DK1478629T3 - N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler - Google Patents

N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler

Info

Publication number
DK1478629T3
DK1478629T3 DK03743112T DK03743112T DK1478629T3 DK 1478629 T3 DK1478629 T3 DK 1478629T3 DK 03743112 T DK03743112 T DK 03743112T DK 03743112 T DK03743112 T DK 03743112T DK 1478629 T3 DK1478629 T3 DK 1478629T3
Authority
DK
Denmark
Prior art keywords
oxazolidinone
carboxamides
aryl
derivatives
antibacterial agents
Prior art date
Application number
DK03743112T
Other languages
Danish (da)
English (en)
Inventor
Toni-Jo Poel
Richard C Thomas
Michael R Barbachyn
Mikhail F Gordeev
Gary W Luehr
Adam Renslo
Upinder Singh
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Application granted granted Critical
Publication of DK1478629T3 publication Critical patent/DK1478629T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK03743112T 2002-02-25 2003-02-24 N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler DK1478629T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35949502P 2002-02-25 2002-02-25
PCT/US2003/003125 WO2003072553A1 (en) 2002-02-25 2003-02-24 N-aryl-2-oxazolidinone-5-carboxamides and their derivates and their use as antibacterials

Publications (1)

Publication Number Publication Date
DK1478629T3 true DK1478629T3 (da) 2007-01-29

Family

ID=27766097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03743112T DK1478629T3 (da) 2002-02-25 2003-02-24 N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler

Country Status (36)

