DK0866967T4 - Anvendelse af kernemagnetisk resonans til identifikation af ligander til mål-biomolekyler - Google Patents
Anvendelse af kernemagnetisk resonans til identifikation af ligander til mål-biomolekylerInfo
- Publication number
- DK0866967T4 DK0866967T4 DK96940448T DK96940448T DK0866967T4 DK 0866967 T4 DK0866967 T4 DK 0866967T4 DK 96940448 T DK96940448 T DK 96940448T DK 96940448 T DK96940448 T DK 96940448T DK 0866967 T4 DK0866967 T4 DK 0866967T4
- Authority
- DK
- Denmark
- Prior art keywords
- ligand
- target molecule
- ligands
- identification
- magnetic resonance
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Compounds Of Iron (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/555,691 US5698401A (en) | 1995-11-14 | 1995-11-14 | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
PCT/US1996/018270 WO1997018471A1 (en) | 1995-11-14 | 1996-11-13 | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0866967T3 DK0866967T3 (da) | 2000-06-26 |
DK0866967T4 true DK0866967T4 (da) | 2007-12-10 |
Family
ID=24218250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96940448T DK0866967T4 (da) | 1995-11-14 | 1996-11-13 | Anvendelse af kernemagnetisk resonans til identifikation af ligander til mål-biomolekyler |
Country Status (13)
Country | Link |
---|---|
US (2) | US5698401A (de) |
EP (2) | EP0866967B2 (de) |
JP (1) | JP3032301B2 (de) |
AT (2) | ATE189063T1 (de) |
AU (1) | AU701810B2 (de) |
CA (1) | CA2237343C (de) |
DE (2) | DE69606324T3 (de) |
DK (1) | DK0866967T4 (de) |
ES (1) | ES2143793T5 (de) |
GR (1) | GR3032361T3 (de) |
IL (2) | IL155988A (de) |
PT (1) | PT866967E (de) |
WO (1) | WO1997018471A1 (de) |
Families Citing this family (78)
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US20010004528A1 (en) * | 1995-11-14 | 2001-06-21 | Stephen W. Fesik | Use of 13c nuclear magnetic resonance to detect binding to target molecules |
US5989827A (en) * | 1995-11-14 | 1999-11-23 | Abbott Laboratories | Use of nuclear magnetic resonance to design ligands to target biomolecules |
US6426058B1 (en) * | 1996-03-29 | 2002-07-30 | The Regents Of The University Of California | Enhancement of NMR and MRI in the presence of hyperpolarized noble gases |
DE19649359C1 (de) * | 1996-11-28 | 1998-02-12 | Thomas Prof Dr Peters | Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken |
AU772620B2 (en) * | 1997-04-18 | 2004-05-06 | Abbvie Inc. | Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules |
US6043024A (en) * | 1997-04-18 | 2000-03-28 | Abbott Laboratories | Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules |
JP2002505004A (ja) * | 1997-06-13 | 2002-02-12 | バーテックス ファマシューティカルズ インコーポレイテッド | 薬剤核を同定する方法 |
US20030143757A1 (en) * | 1997-06-13 | 2003-07-31 | Jonathan Moore | Methods for identifying drug cores |
US6111066A (en) | 1997-09-02 | 2000-08-29 | Martek Biosciences Corporation | Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains |
US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
US20020131972A1 (en) * | 1998-05-21 | 2002-09-19 | Daniel Sem | Multi-partite ligands and methods of identifying and using same |
WO1999063929A2 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
JP2002534687A (ja) * | 1998-12-30 | 2002-10-15 | アメルシャム・パブリック・リミテッド・カンパニー | 過分極を使用したnmr分光学アッセイ |
US6897337B2 (en) * | 1999-04-09 | 2005-05-24 | Abbott Laboratories | Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor |
TWI283659B (en) * | 1999-04-09 | 2007-07-11 | Abbott Lab | Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor |
US6333149B1 (en) * | 1999-06-04 | 2001-12-25 | Triad Biotechnology, Inc. | NMR-solve method for rapid identification of bi-ligand drug candidates |
US6171804B1 (en) | 1999-07-12 | 2001-01-09 | The Rockefeller University | Method of determining interdomain orientation and changes of interdomain orientation on ligation |
WO2001006260A1 (en) * | 1999-07-19 | 2001-01-25 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
US7105310B1 (en) * | 2000-07-19 | 2006-09-12 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
AU6937100A (en) * | 1999-08-23 | 2001-03-19 | Polaris Pharmaceuticals, Inc. | Inhibitors of binding between proteins and macromolecular ligands |
