DK181484A - Middel mod svulster og fremgangsmaade til fremstilling deraf - Google Patents

Middel mod svulster og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number
DK181484A
DK181484A DK181484A DK181484A DK181484A DK 181484 A DK181484 A DK 181484A DK 181484 A DK181484 A DK 181484A DK 181484 A DK181484 A DK 181484A DK 181484 A DK181484 A DK 181484A
Authority
DK
Denmark
Prior art keywords
preparation
means against
against tumors
tumors
Prior art date
Application number
DK181484A
Other languages
Danish (da)
English (en)
Other versions
DK181484D0 (da
Inventor
Yoshiharu Oguchi
Koishi Niimura
Takayoshi Fujii
Masahiko Fujii
Kenichi Matsunaga
Chikao Yoshikumi
Original Assignee
Kureha Chemical Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Chemical Ind Co Ltd filed Critical Kureha Chemical Ind Co Ltd
Publication of DK181484D0 publication Critical patent/DK181484D0/da
Publication of DK181484A publication Critical patent/DK181484A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK181484A 1983-04-08 1984-04-06 Middel mod svulster og fremgangsmaade til fremstilling deraf DK181484A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58061923A JPS59186924A (ja) 1983-04-08 1983-04-08 ヒト免疫グロブリン結合抗腫瘍剤

Publications (2)

Publication Number Publication Date
DK181484D0 DK181484D0 (da) 1984-04-06
DK181484A true DK181484A (da) 1984-10-09

Family

ID=13185161

Family Applications (1)

Application Number Title Priority Date Filing Date
DK181484A DK181484A (da) 1983-04-08 1984-04-06 Middel mod svulster og fremgangsmaade til fremstilling deraf

Country Status (7)

Country Link
US (2) US4738843A (cs)
EP (1) EP0122132A3 (cs)
JP (1) JPS59186924A (cs)
CA (1) CA1301066C (cs)
DK (1) DK181484A (cs)
SE (2) SE462261B (cs)
ZA (1) ZA842272B (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0653682B2 (ja) * 1983-04-08 1994-07-20 呉羽化学工業株式会社 ヒト免疫グロブリン結合抗腫瘍剤
CA1260828A (en) * 1983-07-04 1989-09-26 Masakazu Iwai Therapeutic and prophylactic agent for gastrointestinal ulcers
FR2581313A1 (fr) * 1985-05-02 1986-11-07 Pasteur Institut Composes suscitant la formation d'anticorps, compositions immunogeniques et compositions immunoprotectrices les contenant et procede d'obtention d'anticorps les mettant en oeuvre
AU605132B2 (en) * 1986-01-03 1991-01-10 Consolidated Pharmaceuticals Limited Melphalan derivatives
CA1330378C (en) * 1986-05-08 1994-06-21 Daniel J. Coughlin Amine derivatives of folic acid analogs
JPH0662438B1 (cs) * 1986-08-28 1994-08-17 Teijin Ltd
US5030719A (en) * 1986-08-28 1991-07-09 Teijin Limited Cytotoxic antibody conjugates and a process for preparation thereof
YU46858B (sh) * 1987-03-11 1994-06-24 Farmitalia Carlo Erba S.R.L. Postupak za dobijanje imunoglobulinskih konjugata
US4900547A (en) * 1987-10-23 1990-02-13 University Of British Columbia Method to immunize mammals against tumors
GB8727157D0 (en) * 1987-11-19 1987-12-23 Wellcome Found Pharmaceutical formulations
US4994440A (en) * 1989-02-13 1991-02-19 Creaven Patrick J Method for the treatment of renal cell carcinoma
US6326467B1 (en) * 1989-02-23 2001-12-04 Colorado State University Research Foundation Hormone-recombinant toxin compounds and methods for using same
CA2021942C (en) * 1989-08-10 2001-04-10 Michel Page Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
GB2246779B (en) * 1990-08-03 1994-08-17 Delta Biotechnology Ltd Tumour-associated protease inhibitors targeted to tumour cells
ATE127018T1 (de) * 1992-03-06 1995-09-15 Fiutowski Zdzislaw Pharmazeutische zusammensetzung mit antiviraler und antibakterieller wirkung.
JP2578044B2 (ja) * 1992-03-14 1997-02-05 呉羽化学工業株式会社 フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤
WO1994014437A1 (en) * 1992-12-21 1994-07-07 Ophidian Pharmaceuticals, Inc. Prevention and treatment of sepsis
EP0608546A3 (en) * 1992-12-22 1995-09-27 Takeda Chemical Industries Ltd Glia activating factor (gaf), antibodies against it and their uses.
US5382582A (en) * 1993-03-26 1995-01-17 Chan; Carcy L. Methotrexate analogs and methods of using same
US5502037A (en) * 1993-07-09 1996-03-26 Neuromed Technologies, Inc. Pro-cytotoxic drug conjugates for anticancer therapy
US5698556A (en) * 1995-06-07 1997-12-16 Chan; Carcy L. Methotrexate analogs and methods of using same
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
PT923941E (pt) * 1996-06-27 2006-09-29 Chugai Pharmaceutical Co Ltd Medicamentos para mieloma a serem utilizados com agentes antitumorais de mostarda nitrogenada
US20080312201A1 (en) * 2004-09-10 2008-12-18 Patrick Fogarty Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
AU2006292433B2 (en) * 2005-09-20 2011-05-19 Amgen Inc. Method for generating F(ab')2 antibody fragments
NZ568288A (en) 2005-11-28 2012-02-24 Verrow Pharmaceuticals Inc Compositions comprising a a cyclodextrin and a nephrotoxic anticancer drug
RU2472812C2 (ru) 2005-12-05 2013-01-20 НИТТО ДЕНКО КОРПОРЭЙШН (Джэпэн/Джэпэн) Конъюгаты полиглутамат-аминокислота и способы
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
US20080253969A1 (en) * 2007-04-10 2008-10-16 Nitto Denko Corporation Multi-functional polyglutamate drug carriers
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
WO2008141107A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
US7998967B2 (en) 2008-03-03 2011-08-16 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
AR077384A1 (es) 2010-07-05 2011-08-24 Eriochem Sa Una formulacion farmaceutica inyectable de melfalano.
MX367055B (es) 2012-06-26 2019-08-02 Del Mar Pharmaceuticals El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
US10854554B2 (en) 2018-01-23 2020-12-01 Ferro Corporation Carbide, nitride and silicide enhancers for laser absorption
US10723160B2 (en) 2018-01-23 2020-07-28 Ferro Corporation Carbide, nitride and silicide enhancers for laser absorption

