DK167797B1 - Nmr-kontrastmiddel indeholdende paramagnetiske polyvalente metalsalte af poly(syre-alkylen-amino)alkaner samt anvendelse af et paramagnetisk chelatkompleks sammen med et calciumsalt til fremstilling af et saadant kontrastmiddel til brug ved nmr-afbildning - Google Patents

Nmr-kontrastmiddel indeholdende paramagnetiske polyvalente metalsalte af poly(syre-alkylen-amino)alkaner samt anvendelse af et paramagnetisk chelatkompleks sammen med et calciumsalt til fremstilling af et saadant kontrastmiddel til brug ved nmr-afbildning Download PDF

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Publication number
DK167797B1
DK167797B1 DK401087A DK401087A DK167797B1 DK 167797 B1 DK167797 B1 DK 167797B1 DK 401087 A DK401087 A DK 401087A DK 401087 A DK401087 A DK 401087A DK 167797 B1 DK167797 B1 DK 167797B1
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DK
Denmark
Prior art keywords
acid
complex
calcium
salt
paramagnetic
Prior art date
Application number
DK401087A
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Danish (da)
English (en)
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DK401087A (da
DK401087D0 (da
Inventor
Karl F Kraft
Steven C Quay
Scott M Rocklage
Dilip Worah
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/057,709 external-priority patent/US5039512A/en
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Publication of DK401087D0 publication Critical patent/DK401087D0/da
Publication of DK401087A publication Critical patent/DK401087A/da
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Publication of DK167797B1 publication Critical patent/DK167797B1/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
DK401087A 1986-08-04 1987-07-31 Nmr-kontrastmiddel indeholdende paramagnetiske polyvalente metalsalte af poly(syre-alkylen-amino)alkaner samt anvendelse af et paramagnetisk chelatkompleks sammen med et calciumsalt til fremstilling af et saadant kontrastmiddel til brug ved nmr-afbildning DK167797B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US89313686A 1986-08-04 1986-08-04
US89313686 1986-08-04
US90093086A 1986-08-27 1986-08-27
US90093086 1986-08-27
US07/057,709 US5039512A (en) 1986-08-04 1987-06-15 NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
US5770987 1987-06-15

Publications (3)

Publication Number Publication Date
DK401087D0 DK401087D0 (da) 1987-07-31
DK401087A DK401087A (da) 1988-02-05
DK167797B1 true DK167797B1 (da) 1993-12-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK401087A DK167797B1 (da) 1986-08-04 1987-07-31 Nmr-kontrastmiddel indeholdende paramagnetiske polyvalente metalsalte af poly(syre-alkylen-amino)alkaner samt anvendelse af et paramagnetisk chelatkompleks sammen med et calciumsalt til fremstilling af et saadant kontrastmiddel til brug ved nmr-afbildning

Country Status (16)

Country Link
EP (2) EP0463644B1 (ja)
JP (1) JP2667666B2 (ja)
AT (1) ATE138809T1 (ja)
AU (1) AU608759B2 (ja)
CA (1) CA1321346C (ja)
DE (2) DE3777727D1 (ja)
DK (1) DK167797B1 (ja)
ES (2) ES2087938T3 (ja)
FI (1) FI88677C (ja)
GR (1) GR3004576T3 (ja)
HK (1) HK96597A (ja)
IE (1) IE64108B1 (ja)
IL (2) IL83377A0 (ja)
NO (1) NO173767C (ja)
NZ (1) NZ221288A (ja)
SG (1) SG78250A1 (ja)

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GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
FR2654344B1 (fr) * 1989-11-16 1994-09-23 Cis Bio Int Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm.
US5516503A (en) * 1989-11-16 1996-05-14 Guerbet S.A. Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging
WO1991007911A1 (en) * 1989-11-27 1991-06-13 Concat Ltd. Mri image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
DE4011684A1 (de) 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
IT1252145B (it) * 1991-11-29 1995-06-05 Bracco Ind Chimica Spa Metodo e formulazioni adatte a migliorare lo studio degli organi cavi nell'uomo
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (ja) 1995-02-01 1997-11-11 Epix Medical Inc
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US5980863A (en) * 1998-11-02 1999-11-09 Eagle Vision Pharmaceutical Corporation Manganese compositions and methods for MRI
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2007062462A (ja) * 2005-08-30 2007-03-15 Nifco Inc 多用途収容装置
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
NO331773B1 (no) 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
US10918743B2 (en) 2013-04-26 2021-02-16 Guerbet Contrast medium formulation and related preparation method
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
RU2769699C2 (ru) 2016-12-21 2022-04-05 ДжиИ Хелткер АС Хелатные соединения марганца на основе тетраазабицикло-макроцикла, подходящие в качестве визуализирующих агентов для MRI
US11110186B2 (en) 2017-12-20 2021-09-07 General Electric Company Anionic chelate compounds
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Also Published As

Publication number Publication date
FI88677C (fi) 1993-06-28
DK401087A (da) 1988-02-05
ES2030023T3 (es) 1992-10-16
EP0463644A2 (en) 1992-01-02
NO873237D0 (no) 1987-08-03
IL83377A0 (en) 1987-12-31
ATE138809T1 (de) 1996-06-15
JPS63119446A (ja) 1988-05-24
NO873237L (no) 1988-02-05
EP0463644B1 (en) 1996-06-05
EP0258616A1 (en) 1988-03-09
ES2087938T3 (es) 1996-08-01
DK401087D0 (da) 1987-07-31
FI88677B (fi) 1993-03-15
CA1321346C (en) 1993-08-17
SG78250A1 (en) 2001-02-20
AU608759B2 (en) 1991-04-18
NZ221288A (en) 1990-10-26
NO173767C (no) 1994-02-02
NO173767B (no) 1993-10-25
AU7573587A (en) 1988-02-11
FI873382A0 (fi) 1987-08-04
FI873382A (fi) 1988-02-05
IL101210A (en) 1996-10-31
DE3751829D1 (de) 1996-07-11
EP0258616B1 (en) 1992-03-25
JP2667666B2 (ja) 1997-10-27
DE3751829T2 (de) 1996-10-31
IE64108B1 (en) 1995-07-12
DE3777727D1 (de) 1992-04-30
GR3004576T3 (ja) 1993-04-28
EP0463644A3 (en) 1992-11-19
HK96597A (en) 1997-08-08
IE872076L (en) 1988-02-04

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