DK0785789T3 - Diazepinindoler som phosphodiesterase IV-inhibitorer - Google Patents
Diazepinindoler som phosphodiesterase IV-inhibitorerInfo
- Publication number
- DK0785789T3 DK0785789T3 DK95935495T DK95935495T DK0785789T3 DK 0785789 T3 DK0785789 T3 DK 0785789T3 DK 95935495 T DK95935495 T DK 95935495T DK 95935495 T DK95935495 T DK 95935495T DK 0785789 T3 DK0785789 T3 DK 0785789T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- racemic forms
- diazepin
- indoles
- phosphodiesterase
- Prior art date
Links
- RHWPYOBZHMUSIP-UHFFFAOYSA-N N1C=CC=CC=N1.C1=CC=C2NC=CC2=C1 Chemical class N1C=CC=CC=N1.C1=CC=C2NC=CC2=C1 RHWPYOBZHMUSIP-UHFFFAOYSA-N 0.000 title 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 2-indolyl Chemical group 0.000 abstract 2
- 101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- BSYFXFLGOGQHFU-UHFFFAOYSA-N pyrrolo[2,3-g][1,2]benzodiazepine Chemical class N1=NC=CC=C2C3=NC=CC3=CC=C21 BSYFXFLGOGQHFU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9412282A FR2725719B1 (fr) | 1994-10-14 | 1994-10-14 | Diazepino-indoles inhibiteurs de phosphodiesterases iv |
| PCT/FR1995/001354 WO1996011690A1 (fr) | 1994-10-14 | 1995-10-13 | Diazepino-indoles inhibiteurs de phosphodiesterases iv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0785789T3 true DK0785789T3 (da) | 2003-01-20 |
Family
ID=9467863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95935495T DK0785789T3 (da) | 1994-10-14 | 1995-10-13 | Diazepinindoler som phosphodiesterase IV-inhibitorer |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5852190A (cs) |
| EP (1) | EP0785789B1 (cs) |
| JP (1) | JPH10507447A (cs) |
| KR (1) | KR970706826A (cs) |
| CN (1) | CN1097459C (cs) |
| AT (1) | ATE223720T1 (cs) |
| AU (1) | AU703773B2 (cs) |
| BR (1) | BR9509353A (cs) |
| CA (1) | CA2200628A1 (cs) |
| CZ (1) | CZ111497A3 (cs) |
| DE (1) | DE69528189T2 (cs) |
| DK (1) | DK0785789T3 (cs) |
| ES (1) | ES2181793T3 (cs) |
| FR (1) | FR2725719B1 (cs) |
| HU (1) | HUT77411A (cs) |
| NO (1) | NO971687L (cs) |
| NZ (1) | NZ294642A (cs) |
| PL (1) | PL319659A1 (cs) |
| PT (1) | PT785789E (cs) |
| RU (1) | RU2174517C2 (cs) |
| SK (1) | SK282766B6 (cs) |
| UA (1) | UA42793C2 (cs) |
| WO (1) | WO1996011690A1 (cs) |
| ZA (1) | ZA958669B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2746800B1 (fr) * | 1996-03-29 | 1998-06-05 | Jouveinal Inst Rech | Diazepino-indoles inhibiteurs de phosphodiesterases 4 |
| FR2762841B1 (fr) * | 1997-04-30 | 1999-07-02 | Jouveinal Inst Rech | Diazepino-indolones inhibitrices de phosphodiesterases iv |
| FR2776660B1 (fr) * | 1998-03-27 | 2000-05-12 | Parke Davis | Diazepino-indoles de phosphodiesterases iv |
| TR200201317T2 (tr) | 1999-08-21 | 2002-11-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Sinerjistik kombinasyon. |
| KR100641802B1 (ko) * | 1999-12-28 | 2006-11-02 | 에자이 가부시키가이샤 | 술폰아미드 함유 복소환 화합물 |
| AU2001232175B2 (en) * | 2000-03-03 | 2005-07-07 | Pfizer Products Inc. | Pyrazole ether derivatives as anti-inflammatory/analgesic agents |
| EP1161949A1 (en) | 2000-06-09 | 2001-12-12 | Warner-Lambert Company | Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease |
| EP1199074A1 (en) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production |
| EP1188438A1 (en) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
| DE10148290A1 (de) * | 2001-09-29 | 2003-04-17 | Bayer Cropscience Gmbh | Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| RU2378279C1 (ru) * | 2008-05-28 | 2010-01-10 | Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | CПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 1,2,3,6-ТЕТРАГИДРОПИРРОЛО[1,2-d][1,4]ДИАЗОЦИНОВ |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840947A (en) * | 1986-10-14 | 1989-06-20 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas |
| FR2630440B1 (fr) * | 1988-04-25 | 1991-09-20 | Jouveinal Sa | Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique |
| US5248679A (en) * | 1988-09-09 | 1993-09-28 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclic compounds |
| IL91361A (en) * | 1988-09-09 | 1994-10-07 | Fujisawa Pharmaceutical Co | Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same |
| FR2652352A1 (fr) * | 1989-09-28 | 1991-03-29 | Jouveinal Sa | Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique. |
| JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
-
1994
- 1994-10-14 FR FR9412282A patent/FR2725719B1/fr not_active Expired - Fee Related
-
1995
- 1995-02-22 US US08/391,865 patent/US5852190A/en not_active Expired - Fee Related
- 1995-10-13 WO PCT/FR1995/001354 patent/WO1996011690A1/fr not_active Application Discontinuation
- 1995-10-13 HU HU9702065A patent/HUT77411A/hu unknown
- 1995-10-13 EP EP95935495A patent/EP0785789B1/fr not_active Expired - Lifetime
- 1995-10-13 DE DE69528189T patent/DE69528189T2/de not_active Expired - Fee Related
- 1995-10-13 ES ES95935495T patent/ES2181793T3/es not_active Expired - Lifetime
- 1995-10-13 BR BR9509353A patent/BR9509353A/pt not_active Application Discontinuation
- 1995-10-13 AU AU37494/95A patent/AU703773B2/en not_active Ceased
- 1995-10-13 AT AT95935495T patent/ATE223720T1/de not_active IP Right Cessation
- 1995-10-13 PT PT95935495T patent/PT785789E/pt unknown
- 1995-10-13 CN CN95195634A patent/CN1097459C/zh not_active Expired - Fee Related
- 1995-10-13 DK DK95935495T patent/DK0785789T3/da active
- 1995-10-13 SK SK448-97A patent/SK282766B6/sk unknown
- 1995-10-13 KR KR1019970702405A patent/KR970706826A/ko not_active Abandoned
- 1995-10-13 PL PL95319659A patent/PL319659A1/xx unknown
- 1995-10-13 ZA ZA958669A patent/ZA958669B/xx unknown
- 1995-10-13 JP JP8512999A patent/JPH10507447A/ja not_active Withdrawn
- 1995-10-13 CA CA002200628A patent/CA2200628A1/fr not_active Abandoned
- 1995-10-13 CZ CZ971114A patent/CZ111497A3/cs unknown
- 1995-10-13 RU RU97108048/14A patent/RU2174517C2/ru not_active IP Right Cessation
- 1995-10-13 UA UA97052184A patent/UA42793C2/uk unknown
-
1997
- 1997-04-11 NO NO971687A patent/NO971687L/no not_active Application Discontinuation
- 1997-04-14 NZ NZ294642A patent/NZ294642A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL319659A1 (en) | 1997-08-18 |
| SK44897A3 (en) | 1998-12-02 |
| KR970706826A (ko) | 1997-12-01 |
| BR9509353A (pt) | 1997-12-30 |
| PT785789E (pt) | 2002-12-31 |
| CA2200628A1 (fr) | 1996-04-25 |
| EP0785789A1 (fr) | 1997-07-30 |
| HUT77411A (hu) | 1998-04-28 |
| EP0785789B1 (fr) | 2002-09-11 |
| US5852190A (en) | 1998-12-22 |
| CN1097459C (zh) | 2003-01-01 |
| FR2725719A1 (fr) | 1996-04-19 |
| DE69528189D1 (de) | 2002-10-17 |
| MX9702637A (es) | 1997-07-31 |
| ES2181793T3 (es) | 2003-03-01 |
| UA42793C2 (uk) | 2001-11-15 |
| AU703773B2 (en) | 1999-04-01 |
| ATE223720T1 (de) | 2002-09-15 |
| NZ294642A (en) | 2001-06-29 |
| AU3749495A (en) | 1996-05-06 |
| CZ111497A3 (cs) | 1998-01-14 |
| DE69528189T2 (de) | 2003-01-09 |
| RU2174517C2 (ru) | 2001-10-10 |
| NO971687L (no) | 1997-06-13 |
| NO971687D0 (no) | 1997-04-11 |
| JPH10507447A (ja) | 1998-07-21 |
| CN1160352A (zh) | 1997-09-24 |
| FR2725719B1 (fr) | 1996-12-06 |
| SK282766B6 (sk) | 2002-12-03 |
| ZA958669B (en) | 1997-04-14 |
| WO1996011690A1 (fr) | 1996-04-25 |
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