CA2400094A1 (en) * | 1999-09-29 | 2001-04-05 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
JP2003510608A (ja) * | 1999-09-29 | 2003-03-18 | スミスクライン・ビーチャム・コーポレイション | 標的生体分子と相互作用する化合物を同定するための一次元および多次元核磁気共鳴の使用法 |
US6677160B1 (en) | 1999-09-29 | 2004-01-13 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
US6764858B2 (en) | 1999-09-29 | 2004-07-20 | Pharmacia & Upjohn Company | Methods for creating a compound library |
GB9925677D0 (en) * | 1999-10-29 | 1999-12-29 | Pharmacia & Upjohn Spa | Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules |
JP2003524167A (ja) * | 2000-02-25 | 2003-08-12 | ワイス | Ms/nmrを用いた構造に基づく薬物設計の方法 |
WO2001079852A2 (en) * | 2000-04-17 | 2001-10-25 | Pharmacia & Upjohn Company | Nmr-methods for indentifying sites in papillomavirus e2 protein |
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US7146277B2 (en) * | 2000-06-13 | 2006-12-05 | James H. Prestegard | NMR assisted design of high affinity ligands for structurally uncharacterized proteins |
US6652833B2 (en) | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
EP2280272A1 (de) | 2000-09-27 | 2011-02-02 | Universiteit Leiden | Verfahren zur Anwendung der Kernspinresonanz zur Entdeckung von Liganden oder als ein Werkzeug zum Aussieben von medizinisch wirksamen Substanzen |
SE0003811D0 (sv) * | 2000-10-20 | 2000-10-20 | Pharmacia Ab | Screening methods |
CA2432924A1 (en) * | 2000-12-21 | 2002-06-27 | Triad Therapeutics, Inc. | Sea-trosy and related methods |
MXPA03005777A (es) * | 2000-12-22 | 2005-02-14 | Johnson & Johnson | Derivados de triazol diaminas sustituidos como inhibidores de cinasa. |
US6656694B2 (en) | 2001-01-11 | 2003-12-02 | Theravance, Inc. | Method for identifying a ligand for a biological substrate |
US7645569B2 (en) * | 2001-01-26 | 2010-01-12 | Board Of Regents, The University Of Texas System | NMR detection of foreign PAS domain ligands |
US20020172967A1 (en) * | 2001-02-13 | 2002-11-21 | Gadek Thomas R. | Identification of non-covalent complexes by mass spectrometry |
DE10119455B4 (de) * | 2001-04-20 | 2010-12-16 | Siemens Ag | Verfahren zum Auswerten von Daten, die mittels der Magnetresonanztechnik erzeugt werden und spektroskopische Information beinhalten |
CA2448567C (en) | 2001-05-25 | 2014-05-20 | Duke University | Modulators of nucleic acid ligands |
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US20030129672A1 (en) * | 2001-08-29 | 2003-07-10 | Dyer Richard Dennis | Method for identifying metalloenzyme inhibitors |
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DE10160177A1 (de) * | 2001-12-07 | 2003-06-26 | Novaspin Biotech Gmbh | Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie |
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US20030180797A1 (en) * | 2002-03-20 | 2003-09-25 | Lin Yu | Identification of ligands for a receptor family and related methods |
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EP1558751A4 (de) * | 2002-09-16 | 2007-08-22 | Plexxikon Inc | Kristallstruktur von pim-1-kinase |
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US20040132102A1 (en) * | 2002-10-29 | 2004-07-08 | Maurizio Pellecchia | Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy |
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US20050170431A1 (en) * | 2003-02-28 | 2005-08-04 | Plexxikon, Inc. | PYK2 crystal structure and uses |
US7964534B2 (en) * | 2003-03-13 | 2011-06-21 | Triad Liquidating Company, Llc | Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes |
WO2004092727A2 (en) * | 2003-04-11 | 2004-10-28 | Structural Genomix, Inc. | Compound libraries and methods for drug discovery |
EP1617221A4 (de) * | 2003-04-23 | 2006-08-02 | Olympus Corp | Screening-verfahren für eine zur bindung an einen rezeptor fähige substanz |
JP2004331832A (ja) * | 2003-05-08 | 2004-11-25 | Ricoh Co Ltd | Dnaインク組成物とそれを用いた識別画像印刷体、及びインクジェット記録装置 |
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JP4192078B2 (ja) * | 2003-11-26 | 2008-12-03 | 株式会社日立製作所 | 核磁気共鳴方法 |
JP4546400B2 (ja) * | 2003-11-28 | 2010-09-15 | 株式会社日立製作所 | 核磁気共鳴法を用いた、標的タンパク質のアゴニストおよびアンタゴニストの同定方法、およびこの方法に用いるプログラム |
