DK0619315T3 - Thioxanthenoner som antitumormidler - Google Patents

Thioxanthenoner som antitumormidler

Info

Publication number
DK0619315T3
DK0619315T3 DK94200892T DK94200892T DK0619315T3 DK 0619315 T3 DK0619315 T3 DK 0619315T3 DK 94200892 T DK94200892 T DK 94200892T DK 94200892 T DK94200892 T DK 94200892T DK 0619315 T3 DK0619315 T3 DK 0619315T3
Authority
DK
Denmark
Prior art keywords
ch2n
alkyl
hydrogen
hydroxy
thioxanthenones
Prior art date
Application number
DK94200892T
Other languages
Danish (da)
English (en)
Inventor
Mark Philip Wentland
Robert Bruno Perni
Joseph William Guiles
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of DK0619315T3 publication Critical patent/DK0619315T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D335/16—Oxygen atoms, e.g. thioxanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94200892T 1993-04-08 1994-03-31 Thioxanthenoner som antitumormidler DK0619315T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/044,843 US5346917A (en) 1991-06-10 1993-04-08 Thioxanthenone antitumor agents

Publications (1)

Publication Number Publication Date
DK0619315T3 true DK0619315T3 (da) 1999-12-27

Family

ID=21934632

Family Applications (3)

Application Number Title Priority Date Filing Date
DK94200892T DK0619315T3 (da) 1993-04-08 1994-03-31 Thioxanthenoner som antitumormidler
DK02000949T DK1197491T3 (da) 1993-04-08 1994-03-31 Thioxanthenon-antitumormiddel
DK98113469T DK0882723T3 (da) 1993-04-08 1994-03-31 Thioxanthenon som antitumormiddel

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK02000949T DK1197491T3 (da) 1993-04-08 1994-03-31 Thioxanthenon-antitumormiddel
DK98113469T DK0882723T3 (da) 1993-04-08 1994-03-31 Thioxanthenon som antitumormiddel

Country Status (24)

Country Link
US (2) US5346917A (cs)
EP (3) EP1197491B1 (cs)
JP (1) JPH06340655A (cs)
KR (1) KR100344136B1 (cs)
AT (3) ATE181068T1 (cs)
AU (1) AU679717B2 (cs)
CA (1) CA2120782C (cs)
CZ (1) CZ289473B6 (cs)
DE (3) DE69434216T2 (cs)
DK (3) DK0619315T3 (cs)
ES (3) ES2180100T3 (cs)
FI (2) FI941638L (cs)
GR (1) GR3030949T3 (cs)
HU (1) HUT67899A (cs)
IL (1) IL109241A (cs)
MY (1) MY131770A (cs)
NO (1) NO306947B1 (cs)
NZ (1) NZ260255A (cs)
PT (2) PT882723E (cs)
RU (1) RU2138495C1 (cs)
SG (1) SG52765A1 (cs)
SK (1) SK283799B6 (cs)
TW (1) TW242623B (cs)
UA (1) UA41281C2 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665760A (en) * 1995-09-18 1997-09-09 Sanofi Winthrop, Inc. Lyophilized thioxanthenone antitumor agents
US7126011B2 (en) * 2000-11-15 2006-10-24 Prom Limited Process for the preparation of thioxanthones
GB0115893D0 (en) * 2001-06-28 2001-08-22 Sanofi Synthelabo Formulations
US6747039B2 (en) * 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
US20030212061A1 (en) * 2002-03-12 2003-11-13 Haydar Simon N. Aza-thioxanthenones with antitumor activity
AU2003295738A1 (en) * 2002-11-18 2004-06-15 Arqule, Inc. Novel lapachone compounds and methods of use thereof
US6767919B2 (en) * 2002-12-17 2004-07-27 Walker Cancer Research Institute, Inc. High specificity anticancer agents
RU2296756C2 (ru) * 2005-05-17 2007-04-10 Федеральное унитарное государственное предприятие "Государственный научно-исследовательский институт биологического приборостроения" (ГосНИИ БП) Комплексообразующие дибензосодержащие пятичленные циклические соединения, содержащие два симметричных бета-дикарбонильных заместителя с фторированными радикалами
US20080114055A1 (en) * 2006-11-10 2008-05-15 Zoltan Laboratories Llc Thioxanthone Compounds to Reverse Weight Loss
US20080207738A1 (en) * 2007-02-28 2008-08-28 Cancure Laboratories, Llc Drug combinations to treat drug resistant tumors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312598A (en) * 1965-06-14 1967-04-04 Sterling Drug Inc Fermentative oxidation of substituted thioxanthenes and xanthenes
US3745172A (en) * 1970-10-05 1973-07-10 Sterling Drug Inc 1-(di-(lower-alkyl)aminoalkylamino)-9-oxothioxanthenes
US4539412A (en) * 1982-07-08 1985-09-03 Rensselaer Polytechnic Institute 7-Hydroxylucanthone, 7-hydroxhycanthone and their analogs
GB8400203D0 (en) * 1984-01-05 1984-02-08 Wellcome Found Tricyclic compounds
US4582851A (en) * 1984-02-06 1986-04-15 Warner-Lambert Company Anti-bacterial 1,4-aminoalkylamino-9H-thioxanthen-9-one derivatives, compositions, and method of use therefor
US4571405A (en) * 1984-05-29 1986-02-18 Miles Laboratories, Inc. Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor
AU3008289A (en) * 1988-02-22 1989-08-24 Eastman Kodak Company Novel thiorhodamines and a novel method of preparation
US5091410A (en) * 1991-06-10 1992-02-25 Sterling Winthrop Inc. Thioxanthenone antitumor agents
AU642596B2 (en) * 1991-06-10 1993-10-21 Sanofi-Synthelabo Thioxanthenone antitumor agents

