DK0963980T3 - 1,2,4,-trianzinderivat, fremstilling deraf og anvendelse deraf som referencemarkør til bestemmelse af "lamotrigins"-renhed og stabilitet - Google Patents
1,2,4,-trianzinderivat, fremstilling deraf og anvendelse deraf som referencemarkør til bestemmelse af "lamotrigins"-renhed og stabilitetInfo
- Publication number
- DK0963980T3 DK0963980T3 DK99200695T DK99200695T DK0963980T3 DK 0963980 T3 DK0963980 T3 DK 0963980T3 DK 99200695 T DK99200695 T DK 99200695T DK 99200695 T DK99200695 T DK 99200695T DK 0963980 T3 DK0963980 T3 DK 0963980T3
- Authority
- DK
- Denmark
- Prior art keywords
- trianzin
- lamotrigine
- purity
- derivative
- stability
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812413.4A GB9812413D0 (en) | 1998-06-10 | 1998-06-10 | Compound and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0963980T3 true DK0963980T3 (da) | 2002-09-16 |
Family
ID=10833464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99200695T DK0963980T3 (da) | 1998-06-10 | 1999-03-10 | 1,2,4,-trianzinderivat, fremstilling deraf og anvendelse deraf som referencemarkør til bestemmelse af "lamotrigins"-renhed og stabilitet |
Country Status (31)
Country | Link |
---|---|
US (1) | US6333198B1 (hr) |
EP (2) | EP0963980B1 (hr) |
JP (1) | JP2989189B1 (hr) |
KR (1) | KR100322354B1 (hr) |
CN (2) | CN1238454A (hr) |
AP (3) | AP9901481A0 (hr) |
AR (1) | AR014074A1 (hr) |
AT (1) | ATE218552T1 (hr) |
AU (1) | AU2031999A (hr) |
BR (1) | BR9900984A (hr) |
CA (1) | CA2265194C (hr) |
DE (1) | DE69901656T2 (hr) |
DK (1) | DK0963980T3 (hr) |
EA (1) | EA000666B1 (hr) |
ES (1) | ES2178342T3 (hr) |
GB (1) | GB9812413D0 (hr) |
HR (1) | HRP990074A2 (hr) |
HU (1) | HUP9900592A3 (hr) |
ID (1) | ID22957A (hr) |
MA (1) | MA24777A1 (hr) |
NO (2) | NO991151L (hr) |
NZ (1) | NZ334590A (hr) |
PE (1) | PE20000332A1 (hr) |
PL (1) | PL331870A1 (hr) |
PT (1) | PT963980E (hr) |
SG (1) | SG85628A1 (hr) |
SI (1) | SI0963980T1 (hr) |
TR (1) | TR199900520A2 (hr) |
UY (1) | UY25946A1 (hr) |
YU (1) | YU12399A (hr) |
ZA (1) | ZA991951B (hr) |
Families Citing this family (92)
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PT1309555E (pt) | 2000-12-29 | 2005-10-31 | Pfizer Ltd | Processo para a producao de maleato amlodipina |
BR0116552A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Hemi-maleato de amlodipina, processo, método para o tratamento ou prevenção de angina ou hipertensão, composição farmacêutica, para uso no tratamento e/ou de angina ou da hipertensão |
AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
EP1346214A2 (en) * | 2000-12-29 | 2003-09-24 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
MXPA03005886A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado de aspartato de amlodipina como antagonista del canal de calcio. |
EP1309556B1 (en) | 2000-12-29 | 2004-11-24 | Pfizer Limited | Amlodipine fumarate |
WO2002053541A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
DE10134980C2 (de) | 2001-07-17 | 2003-05-28 | Helm Ag | Verfahren zur Herstellung von Lamotrigin |
CA2366521C (en) | 2001-12-24 | 2007-03-06 | Brantford Chemicals Inc. | A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines |
IL164155A0 (en) * | 2002-03-20 | 2005-12-18 | Teva Pharma | Crystalline forms of quetiapine hemifumarate |
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ES2209639B1 (es) | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
GB2395483A (en) * | 2003-07-03 | 2004-05-26 | Jubilant Organosys Ltd | Crystalline lamotrigine and its monohydrate |
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DE602004032465D1 (de) * | 2003-12-02 | 2011-06-09 | Teva Pharma | Referenzstandard zur charakterisierung von rosuvastatin |
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JP2007518826A (ja) * | 2004-01-30 | 2007-07-12 | テバ ファーマシューティカル インダストリーズ リミティド | モンテルカスト遊離酸多形体 |
