DK175425B1 - Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat - Google Patents

Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat Download PDF

Info

Publication number
DK175425B1
DK175425B1 DK198800534A DK53488A DK175425B1 DK 175425 B1 DK175425 B1 DK 175425B1 DK 198800534 A DK198800534 A DK 198800534A DK 53488 A DK53488 A DK 53488A DK 175425 B1 DK175425 B1 DK 175425B1
Authority
DK
Denmark
Prior art keywords
enzyme
sank
cytochrome
ferm
hydroxylation
Prior art date
Application number
DK198800534A
Other languages
Danish (da)
English (en)
Other versions
DK53488A (da
DK53488D0 (da
Inventor
Tatsuji Matsuoka
Shunichi Miyakoshi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK53488D0 publication Critical patent/DK53488D0/da
Publication of DK53488A publication Critical patent/DK53488A/da
Application granted granted Critical
Publication of DK175425B1 publication Critical patent/DK175425B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198800534A 1987-02-02 1988-02-02 Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat DK175425B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2195487 1987-02-02
JP2195487 1987-02-02
JP21021787 1987-08-26
JP21021787 1987-08-26

Publications (3)

Publication Number Publication Date
DK53488D0 DK53488D0 (da) 1988-02-02
DK53488A DK53488A (da) 1988-08-03
DK175425B1 true DK175425B1 (da) 2004-10-18

Family

ID=26359108

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198800534A DK175425B1 (da) 1987-02-02 1988-02-02 Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat

Country Status (11)

Country Link
EP (1) EP0281245B1 (sv)
KR (1) KR960011917B1 (sv)
AT (1) ATE108483T1 (sv)
AU (1) AU605543B2 (sv)
CA (1) CA1313637C (sv)
DE (1) DE3850589T2 (sv)
DK (1) DK175425B1 (sv)
ES (1) ES2059499T3 (sv)
FI (1) FI94647C (sv)
HK (1) HK1005747A1 (sv)
IE (1) IE63843B1 (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212296A (en) * 1989-09-11 1993-05-18 E. I. Du Pont De Nemours And Company Expression of herbicide metabolizing cytochromes
WO1994026916A1 (en) * 1993-05-17 1994-11-24 University Of Toronto Innovations Foundation Monooxygenase-like activity of heme proteins
WO1995016041A1 (en) * 1993-12-08 1995-06-15 Ciba-Geigy Ag Cytochrome p-450 monooxygenases
NZ299835A (en) 1995-11-29 1997-08-22 Sankyo Co Actinomycete promoter for the expression of p-450 cytochromes
KR102403210B1 (ko) * 2020-05-08 2022-05-27 경북대학교 산학협력단 시토크롬 p450 활성 저해제 및 이의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215665B1 (en) * 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use

Also Published As

Publication number Publication date
FI94647B (sv) 1995-06-30
DE3850589T2 (de) 1995-04-27
ATE108483T1 (de) 1994-07-15
CA1313637C (en) 1993-02-16
EP0281245B1 (en) 1994-07-13
EP0281245A3 (en) 1988-12-21
IE63843B1 (en) 1995-06-14
AU1117988A (en) 1988-08-04
DE3850589D1 (de) 1994-08-18
ES2059499T3 (es) 1994-11-16
IE880278L (en) 1988-08-02
EP0281245A2 (en) 1988-09-07
FI880458A (sv) 1988-08-03
KR880010123A (ko) 1988-10-07
FI94647C (sv) 1995-10-10
FI880458A0 (sv) 1988-02-02
DK53488A (da) 1988-08-03
AU605543B2 (en) 1991-01-17
DK53488D0 (da) 1988-02-02
HK1005747A1 (en) 1999-01-22
KR960011917B1 (ko) 1996-09-04

Similar Documents

Publication Publication Date Title
US5179013A (en) Cytochrome P-450 enzymes
EP0029329B1 (en) Enzyme inhibitor produced by cultivation of a streptomyces microorganism, a process for producing it and a culture of the microorganism
KR910002225B1 (ko) 비-천연 데메틸아베르멕틴 및 이의 제조방법
US8101732B2 (en) Methods of producing validamycin A analogs and uses thereof
US5149701A (en) C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents
NO172447B (no) Fremgangsmaate for fremstilling av b-avermectiner
US4987139A (en) FK-520 microbial transformation product
NZ222884A (en) Macrolide compounds and parasiticidal compositions
DK175425B1 (da) Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat
US4975372A (en) Microbial transformation product of L-683,590
US5221625A (en) Cyclcic FR-900520 microbial biotransformation agent
US5273979A (en) C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
KR860001820B1 (ko) 마크로라이드 유도체의 제조방법
JPWO2002099109A1 (ja) 新規なポリペプチド、そのポリペプチドをコードするdnaおよびそれらの用途
JPH0695947B2 (ja) エチル化アベルメクチン
EP0528452A1 (en) Immunomycin enzymatic and/or microbial methylation products
US5198358A (en) Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
JP2603677B2 (ja) 新規なチトクロムp−450及びその製造法
JP2750124B2 (ja) 新規ミルベマイシン類およびその製造法
US5202258A (en) Immunosuppressant-producing culture
US5268370A (en) Microbial transformation product of L-679,934
CA2007679A1 (en) Microbial transformation product
EP0526935A1 (en) New microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal
JPS5995253A (ja) アシル基を有するペプチド、微生物によるその製法及びそれからなる環状アデノシン3′,5′−モノリン酸ホスホジエステラ−ゼ阻害剤
JPH01199591A (ja) マクロライド化合物の製造法

Legal Events

Date Code Title Description
PUP Patent expired