DK0987251T3 - 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoliner som CETP-inhibitorer - Google Patents
4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoliner som CETP-inhibitorerInfo
- Publication number
- DK0987251T3 DK0987251T3 DK99307264T DK99307264T DK0987251T3 DK 0987251 T3 DK0987251 T3 DK 0987251T3 DK 99307264 T DK99307264 T DK 99307264T DK 99307264 T DK99307264 T DK 99307264T DK 0987251 T3 DK0987251 T3 DK 0987251T3
- Authority
- DK
- Denmark
- Prior art keywords
- cholesterol
- inhibitors
- levels
- ldl
- prodrug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10072998P | 1998-09-17 | 1998-09-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0987251T3 true DK0987251T3 (da) | 2004-09-27 |
Family
ID=22281233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99307264T DK0987251T3 (da) | 1998-09-17 | 1999-09-14 | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoliner som CETP-inhibitorer |
Country Status (10)
Country | Link |
---|---|
US (2) | US6140342A (fr) |
EP (1) | EP0987251B1 (fr) |
JP (1) | JP3626641B2 (fr) |
AT (1) | ATE267172T1 (fr) |
BR (1) | BR9904141A (fr) |
CA (1) | CA2282183C (fr) |
DE (1) | DE69917400T2 (fr) |
DK (1) | DK0987251T3 (fr) |
ES (1) | ES2220013T3 (fr) |
PT (1) | PT987251E (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
US6140342A (en) * | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
US6147089A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
DE10035352A1 (de) * | 2000-07-20 | 2002-01-31 | Zlb Bioplasma Ag Bern | Verfahren zur Behandlung von instabiler Angina pectoris |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
US6777427B2 (en) | 2000-09-14 | 2004-08-17 | Kaken Pharmaceutical Co., Ltd. | Tetrahydroquinoline compounds |
DE10063486A1 (de) * | 2000-12-20 | 2002-07-04 | Bayer Ag | Dichlorpyridylmethylamide |
SK15172003A3 (en) * | 2001-06-21 | 2004-11-03 | Pfizer Prod Inc | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors |
WO2003000235A1 (fr) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Compositions pharmaceutiques de dispersions de medicaments et de polymeres neutres |
ATE486586T1 (de) * | 2001-06-22 | 2010-11-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen, enthaltend adsorbate eines arzneimittels in amorpher form |
EP1269994A3 (fr) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Compositions Pharmaceutiques comprenant un médicament et un polymère permettant d'améliorer la concentration du médicament |
US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
JP2005523262A (ja) * | 2002-02-01 | 2005-08-04 | ファイザー・プロダクツ・インク | 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物 |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
IL162870A0 (en) * | 2002-02-01 | 2005-11-20 | Pfizer Prod Inc | Controlled release pharmaceutical dosage forms of a cholesteryl estertransfer protein inhibitor |
US20040053842A1 (en) * | 2002-07-02 | 2004-03-18 | Pfizer Inc. | Methods of treatment with CETP inhibitors and antihypertensive agents |
US7071210B2 (en) * | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
US7504508B2 (en) | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
CN100363348C (zh) | 2002-10-04 | 2008-01-23 | 千禧药品公司 | 治疗炎性疾病的前列腺素d2受体拮抗剂 |
ATE327977T1 (de) * | 2002-10-21 | 2006-06-15 | Warner Lambert Co | Tetrahydrochinolin-derivate als crth2 antagonisten |
JP2006513186A (ja) | 2002-12-20 | 2006-04-20 | ファイザー・プロダクツ・インク | Cetp阻害剤およびhmg−coaレダクターゼ阻害剤を含む剤形 |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
EP1435356A1 (fr) * | 2003-01-06 | 2004-07-07 | Warner-Lambert Company LLC | Dérivés de la quinoléine en tant qu'antagonistes de CRTH2 |
KR20080008440A (ko) * | 2003-03-17 | 2008-01-23 | 니뽄 다바코 산교 가부시키가이샤 | Cetp 억제제의 약제학적 조성물 |
CA2519458A1 (fr) * | 2003-03-17 | 2004-09-30 | Japan Tobacco Inc. | Procede pour accroitre la biodisponibilite orale de s- 2-( '1-(2-ethylbutyl)cyclohexyl!carbonyl!amino)phenyl!-2-methylpropanethioate |
US20040204450A1 (en) * | 2003-03-28 | 2004-10-14 | Pfizer Inc | Quinoline and quinoxaline compounds |
TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
MXPA06001417A (es) | 2003-08-04 | 2006-05-15 | Pfizer Prod Inc | Composiciones farmaceuticas de adsorbatos de farmacos amorfos y materiales que forman microfases lipofilas. |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