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US7358247B2 (en) * | 2004-04-27 | 2008-04-15 | TEVA Gyógyszergyár Zártköruen Muködö Részvénytársaság | Mycophenolate mofetil impurity |
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US20060194869A1 (en) * | 2004-12-23 | 2006-08-31 | Santiago Ini | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
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US20070167625A1 (en) * | 2005-02-22 | 2007-07-19 | Anna Balanov | Preparation of rosuvastatin |
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US7247751B2 (en) | 2005-05-23 | 2007-07-24 | Teva Pharmaceutical Industries Ltd | Processes for preparing cinacalcet hydrochloride crystal Form I |
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US20080242877A1 (en) * | 2007-02-26 | 2008-10-02 | Vinod Kumar Kansal | Intermediates and processes for the synthesis of Ramelteon |
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KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
CN113156009B (zh) * | 2021-04-20 | 2023-12-22 | 三金集团湖南三金制药有限责任公司 | 高效液相色谱分析拉莫三嗪的方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1147087B (it) | 1979-06-01 | 1986-11-19 | Wellcome Found | Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione |
EP0021120B1 (en) | 1979-06-01 | 1983-04-06 | The Wellcome Foundation Limited | 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
AU4311596A (en) * | 1994-12-30 | 1996-07-24 | Wellcome Foundation Limited, The | Process for the preparation of lamotrigine |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
-
1998
- 1998-06-10 GB GBGB9812413.4A patent/GB9812413D0/en not_active Ceased
-
1999
- 1999-02-24 EA EA199900159A patent/EA000666B1/ru not_active IP Right Cessation
- 1999-02-25 SG SG9901252A patent/SG85628A1/en unknown
- 1999-03-09 HR HR990074A patent/HRP990074A2/hr not_active Application Discontinuation
- 1999-03-09 KR KR1019990007632A patent/KR100322354B1/ko active IP Right Review Request
- 1999-03-10 NO NO991151A patent/NO991151L/no unknown
- 1999-03-10 PT PT99200695T patent/PT963980E/pt unknown
- 1999-03-10 PE PE1999000190A patent/PE20000332A1/es not_active Application Discontinuation
- 1999-03-10 ID IDP990201D patent/ID22957A/id unknown
- 1999-03-10 US US09/265,670 patent/US6333198B1/en not_active Expired - Fee Related
- 1999-03-10 CA CA002265194A patent/CA2265194C/en not_active Expired - Fee Related
- 1999-03-10 AP APAP/P/1999/001481A patent/AP9901481A0/en unknown
- 1999-03-10 MA MA25489A patent/MA24777A1/fr unknown
- 1999-03-10 AT AT99200695T patent/ATE218552T1/de not_active IP Right Cessation
- 1999-03-10 AP APAP/P/2001/002286A patent/AP0102286A0/en unknown
- 1999-03-10 NZ NZ334590A patent/NZ334590A/xx unknown
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- 1999-03-10 YU YU12399A patent/YU12399A/sh unknown
- 1999-03-10 HU HU9900592A patent/HUP9900592A3/hu unknown
- 1999-03-10 SI SI9930088T patent/SI0963980T1/xx unknown
- 1999-03-10 EP EP99200695A patent/EP0963980B1/en not_active Expired - Lifetime
- 1999-03-10 BR BR9900984-6A patent/BR9900984A/pt not_active IP Right Cessation
- 1999-03-10 JP JP11063792A patent/JP2989189B1/ja not_active Expired - Fee Related
- 1999-03-10 AU AU20319/99A patent/AU2031999A/en not_active Abandoned
- 1999-03-10 DE DE69901656T patent/DE69901656T2/de not_active Expired - Fee Related
- 1999-03-10 EP EP01203376A patent/EP1170588A1/en not_active Withdrawn
- 1999-03-10 CN CN99103445A patent/CN1238454A/zh active Pending
- 1999-03-10 ZA ZA9901951A patent/ZA991951B/xx unknown
- 1999-03-10 DK DK99200695T patent/DK0963980T3/da active
- 1999-03-10 ES ES99200695T patent/ES2178342T3/es not_active Expired - Lifetime
- 1999-03-10 AR ARP990101018A patent/AR014074A1/es not_active Application Discontinuation
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2000
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2001
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2003
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