DK151382A - Fremgangsmaade til fremstilling af acylerede benzothiophener - Google Patents

Fremgangsmaade til fremstilling af acylerede benzothiophener Download PDF

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Publication number
DK151382A
DK151382A DK151382A DK151382A DK151382A DK 151382 A DK151382 A DK 151382A DK 151382 A DK151382 A DK 151382A DK 151382 A DK151382 A DK 151382A DK 151382 A DK151382 A DK 151382A
Authority
DK
Denmark
Prior art keywords
benzothiophenes
acylated
procedure
preparation
acylated benzothiophenes
Prior art date
Application number
DK151382A
Other languages
Danish (da)
English (en)
Inventor
M K Peters
C D Jones
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/331,046 external-priority patent/US4380635A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK151382A publication Critical patent/DK151382A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK151382A 1981-04-03 1982-04-02 Fremgangsmaade til fremstilling af acylerede benzothiophener DK151382A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24633581A 1981-04-03 1981-04-03
US24633381A 1981-04-03 1981-04-03
US33104581A 1981-12-16 1981-12-16
US06/331,046 US4380635A (en) 1981-04-03 1981-12-16 Synthesis of acylated benzothiophenes

Publications (1)

Publication Number Publication Date
DK151382A true DK151382A (da) 1982-10-04

Family

ID=27500218

Family Applications (1)

Application Number Title Priority Date Filing Date
DK151382A DK151382A (da) 1981-04-03 1982-04-02 Fremgangsmaade til fremstilling af acylerede benzothiophener

Country Status (13)

Country Link
EP (1) EP0062505B1 (fi)
BG (1) BG37378A3 (fi)
DE (1) DE3264853D1 (fi)
DK (1) DK151382A (fi)
ES (1) ES8304116A1 (fi)
FI (1) FI821161L (fi)
GB (1) GB2096608B (fi)
GR (1) GR78364B (fi)
HU (1) HU191084B (fi)
IL (1) IL65379A0 (fi)
PL (1) PL130584B1 (fi)
PT (1) PT74693B (fi)
RO (1) RO84584B (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
USRE38968E1 (en) 1992-07-28 2006-02-07 Eli Lilly And Company Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5462949A (en) * 1993-12-21 1995-10-31 Eli Lilly And Company Methods of inhibiting fertility in women
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5731436A (en) * 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
DE69616396T2 (de) * 1995-02-28 2002-07-11 Eli Lilly And Co., Indianapolis Benzothiophen-Verbindungen, Zwischenprodukte, Zusammensetzungen und Verfahren
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
CA2215902A1 (en) * 1995-04-21 1996-10-24 Charles David Jones Benzothiophenes with novel basic side chains
EP0830362A4 (en) * 1995-06-07 1998-09-02 Lilly Co Eli METHOD FOR SYNTHESISING VINYLSULFENIC ACID DERIVATIVES
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
WO1997034888A1 (en) * 1996-03-19 1997-09-25 Eli Lilly And Company SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES
AR013321A1 (es) * 1996-09-25 2000-12-27 Lilly Co Eli Procedimiento para preparar 2-(4-alcoxifenil)-6-alcoxi-benzo[b]tiofenos.
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
CA2287918A1 (en) * 1997-04-30 1998-11-05 John Mcneill Mcgill Iii A regioselective alkylation process for preparing substituted benzo¬b|thiophenes
EP0979076A4 (en) * 1997-04-30 2003-03-19 Lilly Co Eli INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF BENZO b] THIOPHENES
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
CN1252717A (zh) * 1997-04-30 2000-05-10 伊莱利利公司 制备苯并[b]噻吩的中间体和方法
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
CN1253556A (zh) * 1997-04-30 2000-05-17 伊莱利利公司 制备苯并噻吩的方法
EP1832582A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene malonic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
FI821161A0 (fi) 1982-04-02
RO84584A (ro) 1984-07-17
GR78364B (fi) 1984-09-26
ES511123A0 (es) 1983-02-16
PT74693B (en) 1985-01-08
BG37378A3 (en) 1985-05-15
GB2096608A (en) 1982-10-20
IL65379A0 (en) 1982-05-31
EP0062505A1 (en) 1982-10-13
RO84584B (ro) 1984-09-30
HU191084B (en) 1987-01-28
ES8304116A1 (es) 1983-02-16
EP0062505B1 (en) 1985-07-24
PT74693A (en) 1982-05-01
PL130584B1 (en) 1984-08-31
PL235751A1 (fi) 1982-11-22
GB2096608B (en) 1985-06-12
DE3264853D1 (en) 1985-08-29
FI821161L (fi) 1982-10-04

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ATS Application withdrawn
PBP Patent lapsed