DK1149074T3 - Acetyleniske sulfonamid-thiol-TACE-inhibitirer - Google Patents
Acetyleniske sulfonamid-thiol-TACE-inhibitirerInfo
- Publication number
- DK1149074T3 DK1149074T3 DK00905787T DK00905787T DK1149074T3 DK 1149074 T3 DK1149074 T3 DK 1149074T3 DK 00905787 T DK00905787 T DK 00905787T DK 00905787 T DK00905787 T DK 00905787T DK 1149074 T3 DK1149074 T3 DK 1149074T3
- Authority
- DK
- Denmark
- Prior art keywords
- tace inhibitors
- thiol
- acetylenic
- acetylenic sulfonamide
- sulfonamide thiol
- Prior art date
Links
- -1 sulfonamide thiol Chemical class 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title 1
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 title 1
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23839399A | 1999-01-27 | 1999-01-27 | |
PCT/US2000/002143 WO2000044716A1 (en) | 1999-01-27 | 2000-01-27 | Acetylenic sulfonamide thiol tace inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1149074T3 true DK1149074T3 (da) | 2005-01-10 |
Family
ID=22897697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00905787T DK1149074T3 (da) | 1999-01-27 | 2000-01-27 | Acetyleniske sulfonamid-thiol-TACE-inhibitirer |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1149074B1 (zh) |
JP (1) | JP2002535386A (zh) |
KR (1) | KR20010101691A (zh) |
CN (1) | CN1224612C (zh) |
AT (1) | ATE280152T1 (zh) |
AU (1) | AU766192B2 (zh) |
BR (1) | BR0007727A (zh) |
CA (1) | CA2356480A1 (zh) |
CZ (1) | CZ20012545A3 (zh) |
DE (1) | DE60015079T2 (zh) |
DK (1) | DK1149074T3 (zh) |
EA (1) | EA200100811A1 (zh) |
ES (1) | ES2230064T3 (zh) |
HK (1) | HK1038915A1 (zh) |
HU (1) | HUP0105282A3 (zh) |
IL (1) | IL144347A0 (zh) |
NO (1) | NO20013638L (zh) |
NZ (1) | NZ512306A (zh) |
PL (1) | PL350420A1 (zh) |
WO (1) | WO2000044716A1 (zh) |
ZA (1) | ZA200105069B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
WO2003033477A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor |
NZ533603A (en) | 2001-12-20 | 2007-02-23 | Bristol Myers Squibb Co | Alpha-(N-sulphonamido)acetamide derivatives as beta-amyloid inhibitors used for treating Alzheimer's Disease and Down's syndrome |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2005021489A2 (en) | 2002-12-23 | 2005-03-10 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors |
US8093276B2 (en) | 2007-10-31 | 2012-01-10 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US8084477B2 (en) | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
US8252821B2 (en) | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
WO2020070239A1 (en) | 2018-10-04 | 2020-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001505869A (ja) * | 1996-07-22 | 2001-05-08 | モンサント カンパニー | チオールスルホン メタロプロテアーゼ阻害剤 |
CZ16899A3 (cs) * | 1996-07-22 | 1999-08-11 | Monsanto Company | Thiolsulfonamidové inhibitory metaloproteázy |
-
2000
- 2000-01-27 CA CA002356480A patent/CA2356480A1/en not_active Abandoned
- 2000-01-27 AU AU27417/00A patent/AU766192B2/en not_active Ceased
- 2000-01-27 NZ NZ512306A patent/NZ512306A/en unknown
- 2000-01-27 PL PL00350420A patent/PL350420A1/xx not_active Application Discontinuation
- 2000-01-27 KR KR1020017009365A patent/KR20010101691A/ko not_active Application Discontinuation
- 2000-01-27 EP EP00905787A patent/EP1149074B1/en not_active Expired - Lifetime
- 2000-01-27 EA EA200100811A patent/EA200100811A1/ru unknown
- 2000-01-27 CN CNB008030286A patent/CN1224612C/zh not_active Expired - Fee Related
- 2000-01-27 WO PCT/US2000/002143 patent/WO2000044716A1/en not_active Application Discontinuation
- 2000-01-27 DE DE60015079T patent/DE60015079T2/de not_active Expired - Fee Related
- 2000-01-27 HU HU0105282A patent/HUP0105282A3/hu unknown
