DK2382474T3 - Opløselig icam-1 som biomarkør til forudsigelse af terapeutisk respons - Google Patents
Opløselig icam-1 som biomarkør til forudsigelse af terapeutisk respons Download PDFInfo
- Publication number
- DK2382474T3 DK2382474T3 DK10704115T DK10704115T DK2382474T3 DK 2382474 T3 DK2382474 T3 DK 2382474T3 DK 10704115 T DK10704115 T DK 10704115T DK 10704115 T DK10704115 T DK 10704115T DK 2382474 T3 DK2382474 T3 DK 2382474T3
- Authority
- DK
- Denmark
- Prior art keywords
- sicam
- vector
- patient
- immunogenic composition
- recombinant
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Claims (16)
1. Ex-vivo-fremgangsmåde til at teste hvorvidt en patient vil respondere terapeutisk på en behandlingsfremgangsmåde omfattende administration af en immunogen sammensætning, hvor testfremgangsmåden omfatter trinnet at måle niveauer af sICAM-1 i en blodprøve taget fra patienten før administration af den immunogene sammensætning hvor lave niveauer af sICAM-1 indikerer at patienten vil udvikle et profylaktisk eller terapeutisk respons mod den immunogene sammensætning hvor lave niveauer af sICAM-1 værende mindre end 300 ng/ml, og hvor den immunogene sammensætning indeholder alt eller del af mindst et mål-antigen eller mindst en rekombinant vektor der udtrykker in vivo alt eller del af mindst en heterolog nukleotidsekvens der koder for alt eller del af mindst et målantigen.
2. Fremgangsmåden ifølge krav 1, hvor de lave niveauer af sICAM-1 betyder niveauer på mindre end 250 ng/ml.
3. Fremgangsmåden ifølge krav 1, hvor de lave niveauer af sICAM-1 betyder niveauer på mindre end 224 ng/ml.
4. Fremgangsmåden ifølge krav 1, hvor de lave niveauer af sICAM-1 betyder niveauer på mindre end 200 ng/ml.
5. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 4, hvor behandlingsfremgangsmåden er en fremgangsmåde til behandling af cancer.
6. Fremgangsmåden ifølge et hvilket som helst af de foregående krav, hvor niveauet af sICAM-1 måles med multi-analyt-plasmaprotein-profil eller enzym-bundet immunosorbent-assays.
7. Fremgangsmåden ifølge et hvilket som helst af de foregående krav, hvor niveauet af sICAM-1 bestemmes under anvendelse af antistoffer.
8. Fremgangsmåden ifølge et hvilket som helst af de foregående krav, hvor blodprøven vælges fra gruppen bestående af total blodprøve, plasma eller serum.
9. Fremgangsmåden ifølge et hvilket som helst af kravene 1 til 8, hvor den rekombinante vektor er en virusvektor.
10. Fremgangsmåden ifølge krav 9, hvor virusvektoren er replikations-kompetent.
11. Fremgangsmåden ifølge krav 9, hvor virusvektoren er replikations-defekt.
12. Fremgangsmåden ifølge et hvilket som helst af kravene 9 to 11, hvor den rekombinante vektor er en rekombinant adenovirusvektor.
13. Fremgangsmåden ifølge et hvilket som helst af kravene 9 to 11, hvor den rekombinante vektor er en rekombinant vaccinia-vektor.
14. Fremgangsmåden ifølge krav 13, hvor den rekombinante vaccinia-vektor er en rekombinant MVA-vektor.
15. Fremgangsmåden ifølge et hvilket som helst af de foregående krav, hvor patienten er en patient behandlet med et kemoterapeutisk middel.
16. Anvendelse af niveauer af sICAM-1 i en blodprøve som en biomarkør til forudsigelse af hvorvidt en patient er eller ikke mistænkt for at udvikle et profylaktisk eller terapeutisk immunrespons ved administration af en immunogen sammensætning, hvor blodprøven er taget fra patienten før administration af den immunogene sammensætning og hvor den immunogene sammensætning indeholder alt eller del af mindst et mål-antigen eller mindst en rekombinant vektor der udtrykker in vivo alt eller del af mindst en heterolog nukleotidsekvens der koder for alt eller del af mindst et mål-antigen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09305044 | 2009-01-20 | ||
EP09305294 | 2009-04-07 | ||
PCT/EP2010/050532 WO2010084100A1 (en) | 2009-01-20 | 2010-01-18 | Soluble icam-1 as biomarker for prediction of therapeutic response |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2382474T3 true DK2382474T3 (da) | 2015-04-07 |
Family
ID=42028081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10704115T DK2382474T3 (da) | 2009-01-20 | 2010-01-18 | Opløselig icam-1 som biomarkør til forudsigelse af terapeutisk respons |
Country Status (24)
Country | Link |
