DK260386A - Pyrimidinderivater samt deres anvendelse som laegemidler - Google Patents

Pyrimidinderivater samt deres anvendelse som laegemidler Download PDF

Info

Publication number
DK260386A
DK260386A DK260386A DK260386A DK260386A DK 260386 A DK260386 A DK 260386A DK 260386 A DK260386 A DK 260386A DK 260386 A DK260386 A DK 260386A DK 260386 A DK260386 A DK 260386A
Authority
DK
Denmark
Prior art keywords
medicines
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
DK260386A
Other languages
English (en)
Other versions
DK260386D0 (da
Inventor
Karnail S Atwal
George C Rovnyak
Spenser D Kimball
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DK260386D0 publication Critical patent/DK260386D0/da
Publication of DK260386A publication Critical patent/DK260386A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK260386A 1985-06-03 1986-06-03 Pyrimidinderivater samt deres anvendelse som laegemidler DK260386A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74080085A 1985-06-03 1985-06-03

Publications (2)

Publication Number Publication Date
DK260386D0 DK260386D0 (da) 1986-06-03
DK260386A true DK260386A (da) 1986-12-04

Family

ID=24978132

Family Applications (1)

Application Number Title Priority Date Filing Date
DK260386A DK260386A (da) 1985-06-03 1986-06-03 Pyrimidinderivater samt deres anvendelse som laegemidler

Country Status (9)

Country Link
EP (1) EP0204317A3 (da)
JP (2) JPS61282367A (da)
AU (1) AU592569B2 (da)
DK (1) DK260386A (da)
FI (1) FI862359A (da)
HU (1) HUT42077A (da)
IE (1) IE861458L (da)
NZ (1) NZ216389A (da)
ZA (1) ZA864136B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202330A (en) * 1985-06-03 1993-04-13 E. R. Squibb & Sons, Inc. 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters
JPS6287574A (ja) * 1985-10-14 1987-04-22 Suntory Ltd 新規なｎ置換３，４−ジヒドロピリミジン−２−オン誘導体、その製造法及び循環器系疾患治療剤
US4689414A (en) * 1986-02-24 1987-08-25 E. R. Squibb & Sons, Inc. 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs
US4855301A (en) * 1986-10-09 1989-08-08 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters
AU598238B2 (en) * 1986-03-14 1990-06-21 E.R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3- {(substituted amino)carbonyl}-2-thioxo(or oxo)-5-pyrimidine -carboxylic acids and esters
IL81800A0 (en) * 1986-03-14 1987-10-20 Squibb & Sons Inc 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo(or oxo)-5-pyrimidine-carboxylic acids and esters and pharmaceutical compositions containing the same
JPS62267272A (ja) * 1986-05-15 1987-11-19 Sanwa Kagaku Kenkyusho Co Ltd 新規なジヒドロピリミジン化合物及びその塩、これらの製法並びに該化合物を有効成分とする循環器系作用剤
AU595062B2 (en) * 1986-09-02 1990-03-22 University Of Melbourne, The 2-oxo-4-carboxy-pyrimidines
FR2610625B1 (fr) * 1987-02-10 1989-06-30 Inst Organicheskogo Sinteza Ak 2-oxo-4-(2'-difluoromethylthiophenyl)5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine
US4753946A (en) * 1987-04-08 1988-06-28 E. R. Squibb & Sons, Inc. Pyrimidinecarboxylic acid derivatives
US4847379A (en) * 1987-11-30 1989-07-11 E. R. Squibb & Sons, Inc. 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
EP0380592A4 (en) * 1988-01-19 1991-10-09 E.R. Squibb & Sons, Inc. 2-oxo-1-substituted pyrazolo 1,5-a¨pyrimidine-6-carboxylic acid esters
CA2016465A1 (en) * 1989-06-02 1990-12-02 Zola Phillip Horovitz Method for preventing or treating anxiety employing a calcium channel blocker
MD970227A (ro) 1994-11-16 1999-05-31 Synaptic Pharmaceutical Corporation Dihidropirimidine şi utilizarea lor
US6268369B1 (en) 1994-11-16 2001-07-31 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
EP0866708A4 (en) * 1995-11-16 1999-05-06 Synaptic Pharma Corp DIHYDROPIRIMIDINES AND THEIR USES
US6228861B1 (en) 1995-11-16 2001-05-08 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6172066B1 (en) 1996-05-16 2001-01-09 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6245773B1 (en) 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6274585B1 (en) 1998-12-23 2001-08-14 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6680323B2 (en) 1998-12-23 2004-01-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines and uses thereof
US6720324B2 (en) 2000-07-05 2004-04-13 Synaptic Pharmaceutical Corporation Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
EP1542683B1 (en) 2002-09-12 2013-01-09 Diakron Pharmaceuticals, Inc. Calcium channel blockers
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
US7157461B2 (en) 2003-07-23 2007-01-02 Bristol-Myers Squibb Co. Substituted dihydropyrimidine inhibitors of calcium channel function
DK2234985T3 (da) * 2007-12-20 2012-06-25 Bayer Pharma AG 4-(4-cyano-2-thioaryl)-dihydropyrimidinoner og deres anvendelse