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509707A (en) * 1974-09-20 1978-05-04 Searle & Co Immunological compounds
GB1541435A (en) * 1975-02-04 1979-02-28 Searle & Co Immunological materials
IL47372A (en) * 1975-05-27 1979-10-31 Yeda Res & Dev Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same
US4263279A (en) * 1975-08-19 1981-04-21 Yeda Research & Development Co. Ltd Pharmaceutically active compositions containing adriamycin and daunomycin
US4017471A (en) * 1975-09-15 1977-04-12 G. D. Searle & Co. Immunological compounds
JPS5364617A (en) * 1976-11-22 1978-06-09 Furukawa Electric Co Ltd:The Manufacture of oxygen-free high-conductivity copper
JPS54132503A (en) * 1978-04-07 1979-10-15 Kayaku Antibiotic Research Co Immune globulin combined neocarcinostatin
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4493793A (en) * 1978-12-26 1985-01-15 E-Y Laboratories Soluble immunoassay reagent comprising lectin covalently bonded to reactive component
US4315851A (en) * 1978-12-29 1982-02-16 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition having antitumor activity
JPS5616418A (en) * 1979-07-20 1981-02-17 Teijin Ltd Antitumor protein complex and its preparation
US4359457A (en) * 1980-09-30 1982-11-16 Neville Jr David M Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant
FR2504010B1 (fr) * 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
US4489710A (en) * 1981-06-23 1984-12-25 Xoma Corporation Composition and method for transplantation therapy
JPH0651643B2 (ja) * 1983-01-19 1994-07-06 帝人株式会社 殺細胞性修飾免疫グロブリン及びその製造方法

Also Published As

Publication number Publication date
ZA842272B (en) 1984-11-28
DK181484D0 (da) 1984-04-06
SE8401942L (sv) 1984-11-13
SE8401942D0 (sv) 1984-04-06
SE8904004D0 (sv) 1989-11-27
CA1301066C (en) 1992-05-19
JPS6330289B2 (cs) 1988-06-17
EP0122132A2 (en) 1984-10-17
SE462261B (sv) 1990-05-28
JPS59186924A (ja) 1984-10-23
US4738843A (en) 1988-04-19
US4925662A (en) 1990-05-15
SE8904004L (sv) 1991-05-28
EP0122132A3 (en) 1985-11-27

Similar Documents

Publication Publication Date Title
DK181484A (da) Middel mod svulster og fremgangsmaade til fremstilling deraf
DK165321C (da) Oxiranderivater og fremgangsmaade til fremstilling deraf
DK256485D0 (da) Veterinaert praeparat og fremgangsmaade til fremstilling deraf
DK227884A (da) 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanoler, deres fremstilling og anvendelse
DK594884D0 (da) Tvaerbundne polymerisater, deres fremstilling og anvendelse
DK483083D0 (da) Platin-diamin komplekser og fremgangsmade til fremstilling deraf
NO845266L (no) Laminert polyesterholdig substrat og anvendelse derav
DK621484D0 (da) Acylaminomitosaner og fremgangsmaade til fremstilling deraf
DK406384A (da) Imidazobenzodiazepinderivater og disses anvendelse
DK445784D0 (da) Fluorenylalkylimidazol-derivater og fremgangsmaade til fremstilling deraf
DK596784A (da) Phenylderivater og fremgangsmaade til fremstilling deraf
DK135684A (da) 2-cyano-imidazopyridin-derivater og fremgangsmaade til fremstilling heraf
DK26384A (da) Toxoplasmosefaktor og fremgangsmaade til fremstilling deraf
DK140684D0 (da) Phenethanolaminer og deres anvendelse
DK454684A (da) 7beta-acylamino-3-azido-cephalosporiner og fremgangsmaade til fremstilling heraf
DK454784A (da) 6-oxodecahydroquinoliner og fremgangsmaade til fremstilling heraf
DK513784A (da) Iodacetamider, deres fremstilling og anvendelse til skadedyrsbekaempelse
DK552284A (da) 2-chlor-3-trifluormethylbenzaldehyd og fremgangsmaade til fremstilling deraf
NO845134L (no) Dialkanoyloksybenzyliden-dialkanoat og fremgangsmaate til fremstilling derav.
DK284184D0 (da) 1-phenoxy-3-hydroxyindolylalkylamino-3-propanoler og fremgangsmaade til fremstilling deraf
DK596884A (da) Phenylderivater og fremgangsmaade til fremstilling deraf
DK187484D0 (da) Naphthylglycyl-og tetrahydronaphthylglycyl-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf
DK550883A (da) Hexahydrodioxopyrimidiner og fremgangsmaade til fremstilling deraf
DK161315C (da) Trans-d,1-1-alkyl-6-alkoxy-octahydroquinoliner og fremgangsmaade til fremstilling heraf
DK523882A (da) 3-chlorpregnan-derivater og fremgangsmaade til fremstilling deraf

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment