DK0620847T3 - Fremstilling af renkulturer af post-mitotiske humane neuroner - Google Patents

Fremstilling af renkulturer af post-mitotiske humane neuroner

Info

Publication number
DK0620847T3
DK0620847T3 DK92917219T DK92917219T DK0620847T3 DK 0620847 T3 DK0620847 T3 DK 0620847T3 DK 92917219 T DK92917219 T DK 92917219T DK 92917219 T DK92917219 T DK 92917219T DK 0620847 T3 DK0620847 T3 DK 0620847T3
Authority
DK
Denmark
Prior art keywords
cells
post
pure cultures
preparation
human neurons
Prior art date
Application number
DK92917219T
Other languages
Danish (da)
English (en)
Inventor
Virginia Lee
Samuel Pleasure
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of DK0620847T3 publication Critical patent/DK0620847T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/12—Spreading-out the material on a substrate, e.g. on the surface of a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/34—Component parts, details or accessories; Auxiliary operations
    • B29C41/36—Feeding the material on to the mould, core or other substrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2023/00—Tubular articles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/30—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cancer cells, e.g. reversion of tumour cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92917219T 1991-10-21 1992-08-05 Fremstilling af renkulturer af post-mitotiske humane neuroner DK0620847T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/780,715 US5175103A (en) 1991-10-21 1991-10-21 Preparation of pure cultures of post-mitotic human neurons
PCT/US1992/006540 WO1993008266A1 (en) 1991-10-21 1992-08-05 Preparation of pure cultures of post-mitotic human neurons

Publications (1)

Publication Number Publication Date
DK0620847T3 true DK0620847T3 (da) 1998-10-07

Family

ID=25120453

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92917219T DK0620847T3 (da) 1991-10-21 1992-08-05 Fremstilling af renkulturer af post-mitotiske humane neuroner

Country Status (9)

Country Link
US (2) US5175103A (ja)
EP (1) EP0620847B1 (ja)
JP (1) JP3169611B2 (ja)
AT (1) ATE165617T1 (ja)
CA (1) CA2120730A1 (ja)
DE (1) DE69225332T2 (ja)
DK (1) DK0620847T3 (ja)
ES (1) ES2117672T3 (ja)
WO (1) WO1993008266A1 (ja)