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3234684A1 (de) * 1982-09-18 1984-03-22 Bayer Ag, 5090 Leverkusen Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS6025247A (ja) * 1983-07-21 1985-02-08 Nec Corp 半導体装置の製造方法
US4683234A (en) * 1984-05-19 1987-07-28 Suntory Limited 2,6-Dimethyl-3N,5-disubstituted-4-(substituted phenyl)3,4-dihydropyrimidine compounds and a method for treating disorders of cardiocircular system
JPS60246376A (ja) * 1984-05-19 1985-12-06 Suntory Ltd Ｎ置換３，４−ジヒドロピリミジン誘導体、その製造方法および循環系疾患治療剤
JPS6143171A (ja) * 1984-08-03 1986-03-01 Suntory Ltd 新規ｎ置換３，４−ジヒドロピリミジン誘導体および循環系疾患治療剤

Also Published As

Publication number Publication date
HUT42077A (en) 1987-06-29
JPS61282367A (ja) 1986-12-12
NZ216389A (en) 1989-01-27
FI862359A (fi) 1986-12-04
FI862359A0 (fi) 1986-06-03
EP0204317A3 (en) 1987-12-16
AU5829186A (en) 1986-12-11
DK260386D0 (da) 1986-06-03
JPH02268180A (ja) 1990-11-01
EP0204317A2 (en) 1986-12-10
IE861458L (en) 1986-12-03
AU592569B2 (en) 1990-01-18
ZA864136B (en) 1987-02-25

Similar Documents

Publication Publication Date Title
DK260386D0 (da) Pyrimidinderivater samt deres anvendelse som laegemidler
DK289886D0 (da) Substituerede 3-phenyl-4-cyanopyrrol-derivater samt deres fremstilling og anvendelse
DK25992D0 (da) Quinolinderivater, deres fremstilling samt farmaeutisk praeparat indeholdende saadanne derivater
DK157867C (da) Tertiaere hydroxyalkylxanthiner og deres anvendelse som laegemidler
DK49388D0 (da) N-heterocyclo-n-(4-piperidyl)-amider samt deres anvendelse som laegemidler
DK29686A (da) 13beta-alkyl-milbemycinderivater samt deres fremstilling og anvendelse
DK576586A (da) (di)alkoxycarbonyl-amino-s-triazin-derivater samt deres fremstilling og anvendelse
DK74086D0 (da) Forbindelser med pesticid virkning samt fremgangsmaade til deres fremstilling
DK303688A (da) Polyoxygenerede labdanderivater, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK618886D0 (da) 6,7,8,9-tetrahydro-10-methylpyrido-(1,2-a)-indol-9-aminer og derivater deraf, samt deres fremstilling og anvendelse
DK465686A (da) Pyridinylderivater samt deres fremstilling og anvendelse
DK143188A (da) Farmaceutiske praeparater indeholdende pyranoquinolinforbindelser samt deres anvendelse
DK162186A (da) Aminoketonderivater samt laegemidler indeholdende saadanne derivater
DK393788A (da) Substituerede thienoimidazolderivater, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK183886D0 (da) 4-phenylpropylindolderivater og deres salte og fremgangsmaade til deresfremstilling samt deres anvendelse som laegemidler
DK548086D0 (da) Nitroanthracycliner, fremgangsmaade til deres fremstilling samt deres anvendelse
DK172486D0 (da) Heterocyclyl-penem-forbindelser samt deres fremstilling og anvendelse
DK77186D0 (da) 1,4,6-tri-0-acylerede hexosederivater samt deres fremstilling og anvendelse
DK343486A (da) Dihydroquinolinon-derivater, deres fremstilling og anvendelse som laegemidler samt ved fremstillingen anvendte mellemprodukter og disses fremstilling
DK415686D0 (da) Phenylalaninderivater eller salte deraf samt deres anvendelse
DK287487A (da) 4-phenyl-4-oxo-2-butensyrederivater, deres fremstilling samt laegemidler med indhold deraf
DK527886D0 (da) 2,3,4,6-tetrasubstituerede 1,4-dihydropyridin-5-carboxylsyrederivater samt deres fremstilling og anvendelse
DK77286D0 (da) 1-0-acylerede hexosederivater samt deres fremstilling og anvendelse
DK206686A (da) Acylaminomethyl-penem-forbindelser samt deres fremstilling og anvendelse
DK513386A (da) Optisk aktive acyloxazetidinoner samt deres fremstilling og anvendelse

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment