DK2552206T3 - Tricykliske forbindelser og pbk-inhibitorer, der indeholder disse - Google Patents

Tricykliske forbindelser og pbk-inhibitorer, der indeholder disse Download PDF

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DK2552206T3
DK2552206T3 DK11763307.3T DK11763307T DK2552206T3 DK 2552206 T3 DK2552206 T3 DK 2552206T3 DK 11763307 T DK11763307 T DK 11763307T DK 2552206 T3 DK2552206 T3 DK 2552206T3
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quinolin
phenyl
thieno
hydroxy
hydroxythieno
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Yusuke Nakamura
Feryan Ahmed
Raymond Huntley
Zohreh Sajjadi-Hashemi
Wenge Cui
Joel R Walker
Helene Decornez
Mahender Gurram
Yo Matsuo
Shoji Hisada
David M Jenkins
Robert B Kargbo
Polivina Jolicia F Gauuan
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Onco Therapy Science Inc
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Claims (7)

1. Forbindelse med generel formel I:
I eller et farmaceutisk acceptabelt salt deraf, hvor R1 er Ci-C6alkyl, der eventuelt er substitueret med hydroxyl eller halogen, halogen, hydrogen, cyano, C3- Ciocycloalkyl, C2-C6alkenyl eller C2-C6alkynyl; hvor R2 er hydrogen, hydroxyl, halogen, Ci-C6alkoxy eller Ce~ Cioaryl, der eventuelt er substitueret med hydroxyl; hvor R3 er udvalgt fra gruppen, der består af: hydroxyl; hydrogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl, halogen eller hydroxyethylamino; halogen; Ci- Cealkoxy, der eventuelt er substitueret med dimethylamino eller morpholinyl; Ci-C6alkylphenyl, hvor de alifatiske carboner eventuelt er substitueret med -NR51R52; cyano; nitro; amino; 3-til 8-leddet heterocycloalkyl, der eventuelt er substitueret med amino; heteroaryl; -OSO2CH3; -0S02CF3; -OCOR103, hvor R103 er Ci-C6alkyl; -OCOOR104, hvor R104 er Ci-C6alkyl; -OCONR101R102, hvor R101 og R102 hver for sig er hydrogen eller Ci-C6alkyl, eller R101 og R102 sammen danner morpholinyl; og -CONH2; hvor R4 er udvalgt fra gruppen, der består af C6-Ci0aryl, hydroxyl, halogen, amino, Ci-C6alkyl, C2-C6alkenyl, C3-Ciocycloalkyl, C3-Ciocycloalkenyl, Ci-C6alkoxy, indanyl, heteroaryl og 3- til 8-leddet heterocycloalkyl, og R4 eventuelt er substitueret med substituent A; hvor substituent A er udvalgt uafhængigt fra gruppen, der består af: Ci-C6alkyl, der eventuelt er substitueret med substituent B; halogen; hydroxyl; oxo (=0); cyano; C3-Ciocycloalkyl, der eventuelt er substitueret med cyano, eller Ci-C6alkyl, der er substitueret med -NR31R32, hvor R31 og R32 hver for sig er hydrogen eller Ci-C6alkyl; -NR21R22, hvor R21 og R22 hver for sig er hydrogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl, amino, di(Ci-Cealkyl)amino, -SO2 (Ci-C6alkyl) , 3- til 8-leddet heterocycloalkyl eller cyano; eller en 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med -COOR105, hvor R105 er Ci-C6alkyl; Ci-C6alkoxy, der eventuelt er substitueret med halogen, 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med Ci-C6alkyl, eller -NR33R34 hvor R33 og R34 hver for sig er hydrogen, Ci-C6alkylsulfonyl eller Ci-C6alkyl, der eventuelt er substitueret med Ci-C6alkylsulfonyl eller di (Ci-C6alkyl) amino; -S02NR23R24, hvor R23 og R24 hver for sig er hydrogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl, Ci-C6alkoxy, halogen, C3-Ciocycloalkyl, heteroaryl eller -NR35R36, hvor R35 og R36 hver for sig er hydrogen eller Ci-C6alkyl; C3-Ci0cycloalkyl, der eventuelt er substitueret med Ci-C6hydroxyalkyl; 3- til 8-leddet heterocycloalkyl; eller R23 og R24 sammen danner 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med amino eller halogen; Ci-C6alkylsulfonyl, der eventuelt er substitueret med hydroxyl; -NHSO2 (Ci-C6alkyl), hvor carbonatomerne eventuelt er substitueret med -NR R , hvor R og R hver for sig er hydrogen eller Ci-C6alkyl; 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med -NR39R40, hvor R39 og R40 hver for sig er hydrogen, Ci-C6alkyl eller Ci-C6alkylsulfonyl; Ci-C6alkyl, der eventuelt er substitueret med -NR41R42, hvor R41 og R42 hver for sig er hydrogen eller Ci-C6alkyl; hydroxyl; eller Ci-Cealkylsulfonyl; aryl, der eventuelt er substitueret med Ci-C6alkyl, der eventuelt er substitueret med cyano eller amino; heteroaryl; -COOR11, hvor R11 er hydrogen eller Ci-C6alkyl; og -COR12, hvor R12 er Ci-C6alkyl; C3-Ci0cycloalkyl; cyanomethyl; aminomethyl; -NR25R26, hvor R25 og R26 hver for sig er hydrogen eller Ci-C6alkyl, der eventuelt er substitueret med hydroxyl eller -NR43R44, hvor R43 og R44 hver for sig er hydrogen eller Ci-C6alkyl; eller 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med Ci-C6alkyl; hvor substituent B er udvalgt uafhængigt fra gruppen, der består af: -NR51R52, hvor R51 og R52 hver for sig er hydrogen; Ci-Csalkyl, der eventuelt er substitueret med Ci-C6alkylsulfonyl eller 3-til 8-leddet heterocycloalkyl, der eventuelt er substitueret med -COOR53, hvor R53 er hydrogen eller Ci-C6alkyl; 3- til 8-leddet heterocycloalkyl; Ci-C6alkylsulfonyl; C3-Ciocycloalkyl; -COR55, hvor R55 er Ci-C6alkyl; -COOR56, hvor R56 er Ci-C6alkyl; eller -CONR57R58, hvor R57 og R58 hver for sig er hydrogen eller Ci-C6alkyl; halogen; hydroxyl; Ci-C6alkoxy; cyano; cycloalkyl; C6-Ci0aryl, der eventuelt er substitueret med cyano; heteroaryl; 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med Ci-Cgalkyl, hydroxyl, amino, Ci-C6aminoalkyl eller Ci-C6alkyl, der er substitueret med C2-C?alkyloxycarbonylamino; -COOR54, hvor R54 er hydrogen eller Ci-C6alkyl; -CONH2; -SO2NR106R107, hvor R106 og R107 hver for sig er hydrogen, Ci-Cealkyl eller C3-Ciocycloalkyl; Ci-C6alkylsulfinyl; og Ci-C6alkylsulfonyl; hvor R5 er hydrogen eller Ci-C6alkyl; og hvor -X- - - -Y- - - -Z- er -S-CR7=CR6, -hvor R6 er udvalgt fra gruppen, der består af: hydrogen, hydroxyl, Ci-C6alkyl, C6-Ci0aryl, der eventuelt er substitueret med hydroxyl, og 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med -NR61R62, hvor R61 og R62 hver for sig er hydrogen eller Ci-C6alkyl; hvor R7 er udvalgt fra gruppen, der består af: hydrogen; halogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl, -NR71R72, hvor R71 og R72 hver for sig er hydrogen; Ci-Cealkyl, der eventuelt er substitueret med dimethylamino; C3-Ciocycloalkyl, der eventuelt er substitueret med amino eller 3-til 8-leddet heterocycloalkyl; eller 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med CR-Ceaminoalkyl; C6-Ci0aryl, der eventuelt er substitueret med hydroxyl; C6-Ci0arylsulf onyl; og -COR73, hvor R73 er 3- til 8-leddet heterocycloalkyl, der eventuelt er substitueret med amino; eller -NR74R75, hvor R74 og R75 hver for sig er hydrogen, 3- til 8-leddet heterocycloalkyl eller C3-Ci0cycloalkyl, der eventuelt er substitueret med amino.
2. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt deraf, hvor R6 er hydrogen; hydroxyl; Ci-Cealkyl; phenyl, der eventuelt er substitueret med 1 til 3 hydroxyler; piperidyl, der eventuelt er substitueret med amino; eller piperazinyl.
3. Forbindelse ifølge krav 2 eller et farmaceutisk acceptabelt salt deraf, hvor R7 er hydrogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl eller piperidyl; eller halogen.
4. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt deraf, hvor R7 er hydrogen; Ci-C6alkyl, der eventuelt er substitueret med hydroxyl; NR71aR72a, hvor R71a og R72A hver for sig er hydrogen, Ci-C6alkyl, der eventuelt er substitueret med dimethylamino, C3-Ciocycloalkyl, der eventuelt er substitueret med amino, eller piperidyl; eller 3- til 8-leddet heterocycloalkyl, der er udvalgt fra gruppen, der består af piperidyl og morpholinyl, hvor den ene eller den anden eventuelt er substitueret med Ci-Ceaminoalkyl ; phenyl, der eventuelt er substitueret med 1 til 2 hydroxyler; phenylsulfonyl; eller -COR73a, hvor R73a er piperidyl, der eventuelt er substitueret med amino, eller -NR74AR75A, hvor R74A og R75A hver for sig er hydrogen, piperidyl eller C3_Ciocycloalkyl, der eventuelt er substitueret med amino.
5. Forbindelse ifølge krav 1, som er udvalgt fra gruppen, der består af: (6) : 7,9-dimethoxythieno[2,3-c]quinolin-4(5H)-on; (7) : 7, 9-dihydroxythieno[2,3-c]quinolin-4(5H)-on; (8) : 7,8,9-trimethoxythieno[2,3-c]quinolin-4(5H)-on; (10) : 7,8,9-trihydroxythieno[2,3-c]quinolin-4(5H)-on; (11) : 9-(3-(2-aminoethyl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (42) : 9-brom-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (43) : 9-(3,4-dihydroxyphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (47) : 9-(3,5-dihydroxyphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (48) : 8-hydroxy-9-(3-hydroxyphenyl)thieno[2,3-c]quinolin- 4(5H)-on; (49) : 8-hydroxy-9-(4-hydroxyphenyl)thieno[2,3-c]quinolin- 4(5H)-on; (50) : 9-(3, 4-difluorphenyl)-8-methoxythieno[2,3-c]quinolin- 4(5H)-on; (52) : 5-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)picolinonitril; (53) : 9-(6-aminopyridin-3-yl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (54) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzamid; (55) : 9-(3-fluor-4-hydroxyphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (58) : 9-(3,4-difluorphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (59) : 9-(4-fluor-3-hydroxyphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (60) : 8-hydroxy-9-(3-hydroxy-5- (trifluormethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (61) : 8-hydroxy-9-(lH-indazol-6-yl)thieno[2,3-c]quinolin- 4(5H)-on; (62) : 8-hydroxy-9-(3,4,5-trihydroxyphenyl)thieno[2,3- c]quinolin-4(5H)-on; (63) : 9-(4-hydroxyphenyl)-8-methoxythieno[2,3-c]quinolin- 4(5H)-on; (64) : 9-(4-(lH-tetrazol-5-yl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (65) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (66) : 9-(3-chlor-4-fluorphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (67) : 9-(4-chlor-3-fluorphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (68) : 9-(3,4-dichlorphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (69) : 9-(4-fluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)- on; (7 0) : 8-hydroxy-9-phenylthieno[2,3-c]quinolin-4(5H)-on; (71) : 9-(4-(difluormethoxy)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (72) : 9-(4-(aminomethyl)phenyl)-8-hydroxythieno [2,3- c]quinolin-4(5H)-on; (73) : 9-(4-(aminomethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (74) : 9-(3-aminophenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)- on; (75) : 3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzensulfonamid; (76) : 8-hydroxy-9-(3,4,5-trifluorphenyl)thieno[2,3-c]quinolin- 4(5H)-on; (77) : N-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)methansulfonamid; (78) : 8-methoxy-9-phenylthieno[2,3-c]quinolin-4(5H) -on; (79) : 8-hydroxy-9-(naphthalen-2-yl)thieno[2,3-c]quinolin- 4(5H)-on; (80) : 8-hydroxy-9-(4-(hydroxymethyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (81) : 2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)acetonitril; (82) : 8-hydroxy-9-(4-(methylsulfonyl) phenyl)thieno[2,3- c]quinolin-4(5H)-on; (83) : 8-hydroxy-9-(pyridin-4-yl)thieno[2,3-c]quinolin-4(5H)- on; (84) : 8-hydroxy-9-(1,2,3,6-tetrahydropyridin-4-yl)thieno [2,3-c]quinolin-4(5H)-on; (85) : 8-hydroxy-9-(4-hydroxy-3-methoxyphenyl)thieno[2,3- c]quinolin-4(5H)-on; (86) : 9-(3-fluor-4-(morpholinomethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (87) : 9-(3-(aminomethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (88) : 9-(4-(aminomethyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (89) : 9-(3-(difluormethyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (90) : 9-(3-(aminomethyl)phenyl)-8-hydroxy-2-methylthieno[2,3- c]quinolin-4(5H)-on; (91) : 9-cyclohexenyl-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (92) : 9-(3, 5-difluorphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (93) : 9-(4-(2-(dimethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (94) : 9-(3-(aminomethyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (95) : 9-(4-(aminomethyl)phenyl)-8-hydroxy-2-methylthieno[2,3- c]quinolin-4(5H)-on; (96) : 9-cyclopropyl-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (97) : 9-([l,2,4]triazolo[l,5-a]pyridin-6-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; ( 98) : 8-methoxy-9-(1,2,3,6-tetrahydropyridin-4-yl)thieno[2,3- c]quinolin-4(5H)-on; (99) : 9-cyclohexenyl-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (100) : 8-methoxy-9-(4-(2-(piperidin-1- yl)ethylamino)phenyl)thieno[2,3-c]quinolin-4 (5H)-on; (102) : 9-(ΙΗ-benzo[d]imidazol-5-yl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (103) : 9-(4-(difluormethyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (105) : 8-hydroxy-9-(4-(2-(piperidin-1- yl)ethylamino)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (106) : 8-hydroxy-9-(4-(piperazin-l-yl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (109) : 5-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzo[d]oxazol-2(3H)-on; (110) : tert-butyl-4-(2-(hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzylamino)ethyl)piperidine-1 -carboxylate; (111) : 8-methoxy-9-(4-(piperazin-l-yl) phenyl)thieno[2,3-c]quinolin-4(5H)-on; (112) : 8-hydroxy-9-(4-(4-(methylsulfonyl)piperazin-l- yl) phenyl)thieno[2,3-c]quinolin-4 (5H)-on; (113) : 8-hydroxy-9-(4-((piperidin-3- ylamino)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (114) : N-(2-(dimethylamino)ethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (115) : 9-(4-(3-(dimethylamino)propoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (116) : 8-methoxy-9-(1-(piperidin-4-yl)-lH-pyrazol-4- yl)thieno[2,3-c]quinolin-4(5H)-on; (117) : 8-hydroxy-9-(1-(piperidin-4-yl)-lH-pyrazol-4- yl)thieno[2,3-c]quinolin-4(5H)-on; (120) : N-(2-(dimethylamino)ethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (122) : (E)-butyl-3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)acrylat; (123) : 8-methoxy-9-(lH-pyrrolo[2,3-b]pyridin-5-yl)thieno[2,3- c]quinolin-4(5H)-on; (124) : 8-hydroxy-9-(lH-pyrrolo[2,3-b]pyridin-5-yl)thieno[2,3- c]quinolin-4(5H)-on; (125) : N-(methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)phenethyl)acetamid; (126) : N-(2-aminoethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (127) : N-(2-aminoethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (128) : N-(hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)phenethyl)acetamid; (130) : 8-hydroxy-9-(4-(4-methylpiperazine-l- carbonyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (131) : 8-methoxy-9-(4-(4-methylpiperazine-l- carbonyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (132) : 8-hydroxy-9-(4-((4-methylpiperazin-l- yl)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (133) : 8-methoxy-9-(4-((4-methylpiperazin-l- yl)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (134) : (E)-9-(3-(diethylamino)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (135) : (E)-9-(3-(4-(aminomethyl)piperidin-l-yl)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (136) : (E)-9-(3-(2-(diethylamino)ethylamino)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (138) : 9-(2-(dimethylamino)pyrimidin-5-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (139) : tert-butyl-(1-(methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzyl)piperidin-4-yl)methylcarbamat; (140) : 8-hydroxy-9-(4-(4-methylpiperazin-l- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (141) : 8-methoxy-9-(4-(4-methylpiperazin-l- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (142) : 8-methoxy-9-(1-(methylsulfonyl)-1,2,3,6- tetrahydropyridin-4-yl)thieno [2,3-c]quinolin-4(5H)-on; (143) : (E)-9-(3-(diethylamino)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (144) : 9-(3-(4-(aminomethyl)piperidin-l-yl)propyl)-8- methoxythieno[2,3-c] quinolin-4(5H)-on; (145) : 9-(4-(3-(2-(diethylamino)ethylamino)propoxy)phenyl)-8- methoxythieno[2, 3-c]quinolin-4(5H)-on; (146) : 9-(4-(3-(diethylamino)propoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (147) : 9-(4-(3-(2-(diethylamino)ethylamino)propoxy)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (148) : (E)-9-(3-(4-(aminomethyl)piperidin-l-yl)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (149) : 9-(4-(3-(dimethylamino)propoxy)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (150) : 8-hydroxy-9-(4-(2-(piperidin-l- yl) ethoxy) phenyl)thieno[2,3-c]quinolin-4(5H)-on; (151) : 9-(4-(2-(ethylamino)ethoxy)phenyl)-8-hydroxythieno [2,3- c]quinolin-4(5H)-on; (152) : (E)-9-(3-(4-aminopiperidin-l-yl)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (153) : 9-(1-(2-aminoethyl)-1,2,3,6-tetrahydropyridin-4-yl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (154) : 9-(4-(2-(ethylamino)ethoxy)phenyl)-8-methoxythieno[2,3— c]quinolin-4(5H)-on; (155) : 9-(4-(2-(diethylamino)ethoxy)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (156) : 9-(4-(2-(diethylamino)ethoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (157) : 9-(4-(2-(dimethylamino)ethoxy)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (158) : 9-(4-(2-(dimethylamino)ethoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (159) : 8-methoxy-9-(4-(2-(piperidin-l- yl) ethoxy)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (160) : 8-methoxy-9-(3-(2-(4-methylpiperazin-l- yl)ethoxy)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (161) : 9-(3-(2-(diethylamino)ethoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (162) : 9-(3-(3-(diethylamino)propoxy)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (163) : 9-(4-(2-(dimethylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (164) : 9-(4-((dimethylamino)methyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (165) : 9-(4-((dimethylamino)methyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (166) : 9-(3-(2-(diethylamino)ethoxy)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (167) : 8-hydroxy-9-(3-(2-(4-methylpiperazin-l- yl)ethoxy)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (168) : N-ethyl-N-(2-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenylmethoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenoxy)ethyl)methansulfonamid; (169) : 9-(4-(2-aminoethyl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (170) : 2-(3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)acetonitril; (171) : 2-(3-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)acetonitril; (172) : 9-(1-(2-(dimethylamino)ethyl)-1,2,3,6- tetrahydropyridin-4-yl)-8-hydroxythieno[2,3-c]quinolin-4(5H)- on; (173) : N-(hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)phenethyl)methansulfonamid; (174) : 9-(1-(2-(diethylamino)ethyl)-1,2,3,6-tetrahydropyridin- 4-yl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (175) : 9-(4-(2-aminoethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (176) : 9-(4-(2-aminoethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (177) : N-(methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)phenethyl)methansulfonamid; (178) : N-(methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)phenethyl)methansulfonamid; (179) : N-(2-aminoethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (183) : 9-(4-((diethylamino)methyl)phenyl)-8-methoxythieno[2,3— c]quinolin-4(5H)-on; (184) : 9-(4-((diethylamino)methyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (185) : 9-(3-(2-(dimethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (186) : 9-(3-(2-aminoethyl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (187) : 8-hydroxy-9-(4-((methylamino)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (188) : 8-methoxy-9-(4-((methylamino)methyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (189) : 9-(4-amino-3-methoxyphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (190) : 3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzonitril; (191) : 9-(4-(1-(dimethylamino)ethyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (192) : 9-(4-(1-(dimethylamino)ethyl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (193) : N-(1-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)ethyl)methansulfonamid; (194) : 8-hydroxy-9-(4-(1-(pyrrolidin-1- yl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (195) : 9-(4-(1-aminoethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (196) : 9-(4-(1-(diethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (197) : N-(2-aminoethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (198) : N-(2-(dimethylamino)ethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (199) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(pyrrolidin-3-yl)benzensulfonamid; (200) : N-(azetidin-3-yl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (201) : 9-(4-(2-(diethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (202) : 2-amino-N-(3-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)ethansulfonamid; (203) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzonitril; (204) : 4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)benzonitril; (205) : (E)-9-(3-(3-aminopyrrolidin-l-yl)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (206) : N-(2-hydroxyethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (207) ; 8-methoxy-9-(5-methoxypyridin-3-yl)thieno[2,3- c]quinolin-4(5H)-on; (209) : 9-(4-(3-aminopyrrolidin-l-ylsulfonyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (210) : N-(2-bromethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (211) : 9-(4-((diisopropylamino)methyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (212) : N-(hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl) benzyl) methansulfonamid; (213) : 9-(4-((isopropylamino)methyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (214) : 2-(dimethylamino)-N-(3-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl) phenyl)ethansulfonamid; (215) : 2-amino-N-(3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)ethansulfonamid; (216) : 8-methoxy-9-(4-(1-(pyrrolidin-1- yl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (217) : 9-(4-amino-3-hydroxyphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (218) : N-(2-methoxy-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)methansulfonamid; (219) : 9-(3, 5-difluor-4-hydroxyphenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (220) : N-(2-hydroxy-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)methansulfonamid; (221) : 9-(4-((4-(aminomethyl)piperidin-l-yl)methyl)-3- fluorphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (222) : 9-(4-(2-(dimethylamino)ethyl)phenyl)-6-fluor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (223) : 9-(3, 5-difluor-4-hydroxyphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (224) : 6-fluor-8-methoxy-9-(1,2,3,6-tetrahydropyridin-4- yl)thieno[2, 3-c]quinolin-4(5H)-on; (225) : 9-(4-(1-(dimethylamino)ethyl)phenyl)-6-fluor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (226) : 9-(4-((diethylamino)methyl)-3-fluorphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (227) : (E)-9-(3-(3-hydroxypyrrolidin-l-yl)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (228) : (E)-8-hydroxy-9-(3-(3-hydroxypyrrolidin-l-yl)prop-l- enyl) thieno[2,3-c]quinolin-4(5H)-on; (229) : 8-hydroxy-9-(4- ((isopropylamino)methyl) phenyl)thieno[2,3-c]quinolin-4(5H)-on; (230) : (E)-9-(3-(3-aminoazetidin-l-yl)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (231) : (E)-8-methoxy-9-(3-(2-(methylsulfonyl)ethylamino)prop- l-enyl) thieno[2,3-c]quinolin-4(5H)-on; (232) : (S)-9-(4-(1-aminoethyl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (233) : (S)-9-(4-(1-aminoethyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (235) : 9-(4-((4-(aminomethyl) piperidin-l-yl)methyl)-3-fluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (236) : 8-methoxy-9-(4-(1-(2- (methylsulfonyl)ethylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (237) : 9-(4-((3-aminopyrrolidin-l-yl)methyl)-3-fluorphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (238) : (E)-9-(3-(3-aminoazetidin-l-yl)prop-l-enyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (239) : (E) —9—(3—(ethylamino)prop-l-enyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (240) : 9-(4-((3-aminopiperidin-l-yl)methyl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (241) : 9-(4-((3-aminopyrrolidin-l-yl)methyl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (242) : 9-(4-((3-aminopiperidin-l-yl)methyl)-3-fluorphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (243) : 8-hydroxy-9-(4-(1-(2-(methylsulfonyl)ethylamino)ethyl)phenyl)thieno[2,3-c]quinolin- 4(5H)-on; (244) : (E)-9-(3-(3-aminopiperidin-l-yl)prop-l-enyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (245) : (E)-9-(3-(3-aminopyrrolidin-l-yl)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (246) : (E)-9-(3-(3-aminopiperidin-l-yl)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (247) : (E)-8-hydroxy-9-(3-(2-(methylsulfonyl)ethylamino)prop- l-enyl) thieno[2,3-c]quinolin-4(5H)-on; (248) : 8-methoxy-9-(4-(2-(2- (methylsulfonyl)ethylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (249) : 2-(2-fluor-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)acetonitril; (250) : (E)-N-(1-(3-(8-methoxy-4-oxo-4,5-dihydrothieno [2,3- c]quinolin-9-yl)allyl)azetidin-3-yl)methansulfonamid; (251) : 4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N,N-dimethylbenzensulfonamid; (252) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-methylbenzensulfonamid; (253) : tert-butyl-(5-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)furan-2-yl)methylcarbamat; (254) : N-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)-2-methylphenyl)methansulfonamid; (255) : N-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)-2-methylphenyl)methansulfonamid; (25 6) : 9-(4-(aminomethyl)phenyl)-6-fluor-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (257) : 9-(4-(aminomethyl)phenyl)-6-fluor-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (258) : 6-fluor-8-hydroxy-9-(1,2,3,6-tetrahydropyridin-4- yl)thieno[2,3-c]quinolin-4(5H)-on; (259) : 9-(4-((diethylamino)methyl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (260) : 8-methoxy-9-(4-(1-(piperidin-1- yl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (261) : 2-(2-fluor-4-(8-hydroxy-4-oxo-4,5-dihydrothieno [2,3- c]quinolin-9-yl)phenyl)acetonitril; (262) : 8-hydroxy-9-(4-(1-(piperidin-1- yl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (263) : (E)-9-(3-(3-(dimethylamino)piperidin-l-yl)prop-l-enyl)- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (264) : (E)-9-(3-(3-(dimethylamino)pyrrolidin-l-yl)prop-l- enyl) -8-hydroxythieno[2,3-c]quinolin-4 (5H)-on; (265) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (266) : 9-(5-(aminomethyl)thiophen-2-yl)-8-hydroxythieno [2,3- c]quinolin-4(5H)-on; (267) : 9-(4-((ethylamino)methyl)phenyl)-8-hydroxythieno [2,3-c]quinolin-4(5H)-on; (268) : (E)-9-(3-(4-aminopiperidin-l-yl)prop-l-enyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (269) : 9-(4-((ethylamino)methyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (270) : 9-(4-(aminomethyl)phenyl)-6-brom-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (271) : 9-(3-chlor-4-((diethylamino)methyl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (272) : (R)-9-(4-(1-(dimethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (273) : 9-(4-(3-aminopropyl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (274) : (R)-9-(4-(1-aminoethyl) phenyl)-8-methoxythieno[2,3 — c]quinolin-4(5H)-on; (275) : (R)-9-(4-(1-aminoethyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (276) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (277) : 9-(4-(l-amiao-2-methylpropan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (278) : 9-(3-fluor-4-((3-hydroxypyrrolidin-l-yl)methyl)phenyl)- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (279) : 9-(3-fluor-4-((3-hydroxypyrrolidin-l-yl)methyl)phenyl)- 8-methoxythieno[2,3-c]quinolin-4(5H)-on; (280) : 4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2,2,2-trifluorethyl)benzensulfonamid; (281) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2,2,2-trifluorethyl)benzensulfonamid; (282) : N-(2-(dimethylamino)ethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (283) : 8-hydroxy-9-(4-((2-(methylsulfonyl)ethylamino)methyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (284) : 9-(3-(3-(dimethylamino)pyrrolidin-l-yl)propyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (285) : 9-(1-(2-aminoethyl)-lH-pyrazol-4-yl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (286) : 9-(3-chlor-4-((diethylamino)methyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (287) : 4-(7 — fluor-8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)-N-(2-hydroxyethyl)benzensulfonamid; (288) : 9-(3-acetylphenyl)-8-methoxythieno[2,3-c]quinolin- 4(5H)-on; (289) : 2-fluor-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)-N-(2-hydroxyethyl)benzamid; (290) : 3-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl) phenyl)propannitril; (291) : 9-(4-acetylphenyl)-8-methoxythieno[2,3-c]quinolin- 4(5H)-on; (292) : 2-fluor-N-(2-hydroxyethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (293) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2-hydroxyethyl)benzamid; (294) : l,l-diethyl-3-(hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzyl)urea; (295) : N-(2-hydroxyethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzamid; (296) : 9-(4-acetylphenyl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (297) : N-(2-bromethyl)-2-fluor-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (298) : 9-(3-(3-(dimethylamino)piperidin-l-yl)propyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (299) : N-(2-fluor-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenethyl)methansulfonamid; (300) : 9-(3-fluor-4-(2-(methylsulfonamido)ethyl)phenyl)-4-oxo- 4,5-dihydrothieno[2,3-c]quinolin-8-yl-methansulfonat; (301) : (R)-N-(1-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)ethyl)methansulfonamid; (302) : (R)—9—(4—(1—(methylsulfonamido)ethyl)phenyl)-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-8-yl-methansulfonat; (303) : 2-fluor-N-(2-hydroxyethyl)-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (304) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N,N-dimethylbenzensulfonamid; (305) : 9-(4-(2-(dimethylamino)ethyl)phenyl)-7-fluor-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (306) : N-(2-bromethyl)-4-(7-fluor-8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (307) : 4-(7-fluor-8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)-N-(2-hydroxyethyl)benzensulfonamid; (308) : 9-(4-(1-(dimethylamino)-2-methylpropan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (309) : N-(2-chlor-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl) benzyl)-N-methylmethansulfonamid; (310) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2-methoxyethyl)benzensulfonamid; (311) : (E)-3-(8-methoxy-4-oxo-4,5-dihydrothieno[2,Ι ο] quinolin-9-yl)-2-methylacrylonitril; (312) : N-(2-fluor-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,Ι ο] quinolin-9-yl)phenethyl)methansulfonamid; (313) : 8-hydroxy-9-(4-(1-hydroxyethy1)phenyl)thieno [2,3-c]quinolin-4(5H)-on; (314) : 9-(4-(1-(cyclopentylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (315) : 9-(4-(1-(cyclopentylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (316) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2-hydroxyethyl)benzensulfonamid; (317) : 9-(5-(aminomethyl)furan-2-yl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (318) : 9-(3-chlor-4-((methylamino)methyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (319) : 9-(4-(2-aminopropan-2-yl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (320) : N-(3-hydroxypropyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (321) : 2-fluor-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)-N-(2-hydroxyethyl)benzensulfonamid; (322) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(3-hydroxypropyl)benzensulfonamid; (323) : N-(3-brompropyl)-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (324) : 2-fluor-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)-N-(2-methoxyethyl)benzensulfonamid; (325) : 9-(3-chlor-4-((methylamino)methyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (32 6) : 9-(4-(aminomethyl)phenyl)-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-8-carbonitril; (327) : 9-(4-(2-(dimethylamino)ethyl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (328) : 9-(4-(aminomethyl)phenyl)-6,7-dichlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (329) : 9-(4-(aminomethyl)phenyl)-6-chlor-8-hydroxythieno [2,3- c]quinolin-4(5H)-on; (330) : 9-(4-(aminomethyl)phenyl)-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-8-yl trifluormethansulfonat; (331) : 9-(4-(2-(dimethylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (332) : N-(2-chlorethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (333) : N-(2-fluorethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (334) : 9-(4-(2-aminopropan-2-yl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (335) : (S)-9-(4-(1-(dimethylamino)ethyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (33 6) : 9-(4-(1-aminopropyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (337) : 9-(4-(1-aminopropyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (338) : 9-(4-(1-(diethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (339) : 9-(4-(1-(dimethylamino)propyl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (340) : 9-amino-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (341) : 9-(4-(1-(dimethylamino)ethyl)phenyl)-6,7-difluor-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (342) : 9-(4-(1-(dimethylamino)ethyl)phenyl)-6,7-difluor-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (343) : N-cyclopropyl-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzensulfonamid; (344) : N-cyclopropyl-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzensulfonamid; (345) : 9-(2-amino-2,3-dihydro-lH-inden-5-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (346) : 9-(4-(1-(dimethylamino)ethyl)phenyl)thieno[2,3- c]]quinolin-4(5H)-on; (347) : (S)-N-(1-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl) phenyl)ethyl)methansulfonamid; (348) : 9-(4-(1-(aminomethyl)cyclopropyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (349) : 9-(4-(1-(dimethylamino)ethyl)-3-fluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (350) : N-(1-(hydroxymethyl)cyclopentyl)-4-(8-methoxy-4-oxo- 4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (351) : 9-(2-(diethylamino)-2,3-dihydro-lH-inden-5-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (352) : 9-(2-(dimethylamino)-2,3-dihydro-lH-inden-5-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (353) : 8-hydroxy-9-(1,2,3,4-tetrahydroisoquinolin-7- yl)thieno[2,3-c]quinolin-4(5H)-on; (354) : 8-methoxy-9-(1,2,3,4-tetrahydroisoquinolin-7- yl)thieno[2,3-c]quinolin-4(5H)-on; (355) : 3-(3-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl) phenyl)propannitril; (356) : 9-(4-(1-(diethylamino)ethyl)-3-fluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (357) : 1-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl) phenyl)cyclopropancarbonitril; (358) : 9-(2-ethyl-l,2,3,4-tetrahydroisoquinolin-7-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (359) : 9-(4-(1-aminoethyl)-3-fluorphenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (360) : 3-(3-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl) phenyl)propannitril; (361) : 1-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)cyclopropancarbonitril; (362) : 9-(2-amino-2,3-dihydro-lH-inden-5-yl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (363) : N-isopentyl-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)benzensulfonamid; (364) : 9-(2-(dimethylamino)-2,3-dihydro-lH-inden-5-yl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (365) : 9-(4-(1-(ethylamino)ethyl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (366) : 6-chlor-9-(4-(1-(dimethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (367) : 9-(4-(cyclopropanecarbonyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (368) : 9-(4-(aminomethyl)phenyl)-4-oxo-4,5-dihydrothieno[2,3— c]quinolin-8-carboxamid; (369) : 9-(2-aminoethyl)-8-methoxythieno[2,3-c]quinolin-4 (5H)- on; (370) : 8-hydroxy-9-(4-(2- hydroxyethylsulfonyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (371) : 9-(4-(2-hydroxyethylsulfonyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (372) : 9-(l-ethylindolin-5-yl)-8-hydroxythieno[2,3-c]quinolin- 4(5H)-on; (373) : 9-(4-(l-aminopropan-2-yl)phenyl)-8-methoxythieno[2,3— c]quinolin-4(5H)-on; (374) : 8-hydroxy-9-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7- yl)thieno[2,3-c]quinolin-4(5H)-on; (375) : 