DK1565212T3 - Gastrinsammensætninger og formuleringer, og fremgangsmåde til anvendelse og fremstilling - Google Patents
Gastrinsammensætninger og formuleringer, og fremgangsmåde til anvendelse og fremstillingInfo
- Publication number
- DK1565212T3 DK1565212T3 DK03778179T DK03778179T DK1565212T3 DK 1565212 T3 DK1565212 T3 DK 1565212T3 DK 03778179 T DK03778179 T DK 03778179T DK 03778179 T DK03778179 T DK 03778179T DK 1565212 T3 DK1565212 T3 DK 1565212T3
- Authority
- DK
- Denmark
- Prior art keywords
- seq
- residues
- gastrin
- amino acid
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2207—Gastrins; Cholecystokinins [CCK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42810002P | 2002-11-21 | 2002-11-21 | |
US42856202P | 2002-11-22 | 2002-11-22 | |
US43059002P | 2002-12-03 | 2002-12-03 | |
US51993303P | 2003-11-14 | 2003-11-14 | |
PCT/CA2003/001778 WO2004045640A1 (en) | 2002-11-21 | 2003-11-21 | Gastrin compositions and formulations, and methods of use and preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1565212T3 true DK1565212T3 (da) | 2008-02-25 |
Family
ID=32330051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03778179T DK1565212T3 (da) | 2002-11-21 | 2003-11-21 | Gastrinsammensætninger og formuleringer, og fremgangsmåde til anvendelse og fremstilling |
Country Status (14)
Country | Link |
---|---|
US (3) | US20040266682A1 (da) |
EP (3) | EP1837031B1 (da) |
JP (2) | JP2006513719A (da) |
KR (1) | KR20050083933A (da) |
AT (1) | ATE378065T1 (da) |
AU (1) | AU2003285229C1 (da) |
BR (1) | BR0316489A (da) |
CA (1) | CA2505167A1 (da) |
DE (1) | DE60317554T2 (da) |
DK (1) | DK1565212T3 (da) |
MX (1) | MXPA05005330A (da) |
NO (1) | NO20053027L (da) |
PL (1) | PL376622A1 (da) |
WO (1) | WO2004045640A1 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
GB9409496D0 (en) * | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
ATE411077T1 (de) | 2001-01-12 | 2008-10-15 | Waratah Pharmaceuticals Inc | Zusammensetzungen, welche gastrin/cck- rezeptorligande und egf-rezeptorligande enthalten,zur induzierung der neogenese von inselzellen |
JP2005508838A (ja) | 2001-03-23 | 2005-04-07 | アフトン コーポレーション | 膵癌の組合せ治療 |
US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
US7037504B2 (en) * | 2001-10-23 | 2006-05-02 | Waratah Pharmaceuticals, Inc. | Epidermal growth factor protein and gene, and methods of use therefor |
IL165242A0 (en) * | 2002-05-24 | 2005-12-18 | Waratah Pharmaceuticals Inc | Treatment for diabetes |
ES2334268T3 (es) | 2002-06-07 | 2010-03-08 | Waratah Pharmaceuticals, Inc. | Procedimientos y composiciones para el tratamiento de la diabetes. |
EP1837031B1 (en) | 2002-06-07 | 2009-10-14 | Waratah Pharmaceuticals, Inc. | Compositions and methods for treating diabetes |
US20040229810A1 (en) * | 2002-10-22 | 2004-11-18 | Antonio Cruz | Gastrin compositions and formulations, and methods of use and preparation |
CN1781023A (zh) * | 2003-03-28 | 2006-05-31 | 埃弗顿有限公司 | 胃泌素激素免疫测定 |
US20080039379A1 (en) * | 2003-05-27 | 2008-02-14 | Waratah Pharmaceuticals, Inc. | Compositions Comprising Gastrin Compounds and Their Use in Diabetes |
CA2554458A1 (en) * | 2004-01-30 | 2005-08-11 | Waratah Pharmaceuticals, Inc. | The combined use of glp-1 agonists and gastrin for regulating blood glucose levels |
CA2571957A1 (en) * | 2004-07-01 | 2006-01-12 | Waratah Pharmaceuticals, Inc. | Methods and compositions using cd3 agonists |
KR101333168B1 (ko) | 2004-09-22 | 2013-11-28 | 리셉터 바이오로직스 인크 | 프로가스트린에 대한 모노클로날 항체 |
AU2006301892A1 (en) * | 2005-10-07 | 2007-04-19 | Waratah Pharmaceuticals, Inc. | Combined use of DPP IV inhibitors and gastrin compounds |
KR20100059867A (ko) * | 2007-09-11 | 2010-06-04 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 밴드 3 단백질 및 pacap-27의 용도 |
KR20100056506A (ko) * | 2007-09-11 | 2010-05-27 | 몬도바이오테크 래보래토리즈 아게 | 항―hiv제로서의 부갑상선 호르몬 (1-34)의 용도 |
AU2010232989A1 (en) * | 2009-04-03 | 2011-09-22 | The University Of Toledo | A PEG-albumin composition having at least one protected thiol region as a platform for medications |
KR101286721B1 (ko) * | 2009-06-05 | 2013-07-16 | 한국과학기술연구원 | 폴리-시스테인 펩티드 융합 재조합 알부민 및 이의 제조방법 |
US9040660B2 (en) * | 2010-04-20 | 2015-05-26 | Novo Nordisk A/S | Long-acting gastrin derivatives |
JP5969461B2 (ja) | 2010-04-27 | 2016-08-17 | ジーランド ファーマ アクティーゼルスカブ | Glp−1受容体作動薬とガストリンとのペプチド複合体及びその使用 |
CN102260868A (zh) * | 2011-07-22 | 2011-11-30 | 上海交通大学 | 高耐蚀性钝化液及其生产工艺 |
TW201326194A (zh) * | 2011-11-03 | 2013-07-01 | Zealand Pharma As | Glp-1胃泌素受體促效劑肽結合物 |
CA2867611A1 (en) * | 2012-03-16 | 2013-09-19 | Belrose Pharma, Inc. | Polymeric conjugates of c1-inhibitors |
EA035688B1 (ru) | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
US10093713B2 (en) | 2013-11-06 | 2018-10-09 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
BR112017008659A2 (pt) | 2014-10-29 | 2018-01-30 | Zealand Pharma As | ?métodos e compostos de agonista de gip? |
EP3551651B1 (en) | 2016-12-09 | 2024-03-06 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
AU2018283284A1 (en) | 2017-06-15 | 2020-01-30 | Cancer Advances Inc. | Compositions and methods for inducing humoral and cellular immunities against tumors and cancer |
US11358994B2 (en) * | 2017-07-27 | 2022-06-14 | Saint Louis University | Fatty acid modified human epidermal growth factor |
KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
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US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
US5885956A (en) * | 1992-12-14 | 1999-03-23 | Research Triangle Pharmaceuticals | Treatment for diabetes using a gastrin/CCK receptor ligand and an EGF receptor ligand |
ES2185663T3 (es) * | 1994-01-24 | 2003-05-01 | Waratah Pharmaceuticals Inc | Tratamiento de la diabetes. |
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GB9409496D0 (en) * | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
DE19514087A1 (de) * | 1995-04-13 | 1996-10-17 | Deutsches Krebsforsch | Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein |
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US20040037818A1 (en) | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
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CA2351522A1 (en) | 1998-11-19 | 2000-05-25 | Samantha Busfield | Egf-like nucleic acids and polypeptides and uses thereof |
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ATE411077T1 (de) * | 2001-01-12 | 2008-10-15 | Waratah Pharmaceuticals Inc | Zusammensetzungen, welche gastrin/cck- rezeptorligande und egf-rezeptorligande enthalten,zur induzierung der neogenese von inselzellen |
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US7037504B2 (en) * | 2001-10-23 | 2006-05-02 | Waratah Pharmaceuticals, Inc. | Epidermal growth factor protein and gene, and methods of use therefor |
IL165242A0 (en) | 2002-05-24 | 2005-12-18 | Waratah Pharmaceuticals Inc | Treatment for diabetes |
ES2334268T3 (es) | 2002-06-07 | 2010-03-08 | Waratah Pharmaceuticals, Inc. | Procedimientos y composiciones para el tratamiento de la diabetes. |
EP1837031B1 (en) | 2002-06-07 | 2009-10-14 | Waratah Pharmaceuticals, Inc. | Compositions and methods for treating diabetes |
ES2320754T3 (es) | 2002-10-22 | 2009-05-28 | Waratah Pharmaceuticals, Inc. | Tratamiento de la diabetes. |