BRPI0414822A (pt) * | 2003-09-26 | 2006-11-14 | Japan Tobacco Inc | método de inibir a produção de lipoproteìna remanescente |
US20050282812A1 (en) * | 2004-06-18 | 2005-12-22 | JONES Zachary | Inhibitors of cholesteryl ester transfer protein |
RU2424232C2 (ru) * | 2004-08-04 | 2011-07-20 | Мейдзи Сейка Кайся, Лтд. | Производные хинолина и инсектициды, включающие их в качестве активного ингредиента |
US20060063803A1 (en) * | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
WO2006082518A1 (fr) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Compositions pharmaceutiques a efficacite amelioree |
AU2006216713A1 (en) | 2005-02-24 | 2006-08-31 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
US20060270675A1 (en) * | 2005-03-10 | 2006-11-30 | Groneberg Robert D | Inhibitors of cholesterol ester transfer protein |
WO2006098394A1 (fr) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | Méthode pour inhiber l’absorption de lipides et l’inhibiteur de l'absorption de lipides |
US7678818B2 (en) * | 2006-02-07 | 2010-03-16 | Hoffmann-La Roche Inc. | Anthranilamide and 2-amino-heteroarene-carboxamide compounds |
AR061926A1 (es) * | 2006-07-20 | 2008-10-01 | Novartis Ag | Compuestos de piperidina, utiles como inhibidores de la proteina de transfe-rencia de esteres de colesterol, composicion farmaceutica y uso |
UA96942C2 (uk) * | 2006-07-20 | 2011-12-26 | Новартис Аг | Похідні амінопіперидину як інгібітори бпхе (білка-переносника холестерилового ефіру) |
KR101564793B1 (ko) | 2007-11-05 | 2015-10-30 | 노파르티스 아게 | 고지질혈증 또는 동맥경화증과 같은 질환의 치료에 유용한 cetp 억제제로서의 4-벤질아미노-1-카르복시아실-피페리딘 유도체 |
CN101878199B (zh) | 2007-12-03 | 2013-09-18 | 诺瓦提斯公司 | 用于治疗例如高血脂或动脉硬化疾病的作为cetp抑制剂的1,2-二取代的-4-苄基氨基-吡咯烷衍生物 |
US9314438B2 (en) * | 2007-12-05 | 2016-04-19 | Aarhus Universitet | Elevation of the plasma HDL-cholesterol level |
GB0919431D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
LT3464336T (lt) | 2016-06-01 | 2022-05-10 | Athira Pharma, Inc. | Junginiai |
CN114853670B (zh) * | 2022-05-23 | 2023-11-21 | 沈阳药科大学 | 含有酰胺基团的喹啉类化合物及其制备与应用 |
Family Cites Families (9)
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US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
US5276168A (en) * | 1990-06-18 | 1994-01-04 | E. R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
US5401848A (en) * | 1990-11-26 | 1995-03-28 | E. R. Squibb & Sons, Inc. | Indane and quinoline derivatives |
JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ[5,6 シクロヘプタ[1,2−b ピリジン誘導体及びこれを含有する抗アレルギー剤 |
US5288725A (en) * | 1992-10-15 | 1994-02-22 | Merck & Co., Inc. | Pyrroloquinoline Bradykinin antagonist |
DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
HRP970330B1 (en) * | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
US6140342A (en) * | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
-
1999
- 1999-09-07 US US09/390,731 patent/US6140342A/en not_active Expired - Fee Related
- 1999-09-14 DK DK99307264T patent/DK0987251T3/da active
- 1999-09-14 JP JP26018099A patent/JP3626641B2/ja not_active Expired - Fee Related
- 1999-09-14 EP EP99307264A patent/EP0987251B1/fr not_active Expired - Lifetime
- 1999-09-14 DE DE69917400T patent/DE69917400T2/de not_active Expired - Fee Related
- 1999-09-14 PT PT99307264T patent/PT987251E/pt unknown
- 1999-09-14 ES ES99307264T patent/ES2220013T3/es not_active Expired - Lifetime
- 1999-09-14 CA CA002282183A patent/CA2282183C/fr not_active Expired - Fee Related
- 1999-09-14 AT AT99307264T patent/ATE267172T1/de not_active IP Right Cessation
- 1999-09-14 BR BR9904141-3A patent/BR9904141A/pt not_active Application Discontinuation
-
2000
- 2000-09-27 US US09/670,846 patent/US6362198B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT987251E (pt) | 2004-10-29 |
JP3626641B2 (ja) | 2005-03-09 |
CA2282183C (fr) | 2006-08-08 |
DE69917400T2 (de) | 2005-05-19 |
BR9904141A (pt) | 2000-09-12 |
JP2000191645A (ja) | 2000-07-11 |
EP0987251A1 (fr) | 2000-03-22 |
ATE267172T1 (de) | 2004-06-15 |
ES2220013T3 (es) | 2004-12-01 |
CA2282183A1 (fr) | 2000-03-17 |
US6140342A (en) | 2000-10-31 |
US6362198B1 (en) | 2002-03-26 |
EP0987251B1 (fr) | 2004-05-19 |
DE69917400D1 (de) | 2004-06-24 |
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