9-(4-(1-aminoethyl)-3-fluorphenyl)-8-methoxythieno[2,Ι ο] quinolin-4(5H)-on; (376) : 8-hydroxy-9-(l-methylindolin-5-yl)thieno[2,3- c]quinolin-4(5H)-on; (377) : 8-hydroxy-9-(indolin-5-yl)thieno[2,3-c]quinolin-4(5H)- on; (378) : 9-(indolin-5-yl)-8-methoxythieno[2,3-c]quinolin-4(5H)- on; (379) : 9-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (380) : 4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-propylbenzensulfonamid; (381) : N-(cyclopropylmethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl) benzensulfonamid; (382) : N-(3,3-dimethylbutyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl) benzensulfonamid; (383) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-isopentylbenzensulfonamid; (384) : N-(3,3-dimethylbutyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (385) : 9-(4-(1-(ethylamino)ethyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (386) : 3-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin- 9-yl)phenyl)-3-oxopropannitril; (387) : (E)-9-(2-ethoxyvinyl)-8-methoxythieno[2,3-c]quinolin- 4(5H)-on; (388) : N-(1-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)ethyl)acetamid; (389) : 4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(3,3,3-trifluorpropyl)benzensulfonamid; (390) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(1-(hydroxymethyl)cyclopentyl)benzensulfonamid; (391) : N-(2,2-difluorethyl)-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1031) : 8-methoxy-9-(4-(1-methoxyethyl) phenyl)thieno [2,3 — c]quinolin-4(5H)-on; (1032) : 9-(4-(1-aminoethyl)phenyl)-6-brom-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1033) : 8-methoxy-9-(2-((piperidin-3-ylmethyl)amino)ethyl)thieno[2,3-c]quinolin-4(5H)-on; (1034) : 9-(2-(4-((dimethylamino)methyl)piperidin-l-yl)ethyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1035) : tert-butyl-4-((2-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)ethyl)amino)piperidin-1-carboxylat; (1036) : 8-methoxy-9-(2-(piperidin-4-ylamino)ethyl)thieno[2,3- c]quinolin-4(5H)-on; (1037) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(3,3,3-trifluorpropyl)benzensulfonamid; (1039) : 9-(4-(1-aminoethyl)phenyl)-6-cyclopropyl-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1040) : 9-(4-(1-aminoethyl)phenyl)-8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-6-carbonitril; (1041) : 9-(4-(1-aminoethyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1042) : 8-hydroxy-9-(2-(4-((methylamino)methyl)piperidin-l- yl) ethyl)thieno[2,3-c]quinolin-4(5H)-on; (1043) : 8-methoxy-9-(2-(4-((methylamino)methyl)piperidin-l- yl) ethyl)thieno[2,3-c]quinolin-4(5H) -on; (1044) : 9-(2-(4-((dimethylamino)methyl)piperidin-l-yl)ethyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1045) : 9-(4-(1-hydroxypropyl)phenyl)-8-methoxythieno[2,3— c]quinolin-4(5H)-on; (1046) : (R)-8-methoxy-9-(4-(1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1049): 9-(4-(4-hydroxypiperidin-4-yl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1051) : 8-hydroxy-9-(4-(1,2,3,6-tetrahydropyridin-4- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1052) : (R)-8-hydroxy-9-(4-(1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1053) : 8-hydroxy-9-(4-(1-hydroxypropyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (1054) : (R)-8-hydroxy-9-(4-(1-hydroxyethyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (1055) : 8-hydroxy-9-(4-(4-hydroxypiperidin-4- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (105 6) : (S)-8-hydroxy-9-(4-(1-hydroxyethyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (1057) : N-(l-hydroxypropan-2-yl)-4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1058) : 9-(4-(hydroxy(thiazol-2-yl)methyl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1059) : 9-(6-(1-aminoethyl)pyridin-3-yl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1060) : 9-(4-(4-hydroxybutyl)phenyl)-8-methoxythieno [2,3- c]quinolin-4(5H)-on; (1061) : 2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl) phenyl)-2-methylpropanamid; (1062) : N-(l-brompropan-2-yl)-4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1063) : 8-hydroxy-9-(4-(hydroxy(thiazol-2- yl)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1064) : (S)-8-methoxy-9-(4-(1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1065) : 9-(6-(1-(diethylamino)ethyl)pyridin-3-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1066) : 9-(4-(1-aminoethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1067) : 9-(6-(1-aminoethyl)pyridin-3-yl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (1068) : 8-hydroxy-9-(4-(4-hydroxybutyl)phenyl)thieno[2,3- c]quinolin-4(5H)-on; (1069) : 9-(4-(3-amino-l-hydroxypropyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1070) : 9-(6-(1-(dimethylamino)ethyl)pyridin-3-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1071) : 9-(6-(1-(dimethylamino)ethyl)pyridin-3-yl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1072) : 4-((4-(8-methoxy-4-oxo-4,5-dihydrothieno [2,3-c]quinolin-9-yl)-lH-pyrazol-l-yl)methyl)benzonitril; (1074) : 9-(4-((lH-pyrazol-l-yl)methyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1075) : 9-(6-(1-aminoethyl)pyridin-3-yl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (1076) : 9-(4-(1-aminoethyl)phenyl)-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-8-yl dimethylcarbamat; (1077) : 9-(4-(1-aminoethyl) phenyl)-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-8-yl isopropylcarbonat; (1078) : 9-(4-((lH-imidazol-l-yl)methyl) phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1079) : N-(2-brompropyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1080) : (R)—9—(4—(1-aminoethyl)phenyl)-6,7-dichlor-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1081) : (R)-9-(4-(1-aminoethyl)phenyl)-6-chlor-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1082) : (S)—8—hydroxy— 9—(4— (1 — (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1083) : 9-(4-(1-aminoethyl)phenyl)-4-OXO-4,5-dihydrothieno[2,3-c]quinolin-8-yl diethylcarbamat; (1084) : 4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9- yl)-N-(2-hydroxyethyl)-N-methylbenzensulfonamid; (1085) : N-(2-hydroxyethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)-N-methylbenzensulfonamid; (1086) : 9-(4-((lH-pyrazol-l-yl)methyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1087) : (S)-6-chlor-8-hydroxy-9-(4- (1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1088) : 9-(4-(1-aminopropyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1089) : 9-(4-(1-aminoethyl)phenyl)-4-ΟΧΟ-4,5- dihydrothieno(2,3-c]quinolin-8-yl morpholin-4-carboxylat; (1092) : 9-(4-(2-(dimethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1093) : 9-(4-(2-aminopropyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (1095) : 9-(4-(2-aminopropyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1096) : 8-methoxy-9-(1-(2-morpholinoethyl)-lH-pyrazol-4- yl)thieno[2,3-c]quinolin-4(5H)-on; (1097) : 9-(4-(2-(diethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1098) : 9-(4-(1-aminoethyl)phenyl)-8-hydroxy-6- (hydroxymethyl)thieno[2, 3-c]quinolin-4(5H)-on; (1099) : 9-(4-(1-aminoethyl)phenyl)-4-OXO-4,5-dihydrothieno[2,3-c]quinolin-8-yl acetat; (1100) : 9-(1-(1-(dimethylamino)propan-2-yl)-lH-pyrazol-4-yl)- 8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1101) : 9-(4-((lH-imidazol-l-yl)methyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1102) : 9-(4-(aminomethyl)phenyl)-8-(2-morpholinoethoxy)thieno[2,3-c]quinolin-4(5H)-on; (1103) : 8-hydroxy-9-(1-(2-morpholinoethyl)-lH-pyrazol-4- yl)thieno[2,3-c]quinolin-4(5H)-on; (1104) : N-(2-(lH-pyrazol-l-yl)ethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensuitonamid; (1105) : 8-hydroxy-9-(4-(2,2,2-trifluor-l- hydroxyethyl) phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1106) : 9-(4-(2-aminopropyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1107) : N-(2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno [2,Ι ο] quinolin-9-yl)phenyl)-2-methylpropyl)methansulfonamid; (1108) : 9-(4-(2-(dimethylamino)propyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1109) : 9-(4-(1-aminoethyl)phenyl)thieno[2,3-c]quinolin-4(5H)- on; (1110) : 9-(1-(1-(dimethylamino)propan-2-yl)-lH-pyrazol-4-yl)- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1111) : 9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1112) : 9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1113) : 8-methoxy-9-(4-(2,2,2-trifluor-1- hydroxyethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1114) : N-(2-bromethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)-N-methylbenzensulfonamid; (1115) : N-(2-(lH-imidazol-l-yl)ethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1116) : 9-(4-(1-(aminomethyl)cyclopropyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H) -on; (1117) : 3-(4-(8-(2-(dimethylamino)ethoxy)-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propannitril; (1118) : (R)-9-(4-(1-aminopropyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (1119) : N-(2-chlorethyl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)-N-methylbenzensulfonamid; (1120) : (S)-9-(4-(1-aminopropyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1121) : (S)-9-(4-(1-aminopropyl)phenyl)-8-methoxythieno[2,3- c]quinolin-4(5H)-on; (1122) : (R)-9-(4-(1-aminoethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1123) : (R)-9-(4-(1-aminoethyl)phenyl)-6-brom-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1124) : 9-(4-(1-aminoethyl)phenyl)-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-8-carbonitril; (1125) : 9-(4-(1-aminoethyl) phenyl)-8-(hydroxymethyl)thieno[2,3-c]quinolin-4(5H)-on; (1126) : (R)-6-chlor-9-(4-(1-(dimethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1127) : (S)-9-(4-(1-(ethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1128) : (S)-9-(4-(1-(dimethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1129) : 