- 2000-01-27 BR BR0007727-5A patent/BR0007727A/pt not_active IP Right Cessation
- 2000-01-27 ES ES00905787T patent/ES2230064T3/es not_active Expired - Lifetime
- 2000-01-27 CZ CZ20012545A patent/CZ20012545A3/cs unknown
- 2000-01-27 IL IL14434700A patent/IL144347A0/xx unknown
- 2000-01-27 JP JP2000595972A patent/JP2002535386A/ja active Pending
- 2000-01-27 AT AT00905787T patent/ATE280152T1/de not_active IP Right Cessation
- 2000-01-27 DK DK00905787T patent/DK1149074T3/da active
-
2001
- 2001-06-20 ZA ZA200105069A patent/ZA200105069B/en unknown
- 2001-07-24 NO NO20013638A patent/NO20013638L/no not_active Application Discontinuation
-
2002
- 2002-01-18 HK HK02100417.3A patent/HK1038915A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EA200100811A1 (ru) | 2002-12-26 |
CA2356480A1 (en) | 2000-08-03 |
KR20010101691A (ko) | 2001-11-14 |
NZ512306A (en) | 2003-10-31 |
AU766192B2 (en) | 2003-10-09 |
BR0007727A (pt) | 2001-10-30 |
IL144347A0 (en) | 2002-05-23 |
NO20013638D0 (no) | 2001-07-24 |
DE60015079T2 (de) | 2005-03-03 |
JP2002535386A (ja) | 2002-10-22 |
WO2000044716A1 (en) | 2000-08-03 |
HUP0105282A2 (hu) | 2002-05-29 |
CN1224612C (zh) | 2005-10-26 |
ZA200105069B (en) | 2002-09-20 |
DE60015079D1 (de) | 2004-11-25 |
CN1337947A (zh) | 2002-02-27 |
ES2230064T3 (es) | 2005-05-01 |
EP1149074A1 (en) | 2001-10-31 |
ATE280152T1 (de) | 2004-11-15 |
EP1149074B1 (en) | 2004-10-20 |
AU2741700A (en) | 2000-08-18 |
PL350420A1 (en) | 2002-12-16 |
NO20013638L (no) | 2001-07-24 |
HUP0105282A3 (en) | 2005-04-28 |
CZ20012545A3 (cs) | 2002-04-17 |
HK1038915A1 (zh) | 2002-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2000044709A3 (en) | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | |
DK1149074T3 (da) | Acetyleniske sulfonamid-thiol-TACE-inhibitirer | |
MY136789A (en) | Metalloproteinase inhibitors | |
DK0934310T3 (da) | Thiosyreafledte, monocykliske forbindelser som antikoaguleringsmidler | |
DK1149092T3 (da) | 4- og 5-alkynyloxindoler og 4- og 5-alkenyloxindoler | |
NZ512446A (en) | Alkynyl containing hydroxamic acid compounds as TACE inhibitors | |
TR200102131T2 (tr) | Matrisk metaloproteinaz inhitörleri olarak 2,3,4,5-tetrahidro-1H[1,4] benzodiyazepin-3- hidroksamik asitler. | |
IL138688A0 (en) | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme | |
ATE271540T1 (de) | Acetylenische arylsulfonamid- und phosphinsäureamid-hydroxamsäure-derivate als tace inhibitoren | |
MY134437A (en) | Process for lowering level of salt required for dilution thickening | |
WO1999037291A3 (de) | Verwendung von substituierten sulfonamiden als antivirale mittel und neue stoffe | |
BG104292A (en) | Methods and compositions for the treatment of rheumatoid arthritis | |
EA200100808A1 (ru) | ГИДРОКСАМОВЫЕ КИСЛОТЫ НА ОСНОВЕ АЦЕТИЛЕНОВОГО b-СУЛЬФОНАМИДО И АМИДА ФОСФИНОВОЙ КИСЛОТЫ, КАК ИНГИБИТОРЫ TACE | |
MXPA04004010A (es) | Acidos hidroxamicos de aril sulfonamida alenicos como inhibidores de tace y metaloproteinasa de matriz. | |
EA200100814A1 (ru) | Применение ацетиленового орто-сульфонамида и фосфинамидозамещенных бициклических гетероарильных гидроксамовых кислот в качестве ингибиторов tace | |
EA200100805A1 (ru) | Ингибиторы tace на основе гетероарилацетиленсульфонамида и фосфинамида гидроксамовой кислоты | |
YU18399A (sh) | Postupak alkilacije zaštićenih sulfonamida | |
DE69524064D1 (de) | Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren | |
BR0311590A (pt) | Agonistas de brs-3 não-peptìdicos | |
ATE303390T1 (de) | Sulfat von cephemverbindung | |
DK0691986T3 (da) | Hidtil ukendte fremgangsmåder og mellemproduktforbindelser til fremstillingen af blodpladeglycoprotein IIb/IIIa-inhibitorer |