DK0898557T3 - Vandopløselige trisubstituierede 1,2-dioxetan, der har forbedret lagringsstabilitet, syntetiske processer og mellemprodukter - Google Patents
Vandopløselige trisubstituierede 1,2-dioxetan, der har forbedret lagringsstabilitet, syntetiske processer og mellemprodukterInfo
- Publication number
- DK0898557T3 DK0898557T3 DK97949349T DK97949349T DK0898557T3 DK 0898557 T3 DK0898557 T3 DK 0898557T3 DK 97949349 T DK97949349 T DK 97949349T DK 97949349 T DK97949349 T DK 97949349T DK 0898557 T3 DK0898557 T3 DK 0898557T3
- Authority
- DK
- Denmark
- Prior art keywords
- dioxetanes
- water
- dioxetane
- storage stability
- trisubstituted
- Prior art date
Links
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical class C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000543 intermediate Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003093 cationic surfactant Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001378 electrochemiluminescence detection Methods 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Luminescent Compositions (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polyethers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/748,107 US5721370A (en) | 1995-07-31 | 1996-11-08 | Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability |
PCT/US1997/019618 WO1998019989A1 (en) | 1996-11-08 | 1997-11-07 | Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0898557T3 true DK0898557T3 (da) | 2003-08-04 |
Family
ID=25008049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97949349T DK0898557T3 (da) | 1996-11-08 | 1997-11-07 | Vandopløselige trisubstituierede 1,2-dioxetan, der har forbedret lagringsstabilitet, syntetiske processer og mellemprodukter |
Country Status (13)
Country | Link |
---|---|
US (2) | US5721370A (es) |
EP (1) | EP0898557B9 (es) |
JP (1) | JP4199830B2 (es) |
KR (1) | KR100518977B1 (es) |
CN (1) | CN1252029C (es) |
AT (1) | ATE238268T1 (es) |
AU (1) | AU734753B2 (es) |
CA (1) | CA2238365C (es) |
DE (1) | DE69721247T2 (es) |
DK (1) | DK0898557T3 (es) |
ES (1) | ES2197376T3 (es) |
IL (1) | IL124671A (es) |
WO (1) | WO1998019989A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856522A (en) * | 1995-05-04 | 1999-01-05 | Tropix, Inc. | Method of using synthesis of 1,2-dioxetanes and kits therefore |
US5578253A (en) * | 1994-11-23 | 1996-11-26 | Lumigen, Inc. | Chemiluminescent dialkyl-substituted 1,2-dioxetane compounds, methods of synthesis and use |
JP4068144B2 (ja) * | 1995-10-17 | 2008-03-26 | アプレーラ コーポレイション | 改良された性能を有する1,2化学発光性ジオキセタン類 |
WO2000014092A1 (en) * | 1998-09-08 | 2000-03-16 | Giri Brij P | Chemiluminescent 1,2-dioxetanes |
US6555698B1 (en) * | 1998-11-17 | 2003-04-29 | Tropix, Inc. | Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor |
US6623971B2 (en) * | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
US6783948B1 (en) | 1999-07-30 | 2004-08-31 | Bayer Corporation | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes |
WO2006116687A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanoassays |
US7879575B2 (en) * | 2005-04-27 | 2011-02-01 | The Trustees Of The University Of Pennsylvania | Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence |
US7919019B2 (en) * | 2005-04-27 | 2011-04-05 | The Trustees Of The University Of Pennsylvania | Nanostructure enhanced luminescent devices |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959182A (en) * | 1986-07-17 | 1990-09-25 | Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
US4983779A (en) * | 1986-07-17 | 1991-01-08 | The Board Of Governors Of Wayne State University | Process for the preparation of vinyl ethers |
US5013827A (en) * | 1986-07-17 | 1991-05-07 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
US5068339A (en) * | 1986-07-17 | 1991-11-26 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
US5004565A (en) * | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
US5112960A (en) * | 1989-07-17 | 1992-05-12 | Bronstein Irena Y | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes |
US5220005A (en) * | 1986-07-24 | 1993-06-15 | Tropix, Inc. | Substituted adamantyl dioxetanes |
DE3788203T2 (de) * | 1986-07-24 | 1994-03-31 | Tropix Inc | Verfahren zum nachweis einer verbindung unter verwendung des enzymatisch induzierten zerfalls von dioxethanen. |
CA1340590C (en) * | 1986-07-24 | 1999-06-08 | John C. Voyta | Chemiluminescence enhancement |
US5582980A (en) * | 1989-07-17 | 1996-12-10 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
US4952707A (en) * | 1988-06-30 | 1990-08-28 | Tropix, Inc. | Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes |
US5547836A (en) * | 1990-08-30 | 1996-08-20 | Tropix, Inc. | Enhancement of chemiluminescent assays |
DE473984T1 (de) * | 1990-09-07 | 1992-08-13 | The Board Of Governors Of Wayne State University, Detroit, Mich. | 1,2-dioxetan-verbindungen als chemilumineszierende markierungen fuer organische und biologische molekuele. |