6-chlor-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1130) : 9-(4-(1-aminoethyl)phenyl)-6-ethynyl-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1131) : (R)-9-(4-(1-aminopropyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1132) : (R)-6-chlor-8-hydroxy-9-(4-(1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1133) : 9-(4-(2-aminoethyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1134) : 9-(4-(1-aminoethyl) phenyl)-8- (difluormethyl)thieno[2,3-c]quinolin-4(5H)-on; (1135) : (R)-6-brom-8-hydroxy-9- (4- (1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1136) : 9-(4-(l-aminopropan-2-yl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1137) : 9-(4-butylphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1138) : 9-(4-butylphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1139) : N-(2-chlorethyl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1140) : 9-(4-((3-brompyrrolidin-l-yl)sulfonyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1141) : (S)-9-(4-(1-(methylsulfonamido)propyl)phenyl)-4-oxo- 4,5-dihydrothieno[2,3-c]quinolin-8-ylmethansulfonat; (1142) : 9-(4-(2-aminoethyl)phenyl)-6-brom-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1143) : 9-(4-(3-(dimethylamino)-1-hydroxypropyl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1144) : N-(2-bromethyl)-4-(6-chlor-8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1146) : N-(2-bromethyl)-4-(5-ethyl-8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1147) : (S)-8-methoxy-9-(4-(l- (methylamino)propyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1148) : (S)-8-hydroxy-9-(4-(1- (methylamino)propyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1149) : 9-(4-(1-aminoethyl)phenyl)-8-(((2- hydroxyethyl) amino)methyl)thieno[2,3-c]quinolin-4(5H)-on; (1150) : (R)- 9-(4-(1-aminopropyl)phenyl)-6-brom-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1151) : (R)-9-(4-(l-(dimethylamino)propyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1152) : 8-hydroxy-9-(4-pentylphenyl)thieno[2,3-c]quinolin- 4(5H)-on; (1153) : 9-(4-(2-aminoacetyl)phenyl)-8-hydroxythieno[2,3- c]quinolin-4(5H)-on; (1154) : (S)-6-chlor-8-hydroxy-9- (4-(1- (methylamino)propyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1155) : 8-hydroxy-9-(4-(2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1156) : 8-methoxy-9-(4-(2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1157) : (R)-9-(4-(1-aminopropyl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1158) : (R)-9-(4-(1-aminopropyl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1159) : (R)-9-(4-(1-aminopropyl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1160) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1161) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1162) : 2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)butannitril; (1163) : (S) - 9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1164) : (S)—9—(4—(l-aminopropan-2-yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1165) : 6-chlor-8-hydroxy-9-(4-(2-(methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1166) : (R)-9-(4-(-aminopropan-2-yl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1167) : 9-(4-(2-aminoethyl)-3,5-difluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1168) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1169) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1170) : 6-chlor-8-methoxy-9-(4- (2-(methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1171) : 9-(4-(2-aminoethyl)-3-chlorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1172) : (S)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1173) : 6-brom-8-methoxy-9-(4-(2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1174) : 9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1175) : (R)-9-(4-(1-aminopropyl)phenyl)-6-chlor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1176) : (R)-9-(4-(l-aminopropan-2-yl)phenyl) -6-brom-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1177) : 9-(4-(2-aminoethyl)-3,5-difluorphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1178) : 9-(4-(2-(dimethylamino)ethyl)-3,5-difluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1179) : 9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1180) : (S)—9—(4—(1-aminopropan-2-yl)phenyl)-6,7-dichlor-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1181) : (S)-9-(4-(l-aminopropan-2-yl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1182) : (S)-6-chlor-9-(4-(1-(dimethylamino)propan-2- yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1183) : 6-brom-8-hydroxy-9-(4- (2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1185) : N-(2-hydroxyethyl)-4-(8-methoxy-5-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1186) : methyl-3-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propanoat; (1187) : (R)-8-hydroxy-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1188) : (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1189) : (R)-8-methoxy-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1190) : 9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1191) : 9-(4-(2-aminoethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1192) : 9-(4-(2-aminoethyl) phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1193) : 9-(4-(1-(dimethylamino)propan-2-yl)-3-fluorphenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1194) : (S)-6-chlor-8-hydroxy-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1195) : (S)-6-chlor-9-(4-(1-(diethylamino)propan-2-yl)phenyl)- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1196) : (S)-8-methoxy-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1197) : (S)-8-hydroxy-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1198) : 4-(8-hydroxy-5-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)-N-(2-hydroxyethyl)benzensulfonamid; (1199) : N-(2-bromethyl)-4-(8-hydroxy-5-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1200) : (R)-6-chlor-9-(4-(1-(dimethylamino)propan-2- yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1201) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-6-chlor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1202) : 9-(4-(1-aminobutan-2-yl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1203) : 9-(4-(2-aminopropan-2-yl)phenyl)-8-hydroxy-2- (phenylsulfonyl)thieno[2,3-c]quinolin-4(5H)-on; (1204) : N-(l-chlorpropan-2-yl)-4-(8-hydroxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1205) : N-(l-chlorpropan-2-yl)-4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)benzensulfonamid; (1206) : 9-(4-(2-aminoethyl)-3-hydroxyphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1207) : 9-(4-(2-aminoethyl)-3-methoxyphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1208) : 9-(4-(2-aminoethyl)-2-chlor-5-methoxyphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1209) : 9-(4-(3-(aminomethyl)pentan-3-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1210) : (R)-9-(4-(1-aminopropyl)phenyl)-8-hydroxy-5,6- dimethylthieno[2,3-c]quinolin-4(5H)-on; (1211) : 9-(4-(2-aminoethyl)-2-chlor-5-hydroxyphenyl)-6-chlor- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1212) : 9-(4-(aminomethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1213) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-brom-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1214) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-brom-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1215) : (S)-8-hydroxy-6-methyl-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1216) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1217) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1218) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-chlor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1219) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1220) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-cyclopropyl-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1221) : 9-(4-(2-aminoethyl)-3-fluorphenyl)-6-cyclopropyl-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1222) : (S)-8-methoxy-6-methyl-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1223) : (S)-9-(4-(l-aminopropan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1224) : 9-(4-(2-aminoethyl)-2-brom-5-hydroxyphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1225) : (S) -9-(4-(1-aminoethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1226) : 3-(4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propannitril; (1227) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1228) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1229) : 2-(2-fluor-4-(8-hydroxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propannitril; (1230) : 6-cyclopropyl-9-(4-(2-(dimethylamino)ethyl)-3- fluorphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1231) : 6-cyclopropyl-9-(4-(2-(dimethylamino)ethyl)-3- fluorphenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1232) : (S) -9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1233) : (S) -9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1234) : 9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1235) : 9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1236) : 9-(4-(2-amino-l-cyclopentylethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1237) : 9-(4-(2-amino-l,1-dicyclopentylethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1238) : 3-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propannitril; (1239) : 9-(4-(2-amino-l-cyclopentylethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1240) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-6- cyclopropyl-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1241) : 