DK1265882T3 - Process for the preparation of citalopram - Google Patents

Process for the preparation of citalopram

Info

Publication number
DK1265882T3
DK1265882T3 DK01913738T DK01913738T DK1265882T3 DK 1265882 T3 DK1265882 T3 DK 1265882T3 DK 01913738 T DK01913738 T DK 01913738T DK 01913738 T DK01913738 T DK 01913738T DK 1265882 T3 DK1265882 T3 DK 1265882T3
Authority
DK
Denmark
Prior art keywords
group
citalopram
cyano
cor
hydrogen
Prior art date
Application number
DK01913738T
Other languages
Danish (da)
Inventor
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1265882T3 publication Critical patent/DK1265882T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

The invention relates to a method for the preparation of citalopram comprising, in either order, subjecting a compound of formulawherein Y is a cyano group or a group which may be converted to a cyano group, R is hydrogen, -O-R<1>, NH2, NHCH3 or -N(CH3)2 wherein R<1 >is selected from hydrogen, alkyl, alkenyl, alkynyl and optionally alkyl substituted aryl or aralkyl; toi) reduction of the double bond in the side chain of formula -CH=CH-COR:ii) conversion of the group-COR or a reduced form thereof to a dimethylaminomethyl group; andiii) if Y is not cyano, conversion of the group Y to a cyano group;followed by isolation of citalopram base or a pharmaceutically acceptable acid addition salt thereof.
DK01913738T 2000-03-14 2001-03-09 Process for the preparation of citalopram DK1265882T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000415 2000-03-14
PCT/DK2001/000162 WO2001068630A1 (en) 2000-03-14 2001-03-09 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
DK1265882T3 true DK1265882T3 (en) 2004-06-01

Family

ID=8159331

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913738T DK1265882T3 (en) 2000-03-14 2001-03-09 Process for the preparation of citalopram

Country Status (26)

