2 (en) | 2013-12-02 | 2019-04-30 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| TWI745278B (zh) * | 2014-10-10 | 2021-11-11 | 以色列商艾畢克生物實驗有限公司 | 發泡性降低之疫苗組合物 |
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