DK1939287T3 - Fremgangsmåde til genoverførsel, der er specifik for en trophectodermal celle - Google Patents
Fremgangsmåde til genoverførsel, der er specifik for en trophectodermal celle Download PDFInfo
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- DK1939287T3 DK1939287T3 DK06781980.5T DK06781980T DK1939287T3 DK 1939287 T3 DK1939287 T3 DK 1939287T3 DK 06781980 T DK06781980 T DK 06781980T DK 1939287 T3 DK1939287 T3 DK 1939287T3
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
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- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2227/00—Animals characterised by species
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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Claims (10)
1. Fremgangsmåde til specifik indføring af et arbitrært polynukleotid i en ikke-human trophectodermal celle, hvilken fremgangsmåde omfatter trinnene med: (a) at fjerne zona pellucida fra en ikke-human blastocyst; og (b) at indføre et arbitrært polynukleotid i trophectodermale celler af blastocy-sten, der blev opnået i trin (a).
2. Fremgangsmåde til fremstilling af en ikke-human blastocyst, der omfatter en trophectodermal celle, som er specifikt indført med et arbitrært polynukleotid, hvilken fremgangsmåde omfatter trinnene med: (a) at fjerne zona pellucida fra en ikke-human blastocyst; og (b) at indføre et arbitrært polynukleotid i trophectodermale celler af blastocy-sten, der blev opnået i trin (a).
3. Fremgangsmåde ifølge krav 1 eller 2, hvor det arbitrære polynukleotid er et polynukleotid, der koder for et protein, der er essentielt for fosterets udvikling, eller et polynukleotid, der regulerer ekspression af proteinet.
4. Fremgangsmåde ifølge krav 3, hvor polynukleotidet, der koder for et protein, som er essentielt for fosterets udvikling, mindst er et polynukleotid, der er valgt fra gruppen bestående af: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, ρ38α, ρ38β, Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmtl, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Handl, Mdfi, Esx1, Arnt, Tcfeb og Gjb2.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor blasto-cysten er afledt af et ikke-humant dyr, der har en abnormitet i et protein, som er essentielt for fosterets udvikling, eller i reguleringen af ekspression af proteinet.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, hvor zona pellucida fjernes med syrebehandling, enzymbehandling eller fysisk behand- ling.
7. Fremgangsmåde ifølge krav 6, hvor syrebehandlingen er en behandling med surTyrode-opløsning.
8. Fremgangsmåde ifølge krav 6, hvor enzymbehandlingen er en pronasebe-handling.
9. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 8, hvor polynu-kleotidet indføres ved at inficere en blastocyst med en virusvektor, der bærer et ønsket polynukleotid.
10. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 8, hvor po-lynukleotidet indføres ved anvendelse af et nukleinsyre-transfektionsreagens.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005234258 | 2005-08-12 | ||
| PCT/JP2006/315102 WO2007020786A1 (ja) | 2005-08-12 | 2006-07-31 | 栄養外胚葉細胞特異的遺伝子導入法 |
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| Publication Number | Publication Date |
|---|---|
| DK1939287T3 true DK1939287T3 (da) | 2017-02-20 |
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| DK06781980.5T DK1939287T3 (da) | 2005-08-12 | 2006-07-31 | Fremgangsmåde til genoverførsel, der er specifik for en trophectodermal celle |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8815598B2 (da) |
| EP (1) | EP1939287B1 (da) |
| JP (1) | JP5020083B2 (da) |
| DK (1) | DK1939287T3 (da) |
| ES (1) | ES2606912T3 (da) |
| PT (1) | PT1939287T (da) |
| WO (1) | WO2007020786A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK288641B6 (sk) * | 2008-10-15 | 2019-02-04 | Smk Corporation | Spôsob komunikácie s POS terminálom, frekvenčný konventor k POS terminálu |
| CN102460520B (zh) | 2009-05-03 | 2015-01-21 | 洛格摩提公司 | 使用移动通信装置的支付终端,例如移动电话;直接借记支付交易的方法 |
| WO2011108711A1 (ja) * | 2010-03-04 | 2011-09-09 | 扶桑薬品工業株式会社 | 妊娠高血圧症候群モデル動物とその治療方法 |
| TWI650417B (zh) * | 2017-06-07 | 2019-02-11 | 國立嘉義大學 | 利用慢病毒轉染去透明帶早期胚胎的基因轉殖方法 |
| CN108411003A (zh) * | 2018-05-22 | 2018-08-17 | 华中农业大学 | Wnt2基因片段作为影响猪红细胞数目性状的分子标记 |
| CN112795639A (zh) * | 2021-02-04 | 2021-05-14 | 华南农业大学 | 一种psap基因在制备检测猪妊娠早期胚胎死亡产品中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996011713A1 (en) | 1994-10-14 | 1996-04-25 | Daiichi Pharmaceutical Co., Ltd. | Genetic material containing composition |
| JPH1129498A (ja) * | 1997-07-15 | 1999-02-02 | Tanabe Seiyaku Co Ltd | 胎児由来組織への遺伝子導入方法 |
| US6465182B1 (en) | 1999-04-29 | 2002-10-15 | The Regents Of The University Of California | Comparative fluorescence hybridization to oligonucleotide microarrays |
| US20050241012A1 (en) * | 2003-10-17 | 2005-10-27 | Nigam Sanjay K | Multigene profiling in the kidney to tailor drug therapy |
| WO2011108711A1 (ja) | 2010-03-04 | 2011-09-09 | 扶桑薬品工業株式会社 | 妊娠高血圧症候群モデル動物とその治療方法 |
-
2006
- 2006-07-31 US US12/063,576 patent/US8815598B2/en not_active Expired - Fee Related
- 2006-07-31 PT PT67819805T patent/PT1939287T/pt unknown
- 2006-07-31 WO PCT/JP2006/315102 patent/WO2007020786A1/ja active Application Filing
- 2006-07-31 JP JP2007530936A patent/JP5020083B2/ja not_active Expired - Fee Related
- 2006-07-31 EP EP06781980.5A patent/EP1939287B1/en active Active
- 2006-07-31 DK DK06781980.5T patent/DK1939287T3/da active
- 2006-07-31 ES ES06781980.5T patent/ES2606912T3/es active Active
-
2014
- 2014-07-16 US US14/332,738 patent/US20140370602A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090013418A1 (en) | 2009-01-08 |
| WO2007020786A1 (ja) | 2007-02-22 |
| EP1939287B1 (en) | 2016-11-23 |
| US8815598B2 (en) | 2014-08-26 |
| EP1939287A1 (en) | 2008-07-02 |
| JP5020083B2 (ja) | 2012-09-05 |
| PT1939287T (pt) | 2017-02-03 |
| EP1939287A4 (en) | 2009-03-04 |
| ES2606912T3 (es) | 2017-03-28 |
| US20140370602A1 (en) | 2014-12-18 |
| JPWO2007020786A1 (ja) | 2009-02-19 |
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