---|---|
US (2) | US20110312525A1 (da) |
EP (1) | EP2382474B1 (da) |
JP (1) | JP5379243B2 (da) |
KR (1) | KR20110116016A (da) |
CN (1) | CN102292638B (da) |
AU (1) | AU2010206195B2 (da) |
BR (1) | BRPI1006901A2 (da) |
CA (1) | CA2749192A1 (da) |
CO (1) | CO6390020A2 (da) |
CR (1) | CR20110438A (da) |
DK (1) | DK2382474T3 (da) |
ES (1) | ES2536747T3 (da) |
HK (1) | HK1161643A1 (da) |
HR (1) | HRP20150470T1 (da) |
HU (1) | HUE025015T2 (da) |
IL (1) | IL213098A (da) |
MX (1) | MX2011007386A (da) |
NZ (1) | NZ593749A (da) |
PL (1) | PL2382474T3 (da) |
PT (1) | PT2382474E (da) |
SG (2) | SG196837A1 (da) |
TW (1) | TWI440854B (da) |
WO (1) | WO2010084100A1 (da) |
ZA (1) | ZA201105271B (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103175959B (zh) * | 2013-02-28 | 2015-10-14 | 成都创宜生物科技有限公司 | 一种检测胎膜早破免疫层析试纸的制备方法 |
CN103235134B (zh) * | 2013-05-08 | 2015-10-14 | 成都创宜生物科技有限公司 | 一种检测胎膜早破的免疫层析试纸及其制备方法 |
CN103698537A (zh) * | 2014-01-06 | 2014-04-02 | 天津医科大学总医院 | 定量检测人血清可溶性细胞间粘附分子-1的化学发光免疫分析试剂盒及检测方法 |
WO2019173462A1 (en) * | 2018-03-06 | 2019-09-12 | Pepvax, Inc. | Nucleic acid molecules and methods of using the same |
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2010
- 2010-01-18 SG SG2014004030A patent/SG196837A1/en unknown
- 2010-01-18 DK DK10704115T patent/DK2382474T3/da active
- 2010-01-18 ES ES10704115.4T patent/ES2536747T3/es active Active
- 2010-01-18 AU AU2010206195A patent/AU2010206195B2/en not_active Ceased
- 2010-01-18 NZ NZ593749A patent/NZ593749A/xx not_active IP Right Cessation
- 2010-01-18 WO PCT/EP2010/050532 patent/WO2010084100A1/en active Application Filing
- 2010-01-18 MX MX2011007386A patent/MX2011007386A/es active IP Right Grant
- 2010-01-18 CA CA2749192A patent/CA2749192A1/en not_active Abandoned
- 2010-01-18 KR KR1020117016841A patent/KR20110116016A/ko active IP Right Grant
- 2010-01-18 PL PL10704115T patent/PL2382474T3/pl unknown
- 2010-01-18 PT PT107041154T patent/PT2382474E/pt unknown
- 2010-01-18 HU HUE10704115A patent/HUE025015T2/en unknown
- 2010-01-18 BR BRPI1006901A patent/BRPI1006901A2/pt not_active Application Discontinuation
- 2010-01-18 EP EP10704115.4A patent/EP2382474B1/en not_active Not-in-force
- 2010-01-18 CN CN201080004940.8A patent/CN102292638B/zh not_active Expired - Fee Related
- 2010-01-18 US US13/145,336 patent/US20110312525A1/en not_active Abandoned
- 2010-01-18 SG SG2011052404A patent/SG173065A1/en unknown
- 2010-01-18 JP JP2011545757A patent/JP5379243B2/ja not_active Expired - Fee Related
- 2010-01-20 TW TW099101520A patent/TWI440854B/zh not_active IP Right Cessation
-
2011
- 2011-05-24 IL IL213098A patent/IL213098A/en not_active IP Right Cessation
- 2011-07-18 ZA ZA2011/05271A patent/ZA201105271B/en unknown
- 2011-07-19 CO CO11090083A patent/CO6390020A2/es not_active Application Discontinuation
- 2011-08-17 CR CR20110438A patent/CR20110438A/es not_active Application Discontinuation
-
2012
- 2012-02-29 HK HK12102112.5A patent/HK1161643A1/xx not_active IP Right Cessation
-
2013
- 2013-05-23 US US13/900,869 patent/US20140023686A1/en not_active Abandoned
-
2015
- 2015-05-04 HR HRP20150470TT patent/HRP20150470T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
RU2011134415A (ru) | 2013-02-27 |
US20140023686A1 (en) | 2014-01-23 |
MX2011007386A (es) | 2011-08-03 |
JP2012515893A (ja) | 2012-07-12 |
AU2010206195A1 (en) | 2010-07-29 |
IL213098A0 (en) | 2011-07-31 |
CO6390020A2 (es) | 2012-02-29 |
SG196837A1 (en) | 2014-02-13 |
EP2382474A1 (en) | 2011-11-02 |
NZ593749A (en) | 2012-05-25 |
BRPI1006901A2 (pt) | 2016-02-16 |
US20110312525A1 (en) | 2011-12-22 |
ES2536747T3 (es) | 2015-05-28 |
PT2382474E (pt) | 2015-06-03 |
JP5379243B2 (ja) | 2013-12-25 |
CN102292638B (zh) | 2014-05-28 |
ZA201105271B (en) | 2012-03-28 |
PL2382474T3 (pl) | 2015-08-31 |
HK1161643A1 (en) | 2012-07-27 |
HRP20150470T1 (hr) | 2015-06-05 |
SG173065A1 (en) | 2011-08-29 |
EP2382474B1 (en) | 2015-03-04 |
AU2010206195B2 (en) | 2016-03-10 |
CN102292638A (zh) | 2011-12-21 |
HUE025015T2 (en) | 2016-04-28 |
WO2010084100A1 (en) | 2010-07-29 |
CA2749192A1 (en) | 2010-07-29 |
CR20110438A (es) | 2011-12-28 |
IL213098A (en) | 2015-08-31 |
KR20110116016A (ko) | 2011-10-24 |
TWI440854B (zh) | 2014-06-11 |
TW201031917A (en) | 2010-09-01 |
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