BE637389A
(pl)
*
|
1962-09-13 |
|
|
|
GB1560274A
(en)
*
|
1977-02-28 |
1980-02-06 |
Ici Ltd |
Phenylbut 1-ene derivatives having antiostrogenicactivity
|
EP0002097B1
(en)
*
|
1977-08-22 |
1981-08-05 |
Imperial Chemical Industries Plc |
Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
|
US4206234A
(en)
*
|
1977-08-22 |
1980-06-03 |
Imperial Chemical Industries Limited |
Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
|
HU178253B
(en)
*
|
1979-08-15 |
1982-04-28 |
Gyogyszerkutato Intezet |
Process for preparing 1,1,2-triphenyl-propane and -propane derivatives
|
DE3046719C2
(de)
*
|
1980-12-11 |
1983-02-17 |
Klinge Pharma GmbH, 8000 München |
1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
|
EP0127128B1
(en)
*
|
1983-05-24 |
1987-02-25 |
Bristol-Myers Company |
Process for the conversion of the e isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen hcl
|
US4760053A
(en)
*
|
1984-08-02 |
1988-07-26 |
Fernand Labrie |
Combination therapy for selected sex steroid dependent cancers
|
US4775660A
(en)
*
|
1984-08-02 |
1988-10-04 |
Fernand Labrie |
Treatment of breast cancer by combination therapy
|
US4666885A
(en)
*
|
1985-02-08 |
1987-05-19 |
Fernand Labrie |
Combination therapy for treatment of female breast cancer
|
US4806685A
(en)
*
|
1985-08-05 |
1989-02-21 |
Gyogyszerkutato Inteezet/Pharmaceutical Research Institute |
1,1,2-triphenylpropane and -propene derivatives
|
GB8604528D0
(en)
*
|
1986-02-24 |
1986-04-03 |
Ici Plc |
Therapeutic agents
|
CA1289570C
(en)
*
|
1986-06-16 |
1991-09-24 |
Tetsuji Asao |
1,1,2-triaryl-1-alkene derivatives
|
ES2044860T3
(es)
*
|
1987-04-21 |
1994-01-16 |
Heumann Pharma Gmbh & Co |
Estables aductos con disolventes de z-1-(p-beta-di-metil-amino-etoxi-fenil)-1-(p-hidroxi-fenil)-2-fenil-but-1-eno.
|
DE3736682A1
(de)
*
|
1987-10-29 |
1989-05-11 |
Klinge Co Chem Pharm Fab |
Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten
|
US4895715A
(en)
*
|
1988-04-14 |
1990-01-23 |
Schering Corporation |
Method of treating gynecomastia
|
US5204337A
(en)
*
|
1988-10-31 |
1993-04-20 |
Endorecherche Inc. |
Estrogen nucleus derivatives for use in inhibition of sex steroid activity
|
US5364847A
(en)
*
|
1989-03-10 |
1994-11-15 |
Endorecherche |
Inhibitors of sex steroid biosynthesis and methods for their production and use
|
ZA924811B
(en)
*
|
1991-06-28 |
1993-12-29 |
Endorecherche Inc |
Controlled release systems and low dose androgens
|
US5811447A
(en)
|
1993-01-28 |
1998-09-22 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
US6515009B1
(en)
|
1991-09-27 |
2003-02-04 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
US5446203A
(en)
*
|
1992-08-25 |
1995-08-29 |
New York University |
Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
|
US5770609A
(en)
*
|
1993-01-28 |
1998-06-23 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies
|
US6251920B1
(en)
|
1993-05-13 |
2001-06-26 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies
|
US5354861A
(en)
*
|
1992-11-04 |
1994-10-11 |
National University Of Singapore |
2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
|
US6491938B2
(en)
|
1993-05-13 |
2002-12-10 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
ATE406909T1
(de)
*
|
1993-05-13 |
2008-09-15 |
Poniard Pharmaceuticals Inc |
Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
|
ATE157869T1
(de)
*
|
1993-06-24 |
1997-09-15 |
Lilly Co Eli |
Antiöstrogene 2-phenyl-3-aroylbenzothiophene als hypoglykämische mittel
|
US5462950A
(en)
*
|
1993-12-21 |
1995-10-31 |
Eli Lilly And Company |
