DK1379550T3 - Et kimært protein omfattende non-toxisk pseudomonas exotoxin A og en type IV pilin sekvenser - Google Patents
Et kimært protein omfattende non-toxisk pseudomonas exotoxin A og en type IV pilin sekvenserInfo
- Publication number
- DK1379550T3 DK1379550T3 DK01997090T DK01997090T DK1379550T3 DK 1379550 T3 DK1379550 T3 DK 1379550T3 DK 01997090 T DK01997090 T DK 01997090T DK 01997090 T DK01997090 T DK 01997090T DK 1379550 T3 DK1379550 T3 DK 1379550T3
- Authority
- DK
- Denmark
- Prior art keywords
- type
- pseudomonas exotoxin
- chimeric protein
- toxic pseudomonas
- chimeric proteins
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 5
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 title abstract 3
- 231100000252 nontoxic Toxicity 0.000 title abstract 3
- 230000003000 nontoxic effect Effects 0.000 title abstract 3
- 108010000916 Fimbriae Proteins Proteins 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25787700P | 2000-12-21 | 2000-12-21 | |
PCT/US2001/049143 WO2002060935A2 (en) | 2000-12-21 | 2001-12-20 | A chimeric protein comprising non-toxic pseudomonas exotoxin a and type iv pilin sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1379550T3 true DK1379550T3 (da) | 2009-07-06 |
Family
ID=22978159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01997090T DK1379550T3 (da) | 2000-12-21 | 2001-12-20 | Et kimært protein omfattende non-toxisk pseudomonas exotoxin A og en type IV pilin sekvenser |
Country Status (9)
Country | Link |
---|---|
US (2) | US7314625B2 (ja) |
EP (1) | EP1379550B1 (ja) |
JP (2) | JP2004528018A (ja) |
AT (1) | ATE425180T1 (ja) |
CA (1) | CA2432731A1 (ja) |
DE (1) | DE60137969D1 (ja) |
DK (1) | DK1379550T3 (ja) |
ES (1) | ES2322240T3 (ja) |
WO (1) | WO2002060935A2 (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1000163T3 (da) * | 1997-07-11 | 2006-02-06 | Us Gov Health & Human Serv | Pseudomonas-exotoksin A-lignende kimære immunogener |
ATE444081T1 (de) | 1999-10-22 | 2009-10-15 | Us Gov Health & Human Serv | Proteine-abgabe durch polare epithelzellen schichte |
GB0212666D0 (en) | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
US20090155297A1 (en) * | 2004-10-04 | 2009-06-18 | Trinity Biosystems, Inc. | Methods and Compositions for Inducing an Immune Response Against Multiple Antigens |
US7611714B2 (en) * | 2004-10-04 | 2009-11-03 | Trinity Biosystems, Inc. | Methods and compositions for immunizing against Pseudomonas infection |
EP1804832A4 (en) * | 2004-10-04 | 2008-12-24 | Trinity Biosystems Inc | METHOD AND COMPOSITIONS FOR THE NADLESS DELIVERY OF MACROMOLECULES |
WO2006125076A2 (en) * | 2005-05-18 | 2006-11-23 | Trinity Biosystems, Inc. | Methods and compositions for immunizing against chlamydia infection |
EP1919494A4 (en) | 2005-07-22 | 2011-11-09 | Univ Colorado Regents | NON-TOXIC BIOFILM INHIBITOR |
CA2631952A1 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of antibodies |
WO2007067597A2 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of binding partners |
EP2010205A2 (en) * | 2006-03-16 | 2009-01-07 | Trinity Biosystems, Inc. | Methods for increasing the size of animals using needleless delivery constructs |
WO2008012538A2 (en) | 2006-07-25 | 2008-01-31 | The Secretary Of State For Defence | Live vaccine strains of francisella |
US20090092660A1 (en) * | 2006-08-09 | 2009-04-09 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of particles |
US20100189776A1 (en) * | 2007-03-16 | 2010-07-29 | Cancer Research Technology Ltd | Anti-androgen peptides and uses thereof in cancer therapy |
GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
WO2011009624A1 (en) * | 2009-07-22 | 2011-01-27 | Cenix Bioscience Gmbh | Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes |
US8961984B2 (en) | 2009-10-08 | 2015-02-24 | Arch Biophysics, Inc. | Surface-coated structures and methods |
US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
JP2014505064A (ja) * | 2011-01-26 | 2014-02-27 | セニックス バイオサイエンス ゲーエムベーハー | 自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート |
CN112105376A (zh) | 2018-03-08 | 2020-12-18 | 应用分子运输公司 | 用于经口递送的毒素衍生的递送构建体 |
SG11202104734YA (en) | 2018-11-07 | 2021-06-29 | Applied Molecular Transport Inc | Cholix-derived carriers for oral delivery of heterologous payload |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735800A (en) * | 1983-09-09 | 1988-04-05 | Molecular Genetics, Inc. | Vaccines against rift valley fever virus |
