DK0710104T3 - Pharmaceutical preparations for heavily soluble active substances - Google Patents

Pharmaceutical preparations for heavily soluble active substances

Info

Publication number
DK0710104T3
DK0710104T3 DK94923715T DK94923715T DK0710104T3 DK 0710104 T3 DK0710104 T3 DK 0710104T3 DK 94923715 T DK94923715 T DK 94923715T DK 94923715 T DK94923715 T DK 94923715T DK 0710104 T3 DK0710104 T3 DK 0710104T3
Authority
DK
Denmark
Prior art keywords
active agent
component
active substances
pharmaceutical preparations
soluble active
Prior art date
Application number
DK94923715T
Other languages
Danish (da)
Inventor
Ulrich Posanski
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6492300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0710104(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0710104T3 publication Critical patent/DK0710104T3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Abstract

Pharmaceutical prepn. comprises () a pharmaceutically active agent which is sparingly soluble in water; and (b) a carrier compsn. comprising (i) at least one polyglycerine fatty acid ester and/or at least one sorbitan fatty acid ester, (ii) at least 1 conventional pharmaceutical oil contg. a triglyceride as lipophilic component and (iii) at least 1 nonionic surfactant with a HLB value of at least 10. The active agent is pref. a cyclosporin, rapamycin, tacrolimus, deoxyspergualine, nifedipine, nimodipine, etoposide, ibuprofen or alpha-lipoic acid. The active agent has a solubility, in distilled water, of less than 500mg/1000ml. The active agent concn. is 1-30 wt.%, based on the carrier compsn. The carrier compsn. comprises 10-50 wt.% component (i), 5-40 wt% component (ii) and 10-50 wt % component (iii).
DK94923715T 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances DK0710104T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4322826A DE4322826A1 (en) 1993-07-08 1993-07-08 Pharmaceutical preparation
PCT/EP1994/002248 WO1995001786A1 (en) 1993-07-08 1994-07-08 Pharmaceutical compositions for hardly soluble active substances

Publications (1)

Publication Number Publication Date
DK0710104T3 true DK0710104T3 (en) 1999-07-19

Family

ID=6492300

Family Applications (3)

Application Number Title Priority Date Filing Date
DK00122248T DK1092429T3 (en) 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances
DK94923715T DK0710104T3 (en) 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances
DK94922269T DK0710103T3 (en) 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00122248T DK1092429T3 (en) 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94922269T DK0710103T3 (en) 1993-07-08 1994-07-08 Pharmaceutical preparations for heavily soluble active substances

Country Status (24)

Country Link
EP (3) EP1092429B1 (en)
JP (4) JPH08512301A (en)
KR (2) KR100359044B1 (en)
CN (2) CN1313154C (en)
AT (3) ATE172876T1 (en)
AU (2) AU7385094A (en)
BR (1) BR9407002A (en)
CA (2) CA2166204C (en)
CY (2) CY2308B1 (en)
CZ (1) CZ291401B6 (en)
DE (6) DE4322826A1 (en)
DK (3) DK1092429T3 (en)
ES (3) ES2159564T3 (en)
FI (2) FI116197B (en)
GR (1) GR3036571T3 (en)
HU (2) HU223073B1 (en)
NO (2) NO306929B1 (en)
NZ (2) NZ269808A (en)
PL (1) PL179717B1 (en)
PT (2) PT1092429E (en)
RU (1) RU2140291C1 (en)
SI (1) SI1092429T1 (en)
SK (1) SK280615B6 (en)
WO (2) WO1995001786A1 (en)

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Also Published As

Publication number Publication date
CY2604B2 (en) 2010-04-28
CA2166204C (en) 2009-04-14
JPH08512301A (en) 1996-12-24
DE4494850D2 (en) 1996-08-22
NZ269808A (en) 1996-07-26
NO306763B1 (en) 1999-12-20
CY2308B1 (en) 2003-11-14
WO1995001786A1 (en) 1995-01-19
CN1128495A (en) 1996-08-07
AU7345794A (en) 1995-02-06
EP1092429B1 (en) 2004-03-17
DE59407239D1 (en) 1998-12-10
DK0710103T3 (en) 2001-09-24
JPH08512303A (en) 1996-12-24
EP0710104A1 (en) 1996-05-08
KR100359044B1 (en) 2003-02-05
ES2124420T3 (en) 1999-02-01
ATE201985T1 (en) 2001-06-15
DE4494851D2 (en) 1996-12-19
EP0710103B1 (en) 2001-06-13
NO960069L (en) 1996-01-05
ES2159564T3 (en) 2001-10-16
HUT73427A (en) 1996-07-29
CA2166204A1 (en) 1995-01-19
DE4322826A1 (en) 1995-01-12
KR100386533B1 (en) 2003-08-21
GR3036571T3 (en) 2001-12-31
NO960062D0 (en) 1996-01-05
FI960032A (en) 1996-02-09
AU7385094A (en) 1995-02-06
CZ4596A3 (en) 1996-04-17
HU9503965D0 (en) 1996-03-28
CN1313154C (en) 2007-05-02
NO960062L (en) 1996-01-05
BR9407002A (en) 1996-09-03
ATE172876T1 (en) 1998-11-15
DE59409787D1 (en) 2001-07-19
PL179717B1 (en) 2000-10-31
SI1092429T1 (en) 2004-08-31
CN1121853C (en) 2003-09-24
PT1092429E (en) 2004-08-31
FI960032A0 (en) 1996-01-03
CN1496743A (en) 2004-05-19
NZ269552A (en) 1996-07-26
EP0710103A1 (en) 1996-05-08
FI116714B (en) 2006-02-15
EP0710104B1 (en) 1998-11-04
RU2140291C1 (en) 1999-10-27
HU223073B1 (en) 2004-03-01
SK280615B6 (en) 2000-05-16
NO960069D0 (en) 1996-01-05
SK1996A3 (en) 1997-04-09
PL312255A1 (en) 1996-04-01
CZ291401B6 (en) 2003-03-12
DK1092429T3 (en) 2004-07-19
FI116197B (en) 2005-10-14
JP2011153150A (en) 2011-08-11
CA2164100A1 (en) 1995-01-19
EP1092429A1 (en) 2001-04-18
HU9503868D0 (en) 1996-02-28
WO1995001785A1 (en) 1995-01-19
PT710103E (en) 2001-11-30
FI960042A0 (en) 1996-01-04
NO306929B1 (en) 2000-01-17
HU228127B1 (en) 2012-12-28
FI960042A (en) 1996-01-04
ATE261720T1 (en) 2004-04-15
ES2218046T3 (en) 2004-11-16
AU689486B2 (en) 1998-04-02
HUT73661A (en) 1996-09-30
DE59410365D1 (en) 2004-04-22
JP2009138008A (en) 2009-06-25

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