Also Published As

Publication number Publication date
HU9400992D0 (en) 1994-06-28
MY131770A (en) 2007-08-30
EP1197491A1 (en) 2002-04-17
NZ260255A (en) 1995-07-26
EP0619315A1 (en) 1994-10-12
ES2180100T3 (es) 2003-02-01
DE69434216T2 (de) 2005-12-08
FI20041691A7 (fi) 2004-12-30
DE69431131T2 (de) 2003-03-27
DE69418929T2 (de) 2000-01-20
ATE181068T1 (de) 1999-06-15
CZ289473B6 (cs) 2002-01-16
NO306947B1 (no) 2000-01-17
ATE286043T1 (de) 2005-01-15
RU2138495C1 (ru) 1999-09-27
FI20041691L (fi) 2004-12-30
IL109241A0 (en) 1994-07-31
DE69431131D1 (de) 2002-09-05
DK1197491T3 (da) 2005-04-11
CA2120782A1 (en) 1994-10-09
AU679717B2 (en) 1997-07-10
EP0882723A1 (en) 1998-12-09
ES2234935T3 (es) 2005-07-01
SK39094A3 (en) 1995-07-11
PT882723E (pt) 2002-11-29
HUT67899A (en) 1995-05-29
FI941638A7 (fi) 1994-10-09
ES2134314T3 (es) 1999-10-01
CZ74894A3 (en) 1994-11-16
EP0619315B1 (en) 1999-06-09
CA2120782C (en) 2005-10-25
FI941638L (fi) 1994-10-09
DE69434216D1 (de) 2005-02-03
PT1197491E (pt) 2005-04-29
EP0882723B1 (en) 2002-07-31
AU5930194A (en) 1994-10-13
NO941288D0 (no) 1994-04-08
EP1197491B1 (en) 2004-12-29
UA41281C2 (uk) 2001-09-17
SG52765A1 (en) 1998-09-28
ATE221524T1 (de) 2002-08-15
FI941638A0 (fi) 1994-04-08
GR3030949T3 (en) 1999-11-30
US5380749A (en) 1995-01-10
US5346917A (en) 1994-09-13
JPH06340655A (ja) 1994-12-13
TW242623B (cs) 1995-03-11
KR100344136B1 (ko) 2003-09-29
NO941288L (no) 1994-10-10
SK283799B6 (sk) 2004-02-03
IL109241A (en) 2001-10-31
DK0882723T3 (da) 2002-11-25
DE69418929D1 (de) 1999-07-15

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