Methods of treating menstrual symptoms and compositions therefore
|
US5451590A
(en)
*
|
1993-12-21 |
1995-09-19 |
Eli Lilly & Co. |
Methods of inhibiting sexual precocity
|
US5534526A
(en)
*
|
1993-12-21 |
1996-07-09 |
Eli Lilly And Company |
Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome
|
US6417198B1
(en)
|
1993-12-21 |
2002-07-09 |
Eli Lilly And Company |
Methods of inhibiting CNS problems in post-menopausal women
|
GB9326255D0
(en)
*
|
1993-12-23 |
1994-02-23 |
Roussel Lab Ltd |
Medical device for the prevention and treatment of cancer
|
US5650425A
(en)
*
|
1994-04-04 |
1997-07-22 |
Pharmos Corporation |
Permanently ionic derivatives of steroid hormones and their antagonists
|
US5681835A
(en)
*
|
1994-04-25 |
1997-10-28 |
Glaxo Wellcome Inc. |
Non-steroidal ligands for the estrogen receptor
|
NZ272608A
(en)
|
1994-07-22 |
2000-05-26 |
Lilly Co Eli |
Inhibiting bone loss by administering a bisphosphonate and a second compound selected from various compounds, including 2-phenyl-3-aroylbenzothienes; bisphosphonate combination salts
|
CA2223595C
(en)
|
1995-06-07 |
2008-08-05 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
|
DE19526146A1
(de)
*
|
1995-07-07 |
1997-01-09 |
Schering Ag |
Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
|
JP2000503315A
(ja)
|
1996-01-20 |
2000-03-21 |
ブラッドフォード・ユニバーシティ |
タモキシフェンおよびその同族体
|
HN1996000101A
(es)
|
1996-02-28 |
1997-06-26 |
Inc Pfizer |
Terapia combinada para la osteoporosis
|
US6083990A
(en)
|
1997-04-02 |
2000-07-04 |
Pharmos Corporation |
Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
|
WO1998034583A2
(en)
*
|
1997-02-09 |
1998-08-13 |
Pharmos Corporation |
Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
|
WO1998037892A1
(en)
*
|
1997-02-27 |
1998-09-03 |
Pharmacia & Upjohn Company |
Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea
|
GB9715479D0
(en)
*
|
1997-07-23 |
1997-10-01 |
Univ Bradford |
Tamoxifen and analogues thereof
|
WO1999008682A1
(en)
|
1997-08-15 |
1999-02-25 |
Duke University |
A method of preventing or treating estrogen-dependent diseases and disorders
|
UA66370C2
(en)
|
1997-12-16 |
2004-05-17 |
Lilly Co Eli |
Arylpiperazines having activity to setotonin 1 receptors
|
GB9824207D0
(en)
*
|
1998-11-04 |
1998-12-30 |
Zeneca Ltd |
Neurological disorders
|
TW593256B
(en)
|
1999-11-16 |
2004-06-21 |
Hormos Medical Oy Ltd |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
|
US20020013327A1
(en)
*
|
2000-04-18 |
2002-01-31 |
Lee Andrew G. |
Compositions and methods for treating female sexual dysfunction
|
GB0012291D0
(en)
*
|
2000-05-23 |
2000-07-12 |
Astrazeneca Ab |
Pharmaceutical combination
|
US6613083B2
(en)
|
2001-05-02 |
2003-09-02 |
Eckhard Alt |
Stent device and method
|
EP1490030B2
(en)
*
|
2002-03-20 |
2010-07-14 |
Elan Pharma International Limited |
Nanoparticulate compositions of angiogenesis inhibitors
|
CA2493614C
(en)
*
|
2002-07-30 |
2011-09-13 |
Karykion Inc. |
Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors
|
US7332525B2
(en)
*
|
2003-01-17 |
2008-02-19 |
Castle Erik P |
Method of treatment of prostate cancer and composition for treatment thereof
|
US20040248989A1
(en)
|
2003-06-05 |
2004-12-09 |
Risto Santti |
Method for the treatment or prevention of lower urinary tract symptoms
|
CN100496501C
(zh)
*
|
2003-09-19 |
2009-06-10 |
威斯康星州男校友研究基金会 |
包含2-亚烷基-19-去甲-维生素d衍生物与雌激素激动剂/拮抗剂的组合的药物组合物和方法
|
EP2428516A1
(en)
|
2003-11-19 |
2012-03-14 |
Metabasis Therapeutics, Inc. |
Novel phosphorus-containing thyromimetics
|
AU2005219441A1
(en)
|
2004-03-02 |
2005-09-15 |
Acceleron Pharma Inc. |
ALK7 and myostatin inhibitors and uses thereof
|
US20050203086A1
(en)
*
|
2004-03-04 |
2005-09-15 |
Pfizer Inc. |
Methods of treatment using an EP2 selective receptor agonist
|
CA2590533C
(en)
*
|
2004-11-23 |
2010-09-07 |
Warner-Lambert Company Llc |
7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
|
ES2552338T3
(es)
|
2005-01-21 |
2015-11-27 |
Astex Therapeutics Limited |
Compuestos farmacéuticos
|
KR20080035630A
(ko)
|
2005-07-18 |
2008-04-23 |
바이파 사이언스 인코포레이티드 |
암의 치료
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
ES2551690T3
(es)
|
2006-05-22 |
2015-11-23 |
Hormos Medical Ltd. |
Método de tratamiento de la prostatitis crónica no bacteriana con moduladores selectivos del receptor de estrógeno o inhibidores de aromatasa
|
BRPI0711525A2
(pt)
|
2006-06-02 |
2011-11-01 |
Pear Tree Women S Health Care |
composição farmacêutica e método para tratar sintomas de vaginite atrófica
|
US20100160442A1
(en)
*
|
2006-07-18 |
2010-06-24 |
Ossovskaya Valeria S |
Formulations for cancer treatment
|
US8916552B2
(en)
|
2006-10-12 |
2014-12-23 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
US8404896B2
(en)
|
2006-12-01 |
2013-03-26 |
Bristol-Myers Squibb Company |
N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
|
PT2170396T
(pt)
|
2007-08-03 |
2017-03-31 |
Summit Corp Plc |
Combinação de fármacos para o tratamento da distrofia muscular de duchenne
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
CN102940619A
(zh)
|
2007-10-16 |
2013-02-27 |
利普生物药剂公司 |
用于治疗代谢综合征的珠氯米芬
|
WO2010093601A1
(en)
|
2009-02-10 |
2010-08-19 |
Metabasis Therapeutics, Inc. |
Novel sulfonic acid-containing thyromimetics, and methods for their use
|
RU2014135436A
(ru)
|
2012-01-31 |
2016-03-27 |
Новартис Аг |
Комбинация ингибитора rtk с антиэстрогеном и ее применение для лечения рака
|
EP2819676B1
(en)
|
2012-02-29 |
2018-05-30 |
Repros Therapeutics Inc. |
Combination therapy for treating androgen deficiency
|
EP3296300B1
(en)
|
2012-03-05 |
2019-08-07 |
Xavier University |
Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer
|
CN103992234B
(zh)
*
|
2014-06-11 |
2016-05-18 |
扬子江药业集团江苏海慈生物药业有限公司 |
一种枸橼酸他莫昔芬e异构体的制备方法
|
EP3373967B9
(en)
|
2015-11-10 |
2023-10-04 |
Paracrine Therapeutics AB |
Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
|
EP3400009A2
(en)
|
2016-01-05 |
2018-11-14 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Combination of histone deacetylase inhibitor and immunotherapy
|
WO2017136342A1
(en)
|
2016-02-02 |
2017-08-10 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
|
US12059403B2
(en)
|
2016-08-04 |
2024-08-13 |
University Of Iowa Research Foundation |
Use of SWELL1 inhibitors and modulators to treat type 2 diabetes and obesity
|
US11040019B2
(en)
|
2016-08-19 |
2021-06-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
|
CA3090807A1
(en)
|
2018-02-21 |
2019-08-29 |
AI Therapeutics, Inc. |
Combination therapy with apilimod and glutamatergic agents
|
AU2020292279A1
(en)
*
|
2019-06-10 |
2022-01-27 |
University Of Iowa Research Foundation |
Swell 1 modulators for treatment of non-alcoholic fatty liver disease, immune deficiencies, male infertility and vascular diseases
|
CN114133334B
(zh)
*
|
2021-11-09 |
2024-07-19 |
北京京丰制药(山东)有限公司 |
枸橼酸他莫昔芬的工业化制备工艺
|
EP4230196A1
(en)
|
2022-02-21 |
2023-08-23 |
Som Innovation Biotech, S.A. |
Compounds for use in the treatment of dystrophinopathies
|
EP4311546A1
(en)
|
2022-07-26 |
2024-01-31 |
Dynacure |
Combination therapy for myopathies
|