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WO2006082963A1 (ja) * | 2005-02-07 | 2006-08-10 | Mitsubishi Chemical Corporation | 標的分子とリガンドあるいはリガンド候補化合物との結合検出方法 |
EP2013624B1 (de) | 2006-03-14 | 2011-08-03 | Universität Basel | Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten |
US8933209B2 (en) | 2006-04-26 | 2015-01-13 | Abbvie Inc. | Dep2 and its uses in major depressive disorder and other related disorders |
US7760342B2 (en) | 2007-12-21 | 2010-07-20 | Wisconsin Alumni Research Foundation | Multidimensional spectrometer |
US20140024123A1 (en) * | 2011-02-07 | 2014-01-23 | National University Corporation Kobe University | Aqueous Solution Containing Partial Ras Polypeptide and Method for Screening Inhibitor of Ras Function |
KR101855242B1 (ko) | 2012-01-26 | 2018-05-09 | 크리스토퍼 제이. 소레스 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
WO2017025802A1 (en) | 2015-08-11 | 2017-02-16 | Arch Biopartners, Inc. | Dpep-1 binding compositions and methods of use |
ES2965087T3 (es) | 2016-09-02 | 2024-04-10 | Soares Christopher J | Uso de antagonistas de receptor de CGRP en el tratamiento de glaucoma |
Family Cites Families (5)
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---|---|---|---|---|
IE904705A1 (en) * | 1989-12-29 | 1991-07-17 | Univ Technologies Int | Methods for modelling tertiary structures of biologically¹active ligands including agonists and antagonists thereto¹and novel synthetic antagonists based on angiotensin |
US5164297A (en) * | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5726014A (en) * | 1991-06-27 | 1998-03-10 | Genelabs Technologies, Inc. | Screening assay for the detection of DNA-binding molecules |
DK0593618T3 (da) * | 1991-06-27 | 1998-11-23 | Genelabs Tech Inc | Screeningsassay til påvisning af DNA-bindende molekyler |
-
1995
- 1995-11-14 US US08/555,691 patent/US5698401A/en not_active Expired - Lifetime
-
1996
- 1996-11-13 PT PT96940448T patent/PT866967E/pt unknown
- 1996-11-13 WO PCT/US1996/018270 patent/WO1997018471A1/en active IP Right Grant
- 1996-11-13 AT AT96940448T patent/ATE189063T1/de active
- 1996-11-13 EP EP96940448A patent/EP0866967B2/de not_active Expired - Lifetime
- 1996-11-13 CA CA002237343A patent/CA2237343C/en not_active Expired - Lifetime
- 1996-11-13 EP EP99119066A patent/EP0981049B1/de not_active Expired - Lifetime
- 1996-11-13 JP JP9519074A patent/JP3032301B2/ja not_active Expired - Lifetime
- 1996-11-13 DE DE69606324T patent/DE69606324T3/de not_active Expired - Lifetime
- 1996-11-13 ES ES96940448T patent/ES2143793T5/es not_active Expired - Lifetime
- 1996-11-13 IL IL15598896A patent/IL155988A/xx not_active IP Right Cessation
- 1996-11-13 IL IL12392396A patent/IL123923A/xx not_active IP Right Cessation
- 1996-11-13 DE DE69631842T patent/DE69631842D1/de not_active Expired - Lifetime
- 1996-11-13 AU AU77328/96A patent/AU701810B2/en not_active Expired
- 1996-11-13 AT AT99119066T patent/ATE261581T1/de not_active IP Right Cessation
- 1996-11-13 DK DK96940448T patent/DK0866967T4/da active
-
1997
- 1997-02-24 US US08/804,777 patent/US5804390A/en not_active Expired - Lifetime
-
2000
- 2000-01-14 GR GR20000400014T patent/GR3032361T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU7732896A (en) | 1997-06-05 |
JPH11513498A (ja) | 1999-11-16 |
DE69606324D1 (de) | 2000-02-24 |
DE69606324T3 (de) | 2008-02-07 |
ATE189063T1 (de) | 2000-02-15 |
GR3032361T3 (en) | 2000-04-27 |
WO1997018471A1 (en) | 1997-05-22 |
ES2143793T3 (es) | 2000-05-16 |
DE69631842D1 (de) | 2004-04-15 |
JP3032301B2 (ja) | 2000-04-17 |
EP0981049B1 (de) | 2004-03-10 |
EP0981049A1 (de) | 2000-02-23 |
AU701810B2 (en) | 1999-02-04 |
PT866967E (pt) | 2000-04-28 |
ES2143793T5 (es) | 2008-03-01 |
DE69606324T2 (de) | 2000-07-06 |
EP0866967A1 (de) | 1998-09-30 |
US5804390A (en) | 1998-09-08 |
EP0866967B2 (de) | 2007-08-08 |
IL123923A (en) | 2005-07-25 |
EP0866967B1 (de) | 2000-01-19 |
US5698401A (en) | 1997-12-16 |
ATE261581T1 (de) | 2004-03-15 |
CA2237343C (en) | 2009-01-20 |
IL155988A (en) | 2005-07-25 |
DK0866967T3 (da) | 2000-06-26 |
CA2237343A1 (en) | 1997-05-22 |
IL155988A0 (en) | 2003-12-23 |
MX9803810A (es) | 1998-09-30 |
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