DK166729B1 - 13alfa-methyl- og 13alfa-ethylgonaner og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende dem - Google Patents

13alfa-methyl- og 13alfa-ethylgonaner og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende dem Download PDF

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Publication number
DK166729B1
DK166729B1 DK288184A DK288184A DK166729B1 DK 166729 B1 DK166729 B1 DK 166729B1 DK 288184 A DK288184 A DK 288184A DK 288184 A DK288184 A DK 288184A DK 166729 B1 DK166729 B1 DK 166729B1
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DK
Denmark
Prior art keywords
methyl
hydroxy
dimethylaminophenyl
gonadien
ethynyl
Prior art date
Application number
DK288184A
Other languages
Danish (da)
English (en)
Other versions
DK288184A (da
DK288184D0 (da
Inventor
Guenter Neef
Gerhard Sauer
Rudolf Wiechert
Sybille Beier
Walter Elger
David Henderson
Ralph Rohde
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3321826A external-priority patent/DE3321826A1/de
Priority claimed from DE19843413036 external-priority patent/DE3413036A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK288184D0 publication Critical patent/DK288184D0/da
Publication of DK288184A publication Critical patent/DK288184A/da
Application granted granted Critical
Publication of DK166729B1 publication Critical patent/DK166729B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK288184A 1983-06-15 1984-06-12 13alfa-methyl- og 13alfa-ethylgonaner og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende dem DK166729B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3321826 1983-06-15
DE3321826A DE3321826A1 (de) 1983-06-15 1983-06-15 13(alpha)-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19843413036 DE3413036A1 (de) 1984-04-04 1984-04-04 13(alpha)-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3413036 1984-04-04

Publications (3)

Publication Number Publication Date
DK288184D0 DK288184D0 (da) 1984-06-12
DK288184A DK288184A (da) 1984-12-16
DK166729B1 true DK166729B1 (da) 1993-07-05

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK288184A DK166729B1 (da) 1983-06-15 1984-06-12 13alfa-methyl- og 13alfa-ethylgonaner og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende dem

Country Status (16)

Country Link
EP (1) EP0129499B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH02167296A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU572849B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1307784C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD218624A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3468030D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK166729B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8502612A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI78709C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR82210B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU191131B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE57620B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL72085A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO160521C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ208441A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT78732B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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DE3446661A1 (de) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 13(alpha)-alkyl-17(beta)-(3-acyloxypropyl)-gonane
DE3506785A1 (de) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3630030A1 (de) * 1986-09-01 1988-03-03 Schering Ag 13(alpha)-alkylgonan-(delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)1(pfeil hoch))(pfeil hoch)-5,10-epoxide
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (de) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagen- und antiöstrogenwirksame Verbindungen zur Behandlung hormonabhängiger Tumoren
BE1004905A4 (fr) * 1987-12-30 1993-02-23 Roussel Uclaf Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
HUT60139A (en) * 1989-07-07 1992-08-28 Endorecherche Inc Process for producing pharmaceutical composition suitable for treating prostate cancer connected with androgen
HUT60280A (en) * 1989-07-07 1992-08-28 Endorecherche Inc Process for producing androgen derivatives inhibiting sexual steroidal activity, as well as pharmaceutical compositions comprising same
ATE172469T1 (de) * 1989-08-04 1998-11-15 Schering Ag 11 beta-aryl-gona-4,9-dien-3-one
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4008584A1 (de) * 1990-03-15 1991-09-26 Schering Ag Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ES2103818T3 (es) * 1990-08-18 1997-10-01 Schering Ag Procedimiento para la preparacion de 17-oxo-esteroides.
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
MX9301121A (es) * 1992-03-02 1993-09-01 Schering Ag Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
JPH07506575A (ja) * 1992-05-21 1995-07-20 アンドルシェルシュ・インコーポレイテッド テストステロン５α−レダクターゼ活性の阻害剤
DE4413185A1 (de) * 1994-04-12 1995-10-19 Schering Ag 11beta,19-überbrückte 13alpha-Alkylsteroide
DE4415590A1 (de) * 1994-04-28 1995-11-02 Schering Ag Verfahren zur stereoselektiven Einführung einer Alkinylseitenkette an 11ß-Aryl-substituierten 13alpha-Alkylgonan-17-onen
DE4434488A1 (de) 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
RU2129125C1 (ru) * 1995-04-06 1999-04-20 Украинский научно-исследовательский институт фармакотерапии эндокринных заболеваний СПОСОБ ПОЛУЧЕНИЯ 13α--1,3,510-ТРИЕН-19-НОРАНДРОСТАН-3-ОЛ-17-ОНА И ЕГО МЕТИЛОВОГО ЭФИРА
EP0900234B1 (en) 1996-05-01 2000-07-05 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
AU2015350241B2 (en) 2014-11-17 2021-05-20 Context Biopharma Inc. Onapristone extended-release compositions and methods
BR112018005999A2 (pt) 2015-09-25 2019-01-08 Context Biopharma Inc métodos para a produção de intermediários de onapristona
HK1255104A1 (zh) * 2015-12-15 2019-08-02 Context Biopharma Inc. 无定形的奥那司酮组合物及其制备方法
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
CA1304916C (en) * 1984-10-18 1992-07-14 Wilhelm Bannwarth Apparatus for the parallel performance of a plurality of chemical reaction sequences

Also Published As

Publication number Publication date
IE57620B1 (en) 1993-02-10
DK288184A (da) 1984-12-16
GR82210B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-12-13
CA1307784C (en) 1992-09-22
FI78709C (fi) 1989-09-11
EP0129499A2 (de) 1984-12-27
PT78732B (de) 1986-06-03
JPH0369919B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-11-05
NO160521B (no) 1989-01-16
EP0129499B1 (de) 1987-12-09
AU2936184A (en) 1984-12-20
IE841484L (en) 1984-12-15
AU572849B2 (en) 1988-05-19
DD218624A5 (de) 1985-02-13
NO160521C (no) 1989-04-26
HUT36139A (en) 1985-08-28
ES533260A0 (es) 1985-02-01
HU191131B (en) 1987-01-28
JPH02167296A (ja) 1990-06-27
IL72085A (en) 1987-09-16
EP0129499A3 (en) 1985-10-09
NO842394L (no) 1984-12-17
ES8502612A1 (es) 1985-02-01
FI842395A7 (fi) 1984-12-16
FI842395A0 (fi) 1984-06-13
IL72085A0 (en) 1984-10-31
DK288184D0 (da) 1984-06-12
FI78709B (fi) 1989-05-31
NZ208441A (en) 1988-01-08
PT78732A (pt) 1985-01-01
DE3468030D1 (en) 1988-01-21

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed