DK1140935T3 - 1,2-anellerede quinolinderivater - Google Patents
1,2-anellerede quinolinderivaterInfo
- Publication number
- DK1140935T3 DK1140935T3 DK99969220T DK99969220T DK1140935T3 DK 1140935 T3 DK1140935 T3 DK 1140935T3 DK 99969220 T DK99969220 T DK 99969220T DK 99969220 T DK99969220 T DK 99969220T DK 1140935 T3 DK1140935 T3 DK 1140935T3
- Authority
- DK
- Denmark
- Prior art keywords
- celled
- quinoline derivatives
- quinoline
- derivatives
- celled quinoline
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204444 | 1998-12-23 | ||
| PCT/EP1999/010214 WO2000039082A2 (en) | 1998-12-23 | 1999-12-17 | 1,2-annelated quinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1140935T3 true DK1140935T3 (da) | 2003-09-01 |
Family
ID=8234557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99969220T DK1140935T3 (da) | 1998-12-23 | 1999-12-17 | 1,2-anellerede quinolinderivater |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6458800B1 (cs) |
| EP (1) | EP1140935B1 (cs) |
| JP (1) | JP4725940B2 (cs) |
| KR (2) | KR100712226B1 (cs) |
| CN (1) | CN1178938C (cs) |
| AR (1) | AR021995A1 (cs) |
| AT (1) | ATE240327T1 (cs) |
| AU (1) | AU765437B2 (cs) |
| BG (1) | BG65124B1 (cs) |
| BR (1) | BR9916827A (cs) |
| CA (1) | CA2355717C (cs) |
| CZ (1) | CZ302374B6 (cs) |
| DE (1) | DE69907964T2 (cs) |
| DK (1) | DK1140935T3 (cs) |
| EA (1) | EA004542B1 (cs) |
| EE (1) | EE04962B1 (cs) |
| ES (1) | ES2200591T3 (cs) |
| HK (1) | HK1038746B (cs) |
| HR (1) | HRP20010454B1 (cs) |
| HU (1) | HU229404B1 (cs) |
| ID (1) | ID29241A (cs) |
| IL (2) | IL143859A0 (cs) |
| NO (1) | NO318922B1 (cs) |
| PL (1) | PL199080B1 (cs) |
| PT (1) | PT1140935E (cs) |
| SI (1) | SI1140935T1 (cs) |
| SK (1) | SK286072B6 (cs) |
| TR (1) | TR200101961T2 (cs) |
| TW (1) | TW531533B (cs) |
| UA (1) | UA71592C2 (cs) |
| WO (1) | WO2000039082A2 (cs) |
| ZA (1) | ZA200105136B (cs) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1255537E (pt) * | 2000-02-04 | 2006-09-29 | Janssen Pharmaceutica Nv | Inibidores da proteina farnesil transferase para tratar cancro da mama |
| DE60130976T2 (de) | 2000-02-24 | 2008-07-17 | Janssen Pharmaceutica N.V. | Dosierschema enthaldend farnesyl protein transferase inhibitoren für die behandlung von krebs |
| JP2003525234A (ja) * | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | カンプトテシン化合物とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤 |
| US20030078281A1 (en) * | 2000-02-29 | 2003-04-24 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents |
| AU2001246477A1 (en) * | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
| EP1267871A2 (en) * | 2000-02-29 | 2003-01-02 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives |
| JP2003525235A (ja) * | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗腫瘍ヌクレオシド誘導体とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤 |
| EP1267872A2 (en) * | 2000-02-29 | 2003-01-02 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
| JP2003525245A (ja) * | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤 |
| EP1263437A2 (en) * | 2000-02-29 | 2002-12-11 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with vinca alkaloids |
| AU2001246478A1 (en) * | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with taxane compounds |
| US20030022918A1 (en) * | 2000-02-29 | 2003-01-30 | Horak Ivan David | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
| JP2003525255A (ja) * | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルタンパク質トランスフェラーゼ阻害剤とさらなる抗癌剤との組み合わせ剤 |
| JO2361B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl |
| EP1322644A1 (en) * | 2000-09-25 | 2003-07-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives |
| DE60118225T2 (de) * | 2000-09-25 | 2007-05-03 | Janssen Pharmaceutica N.V. | Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren |
| ATE409189T1 (de) * | 2000-09-25 | 2008-10-15 | Janssen Pharmaceutica Nv | Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate |
| JP4974437B2 (ja) * | 2000-09-25 | 2012-07-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼを阻害する６−［（置換フェニル）メチル］−キノリンおよびキナゾリン誘導体 |
| PL360677A1 (en) * | 2000-10-02 | 2004-09-20 | Janssen Pharmaceutica N.V. | Metabotropic glutamate receptor antagonists |