Country Link
US (1) US6806376B2 (en)
EP (1) EP1265882B1 (en)
JP (1) JP2003527386A (en)
KR (1) KR20020080476A (en)
CN (1) CN1418205A (en)
AT (1) ATE257832T1 (en)
AU (1) AU2001239213A1 (en)
BG (1) BG107051A (en)
BR (1) BR0109268A (en)
CA (1) CA2402557A1 (en)
DE (1) DE60101786T2 (en)
DK (1) DK1265882T3 (en)
EA (1) EA005094B1 (en)
ES (1) ES2214400T3 (en)
HR (1) HRP20020740A2 (en)
HU (1) HUP0300178A2 (en)
IL (1) IL151488A0 (en)
IS (1) IS6527A (en)
MX (1) MXPA02008653A (en)
NO (1) NO20024198L (en)
PL (1) PL360107A1 (en)
PT (1) PT1265882E (en)
SK (1) SK14512002A3 (en)
TR (2) TR200400611T4 (en)
WO (1) WO2001068630A1 (en)
ZA (1) ZA200206897B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142926C (en) * 1999-04-14 2004-03-24 H·隆德贝克有限公司 Method for preparing citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IL151566A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
NL1017500C1 (en) 2000-03-13 2001-04-26 Lundbeck & Co As H Process for the preparation of Citalopram.
AR032455A1 (en) 2000-05-12 2003-11-12 Lundbeck & Co As H METHOD FOR THE PREPARATION OF CITALOPRAM, AN INTERMEDIARY EMPLOYED IN THE METHOD, A METHOD FOR THE PREPARATION OF THE INTERMEDIARY EMPLOYED IN THE METHOD AND PHARMACEUTICAL COMPOSITION ANTIDEPRESSIVE
PE20040991A1 (en) 2002-08-12 2004-12-27 Lundbeck & Co As H SEPARATION OF INTERMEDIARIES FOR THE PREPARATION OF ESCITALOPRAM
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (en) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 Citalopram intermediate crystalline base
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (en) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (en) 1996-07-03 1998-01-08 Basf Ag Process for the production of phthalides
DE19627697A1 (en) 1996-07-10 1998-01-15 Basf Ag Process for the production of phthalides
PT1015416E (en) 1997-07-08 2002-03-28 Lundbeck & Co As H METHOD FOR THE PRODUCTION OF CITALOPRAM
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
KR100411505B1 (en) 1998-10-20 2003-12-18 하. 룬트벡 아크티에 셀스카브 Method for the preparation of citalopram
PL203275B1 (en) 1998-12-23 2009-09-30 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (en) 1999-01-29 2002-09-04 Lundbeck & Co As H METHOD FOR THE PREPARATION OF 5-CYANOFTALIDE
CN1142926C (en) 1999-04-14 2004-03-24 H·隆德贝克有限公司 Method for preparing citalopram
ITMI991581A1 (en) 1999-06-25 2001-01-15 Lundbeck & Co As H METHOD FOR THE PREPARATION OF CITALOPRAM
ITMI991579A1 (en) 1999-06-25 2001-01-15 Lundbeck & Co As H METHOD FOR THE PREPARATION OF CITALOPRAM
CH692298A5 (en) 1999-10-25 2002-04-30 Lundbeck & Co As H Preparation of citalopram as antidepressant drug and for treating dementia and cerebrovascular disorders comprises reaction of a new intermediate with 3-(N,N-dimethylamino)propyl magnesium halide
AR026063A1 (en) 1999-11-01 2002-12-26 Lundbeck & Co As H METHOD FOR THE PREPARATION OF 5-CARBOXIFTALIDA.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
SK9282002A3 (en) 1999-12-28 2002-11-06 Lundbeck & Co As H Method for the preparation of citalopram, pharmaceutical composition comprising same and intermediates
BR9917604A (en) 1999-12-30 2002-12-31 Lundbeck & Co As H Method for preparing citalopram
EP1254129B1 (en) 2000-01-14 2003-10-22 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (en) 2000-02-24 2001-05-18 Lundbeck & Co As H Process for the preparation of Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
NL1017500C1 (en) 2000-03-13 2001-04-26 Lundbeck & Co As H Process for the preparation of Citalopram.
NZ521059A (en) 2000-03-16 2004-04-30 H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IL148525A0 (en) 2000-07-06 2002-09-12 Lundbeck & Co As H Method for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
EP1462447A3 (en) 2000-12-22 2004-11-17 H. Lundbeck A/S Method for the preparation of pure citalopram
DK1181272T3 (en) 2000-12-28 2002-12-30 Lundbeck & Co As H Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
ZA200206897B (en) 2003-08-28
IS6527A (en) 2002-08-27
JP2003527386A (en) 2003-09-16
DE60101786D1 (en) 2004-02-19
DE60101786T2 (en) 2004-07-15
MXPA02008653A (en) 2003-02-24
CN1418205A (en) 2003-05-14
CA2402557A1 (en) 2001-09-20
ES2214400T3 (en) 2004-09-16
ATE257832T1 (en) 2004-01-15
EA005094B1 (en) 2004-10-28
KR20020080476A (en) 2002-10-23
NO20024198D0 (en) 2002-09-03
EP1265882B1 (en) 2004-01-14
SK14512002A3 (en) 2003-03-04
WO2001068630A1 (en) 2001-09-20
EA200200970A1 (en) 2003-02-27
EP1265882A1 (en) 2002-12-18
TR200202155T2 (en) 2002-12-23
US20030050484A1 (en) 2003-03-13
NO20024198L (en) 2002-09-03
PL360107A1 (en) 2004-09-06
IL151488A0 (en) 2003-04-10
PT1265882E (en) 2004-06-30
HRP20020740A2 (en) 2004-12-31
AU2001239213A1 (en) 2001-09-24
BG107051A (en) 2003-05-30
HUP0300178A2 (en) 2003-05-28
TR200400611T4 (en) 2004-04-21
US6806376B2 (en) 2004-10-19
BR0109268A (en) 2002-12-03

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