DK1337629T3 - Dipeptidylpeptidaser - Google Patents
DipeptidylpeptidaserInfo
- Publication number
- DK1337629T3 DK1337629T3 DK01983275T DK01983275T DK1337629T3 DK 1337629 T3 DK1337629 T3 DK 1337629T3 DK 01983275 T DK01983275 T DK 01983275T DK 01983275 T DK01983275 T DK 01983275T DK 1337629 T3 DK1337629 T3 DK 1337629T3
- Authority
- DK
- Denmark
- Prior art keywords
- pna
- pro
- dipeptidyl
- phevalileglnglugluphe
- leuaspgluasnvalhisphephe
- Prior art date
Links
- IUMFVSMNETWFNX-KBPBESRZSA-N (2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]-n-(4-nitrophenyl)pyrrolidine-2-carboxamide Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([N+]([O-])=O)C=C1 IUMFVSMNETWFNX-KBPBESRZSA-N 0.000 abstract 1
- WUOZBACYMYYTOQ-CABZTGNLSA-N (2s)-1-[(2s)-2-aminopropanoyl]-n-(4-nitrophenyl)pyrrolidine-2-carboxamide Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([N+]([O-])=O)C=C1 WUOZBACYMYYTOQ-CABZTGNLSA-N 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Glass Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR1078A AUPR107800A0 (en) | 2000-10-27 | 2000-10-27 | Peptide and nucleic acid molecule ii |
| PCT/AU2001/001388 WO2002034900A1 (en) | 2000-10-27 | 2001-10-29 | Dipeptidyl peptidases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1337629T3 true DK1337629T3 (da) | 2007-07-23 |
Family
ID=3825122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01983275T DK1337629T3 (da) | 2000-10-27 | 2001-10-29 | Dipeptidylpeptidaser |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7276365B2 (xx) |
| EP (1) | EP1337629B1 (xx) |
| AT (1) | ATE357511T1 (xx) |
| AU (2) | AUPR107800A0 (xx) |
| DE (1) | DE60127441T2 (xx) |
| DK (1) | DK1337629T3 (xx) |
| WO (1) | WO2002034900A1 (xx) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9813233A (pt) * | 1997-09-29 | 2000-08-22 | Point Therapeutics Inc | Estimulação de células hematopoéticas in vitro |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| PT1528931E (pt) | 2002-08-09 | 2008-08-13 | Prosidion Ltd | Inibidores da dipeptidilpeptidase iv para a diminuição da taxa de aumento de peso crónico |
| KR20050122220A (ko) * | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN1867560A (zh) * | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4－嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
| US7790734B2 (en) * | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2007513058A (ja) * | 2003-09-08 | 2007-05-24 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102134230B (zh) * | 2004-03-15 | 2019-06-28 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| WO2005106021A1 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 8 (dpp8) |
| WO2005118555A1 (en) * | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
| EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| CA2622472C (en) | 2005-09-14 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| GEP20135791B (en) * | 2005-09-14 | 2013-03-25 | Takeda Pharmaceutical | Use of dipeptidyl peptidase inhibitors |
| TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| CA2622642C (en) * | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2007054577A1 (en) | 2005-11-14 | 2007-05-18 | Probiodrug Ag | Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2007112368A1 (en) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| AU2007235876A1 (en) | 2006-04-12 | 2007-10-18 | Probiodrug Ag | Enzyme inhibitors |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CN102918027A (zh) | 2010-04-06 | 2013-02-06 | 艾尼纳制药公司 | Gpr119受体调节剂和对与所述受体有关的障碍的治疗 |
| US10894787B2 (en) | 2010-09-22 | 2021-01-19 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
| WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| US20140051714A1 (en) | 2011-04-22 | 2014-02-20 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| GB201415598D0 (en) | 2014-09-03 | 2014-10-15 | Univ Birmingham | Elavated Itercranial Pressure Treatment |
| US10555929B2 (en) | 2015-03-09 | 2020-02-11 | Coherus Biosciences, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| WO2018187350A1 (en) | 2017-04-03 | 2018-10-11 | Coherus Biosciences Inc. | PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1151113A2 (en) * | 1999-01-11 | 2001-11-07 | Incyte Pharmaceuticals, Inc. | Human peptidases |
| US20040132158A1 (en) * | 1999-01-11 | 2004-07-08 | Incyte Corporation | Human peptidases |
| EP1165784A2 (en) * | 1999-03-31 | 2002-01-02 | Curagen Corporation | Nucleic acids including open reading frames encoding polypeptides; "orfx" |
| CA2384135A1 (en) * | 1999-09-10 | 2001-03-22 | Catherine Anne Abbott | Dipeptidyl peptidases |
| CA2402563A1 (en) * | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US20020197679A1 (en) * | 2000-06-20 | 2002-12-26 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| EP1346033A2 (en) * | 2000-10-12 | 2003-09-24 | Ferring BV | Novel serine protease genes related to dppiv |
| WO2002046383A2 (en) * | 2000-12-08 | 2002-06-13 | Incyte Genomics, Inc. | Protein modification and maintenance molecules |
-
2000
- 2000-10-27 AU AUPR1078A patent/AUPR107800A0/en not_active Abandoned
-
2001
- 2001-10-29 US US10/415,122 patent/US7276365B2/en not_active Expired - Fee Related
- 2001-10-29 DE DE60127441T patent/DE60127441T2/de not_active Expired - Lifetime
- 2001-10-29 AU AU1478802A patent/AU1478802A/xx active Pending
- 2001-10-29 AT AT01983275T patent/ATE357511T1/de not_active IP Right Cessation
- 2001-10-29 EP EP01983275A patent/EP1337629B1/en not_active Expired - Lifetime
- 2001-10-29 DK DK01983275T patent/DK1337629T3/da active
- 2001-10-29 WO PCT/AU2001/001388 patent/WO2002034900A1/en active IP Right Grant
-
2007
- 2007-09-26 US US11/904,168 patent/US7662944B2/en not_active Expired - Fee Related
-
2010
- 2010-02-08 US US12/702,093 patent/US7888094B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100216235A1 (en) | 2010-08-26 |
| US7888094B2 (en) | 2011-02-15 |
| DE60127441D1 (de) | 2007-05-03 |
| US7662944B2 (en) | 2010-02-16 |
| DE60127441T2 (de) | 2008-02-21 |
| WO2002034900A1 (en) | 2002-05-02 |
| US7276365B2 (en) | 2007-10-02 |
| EP1337629B1 (en) | 2007-03-21 |
| AUPR107800A0 (en) | 2000-11-23 |
| US20040053369A1 (en) | 2004-03-18 |
| EP1337629A4 (en) | 2005-02-16 |
| AU1478802A (en) | 2002-05-06 |
| US20080268532A1 (en) | 2008-10-30 |
| ATE357511T1 (de) | 2007-04-15 |
| EP1337629A1 (en) | 2003-08-27 |
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