US5399497A (en) * | 1992-02-26 | 1995-03-21 | Miles, Inc. | Capsule chemistry sample liquid analysis system and method |
US5393469A (en) * | 1992-03-20 | 1995-02-28 | Lumigen, Inc. | Polymeric phosphonium salts providing enhanced chemiluminescence from 1,2-dioxetanes |
AU5132993A (en) * | 1992-09-21 | 1994-04-12 | Habley Medical Technology Corporation | Device and method for containing an ampule and transferring liquid within the ampule to a container |
US5603868A (en) * | 1992-10-30 | 1997-02-18 | Abbott Laboratories | Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes |
US5451347A (en) * | 1993-06-24 | 1995-09-19 | Lumigen, Inc. | Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants |
US5777135A (en) * | 1995-07-31 | 1998-07-07 | Lumigen, Inc. | Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions |
US5631167A (en) * | 1995-07-31 | 1997-05-20 | Bayer Corporation | Capsule chemistry analytical methods employing dioxetane chemiluminescence |
-
1996
- 1996-11-08 US US08/748,107 patent/US5721370A/en not_active Expired - Lifetime
-
1997
- 1997-07-17 US US08/896,150 patent/US5866045A/en not_active Expired - Lifetime
- 1997-11-07 CN CNB971916241A patent/CN1252029C/zh not_active Expired - Lifetime
- 1997-11-07 EP EP97949349A patent/EP0898557B9/en not_active Expired - Lifetime
- 1997-11-07 JP JP52153198A patent/JP4199830B2/ja not_active Expired - Lifetime
- 1997-11-07 AT AT97949349T patent/ATE238268T1/de not_active IP Right Cessation
- 1997-11-07 WO PCT/US1997/019618 patent/WO1998019989A1/en active IP Right Grant
- 1997-11-07 DE DE69721247T patent/DE69721247T2/de not_active Expired - Lifetime
- 1997-11-07 KR KR1019980705247A patent/KR100518977B1/ko not_active IP Right Cessation
- 1997-11-07 CA CA002238365A patent/CA2238365C/en not_active Expired - Lifetime
- 1997-11-07 AU AU69907/98A patent/AU734753B2/en not_active Expired
- 1997-11-07 ES ES97949349T patent/ES2197376T3/es not_active Expired - Lifetime
- 1997-11-07 IL IL12467196A patent/IL124671A/xx not_active IP Right Cessation
- 1997-11-07 DK DK97949349T patent/DK0898557T3/da active
Also Published As
Publication number | Publication date |
---|---|
AU734753B2 (en) | 2001-06-21 |
CA2238365A1 (en) | 1998-05-14 |
CN1252029C (zh) | 2006-04-19 |
US5866045A (en) | 1999-02-02 |
DE69721247D1 (de) | 2003-05-28 |
JP2000506544A (ja) | 2000-05-30 |
US5721370A (en) | 1998-02-24 |
KR100518977B1 (ko) | 2006-06-29 |
ATE238268T1 (de) | 2003-05-15 |
EP0898557A4 (en) | 2001-01-10 |
CA2238365C (en) | 2008-03-18 |
KR19990077111A (ko) | 1999-10-25 |
EP0898557B1 (en) | 2003-04-23 |
EP0898557B9 (en) | 2003-10-08 |
IL124671A0 (en) | 1998-12-06 |
CN1208399A (zh) | 1999-02-17 |
DE69721247T2 (de) | 2004-03-11 |
JP4199830B2 (ja) | 2008-12-24 |
EP0898557A1 (en) | 1999-03-03 |
WO1998019989A1 (en) | 1998-05-14 |
AU6990798A (en) | 1998-05-29 |
ES2197376T3 (es) | 2004-01-01 |
IL124671A (en) | 2003-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE68925963T2 (de) | Chemilimineszente 1,2-Dioxetan-Verbindungen | |
DK0898557T3 (da) | Vandopløselige trisubstituierede 1,2-dioxetan, der har forbedret lagringsstabilitet, syntetiske processer og mellemprodukter | |
DE69900813T2 (de) | Asymmetrische cyaninfarbstoffe als fluoreszenzlöscher | |
FI905925A (fi) | Heteropolyhapon vaikealiukoisen suolan käyttö analyytin määritykseen, vastaava määritysmenetelmä sekä tähän sopiva aine | |
Han et al. | A fluorescent probe for Hg2+ sensing in solutions and living cells with a wide working pH range | |
ES2056052T3 (es) | Composicion detergente liquida para prendas de vestir. | |
ES2189844T3 (es) | Compuestos de 1,2-dioxetanos sustituidos que presentan una solubilidad en agua aumentada y composiciones de prueba. | |
KR850002377A (ko) | 살충제 조성물 | |
KR840002887A (ko) | 비스(p-알킬페닐에티닐)안트 라센 조성물 | |
ATE306082T1 (de) | Nachweis der bindung von ladungsträgern mittels ph- oder potential-sensitiver sonden | |
ES2128125T3 (es) | Reactivo para suprimir interferencias, destinado a usarse en la determinacion de un analito con un complejo metalico luminiscente. | |
DK0757248T3 (da) | Forbedrede kapsel-kemi analytiske metoder, der benytter dioxetan-kemiluminescens | |
KR900700103A (ko) | 항-알레르기성 점안제 | |
KR830005325A (ko) | 수용성 화학 발광 시스템 | |
EA199700223A1 (ru) | Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции | |
EP0881277A3 (en) | Friction modifier comprising metal sulfonate and lubricating oil composition containing the same | |
KR850001214A (ko) | 트리아졸로-피리미딘 유도체의 제조방법 | |
FR2574184B1 (fr) | Composes fluorescents, derives d'(amino-4 disulfonato-3,6) naphtalimide, leur application aux dosages immunologiques en polarisation de fluorescence | |
EA200200160A1 (ru) | Аналоги псевдомицина с n-ацильной боковой цепью | |
DK120087D0 (da) | 2,3-naphthalendicarboxaldehyder til analysebrug | |
KR830003869A (ko) | 안정화된 고체형상 농약조성물 | |
KR920002515A (ko) | 신규 수산 비스에스텔 유도체 | |
EA200200163A1 (ru) | Аминомодифицированные соединения псевдомицина | |
KR830006169A (ko) | 디페닐 염기의 연속 제조방법 | |
KR890006597A (ko) | 5-알콕시-2-(4-알콕시페닐)피리미딘 |