DK1200384T3 - 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling - Google Patents

2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling

Info

Publication number
DK1200384T3
DK1200384T3 DK00940109T DK00940109T DK1200384T3 DK 1200384 T3 DK1200384 T3 DK 1200384T3 DK 00940109 T DK00940109 T DK 00940109T DK 00940109 T DK00940109 T DK 00940109T DK 1200384 T3 DK1200384 T3 DK 1200384T3
Authority
DK
Denmark
Prior art keywords
sub
alkyl
alkoxy
formula
pent
Prior art date
Application number
DK00940109T
Other languages
Danish (da)
English (en)
Inventor
Peter Herold
Stefan Stutz
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Application granted granted Critical
Publication of DK1200384T3 publication Critical patent/DK1200384T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
DK00940109T 1999-07-29 2000-07-13 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling DK1200384T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140199 1999-07-29
CH442000 2000-01-11
PCT/CH2000/000385 WO2001009079A1 (de) 1999-07-29 2000-07-13 2-alkyl-5-halogen-pent-4-encarbonsäuren und deren herstellung

Publications (1)

Publication Number Publication Date
DK1200384T3 true DK1200384T3 (da) 2004-08-02

Family

ID=25687539

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00940108T DK1200390T3 (da) 1999-07-29 2000-07-13 Fremstilling af N-substituerede 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamider
DK00940109T DK1200384T3 (da) 1999-07-29 2000-07-13 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00940108T DK1200390T3 (da) 1999-07-29 2000-07-13 Fremstilling af N-substituerede 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamider

Country Status (10)

Country Link
US (3) US7009078B1 (ja)
EP (2) EP1200384B1 (ja)
JP (2) JP4922521B2 (ja)
AT (2) ATE265415T1 (ja)
AU (2) AU5518500A (ja)
DE (2) DE50006271D1 (ja)
DK (2) DK1200390T3 (ja)
ES (2) ES2312346T3 (ja)
PT (2) PT1200390E (ja)
WO (2) WO2001009079A1 (ja)

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HU228526B1 (hu) * 2000-07-05 2013-03-28 Speedel Pharma Ag Eljárás szubsztituált oktanoil-amid-származékok elõállítására, valamint az elõállításhoz alkalmazott közbensõ termékek
ATE458066T1 (de) * 2001-05-15 2010-03-15 Novartis Ag Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse
WO2003103653A1 (en) * 2002-06-11 2003-12-18 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
EP1571138B2 (en) * 2002-12-09 2014-12-17 Asahi Glass Company, Limited Processes for producing (4e)-5-chloro-2-isopropyl-4-pentenoic ester and optically active isomer thereof
EP1626093A1 (en) * 2004-08-11 2006-02-15 Dow Global Technologies Inc. Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters
CA2599409A1 (en) * 2005-03-09 2006-09-28 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for preparing enantiopure e-(2s)-alkyl-5-halopent-4-enoic acids and esters
ES2337826T3 (es) * 2005-03-17 2010-04-29 Basf Se Metodo para la produccion de derivados opticamente activos de acido 3-fenilpropionico y productos de reaccion del mismo.
WO2006117057A1 (en) * 2005-05-02 2006-11-09 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for preparing enantiomerically enriched e-(2s)- and (2r)-alkyl-5-halopent-4-enecarboxylic acids or their esters
AT502257B1 (de) * 2005-07-25 2007-04-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von racemischen alkyl-5-halogen-pent-4-en-carbonsäuren bzw. -carbonsäureestern
DE102005042458A1 (de) * 2005-09-06 2007-03-22 Basf Ag Verfahren zur Herstellung von 2-substituierten Carbonsäuren
WO2007036491A1 (de) * 2005-09-30 2007-04-05 Basf Aktiengesellschaft Verfahren zur herstellung von alpha-substituierten carbonsäuren
GB0521083D0 (en) * 2005-10-17 2005-11-23 Novartis Ag Organic compounds
GB2431654A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431640A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
CA2631409C (en) * 2005-12-16 2014-11-18 Asahi Glass Company, Limited Method for producing optically active (4e)-5-chloro-2-isopropyl-4-pentenoic acid or basic amino acid salt thereof
TW200837046A (en) * 2006-11-08 2008-09-16 Speedel Experimenta Ag Process for preparing organic compounds
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
PT2225200E (pt) * 2007-12-24 2014-01-21 Dsm Ip Assets Bv Síntese convergente de inibidores da renina e intermediários úteis nesta
CN102036948A (zh) * 2008-05-23 2011-04-27 特瓦制药工业有限公司 阿利吉仑单富马酸盐及其制备方法
EP2189442B1 (en) 2008-11-20 2014-10-01 Krka Tovarna Zdravil, D.D., Novo Mesto Process and intermediates for the preparation of aliskiren
EP2393489B1 (en) 2009-02-05 2014-10-08 Krka, tovarna zdravil, d.d., Novo mesto Moisture-activated granulation process
WO2011051853A1 (en) 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
CN101774986B (zh) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
TR201002256A1 (tr) 2010-03-24 2011-10-21 Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� Stabil aliskiren formülasyonları
US20110268797A1 (en) 2010-04-30 2011-11-03 Sanovel IIac Sanayi Ve Ticaret Anonim Sirketi Multicoated aliskiren formulations
ES2528701T3 (es) 2010-10-19 2015-02-11 Mylan Laboratories Limited Síntesis de Aliskiren
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
US9090537B2 (en) 2012-02-17 2015-07-28 Mylan Laboratories Limited Process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN103130677B (zh) * 2013-03-12 2015-01-07 博瑞生物医药技术(苏州)有限公司 一种阿利克仑的制备方法
US9550797B2 (en) * 2013-06-27 2017-01-24 Patheon Holdings I B.V. Preparation of Grignard reagents using a fluidized bed
CN103351300A (zh) * 2013-06-30 2013-10-16 北京万全德众医药生物技术有限公司 一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法
CN105294478B (zh) * 2014-07-01 2017-06-13 华润双鹤药业股份有限公司 阿利吉仑的一种非对映异构体、其制备方法及用途

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Also Published As

Publication number Publication date
JP4922521B2 (ja) 2012-04-25
ES2312346T3 (es) 2009-03-01
EP1200390A1 (de) 2002-05-02
EP1200390B1 (de) 2008-08-27
ES2218173T3 (es) 2004-11-16
JP2003506345A (ja) 2003-02-18
US7132569B2 (en) 2006-11-07
US7009078B1 (en) 2006-03-07
US20060041169A1 (en) 2006-02-23
EP1200384B1 (de) 2004-04-28
DK1200390T3 (da) 2008-12-01
JP4580606B2 (ja) 2010-11-17
AU5518400A (en) 2001-02-19
US6777574B1 (en) 2004-08-17
PT1200390E (pt) 2008-12-05
AU5518500A (en) 2001-02-19
WO2001009083A1 (de) 2001-02-08
ATE406346T1 (de) 2008-09-15
WO2001009079A1 (de) 2001-02-08
DE50015330D1 (de) 2008-10-09
ATE265415T1 (de) 2004-05-15
EP1200384A1 (de) 2002-05-02
DE50006271D1 (de) 2004-06-03
JP2003506347A (ja) 2003-02-18
PT1200384E (pt) 2004-09-30

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