DK1551835T3 - Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse - Google Patents

Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Info

Publication number
DK1551835T3
DK1551835T3 DK03798094T DK03798094T DK1551835T3 DK 1551835 T3 DK1551835 T3 DK 1551835T3 DK 03798094 T DK03798094 T DK 03798094T DK 03798094 T DK03798094 T DK 03798094T DK 1551835 T3 DK1551835 T3 DK 1551835T3
Authority
DK
Denmark
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
DK03798094T
Other languages
Danish (da)
English (en)
Inventor
Dan Neurosearch A S Peters
Gunnar M Olsen
Elsebet Stergaard Nielsen
Tino Dyhring Joergensen
Philip K Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1551835T3 publication Critical patent/DK1551835T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03798094T 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse DK1551835T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15
PCT/DK2003/000639 WO2004029053A1 (fr) 2002-09-30 2003-09-29 Derives de 1,4-diazabicycloalkane, preparation et utilisation

Publications (1)

Publication Number Publication Date
DK1551835T3 true DK1551835T3 (da) 2007-06-04

Family

ID=32045613

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03798094T DK1551835T3 (da) 2002-09-30 2003-09-29 Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse

Country Status (11)

Country Link
US (1) US7220741B2 (fr)
EP (2) EP1551835B1 (fr)
AT (2) ATE426602T1 (fr)
AU (1) AU2003266222B2 (fr)
CA (1) CA2496585C (fr)
DE (2) DE60326894D1 (fr)
DK (1) DK1551835T3 (fr)
ES (1) ES2280836T3 (fr)
NZ (1) NZ538512A (fr)
PL (1) PL375025A1 (fr)
WO (1) WO2004029053A1 (fr)