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US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US6399369B1 (en) * 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US6497872B1 (en) * 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US7166277B1 (en) 1991-07-08 2007-01-23 Neurospheres Holdings Ltd. Remyelination of neurons using multipotent neural stem cell progeny
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US6071889A (en) * 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US6214334B1 (en) * 1991-10-21 2001-04-10 Trustees Of The University Of Pennsylvania Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
US5792900A (en) * 1991-10-21 1998-08-11 The Trustees Of The University Of Pennsylvania Compositions and methods for producing and using homogenous neuronal cell transplants
US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
US7011827B2 (en) * 1993-11-09 2006-03-14 Trustees Of The University Of Pennsylvania Compositions and methods for producing and using homogenous neuronal cell transplants
JPH09505054A (ja) * 1993-11-09 1997-05-20 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 均質なニューロン細胞移植片としての組成物とこれらの移植片の製造及び使用方法
US5449609A (en) * 1994-01-31 1995-09-12 Children's Hospital Of Philadelphia Methods for screening for neurotoxicity using a clonal human teratocarcinoma cell line
US20060029575A1 (en) * 1994-11-09 2006-02-09 Lee Virginia M Compositions and methods for producing and using homogenous neuronal cell transplants
CN1170435A (zh) * 1994-11-14 1998-01-14 纽罗斯菲里斯控股有限公司 神经干细胞增殖的调节
US5753505A (en) 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US6162428A (en) * 1997-02-12 2000-12-19 Layton Bioscience, Inc. hNT-neuron human neuronal cells to replace ganglion cells
AU6897498A (en) * 1997-04-25 1998-11-24 American Home Products Corporation Human neuronal cell line
AU7977198A (en) * 1997-06-17 1999-01-04 University Technology Corporation Neural transplantation for treating neurological disease
US6235527B1 (en) * 1997-11-29 2001-05-22 University Of Utah Research Foundation Lineage restricted glial precursors from the central nervous system
US6734015B1 (en) * 1997-07-04 2004-05-11 University Of Utah Research Foundation Isolation of lineage-restricted neuronal precursors
JP4371179B2 (ja) * 1997-07-04 2009-11-25 ユニバーシティー オブ ユタ リサーチ ファンデーション 系列限定ニューロン前駆体
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
WO1999013726A1 (en) * 1997-09-19 1999-03-25 University Of South Florida Neuronal cells and an immunosuppressant and anti-inflammatory factor
EP1109887A4 (en) * 1998-07-29 2003-05-21 Layton Bioscience Inc PRODUCTION AND USE OF DOPAMINERGIC CELLS TO TREAT DOPAMINERGIC DEFICIENCIES
US20030211085A1 (en) * 2000-03-16 2003-11-13 Sanberg Paul R. Cell therapy for chronic stroke
EP1949904A3 (en) 1999-04-27 2008-08-06 Layton Bioscience, Inc. Cell therapy for chronic stroke
DE19928210B4 (de) * 1999-06-19 2005-08-18 Neuroprogen Gmbh Leipzig Neuronales Zellmaterial und Verfahren zu dessen Herstellung
US6749850B1 (en) 1999-08-18 2004-06-15 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system
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EP1272203B1 (en) 2000-04-13 2006-10-18 The Board Of Regents, The University Of Texas System Treatment of neurodegenerative gastrointestinal disorders by implanting neural stem cells and/or progeny thereof into gastrointestinal organs
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US6897061B1 (en) * 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
JP4031901B2 (ja) * 2000-07-19 2008-01-09 株式会社東芝 固体撮像装置
AU2001292350A1 (en) * 2000-10-05 2002-04-15 Takeda Chemical Industries Ltd. Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells
WO2002063938A2 (en) * 2000-12-05 2002-08-22 Layton Bioscience Inc. Production and use of dopaminergic cells to treat dopaminergic deficiencies
WO2002099087A2 (de) * 2001-06-05 2002-12-12 Thomas Rohrmeier Zellpopulationen zur auffindung neuronaler targets und potentieller wirkstoffe
US7576065B2 (en) * 2002-02-15 2009-08-18 Cornell Research Foundation, Inc. Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
GB0217981D0 (en) * 2002-08-02 2002-09-11 Univ Durham Method for preparation, purification and differentiation of neurospheres from mammalian stem cells
EP1576134B1 (en) * 2002-12-09 2013-03-06 Judith Kelleher-Andersson Method for discovering neurogenic agents
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
DE10259617A1 (de) * 2002-12-18 2004-07-08 Cardion Ag Verfahren zur Inhibierung des Proliferationspotentials von Zellpopulationen und Geweben
AU2003267969A1 (en) * 2003-04-17 2004-11-26 U.S. Department Of Veterans Affairs Isolated/cloned human nt2 cell lines expressing serotonin and gaba
FR2859219B1 (fr) * 2003-09-02 2005-10-14 Alain Privat Procede de production de neurones a partir de cellules d'une lignee cellulaire
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US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons

Also Published As

Publication number Publication date
DE69225332D1 (de) 1998-06-04
WO1993008266A1 (en) 1993-04-29
US5654189A (en) 1997-08-05
JP3169611B2 (ja) 2001-05-28
DE69225332T2 (de) 1998-08-27
ATE165617T1 (de) 1998-05-15
ES2117672T3 (es) 1998-08-16
CA2120730A1 (en) 1993-04-29
US5175103A (en) 1992-12-29
EP0620847A1 (en) 1994-10-26
EP0620847A4 (en) 1995-03-29
JPH07502645A (ja) 1995-03-23
EP0620847B1 (en) 1998-04-29

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