Country Link
US (1) US6919329B2 (es)
EP (1) EP1478629B1 (es)
JP (1) JP2005524660A (es)
KR (1) KR100613532B1 (es)
CN (1) CN1639135A (es)
AP (1) AP1902A (es)
AR (1) AR038536A1 (es)
AT (1) ATE342258T1 (es)
AU (1) AU2003210807A1 (es)
BR (1) BR0307924A (es)
CA (1) CA2476038A1 (es)
CO (1) CO5611128A2 (es)
CY (1) CY1105797T1 (es)
DE (1) DE60308998T2 (es)
DK (1) DK1478629T3 (es)
EA (1) EA007490B1 (es)
EC (1) ECSP045245A (es)
ES (1) ES2271615T3 (es)
GE (1) GEP20074198B (es)
HR (1) HRP20040717A2 (es)
IS (1) IS7376A (es)
MA (1) MA27180A1 (es)
MX (1) MXPA04008205A (es)
MY (1) MY135233A (es)
NO (1) NO20044062L (es)
NZ (1) NZ534521A (es)
OA (1) OA12779A (es)
PL (1) PL372461A1 (es)
PT (1) PT1478629E (es)
SI (1) SI1478629T1 (es)
TN (1) TNSN04163A1 (es)
TW (1) TW200305568A (es)
UA (1) UA80112C2 (es)
WO (1) WO2003072553A1 (es)
YU (1) YU72804A (es)
ZA (1) ZA200406362B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AU2003265090A1 (en) * 2002-10-10 2004-05-04 Pharmacia & Upjohn Comapny LLC Antimicrobial 1-aryl dihydropyridone compounds
CA2521685A1 (en) * 2003-04-09 2004-10-21 Pharmacia & Upjohn Company Llc Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
PL1656370T3 (pl) 2003-06-03 2013-03-29 Melinta Subsidiary Corp Biarylowe związki heterocykliczne oraz sposoby ich wytwarzania i stosowania
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US20060247286A1 (en) * 2003-07-02 2006-11-02 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
NZ544237A (en) 2003-07-02 2008-09-26 Merck & Co Inc Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US7129259B2 (en) 2003-12-17 2006-10-31 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
EA200700322A1 (ru) * 2004-08-06 2007-08-31 Фармация Энд Апджон Компани Ллс Оксазолидиноны, содержащие оксиндолы, в качестве антибактериальных агентов
WO2006056877A2 (en) * 2004-11-29 2006-06-01 Pharmacia & Upjohn Company Llc Diazepine oxazolidinones as antibacterial agents
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2598423C (en) 2005-02-18 2014-05-27 Astrazeneca Ab Antibacterial piperidine derivatives
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
WO2006109156A1 (en) 2005-04-15 2006-10-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
JP2008544979A (ja) 2005-06-29 2008-12-11 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのホモモルホリンオキサゾリジノン
WO2007004032A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidiones containing cyclobutane as antibacterial agents
JP2009500389A (ja) * 2005-07-06 2009-01-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのアゼチジンおよびシクロブタンを含むオキサゾリジノンカルボキサミド
US20080312211A1 (en) * 2005-12-23 2008-12-18 Astrazeneca Ab Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154
WO2007088478A1 (en) * 2006-02-01 2007-08-09 Pfizer Products Inc. Indazole oxazolidinones as antibacterial agents
TW200804358A (en) * 2006-03-31 2008-01-16 Res Found Itsuu Lab Novel compound having heterocycle
WO2008026563A1 (fr) * 2006-08-30 2008-03-06 Shionogi & Co., Ltd. Dérivé d'hydrazine amide
US8088777B2 (en) 2006-08-30 2012-01-03 Shionogi & Co., Ltd. Urea derivative
EP2185549B1 (en) * 2007-08-06 2018-10-03 Micurx Pharmaceuticals, Inc. Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections
CN101883768A (zh) 2007-10-02 2010-11-10 财团法人乙卯研究所 具有7元杂环的噁唑烷酮衍生物
BRPI0917394A2 (pt) * 2008-08-18 2019-09-24 Univ Yale moduladores de mif
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
US8841306B2 (en) 2008-11-20 2014-09-23 Panacea Biotec Ltd. Antimicrobials
ES2734724T3 (es) 2009-02-03 2019-12-11 Merck Sharp & Dohme Forma cristalina de dihidrogenofosfato de (R)-3-(4-(2-(2-metiltetrazol-5-il)piridin-5-il)-3-fluorofenil)-5-hidroximetiloxazolidin-2-ona
BR112012000657A2 (pt) 2009-06-26 2016-11-16 Panacea Biotec Ltd novos azabicilohexanos
BR112013000925A2 (pt) 2010-07-15 2020-12-01 Bayer Intellectual Property Gmbh compostos heterocíclicos como pesticidas
UA112897C2 (uk) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
EP3107923B1 (en) 2014-02-21 2021-11-03 Shanghai MicuRx Pharmaceutical Co., Ltd. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
CN111699184B (zh) * 2018-02-26 2023-05-23 住友化学株式会社 噁唑烷酮化合物的制造方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
EP0417044A3 (en) 1989-09-07 1991-06-12 Ciba-Geigy Ag Oxazolidinones and thiones as plantgrowth regulators
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
KR100257418B1 (ko) * 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
JPH07508985A (ja) 1992-07-08 1995-10-05 ジ・アップジョン・カンパニー マイコバクテリウム・チュバーキュローシスに対して有効な5’−インドリニルオキサゾリジノン類
PL175782B1 (pl) * 1992-12-08 1999-02-26 Upjohn Co Nowe podstawione troponem pochodne fenylooksazolidynonowe
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
EP0730591B1 (en) * 1993-11-22 1999-07-14 PHARMACIA & UPJOHN COMPANY Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
JPH0873455A (ja) 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
DE4429461A1 (de) * 1994-08-19 1996-02-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
SK282869B6 (sk) 1994-10-26 2003-01-09 Pharmacia + Upjohn Company Antimikrobiálne fenyloxazolidinóny
JPH10508844A (ja) * 1994-11-15 1998-09-02 ファルマシア・アンド・アップジョン・カンパニー 二環式オキサジンおよびチアジンオキサゾリジノン抗菌剤
NZ302844A (en) 1995-02-03 1999-06-29 Upjohn Co Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
JPH11506430A (ja) 1995-05-11 1999-06-08 ファルマシア・アンド・アップジョン・カンパニー スピロ環式および二環式ジアジニル−およびカルバジニル−オキサゾリジノン
BR9610474A (pt) * 1995-09-01 1999-03-02 Upjohn Co Feniloxazolidinonas tendo uma ligação c-c a anéis heterocíclicos com 4-8 membros
DE19601264A1 (de) * 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
PT920421E (pt) * 1996-08-21 2003-03-31 Upjohn Co Derivados de isoxazolina uteis como agentes antimicrobianos
JP2002501530A (ja) 1997-05-30 2002-01-15 ファルマシア・アンド・アップジョン・カンパニー チオカルボニル官能基を有するオキサゾリジノン抗菌剤
DE19730847A1 (de) 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717804D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
US6083967A (en) 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
DE19802235A1 (de) 1998-01-22 1999-07-29 Bayer Ag Mit tricyclischen Indolen substituierte Oxazolidinone
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
CN1288462A (zh) * 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
CN1311787A (zh) 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
DE60001807T2 (de) * 1999-02-01 2003-11-06 Pharmacia & Upjohn Co., Kalamazoo VERFAHREN ZU HERSTELLUNG VON o-FLUORIERTEN TETRAHYDROTHIOPYRAN CARBAMATEN
BR0010982A (pt) 1999-05-27 2002-03-05 Upjohn Co Novas oxazolidinonas bicìclicas como agentes antibacterianos
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
CZ20022142A3 (cs) 1999-12-21 2002-11-13 Pharmacia & Upjohn Company Oxazolidinony mající sulfoximinovou funkční skupinu
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
GB0100110D0 (en) 2001-01-04 2001-02-14 Univ Leeds Modulation of calcium channel activity
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
WO2003006440A2 (en) 2001-07-12 2003-01-23 Pharmacia & Upjohn Company Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound

Also Published As

Publication number Publication date
US20040044052A1 (en) 2004-03-04
WO2003072553A8 (en) 2004-09-16
AP2004003110A0 (en) 2004-09-30
MA27180A1 (fr) 2005-01-03
EP1478629B1 (en) 2006-10-11
PT1478629E (pt) 2007-01-31
IS7376A (is) 2004-07-29
KR100613532B1 (ko) 2006-08-16
CY1105797T1 (el) 2011-02-02
OA12779A (en) 2006-07-06
NO20044062L (no) 2004-10-26
MY135233A (en) 2008-03-31
CA2476038A1 (en) 2003-09-04
EA200400893A1 (ru) 2005-02-24
CN1639135A (zh) 2005-07-13
ES2271615T3 (es) 2007-04-16
NZ534521A (en) 2007-02-23
PL372461A1 (en) 2005-07-25
CO5611128A2 (es) 2006-02-28
YU72804A (sh) 2006-08-17
BR0307924A (pt) 2004-12-07
AP1902A (en) 2008-10-15
TW200305568A (en) 2003-11-01
WO2003072553A1 (en) 2003-09-04
UA80112C2 (en) 2007-08-27
KR20040091668A (ko) 2004-10-28
AU2003210807A1 (en) 2003-09-09
DE60308998D1 (de) 2006-11-23
EP1478629A1 (en) 2004-11-24
GEP20074198B (en) 2007-09-25
EA007490B1 (ru) 2006-10-27
ATE342258T1 (de) 2006-11-15
US6919329B2 (en) 2005-07-19
HRP20040717A2 (en) 2005-02-28
DE60308998T2 (de) 2007-03-01
JP2005524660A (ja) 2005-08-18
AR038536A1 (es) 2005-01-19
ECSP045245A (es) 2004-09-28
MXPA04008205A (es) 2004-11-26
SI1478629T1 (sl) 2007-02-28
ZA200406362B (en) 2006-02-22
TNSN04163A1 (fr) 2007-03-12

Similar Documents

Publication Publication Date Title
DK1478629T3 (da) N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
DK1480955T3 (da) O-cyclopropyl-carboxanilider og deres anvendelse som fungicider
NO20021253L (no) Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
NO20020383D0 (no) Mutilinderivater og deres anvendelse som anti-bakterielle midler
NO20051451D0 (no) Pyrimidinderivater og deres anvendelse som CB2 modulatorer
NO20033565D0 (no) Acylerte indanylaminer og deres anvendelse som farmasöytiske midler
DK1498413T3 (da) 4-aminopicolinater og deres anvendelse som herbicider
NO20053569D0 (no) Substituerte 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazinderivater og deres anvendelse som nevrokininantagonister
DK1204649T3 (da) Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidler
NO20050830L (no) Acylerte heteroarylkondenserte sykloalkenylaminer og deres anvendelse som farmasoytiske midler
DK1578755T3 (da) Phosphonooxyguinalinderivater og deres farmaceutiske anvendelse
NO20050426L (no) Arylkarbonylderivater som terapeutiske midler
NO20026010L (no) Substituerte quinazolinderivater og deres anvendelse som inhibitorer
DK1497266T3 (da) Quinolinderivater og deres anvendelse som 5HT6-ligander
DK1480962T3 (da) 5-Phenylthiazol-derivater og deres anvendelse som P1-3-kinaseinhibitorer
DK1345937T3 (da) Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister
NO20025357L (no) Antranylamider og deres anvendelse som legemidler
NO20025150D0 (no) 2-acylindolderivater og deres anvendelse som antitumormidler
NO20042719L (no) Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
NO20043580D0 (no) Quinazolinonderivater og deres bruk som CB agonister
DK1387838T3 (da) Cyanoanthranylamid-derivater og deres anvendelse som lægemidler
NO20055515D0 (no) 7-azaindoler og deres anvendelse som terapeutiske midler
DK1663982T3 (da) Aminoquinolinderivater og deres anvendelse som adenosin-A3-ligander
NO20053598D0 (no) Substituerte 1-piperidin-3-yl-4-pyrrolidin-4-yl-piperazinderivater og deres anvendelse som nevrokininantagonister.
NO20043173L (no) Benzotiazol- og benzoksazol-4,7-dionderivater og deres anvendelse som CDC25-fosfataseinhibitorer