9-(4-(3-aminopropyl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1242) : 9-(4-(2-aminopropyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1243) : 9-(4-(2-aminopropyl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1244) : 9-(4-(-amino-2-methylpropan-2-yl)phenyl)-6- cyclopropyl-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1245) : 6-brom-9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1246) : 6-brom-9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1247) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-6-brom-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1248) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-6-brom-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1249) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-6-methyl-4-oxo- 4,5-dihydrothieno[2,3-c]quinolin-8-carbonitril; (1250) : (R)-9-(4-(1-aminoethyl)phenyl)-8-hydroxy-6- vinylthieno[2,3-c]quinolin-4(5H)-on; (1251) : 9-(4-(1-(aminomethyl)cyclopropyl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1252) : 9-(4-(l-amino-3-methylbutan-2-yl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1253) : 9-(4-(l-amino-3-methylbutan-2-yl) phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1254) : 9-(4-(1-(aminomethyl) cyclopropyl)phenyl) -8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1255) : (R)-9-(4-(1-aminoethyl)phenyl)-6-ethyl-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1256) : (R)-9-(4-(1-aminoethyl) phenyl)-6-(difluormethyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1257) : 9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8-methoxy- 6-methylthieno[2,3-c]quinolin-4(5H)-on; (1258) : 9-(3-fluor-4-(2-(methylamino)ethyl)phenyl)-8-hydroxy- 6-methylthieno[2,3-c]quinolin-4(5H)-on; (1259) : 6-brom-9-(4-(1-(dimethylamino)-2-methylpropan-2- yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4 (5H)-on; (1260) : 9-(4-(l-amino-2-methylpropan-2-yl)phenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1261) : 9-(4-(3-aminopropyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1262) : (R)-8-hydroxy-6-methyl-9-(4- (1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1263) : 9-(4-(2-aminoethyl)-3-chlorphenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1264) : 9-(4-(2-aminoethyl)-3-chlorphenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1265) : (R)-8-methoxy-6-methyl-9-(4-(1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1266) : 9-(4-(2-aminopropyl)phenyl)-6-ethyl-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1267) : (R)-9-(4-(1-aminoethyl) phenyl)-6-butyl-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1268) : 9-(4-(2-aminoethyl)-3-chlorphenyl)-6-chlor-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1269) : 9-(4-(2-aminopropyl)phenyl)-6-ethyl-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1270) : 2-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)-2-(oxetan-3-yl)acetonitril; (1271) : 9-(4-(l-amino-2-methylpropan-2-yl)-3-fluorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1272) : (R)-6-ethyl-8-hydroxy-9- (4- (1- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1273) : 9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1274) : 9-(4-(l-amino-3-methylbutan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1275) : 9-(4-(l-aminopropan-2-yl)-3-chlorphenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1276) : 9-(4-(l-aminopropan-2-yl)-3-chlorphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1277) : 9-(4-(l-aminobutan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1278) : 9-(4-(l-amino-2-methylpropan-2-yl)-3-fluorphenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1279) : 9-(4-(l-aminopropan-2-yl)-3-chlorphenyl)-8-hydroxy-6- methylthieno[2, 3-c]quinolin-4(5H)-on; (1280) : 9-(4-(l-aminopropan-2-yl)-3-chlorphenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1281) : 9-(4-(2-amino-2-methylpropyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1282) : 9-(4-(2-amino-2-methylpropyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1283) : 9-(4-(l-amino-3-methylbutan-2-yl)-3-fluorphenyl)-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1284) : 8-methoxy-6-methyl-9-(4-(3-methyl-l- (methylamino)butan-2-yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1285) : 8-hydroxy-6-methyl-9-(4-(3-methyl-l- (methylamino)butan-2-yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1286) : 9-(3-fluor-4-(1-(methylamino)propan-2-yl)phenyl)-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1287) : 9-(4-(l-amino-2-methylpropan-2-yl)-3-fluorphenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1288) : 9-(4-(l-amino-3-methylbutan-2-yl)-3-fluorphenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1289) : 9-(4-(2-amino-2-methylpropyl)phenyl)-6-brom-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1290) : 9-(4-(1-(aminomethyl)cyclobutyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1291) : 9-(4-(l-aminobutan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1292) : 9-(4-(2-amino-2-methylpropyl)phenyl)-6-brom-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1293) : 9-(3-fluor-4-(1-(methylamino)propan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1294) : 9-(3-fluor-4-(3-methyl-l-(methylamino)butan-2- yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1295) : 9-(4-(1-(dimethylamino)-3-methylbutan-2-yl)phenyl)-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1296) : 9-(4-(1-(dimethylamino)-3-methylbutan-2-yl)-3- fluorphenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1297) : 9-(4-(1-(aminomethyl)cyclobutyl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1298) : (R)-8-methoxy-6-methyl-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1299) : 9-(4-(1-(aminomethyl) cyclobutyl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1300) : 9-(4-(1-(aminomethyl)cyclobutyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1301) : 8-methoxy-6-methyl-9-(4-(piperidin-3- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1302) : 8-hydroxy-6-methyl-9-(4-(piperidin-3- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1303) : (S)-9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1304) : (S)-9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1305) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1306) : (R)-8-hydroxy-6-methyl-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1307) : (R)-8-hydroxy-6-methyl-9-(4-(1-(methylamino)propan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1309) : 9-(4-(l-aminobutan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1310) : (S)-9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1311) : (R)-9-(4-(1-(dimethylamino)propan-2-yl)-3-fluorphenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1312) : 9-(4-(l-aminobutan-2-yl)phenyl)-6-chlor-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1314) : 9-amino-8-methoxy-6-methylthieno[2,3-c]quinolin-4 (5H)- on; (1315) : (R) -9-(3-fluor-4-(1-(methylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1316) : (R)-9-(3-fluor-4-(1-(methylamino)propan-2-yl)phenyl)- 8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1317) : (R)-9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1318) : (R)-9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4 (5H)-on; (1319) : (R) -9-(4-(l-aminopropan-2-yl)-3-fluorphenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1320) : 9-((4-(2-aminoethyl)phenyl)amino)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1321) : 9-(4-(1-(aminomethyl)cyclobutyl)phenyl)-6-chlor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1324) : (R) -9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1325) : 9-((4-(aminomethyl)phenyl)amino)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1326) : 9-((4-(aminomethyl)phenyl)amino)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1327) : 9-((4-(l-aminopropan-2-yl)phenyl)amino)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1328) : 9-((4-(l-aminopropan-2-yl)phenyl)amino)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1329) : 9-(4-(2-aminopropan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1330) : 9-(4-(2-aminopropan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1331) : 9-(4-(3-(aminomethyl)pentan-3-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1332) : 9-(4-((R)-l-aminopropan-2-yl)phenyl)-8-hydroxy-2-(1- hydroxyethyl)thieno[2,3-c]quinolin-4(5H)-on; (1333) : 9-(4-((R)-l-aminopropan-2-yl)phenyl)-2- (1- hydroxyethyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1335) : 9-((3-(2-aminoethyl)phenyl)amino)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1336) : 9-((4-(2-aminoethyl)phenyl)amino)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1337) : 9-(4-(2-(ethylamino)propyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1338) : 9-(4-(3-(aminomethyl)pentan-3-yl) phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1339) : 9-(4-(3-(aminomethyl)pentan-3-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1340) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-8-hydroxy-2,6- dimethylthieno[2,3-c]quinolin-4(5H)-on; (1341) : (R)-9-(4-(l-aminopropan-2-yl) phenyl)-8-methoxy-2,6- dimethylthieno[2,3-c]quinolin-4(5H)-on; (1342) : 9-(4-((R)-l-aminopropan-2-yl)phenyl)-2- (1- hydroxyethyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)- on; (1343) : 2-((4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)amino)acetonitril; (1344) : (R)-9-(4-(l-aminobutan-2-yl)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1345) : 9-(3-chlor-4-(2-(ethylamino)ethyl)phenyl)-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1346) : 9-(4-(3-((dimethylamino)methyl) pentan-3-yl) phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1347) : (R)-6-chlor-9-(4-(-(dimethylamino)propan-2-yl)phenyl)- 8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1348) : 