| JP4348080B2 (ja) | 2000-11-21 | 2009-10-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体 |
| ATE323490T1 (de) * | 2000-11-28 | 2006-05-15 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung |
| ES2260316T3 (es) | 2000-12-27 | 2006-11-01 | Janssen Pharmaceutica N.V. | Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa. |
| ATE415161T1 (de) * | 2001-02-15 | 2008-12-15 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen |
| WO2002085364A1 (en) * | 2001-04-25 | 2002-10-31 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for treating cachexia |
| US6740757B2 (en) * | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
| JP2005519876A (ja) * | 2001-11-27 | 2005-07-07 | メルク エンド カムパニー インコーポレーテッド | ２−アミノキノリン化合物 |
| ATE425978T1 (de) | 2001-12-19 | 2009-04-15 | Janssen Pharmaceutica Nv | Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren |
| ES2287466T3 (es) * | 2002-03-22 | 2007-12-16 | Janssen Pharmaceutica N.V. | Derivados de 2-quinolinona y quinazolina de bencilimidazolil sustituidas como inhibidores de la farnesil transferasa. |
| JP4573533B2 (ja) * | 2002-03-29 | 2010-11-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 放射能標識付きキノリンおよびキノリノン誘導体および代謝向性グルタメート受容体リガンドとしてのそれらの使用 |
| ATE336496T1 (de) | 2002-04-15 | 2006-09-15 | Janssen Pharmaceutica Nv | Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen |
| US20030125268A1 (en) * | 2002-08-28 | 2003-07-03 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
| US7358259B2 (en) | 2003-09-26 | 2008-04-15 | Rigel Pharmaceuticals, Inc. | HCV inhibitors and methods of using them |
| US20050272068A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | UCH-L1 expression and cancer therapy |
| HRP20130399T1 (hr) | 2004-11-05 | 2013-06-30 | Janssen Pharmaceutica Nv | Terapeutska upotreba inhibitora farenziltransferaze i postupci praä†enja njihove efikasnosti |
| US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
| US20060281769A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| US20060281755A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators |
| AU2006331542A1 (en) | 2005-12-23 | 2007-07-05 | Link Medicine Corporation | Treatment of synucleinopathies |
| DE102006012545A1 (de) * | 2006-03-18 | 2007-09-27 | Sanofi-Aventis | Substituierte 2-Amino-4-phenyl-dihydrochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| JP5089681B2 (ja) | 2006-04-20 | 2012-12-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 |
| MX2008013530A (es) | 2006-04-20 | 2009-01-14 | Janssen Pharmaceutica Nv | Inhibidores de c-fms cinasa. |
| US8697716B2 (en) * | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| US8343996B2 (en) | 2008-11-13 | 2013-01-01 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| BR112014019476A8 (pt) * | 2012-02-13 | 2017-07-11 | Hoffmann La Roche | Novos derivados de imidazolilcetona |
| WO2014025675A1 (en) | 2012-08-07 | 2014-02-13 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| EA201590750A1 (ru) | 2012-10-16 | 2015-09-30 | Янссен Фармацевтика Нв | СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγT |
| KR20150070348A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| MX358508B (es) | 2012-10-16 | 2018-08-22 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de receptor nuclear de acido retinoico-gamma-t. |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| AU2014334616A1 (en) | 2013-10-15 | 2016-04-28 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORyt |
| KR20160070133A (ko) | 2013-10-15 | 2016-06-17 | 얀센 파마슈티카 엔.브이. | RORyt의 알킬 결합 퀴놀리닐 조절제 |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| EP3226973A4 (en) * | 2014-12-04 | 2018-05-30 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| MX2018001769A (es) | 2015-08-17 | 2018-08-15 | Kura Oncology Inc | Metodos de tratamiento de pacientes con cancer con inhibidores de farnesil transferasa. |
| CN109071425B (zh) * | 2016-03-23 | 2021-01-15 | 陈裕仁 | 法尼基转移酶抑制剂及其用途 |
| BR112019009000A2 (pt) | 2016-11-03 | 2019-07-16 | Kura Oncology Inc | método para tratar um carcinoma refratário, método de tratamento de scchn, método de tratamento de carcinoma de células escamosas, método de tratamento para scc |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| DE69635966T2 (de) * | 1995-12-08 | 2006-11-30 | Janssen Pharmaceutica N.V. | (Imidazol-5-yl)Methyl-2-Chinolinonderivate als Farnesyl Protein transferase Inhibitoren |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| NZ336233A (en) * | 1997-04-25 | 2001-01-26 | Janssen Pharmaceutica Nv | Phenyl substituted quinazolines on 4-position and 2-quinazolinone moiety bearing a carbon or nitrogen-linked imidazolyl moiety |
| CA2290992C (en) * | 1997-06-02 | 2008-02-12 | Janssen Pharmaceutica N.V. | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
-
1999
- 1999-12-17 IL IL14385999A patent/IL143859A0/xx active IP Right Grant
- 1999-12-17 EA EA200100708A patent/EA004542B1/ru not_active IP Right Cessation
- 1999-12-17 SK SK873-2001A patent/SK286072B6/sk not_active IP Right Cessation
- 1999-12-17 AT AT99969220T patent/ATE240327T1/de active
- 1999-12-17 PT PT99969220T patent/PT1140935E/pt unknown
- 1999-12-17 SI SI9930350T patent/SI1140935T1/xx unknown
- 1999-12-17 EP EP99969220A patent/EP1140935B1/en not_active Expired - Lifetime
- 1999-12-17 AU AU27953/00A patent/AU765437B2/en not_active Expired
- 1999-12-17 CZ CZ20012142A patent/CZ302374B6/cs not_active IP Right Cessation
- 1999-12-17 DK DK99969220T patent/DK1140935T3/da active
- 1999-12-17 CN CNB99814763XA patent/CN1178938C/zh not_active Expired - Lifetime
- 1999-12-17 BR BR9916827-8A patent/BR9916827A/pt not_active Application Discontinuation
- 1999-12-17 TW TW088122193A patent/TW531533B/zh not_active IP Right Cessation
- 1999-12-17 KR KR1020017006140A patent/KR100712226B1/ko not_active Expired - Lifetime
- 1999-12-17 CA CA2355717A patent/CA2355717C/en not_active Expired - Lifetime
- 1999-12-17 HR HR20010454A patent/HRP20010454B1/xx not_active IP Right Cessation
- 1999-12-17 HU HU0104582A patent/HU229404B1/hu unknown
- 1999-12-17 KR KR1020067021243A patent/KR100818541B1/ko not_active Expired - Lifetime
- 1999-12-17 ID IDW00200101373A patent/ID29241A/id unknown
- 1999-12-17 JP JP2000590995A patent/JP4725940B2/ja not_active Expired - Lifetime
- 1999-12-17 DE DE69907964T patent/DE69907964T2/de not_active Expired - Lifetime
- 1999-12-17 PL PL349504A patent/PL199080B1/pl unknown
- 1999-12-17 UA UA2001064401A patent/UA71592C2/uk unknown
- 1999-12-17 EE EEP200100318A patent/EE04962B1/xx unknown
- 1999-12-17 WO PCT/EP1999/010214 patent/WO2000039082A2/en not_active Ceased
- 1999-12-17 TR TR2001/01961T patent/TR200101961T2/xx unknown
- 1999-12-17 HK HK02100160.2A patent/HK1038746B/en not_active IP Right Cessation
- 1999-12-17 US US09/868,992 patent/US6458800B1/en not_active Expired - Lifetime
- 1999-12-17 ES ES99969220T patent/ES2200591T3/es not_active Expired - Lifetime
- 1999-12-22 AR ARP990106687A patent/AR021995A1/es active IP Right Grant
-
2001
- 2001-06-20 BG BG105631A patent/BG65124B1/bg unknown
- 2001-06-20 IL IL143859A patent/IL143859A/en not_active IP Right Cessation
- 2001-06-21 ZA ZA200105136A patent/ZA200105136B/en unknown
- 2001-06-21 NO NO20013088A patent/NO318922B1/no not_active IP Right Cessation
-
2002
- 2002-06-24 US US10/179,444 patent/US6914066B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE240327T1 (de) | 1,2-annelierte chinolinderivate | |
| ATE435861T1 (de) | 12,13-cyclopropan-epothilonderivate | |
| NO20013003D0 (no) | Kinolin-derivater | |
| ATE250036T1 (de) | Chinolinderivate | |
| ATE228505T1 (de) | Chinolinderivate | |
| NO20010193D0 (no) | Tiobenzimidazol-derivater | |
| ATE236136T1 (de) | Benzosulfonderivate | |
| DK1000048T3 (da) | Substituerede 1,2,3,4-tetrahydronapthalenderivater | |
| ATE229005T1 (de) | Chinolinderivate | |
| NO20010514L (no) | Aminometylkarboksylsyre-derivater | |
| ATE259810T1 (de) | Phenyl-xanthinderivate | |
| EE04089B1 (et) | 1,3,4-oksadiasolooni derivaadid | |
| DE60025958D1 (de) | 14,15-beta-methylen substituierte androgene | |
| DK1115716T3 (da) | 2-phenylpyran-4-on-derivater | |
| ATE233253T1 (de) | Chromanderivate | |
| DK1134219T3 (da) | Cucloalkylsubstituerede aminomethylpyrrolidinderivater | |
| DK1149106T3 (da) | 4,5-azolo-oxindoler | |
| DK1060183T3 (da) | 5-deoxycytidinderivater | |
| DE59907635D1 (de) | Pyrazolyldioxothiochromanoyl-derivate |