DK0456764T3 - Omega-3 fatty acid-containing fat emulsion for endotracheal administration, preparation and use thereof - Google Patents

Omega-3 fatty acid-containing fat emulsion for endotracheal administration, preparation and use thereof

Info

Publication number
DK0456764T3
DK0456764T3 DK90903830.9T DK90903830T DK0456764T3 DK 0456764 T3 DK0456764 T3 DK 0456764T3 DK 90903830 T DK90903830 T DK 90903830T DK 0456764 T3 DK0456764 T3 DK 0456764T3
Authority
DK
Denmark
Prior art keywords
esters
physiologically acceptable
optionally
omega
preparation
Prior art date
Application number
DK90903830.9T
Other languages
Danish (da)
Inventor
Michael Georgieff
Joerg Nehne
Michael Boll
Original Assignee
Braun Melsungen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Braun Melsungen Ag filed Critical Braun Melsungen Ag
Application granted granted Critical
Publication of DK0456764T3 publication Critical patent/DK0456764T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

This emulsion contains $g(v)-3 fatty acids, in particular eikosapentaene acid (EPA), or their physiologically tolerable esters as components of the fatty phase. Altogether, it contains the following: $g(v)-fatty acids, in particular EPA, or their physiologically acceptable esters in their pure form or as components of fish oils and/or fish oil fractions; at least one physiologically acceptable emulsifier; optionally, further fats such as medium-chained triglycerides (MCT); optionally, $g(a)-tocopherol or physiologically acceptable $g(a)-tocopherol-esters; optionally, ascorbic acid or physiologically acceptable ascorbic acid esters; and the usual additives and auxiliary substances. The total fat content is comprised between 2 and 20% and the emulsifier content is comprised between 5 and 20% (relative to the fat content). Production and use of this emulsion are also described.
DK90903830.9T 1989-02-02 1990-01-31 Omega-3 fatty acid-containing fat emulsion for endotracheal administration, preparation and use thereof DK0456764T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3903057A DE3903057A1 (en) 1989-02-02 1989-02-02 FAT EMULSION FOR ENDOTRACHEAL APPLICATION, ITS PRODUCTION AND APPLICATION

Publications (1)

Publication Number Publication Date
DK0456764T3 true DK0456764T3 (en) 1994-01-31

Family

ID=6373277

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90903830.9T DK0456764T3 (en) 1989-02-02 1990-01-31 Omega-3 fatty acid-containing fat emulsion for endotracheal administration, preparation and use thereof

Country Status (5)

Country Link
EP (1) EP0456764B1 (en)
AT (1) ATE93722T1 (en)
DE (2) DE3903057A1 (en)
DK (1) DK0456764T3 (en)
WO (1) WO1990008543A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9107991A (en) * 1990-12-21 1992-07-22 Wade, Jonathan Leslie Adjuvants containing unsaturated lipid
DE4330664A1 (en) * 1993-09-10 1995-03-16 Beiersdorf Ag Uses of vegetable oils
US5574065A (en) * 1994-04-21 1996-11-12 Clintec Nutrition Co. Method and composition for normalizing injury response
DE19503993A1 (en) * 1995-02-08 1996-08-14 Johann Friedrich Dr Med Desaga Enteral product contg n-3-fatty acid or deriv and medium chain length tri:glyceride
US6576264B1 (en) 1995-10-17 2003-06-10 Skyepharma Canada Inc. Insoluble drug delivery
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US8415329B1 (en) 1998-05-29 2013-04-09 Jagotec Ag Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations
CA2349203C (en) 1998-11-20 2013-05-21 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles
AU2001257115B2 (en) 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
AU8847101A (en) 2000-08-31 2002-03-13 Rtp Pharma Inc Milled particles
EP1279400A1 (en) * 2001-07-25 2003-01-29 Target Hit sa Modifying the fatty acid composition of cell membranes of organs and tissues
AU2002951913A0 (en) * 2002-10-08 2002-10-24 Chevis Agriservices & Consulting Pty. Limited Method of treatment
WO2010049142A1 (en) * 2008-10-29 2010-05-06 Lipid4Life Gmbh Nutrition composition containing omega-3 fatty acids and mcts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515174A1 (en) * 1981-10-23 1983-04-29 Roussel Uclaf NOVEL TRIGLYCERIDES, PROCESS FOR THE PREPARATION AND APPLICATIONS IN DIETETICS AND THERAPEUTICS
JPS59172416A (en) * 1983-03-18 1984-09-29 Terumo Corp Fat transfusion solution
JPS59230918A (en) * 1983-06-13 1984-12-25 Eiwa Shoji Kk Clamp feeder for bar material
US4526902A (en) * 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
DE3524788A1 (en) * 1985-07-11 1987-01-22 Lentia Gmbh STABLE, INTRAVENOES APPLICABLE, AQUEOUS FAT EMULSION AND A METHOD FOR THE PRODUCTION THEREOF
JPH0832628B2 (en) * 1986-12-17 1996-03-29 株式会社ミドリ十字 Triglyceride composition
DE3722540A1 (en) * 1987-07-08 1989-01-19 Fresenius Ag FAT EMULSION, METHOD FOR THEIR PRODUCTION AND THEIR USE
DE3734147C2 (en) * 1987-10-09 1998-10-29 Braun Melsungen Ag Isotonic omega-3 fatty acid-containing fat emulsion and its use

Also Published As

Publication number Publication date
WO1990008543A1 (en) 1990-08-09
EP0456764B1 (en) 1993-09-01
ATE93722T1 (en) 1993-09-15
EP0456764A1 (en) 1991-11-21
DE3903057A1 (en) 1990-08-09
DE59002572D1 (en) 1993-10-07

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