US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US6022950A (en) * | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
US5082927A (en) * | 1986-09-24 | 1992-01-21 | The United States Of America As Represented By The Department Of Health And Human Services | Selectively cytotoxic IL-4-PE40 fusion protein |
US6051405A (en) * | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
CA1340530C (en) * | 1989-04-28 | 1999-05-04 | Kok Kheong Lee | Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics |
JPH05502880A (ja) | 1989-12-22 | 1993-05-20 | セラジェン・インコーポレーテッド | トランスロケーション領域および細胞結合領域を有するハイブリッド分子 |
US5458878A (en) * | 1990-01-02 | 1995-10-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity |
CA2082394C (en) * | 1990-05-11 | 1999-07-20 | Ira Pastan | Pseudomonas exotoxins of low animal toxicity and high cytocidal activity |
US5328984A (en) * | 1991-03-04 | 1994-07-12 | The United States As Represented By The Department Of Health & Human Services | Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells |
AU3416693A (en) * | 1991-12-18 | 1993-07-19 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University, The | Antigenic preparations that stimulate production of antibodies which bind to the pili of type IV piliated bacteria |
EP0646175B1 (en) * | 1992-06-18 | 2005-12-28 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant pseudomonas exotoxin with increased activity |
US5635599A (en) * | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
US20020106370A1 (en) | 1994-05-13 | 2002-08-08 | Donald Leonard Nicholas Cardy | Improvements in or relating to peptide delivery |
US5573916A (en) * | 1994-05-19 | 1996-11-12 | Coretech, Inc. | Immunogenic constructs comprising b-cell and t-cell epitopes on common carrier |
WO1996013599A1 (en) * | 1994-11-01 | 1996-05-09 | Winfried Wels | Nucleic acid transfer system |
CA2234666A1 (en) | 1995-10-13 | 1997-04-17 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Immunotoxin containing a disulfide-stabilized antibody fragment |
US6426075B1 (en) * | 1996-11-06 | 2002-07-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Protease-activatable pseudomonas exotoxin A-like proproteins |
AU6769998A (en) * | 1997-03-26 | 1998-10-20 | Board Of Regents, The University Of Texas System | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
US20030054012A1 (en) * | 2000-05-12 | 2003-03-20 | Fitzgerald David J. | Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response |
US7314632B1 (en) * | 1997-07-11 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pseudomonas exotoxin A-like chimeric immunogens |
ES2274573T3 (es) | 1997-07-11 | 2007-05-16 | The United States Government As Represented By The Department Of Health And Human Services | Inmunogenos quimericos tipo exotoxina a de pseudomonas para provocar una respuesta inmunitaria mediada por iga secretora. |
JP2002513802A (ja) * | 1998-05-06 | 2002-05-14 | ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ | Pseudomonasaeruginosaのためのワクチン |
-
2001
- 2001-12-20 DE DE60137969T patent/DE60137969D1/de not_active Expired - Lifetime
- 2001-12-20 EP EP01997090A patent/EP1379550B1/en not_active Expired - Lifetime
- 2001-12-20 JP JP2002561503A patent/JP2004528018A/ja active Pending
- 2001-12-20 DK DK01997090T patent/DK1379550T3/da active
- 2001-12-20 CA CA002432731A patent/CA2432731A1/en not_active Abandoned
- 2001-12-20 ES ES01997090T patent/ES2322240T3/es not_active Expired - Lifetime
- 2001-12-20 US US10/432,412 patent/US7314625B2/en not_active Expired - Fee Related
- 2001-12-20 WO PCT/US2001/049143 patent/WO2002060935A2/en active Application Filing
- 2001-12-20 AT AT01997090T patent/ATE425180T1/de not_active IP Right Cessation
-
2006
- 2006-05-15 US US11/434,934 patent/US20070003578A1/en not_active Abandoned
-
2008
- 2008-06-04 JP JP2008147377A patent/JP2008237227A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20070003578A1 (en) | 2007-01-04 |
WO2002060935A8 (en) | 2004-01-15 |
JP2008237227A (ja) | 2008-10-09 |
US7314625B2 (en) | 2008-01-01 |
JP2004528018A (ja) | 2004-09-16 |
WO2002060935A3 (en) | 2003-11-20 |
DE60137969D1 (de) | 2009-04-23 |
US20040071731A1 (en) | 2004-04-15 |
ATE425180T1 (de) | 2009-03-15 |
EP1379550B1 (en) | 2009-03-11 |
WO2002060935A2 (en) | 2002-08-08 |
EP1379550A2 (en) | 2004-01-14 |
ES2322240T3 (es) | 2009-06-18 |
CA2432731A1 (en) | 2002-08-08 |
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