9-(4-(2-(ethylamino)ethyl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1349) : 9-(4-(2-(ethylamino)ethyl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1350) : 9-(4-(2-(ethyl(methyl)amino)propyl) phenyl)-8-hydroxy-β-methylthieno[2,3-c]quinolin-4(5H)-on; (1352) : (R)-9-(4-(l-aminobutan-2-yl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1353) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-2-chlor-8-hydroxy-6-methylthieno[2,3-c]quinolin-4 (5H)-on; (1354) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-2-chlor-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1355) : 8-methoxy-6-methyl-9-(4- (2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1356) : 9-(4-(2-(ethyl(methyl)amino)ethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1357) : 9-(4-(3-(aminomethyl)pentan-3-yl)phenyl)-6-chlor-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1358) : 9-(4-(3-((dimethylamino)methyl)pentan-3-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1359) : 9-(6-(dimethylamino)pyridin-3-yl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1360) : (R) -9-(4-(1-(dimethylamino)butan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1361) : (R)-8-methoxy-6-methyl-9-(4-(1-(methylamino)butan-2- yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1362) : 9-(4-(3-((diethylamino)methyl)pentan-3-yl) phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1363) : 9-(3-chlor-4-(2-(ethylamino)ethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1364) : 8-hydroxy-6-methyl-9-(4-(2- (methylamino)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1365) : (R)- 9-(4-(1-(dimethylamino)butan-2-yl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1366) : (R)-9-(4-(1-(ethyl(methyl)amino)butan-2-yl)phenyl)-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1367) : (R)-9-(4-(1-(diethylamino)butan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1368) : (R)-9-(4-(1-(ethyl(methyl)amino)butan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1369) : 2-((4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)(methyl)amino)acetonitril; (1370) : 2-((4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)(methyl)amino)acetonitril; (1371) : 9-(3-chlor-4-(2-(ethyl(methyl)amino)ethyl) phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1372) : 9-(4-(1-((dimethylamino)methyl)cyclobutyl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4 (5H)-on; (1373) : (R)-9-(4-(1-aminopropyl)phenyl)-6-brom-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1374) : 9-(6-(2-aminoethoxy)pyridin-3-yl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1375) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-2-fluor-8- methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1376) : 9-(6-(2-aminoethoxy)pyridin-3-yl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1377) : 9-(4-(l-amino-2,2,2-trifluorethyl)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1378) : 9-(4-(l-amino-2,2,2-trifluorethyl) phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1379) : (R)-9-(4-(l-(ethyl(methyl)amino)propan-2-yl) phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1380) : (R)-8-hydroxy-6-methyl-9-(4-(1-(methylamino)butan-2-yl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1381) : 9-(4-(l-amino-2,2,2-trifluorethyl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1383) : (R)-9-(4-(l-aminopropan-2-yl)phenyl)-2-fluor-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1384) : 9-(6-((2-aminoethyl) amino)pyridin-3-yl) -8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1385) : 9-(6-((2-aminoethyl) amino)pyridin-3-yl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1386) : (S)-6-chlor-9-(4-(1-(ethyl(methyl)amino)propan-2- yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-on; (1387) : (S)-9-(4-(1-(dimethylamino)propan-2-yl)-3- fluorphenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1388) : (R)-9-(4-(1-(diethylamino)propan-2-yl)phenyl)-8- hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1389) : 9-(4-(l-amino-2,2,2-trifluorethyl)phenyl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1390) : 9-(4-(l-amino-2,2,2-trifluorethyl)phenyl)-6-brom-8- methoxythieno[2,3-c]quinolin-4(5H)-on; (1391) : 9-(4-(1-(aminomethyl)cyclopropyl)phenyl)- 6-brom-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1392) : (4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl) phenyl)methansulfonamid; (1393) : 8-methoxy-6-methyl-9- (4- (2- (methylsulfinyl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1394) : 8-hydroxy-6-methyl-9-(4-((methylsulfonyl)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1395) : (4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)methansulfonamid; (1396) : 9-(4-((2-aminoethyl)(methyl)amino)phenyl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1397) : (R)-N-(2-(2-fluor-4-(8-hydroxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9- yl)phenyl)propyl)methansulfonamid; (1398) : (R)-N-(2-(2-fluor-4-(8-methoxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9- yl) phenyl) propyl)methansulfonamid; (1399) : (S)-9-(4-(1-(dimethylamino)propan-2-yl)-3- fluorphenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1400) : 9-(4-((2-aminoethyl)(methyl)amino)phenyl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1401) : 9-(4-(1-(aminomethyl)cyclopropyl)phenyl)-6-brom-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1402) : 2-(6-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-3-yl)acetonitril; (1403) : 8-hydroxy-6-methyl-9-(4-(2- (methylsulfinyl)ethyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1404) : 8-methoxy-6-methyl-9-(4- ((methylsulfonyl)methyl)phenyl)thieno[2,3-c]quinolin-4(5H)-on; (1405) : 5-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)nicotinamid; (1406) : 2-(5-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-2-yl)propannitril; (1407) : 2-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propanamid; (1408) : 9-(6-(l-aminopropan-2-yl)pyridin-3-yl)-8-methoxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1409) : 2-(5-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-2-yl)-2-methylpropannitril; (1410) : 2-hydroxy-2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propan-l-sulfonamid; (1411) : N-(tert-butyl)-2-hydroxy-2-(4-(8-methoxy-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propan-1-sulfonamid; (1412) : 2-(4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propanamid; (1413) : 2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propan-1-sulfonamid; (1414) : 9-(4-(2-amino-l-fluorethyl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1415) : 9-(6-(l-aminopropan-2-yl)pyridin-3-yl)-8-hydroxy-6- methylthieno[2,3-c]quinolin-4(5H)-on; (1416) : 2-(5-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-2-yl)-2-methylpropannitril; (1417) : 2-(5-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)pyridin-2-yl)-2-methylpropannitril; (1418) : 2-(5-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)pyridin-2-yl)-2-methylpropannitril; (1419) : 2-(4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propan-1-sulfonamid; (1420) : 9-(4-(2-amino-l-hydroxyethyl)phenyl)-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-on; (1421) : 9-(6-(l-amino-2-methylpropan-2-yl)pyridin-3-yl)-8- hydroxythieno[2,3-c]quinolin-4(5H)-on; (1422) : N-cyclopropyl-1-(4-(8-methoxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)methansulfonamid; (1423) : 2-(5-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-2-yl)propannitril; (1424) : (R)-N-(2-(4-(8-methoxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9- yl)phenyl)propyl)methansulfonamid; (1425) : N-ethyl-1-(4-(8-methoxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)methansulfonamid; (1426) : 9-(6-(l-aminopropan-2-yl)pyridin-3-yl)-8-methoxythieno[2,3-c]quinolin-4(5H)-on; (1427) : N-cyclopropyl-1-(4-(8-hydroxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)methansulfonamid; (1428) : 1-(5-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)pyridin-2-yl)cyclopropancarbonitril; (1429) : N-ethyl-1-(4-(8-hydroxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl) phenyl) methansulfonamid; (1430) : 1-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl) phenyl)ethansulfonamid; (1431) : 1-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)ethansulfonamid; (1432) : (R)-N-(2-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propyl)methansulfonamid; (1433) : (R)-N-(2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno [2,3- c]quinolin-9-yl)phenyl)propyl)-N-methylmethansulfonamid; (1434) : (R)-N-(2-(4-(8-hydroxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9- yl)phenyl)propyl)methansulfonamid; (1435) : (R)-N-(2-(4-(8-hydroxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propyl)methansulfonamid; (1436) : (R) -N-(2-(4-(8-methoxy-4-oxo-4,5-dihydrothieno[2,3- c]quinolin-9-yl)phenyl)propyl)-N-methylmethansulfonamid; (1437) : (R)-N-(2-(4-(8-hydroxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propyl)-N- methylmethansulfonamid; (1438) : (R)-N-(2-(4-(8-methoxy-6-methyl-4-oxo-4,5- dihydrothieno[2,3-c]quinolin-9-yl)phenyl)propyl)-N- methylmethansulfonamid; eller et farmaceutisk acceptabelt salt deraf.
6. Farmaceutisk præparat, der omfatter mindst én forbindelse ifølge krav 1 eller 2 eller et farmaceutisk acceptabelt salt deraf og et farmaceutisk acceptabelt bæremateriale.
7. Forbindelse eller farmaceutisk acceptabelt salt deraf ifølge krav 1 eller 2 til anvendelse til behandling af cancer.
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CA2792941A1 (en) 2011-10-06
TW201136939A (en) 2011-11-01
US9453025B2 (en) 2016-09-27
WO2011123419A1 (en) 2011-10-06
US20150183799A1 (en) 2015-07-02
EP2552206A4 (en) 2013-08-14
JP2013523749A (ja) 2013-06-17
CN102917590B (zh) 2016-02-17

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