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AU2007267175A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
TW200811155A (en) * 2006-05-30 2008-03-01 Glaxo Group Ltd Compounds
AU2007267178A1 (en) * 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their medical use
JP2009544580A (ja) 2006-06-27 2009-12-17 アボット・ラボラトリーズ チアゾリンおよびオキサゾリン誘導体ならびにそれらの使用方法
JP2009544581A (ja) * 2006-06-27 2009-12-17 アボット・ラボラトリーズ ピロール誘導体およびそれの使用方法
WO2008016123A1 (fr) 2006-08-03 2008-02-07 Takeda Pharmaceutical Company Limited INHIBITEUR DE LA GSK-3β
WO2008099186A1 (fr) * 2007-02-15 2008-08-21 Argenta Discovery Limited Dérivés hétérocycliques en tant que récepteurs muscariniques m3
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DE102007053771A1 (de) * 2007-11-12 2009-05-14 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtungen
BRPI0820259A2 (pt) * 2007-11-14 2015-06-16 Neurosearch As Derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, composição farmacêutica, uso do derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, e, método de tratamento, prevenção ou alívio de uma doença ou uma desordem ou uma condição de um corpo de animal vivo
WO2009062989A1 (fr) * 2007-11-14 2009-05-22 Neurosearch A/S Nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl-pyrimidine et leur utilisation à des fins médicales
GB0723719D0 (en) * 2007-12-04 2008-01-16 Glaxo Group Ltd Compounds
GB0723814D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
CA2713519A1 (fr) 2008-02-07 2009-08-13 Abbott Laboratories Derives d'amide en tant que modulateurs allosteriques positifs et procedes d'utilisation associes
EP2257550A1 (fr) * 2008-03-11 2010-12-08 NeuroSearch A/S Nouveaux dérivés de 1,4-diaza-bicycloý3.2.2¨nonyloxadiazolyle utiles en tant que modulateurs de récepteurs d acétylcholine nicotiniques
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
EP2288608A1 (fr) * 2008-06-10 2011-03-02 NeuroSearch A/S Nouveaux dérivés d oxadiazolyl-diazabicyclononane et leur utilisation médicale
WO2010018352A1 (fr) * 2008-08-12 2010-02-18 Argenta Discovery Limited Composés hétérocycliques utilisés dans le traitement de maladies impliquant l’activation améliorée du récepteur m3
WO2010043539A1 (fr) * 2008-10-13 2010-04-22 Neurosearch A/S Nouveaux dérivés d'oxadiazolyl-diazabicyclononane et leur utilisation médicale
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
WO2010084121A1 (fr) 2009-01-21 2010-07-29 Neurosearch A/S Nouveaux dérivés de diaza-bicyclononyl-pyrimidinyle et leurs applications médicales
US20120004214A1 (en) 2009-01-21 2012-01-05 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
MX2011007510A (es) * 2009-01-26 2011-11-04 Neurosearch As N-oxidos de derivados de diazabiciclononil pirimidina y su uso medico.
US8778928B2 (en) * 2009-01-26 2014-07-15 Danpet Ab Indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
WO2010086278A1 (fr) 2009-01-27 2010-08-05 Neurosearch A/S Nouveaux dérivés de benzodioxolyl-oxadiazolyl-diazabicyclononane et leur utilisation médicale
US20110319397A1 (en) 2009-01-27 2011-12-29 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086279A1 (fr) 2009-01-27 2010-08-05 Neurosearch A/S Nouveaux dérivés de dibenzofuranyl-oxadiazolyl-diazabicyclononane, et utilisation médicale de ceux-ci
WO2010130768A1 (fr) * 2009-05-14 2010-11-18 Neurosearch A/S Nouveaux dérivés de 1,4-diazabicyclo[3.2.1]octane utiles comme modulateurs du récepteur nicotinique à l'acétylcholine
EP2498826A1 (fr) 2009-11-11 2012-09-19 NeuroSearch AS Dérivés de pyrrolyl-oxadiazolyl-diazabicyclononane marqués et leur utilisation dans des procédés de diagnostic
EP2513097A1 (fr) 2009-12-18 2012-10-24 NeuroSearch AS Composés diazabicyclononyloxadiazole et leur utilisation en tant que modulateurs des récepteurs nicotiniques de l'acétylcholine
WO2012139925A1 (fr) 2011-04-15 2012-10-18 Neurosearch A/S Dérivés méthyl-pyrrolyl-oxadiazolyl-diazabicyclononane marqués et non marqués et leur application médicale
WO2014060381A1 (fr) 2012-10-18 2014-04-24 Bayer Cropscience Ag Composés hétérocycliques pour la lutte contre les nuisibles
CN105037343B (zh) * 2015-05-27 2018-02-02 山东师范大学 有机配体和Cu(I)双金属硫杂冠醚大环的合成方法
JP2019500352A (ja) 2015-12-10 2019-01-10 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病の治療方法
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
WO2019005980A1 (fr) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Procédés de traitement de la maladie de huntington
EP3689863A1 (fr) 2017-08-04 2020-08-05 Skyhawk Therapeutics, Inc. Procédés et compositions de modulation d'épissage
CN112135815A (zh) 2018-03-27 2020-12-25 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
CN112654625B (zh) 2018-06-27 2024-08-06 Ptc医疗公司 用于治疗亨廷顿氏病的杂环和杂芳基化合物
EP3814360A1 (fr) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Composés hétéroaryles pour le traitement de la maladie de huntington
WO2020163405A1 (fr) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Procédés et compositions pour moduler l'épissage
KR20210135507A (ko) 2019-02-06 2021-11-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물

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Also Published As

Publication number Publication date
US7220741B2 (en) 2007-05-22
EP1551835B1 (fr) 2007-02-14
CA2496585C (fr) 2012-05-29
AU2003266222B2 (en) 2009-10-01
EP1785425A3 (fr) 2007-06-06
NZ538512A (en) 2006-12-22
AU2003266222A1 (en) 2004-04-19
ES2280836T3 (es) 2007-09-16
DE60311853T2 (de) 2007-06-21
DE60311853D1 (de) 2007-03-29
PL375025A1 (en) 2005-11-14
ATE426602T1 (de) 2009-04-15
US20060122172A1 (en) 2006-06-08
CA2496585A1 (fr) 2004-04-08
ATE353899T1 (de) 2007-03-15
WO2004029053A1 (fr) 2004-04-08
DE60326894D1 (de) 2009-05-07
EP1551835A1 (fr) 2005-07-13
EP1785425B1 (fr) 2009-03-25
EP1785425A2 (fr) 2007-05-16

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