US20040229810A1 (en) | 2002-10-22 | 2004-11-18 | Antonio Cruz | Gastrin compositions and formulations, and methods of use and preparation |
AU2004233911A1 (en) | 2003-04-30 | 2004-11-11 | Waratah Pharmaceuticals, Inc. | Combined use of keratinocyte growth factor agonists and gastrin compounds |
MXPA05012605A (es) | 2003-05-27 | 2006-02-22 | Waratah Pharmaceuticals Inc | Composiciones que comprenden compuestos de gastrina y sus usos en la diabetes. |
CA2554458A1 (en) | 2004-01-30 | 2005-08-11 | Waratah Pharmaceuticals, Inc. | The combined use of glp-1 agonists and gastrin for regulating blood glucose levels |
CA2571957A1 (en) | 2004-07-01 | 2006-01-12 | Waratah Pharmaceuticals, Inc. | Methods and compositions using cd3 agonists |
AU2006301892A1 (en) | 2005-10-07 | 2007-04-19 | Waratah Pharmaceuticals, Inc. | Combined use of DPP IV inhibitors and gastrin compounds |
EP1971363A1 (en) | 2005-12-02 | 2008-09-24 | Waratah Pharmaceuticals, Inc. | Combination treatments with gastrin agonists for diabetes and related diseases |
WO2007095737A1 (en) | 2006-02-21 | 2007-08-30 | Waratah Pharmaceuticals Inc. | Combination therapy for the treatment of diabetes comprising an exendin agonist and a gastrin compound |
-
2003
- 2003-06-09 EP EP07010865A patent/EP1837031B1/en not_active Expired - Lifetime
- 2003-11-21 BR BR0316489-6A patent/BR0316489A/pt not_active Application Discontinuation
- 2003-11-21 DK DK03778179T patent/DK1565212T3/da active
- 2003-11-21 EP EP03778179A patent/EP1565212B1/en not_active Expired - Lifetime
- 2003-11-21 CA CA002505167A patent/CA2505167A1/en not_active Abandoned
- 2003-11-21 DE DE60317554T patent/DE60317554T2/de not_active Expired - Lifetime
- 2003-11-21 AT AT03778179T patent/ATE378065T1/de not_active IP Right Cessation
- 2003-11-21 PL PL376622A patent/PL376622A1/pl not_active Application Discontinuation
- 2003-11-21 MX MXPA05005330A patent/MXPA05005330A/es active IP Right Grant
- 2003-11-21 US US10/719,450 patent/US20040266682A1/en not_active Abandoned
- 2003-11-21 WO PCT/CA2003/001778 patent/WO2004045640A1/en active IP Right Grant
- 2003-11-21 EP EP07019263A patent/EP1884247A3/en not_active Withdrawn
- 2003-11-21 JP JP2004570257A patent/JP2006513719A/ja active Pending
- 2003-11-21 KR KR1020057009139A patent/KR20050083933A/ko not_active Application Discontinuation
- 2003-11-21 AU AU2003285229A patent/AU2003285229C1/en not_active Ceased
-
2005
- 2005-06-20 NO NO20053027A patent/NO20053027L/no not_active Application Discontinuation
-
2007
- 2007-01-31 US US11/701,196 patent/US7803766B2/en not_active Expired - Fee Related
-
2010
- 2010-07-09 JP JP2010156522A patent/JP2010265294A/ja not_active Withdrawn
- 2010-07-26 US US12/843,411 patent/US20110034379A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110034379A1 (en) | 2011-02-10 |
AU2003285229B2 (en) | 2009-07-30 |
NO20053027D0 (no) | 2005-06-20 |
WO2004045640A1 (en) | 2004-06-03 |
EP1837031B1 (en) | 2009-10-14 |
PL376622A1 (pl) | 2006-01-09 |
US20090075873A1 (en) | 2009-03-19 |
EP1884247A3 (en) | 2008-02-13 |
MXPA05005330A (es) | 2005-10-26 |
CA2505167A1 (en) | 2004-06-03 |
BR0316489A (pt) | 2005-10-11 |
EP1565212B1 (en) | 2007-11-14 |
AU2003285229A1 (en) | 2004-06-15 |
DE60317554T2 (de) | 2008-09-18 |
ATE378065T1 (de) | 2007-11-15 |
US7803766B2 (en) | 2010-09-28 |
JP2006513719A (ja) | 2006-04-27 |
NO20053027L (no) | 2005-08-22 |
KR20050083933A (ko) | 2005-08-26 |
EP1837031A1 (en) | 2007-09-26 |
US20040266682A1 (en) | 2004-12-30 |
JP2010265294A (ja) | 2010-11-25 |
DE60317554D1 (de) | 2007-12-27 |
EP1565212A1 (en) | 2005-08-24 |
EP1884247A2 (en) | 2008-02-06 |
AU2003285229C1 (en) | 2010-04-01 |
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