DK0861250T3 - Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase - Google Patents

Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase

Info

Publication number
DK0861250T3
DK0861250T3 DK96938584T DK96938584T DK0861250T3 DK 0861250 T3 DK0861250 T3 DK 0861250T3 DK 96938584 T DK96938584 T DK 96938584T DK 96938584 T DK96938584 T DK 96938584T DK 0861250 T3 DK0861250 T3 DK 0861250T3
Authority
DK
Denmark
Prior art keywords
amindine
inhibitors
nitrogen monoxide
isothiourea derivatives
monoxide synthase
Prior art date
Application number
DK96938584T
Other languages
Danish (da)
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0861250T3 publication Critical patent/DK0861250T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Gas Separation By Absorption (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK96938584T 1995-11-07 1996-11-06 Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase DK0861250T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
DK0861250T3 true DK0861250T3 (da) 2002-04-29

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96938584T DK0861250T3 (da) 1995-11-07 1996-11-06 Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase

Country Status (24)

Country Link
EP (1) EP0861250B1 (is)
JP (1) JP2000500132A (is)
KR (1) KR19990067349A (is)
AT (1) ATE213241T1 (is)
AU (1) AU701329B2 (is)
BR (1) BR9611276A (is)
CA (1) CA2235301A1 (is)
CZ (1) CZ139298A3 (is)
DE (1) DE69619259T2 (is)
DK (1) DK0861250T3 (is)
EE (1) EE9800141A (is)
ES (1) ES2171743T3 (is)
HU (1) HUP9900142A3 (is)
IL (1) IL124296A0 (is)
IS (1) IS4725A (is)
NO (1) NO982072L (is)
NZ (1) NZ322227A (is)
PL (1) PL326554A1 (is)
PT (1) PT861250E (is)
SI (1) SI0861250T1 (is)
SK (1) SK61098A3 (is)
TR (1) TR199800813T2 (is)
TW (1) TW458978B (is)
WO (1) WO1997017344A1 (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
CA2470723A1 (en) 2001-12-19 2003-06-26 H. Lundbeck A/S 3,4-dihydro-1h-isoquinolin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
AU2003257300B2 (en) * 2002-08-07 2010-01-21 Neuraxon Inc. Amino benzothiazole compounds with NOS inhibitory activity
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
WO2007004959A1 (en) * 2005-07-05 2007-01-11 Astrazeneca Ab New compounds, process for their preparation, intermediates, pharmaceutical compositions and their use in the treatment of 5-ht6 mediated disorders such as alzheimer's disease, cognitive disorders, cognitive impairment associated with schizophrenia, obesity and parkinson's disease
EP2123644B1 (en) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
WO2018119444A1 (en) 2016-12-23 2018-06-28 Daiichi Sankyo Company, Limited Sulfonamide compounds having tnap inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2132393T3 (es) * 1993-03-23 1999-08-16 Astra Ab Derivados de guanidina utiles en terapeutica.
ATE231126T1 (de) * 1993-08-12 2003-02-15 Astrazeneca Ab Amidin-derivate mit stickstoffoxid-synthease- aktivität
EP0723438A1 (en) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
SI0861250T1 (en) 2002-06-30
HUP9900142A3 (en) 2001-08-28
NO982072D0 (no) 1998-05-06
AU701329B2 (en) 1999-01-28
WO1997017344A1 (en) 1997-05-15
NO982072L (no) 1998-07-03
EP0861250A1 (en) 1998-09-02
TW458978B (en) 2001-10-11
CZ139298A3 (cs) 1998-09-16
EE9800141A (et) 1998-10-15
MX9803453A (es) 1998-09-30
CA2235301A1 (en) 1997-05-15
AU7592796A (en) 1997-05-29
IL124296A0 (en) 1998-12-06
EP0861250B1 (en) 2002-02-13
PT861250E (pt) 2002-07-31
JP2000500132A (ja) 2000-01-11
NZ322227A (en) 1999-11-29
TR199800813T2 (xx) 1998-07-21
IS4725A (is) 1998-04-24
DE69619259T2 (de) 2002-09-19
PL326554A1 (en) 1998-09-28
DE69619259D1 (de) 2002-03-21
KR19990067349A (ko) 1999-08-16
BR9611276A (pt) 1999-01-26
ATE213241T1 (de) 2002-02-15
HUP9900142A2 (hu) 1999-05-28
ES2171743T3 (es) 2002-09-16
SK61098A3 (en) 1999-01-11

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