DE906329C - Process for the production of sulfur-containing organic compounds - Google Patents

Process for the production of sulfur-containing organic compounds

Info

Publication number
DE906329C
DE906329C DEB18978A DEB0018978A DE906329C DE 906329 C DE906329 C DE 906329C DE B18978 A DEB18978 A DE B18978A DE B0018978 A DEB0018978 A DE B0018978A DE 906329 C DE906329 C DE 906329C
Authority
DE
Germany
Prior art keywords
sulfur
production
containing organic
organic compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB18978A
Other languages
German (de)
Inventor
Dr Bruno Boettcher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRUNO BOETTCHER DR
Original Assignee
BRUNO BOETTCHER DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRUNO BOETTCHER DR filed Critical BRUNO BOETTCHER DR
Priority to DEB18978A priority Critical patent/DE906329C/en
Application granted granted Critical
Publication of DE906329C publication Critical patent/DE906329C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung von schwefelhaltigen organischen Verbindungen Gegenstand des Patents 865 903 ist ein Verfahren zur Herstellung von schwefelhaltigen organischen Verbindungen, welches dadurch gekennzeichnet ist, daß Sulfoniumverbindungen von z. B. schwefelhaltigen Heterocyclen, die eine nicht enolisierbare Thioketogruppe enthalten, unter anderem mit Alkalisalzen von organischen Säuren bzw. deren Derivaten zweckmäßig in wäßriger Lösung umgesetzt werden.Process for the production of sulfur-containing organic compounds The subject of the patent 865 903 is a process for the production of sulfur-containing organic compounds, which is characterized in that sulfonium compounds of z. B. sulfur-containing heterocycles which contain a non-enolizable thioketo group, inter alia with alkali salts of organic acids or their derivatives are advantageously reacted in aqueous solution.

Nach dem Verfahren des Patents 865 903 werden die Reaktionskomponenten, z. B. einerseits 5-Thionx, 2-dithiole (Trithione), andererseits Alkaliverbindungen organischer Säuren u. dgl., in wäßriger Lösung zur Umsetzung gebracht. Weitere Versuche haben ergeben, daß zur Bildung besonders reiner Umsetzungsprodukte zweckmäßig in einem Wasserstoffionenkonzentrationsbereich zwischen 4 und 6 gearbeitet wird. Zweckmäßig löst man also die Reaktionskomponenten in Säuren, z. B. Eisessig oder verdünnten Mineralsäuren.According to the method of patent 865 903 , the reaction components, e.g. B. on the one hand 5-thionx, 2-dithiols (trithiones), on the other hand, alkali metal compounds of organic acids and the like, brought to reaction in aqueous solution. Further experiments have shown that it is advisable to work in a hydrogen ion concentration range between 4 and 6 in order to form particularly pure reaction products. It is therefore expedient to dissolve the reaction components in acids, e.g. B. glacial acetic acid or dilute mineral acids.

Die Verfahrensprodukte sollen als chemotherapeutische Mittel Verwendung finden.The products of the process are intended to be used as chemotherapeutic agents Find.

Beispiel Die Lösung von 11,5 g 5-Thion-3-(p-methoxyphenyl)-i, 2-dithiol-Dimethylsulfat in 150 cm3 J-1, C) wird durch Zugabe von verdünnter Essigsäure auf ein pH von etwa 4. bis 6 eingestellt und mit- der Lösung von 5 g salizylsaurem Natrium in i5o cm3 H20 vermengt.EXAMPLE The solution of 11.5 g of 5-thione-3- (p-methoxyphenyl) -i, 2-dithiol-dimethyl sulfate in 150 cm3 of I-1, C) is brought to a pH of about 4 to 6 and mixed with the solution of 5 g of sodium salicylate in 150 cm3 of H20.

Das ausgefallene Reaktionsprodukt von der wahrscheinlichen Formel wird (zur Entfernung der Essigsäure) mit Wasser gewaschen. Es fällt in Form hellgelber Nadeln vom F. 186- an. Zur weiteren Reinigung kann die Komplexverbindung aus heißem Wasser umkristallisiert werden.The precipitated reaction product of the probable formula is washed with water (to remove the acetic acid). It occurs in the form of light yellow needles from F. 186-. For further purification, the complex compound can be recrystallized from hot water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von schwefelhaltigen organischen Verbindungen nach Patent 865 go3, dadurch gekennzeichnet, daß die Umsetzung der organischen Metallverbindungen, besonders Alkaliverbindungen, namentlich solcher, die ionisierbar sind, mit Sulfoniumverbindungen von organischen Substanzen, die eine nicht enolisierbare Thioketogruppe enthalten, hier in saurer Lösung (Wasserstoffionenkonzentrationsbereich zwischen q. und 6) vorgenommen wird.PATENT CLAIM: Process for the production of sulfur-containing organic Compounds according to patent 865 go3, characterized in that the implementation of the organic metal compounds, especially alkali compounds, namely those which are ionizable with sulfonium compounds of organic substances which contain a non-enolizable thioketo group, here in acidic solution (hydrogen ion concentration range between q. and 6) is made.
DEB18978A 1952-02-08 1952-02-08 Process for the production of sulfur-containing organic compounds Expired DE906329C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB18978A DE906329C (en) 1952-02-08 1952-02-08 Process for the production of sulfur-containing organic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB18978A DE906329C (en) 1952-02-08 1952-02-08 Process for the production of sulfur-containing organic compounds

Publications (1)

Publication Number Publication Date
DE906329C true DE906329C (en) 1954-03-11

Family

ID=6959932

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB18978A Expired DE906329C (en) 1952-02-08 1952-02-08 Process for the production of sulfur-containing organic compounds

Country Status (1)

Country Link
DE (1) DE906329C (en)

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