DE701094C - Process for the production of an anterior pituitary hormone preparation - Google Patents
Process for the production of an anterior pituitary hormone preparationInfo
- Publication number
- DE701094C DE701094C DE1937I0056946 DEI0056946D DE701094C DE 701094 C DE701094 C DE 701094C DE 1937I0056946 DE1937I0056946 DE 1937I0056946 DE I0056946 D DEI0056946 D DE I0056946D DE 701094 C DE701094 C DE 701094C
- Authority
- DE
- Germany
- Prior art keywords
- anterior pituitary
- production
- pituitary hormone
- hormone preparation
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003329 adenohypophysis hormone Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000000725 suspension Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 6
- 239000005556 hormone Substances 0.000 claims description 5
- 229940088597 hormone Drugs 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 150000002989 phenols Chemical class 0.000 claims 1
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 6
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000001456 gonadotroph Effects 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 229940031955 anhydrous lanolin Drugs 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung eines Hypophysenvorderlappenhormonpräparates Das Hauptpatent 672 804 betrifft ein Verfahren zur Herstellung eines Hypophysenvorderlappenhormonpräparates, bei dem man Suspensionen des Hormons in physiologisch unschädlichen Ölen unter Zusatz von Wollfett herstellt.Process for the production of an anterior pituitary hormone preparation The main patent 672 804 relates to a process for the production of an anterior pituitary lobe hormone preparation, in which one suspensions of the hormone in physiologically harmless oils with additives of wool fat.
Es hat sich gezeigt, daß im Laufe der Zeit eine gewisse Abnahme der physiologischen Wirkung des Hypophysenvorderlappenhorm,ons in solchen Suspensionen eintritt. Diese Feststellung war überraschend, da bekannt war, daß das Hypophysenvorderlappenhormon in trockener Form haltbar ist.It has been shown that over time a certain decrease in Physiological effect of the anterior pituitary hormone in such suspensions entry. This finding was surprising since it was known that the anterior pituitary hormone is stable in dry form.
Es wurde nun gefunden, daß man den Haltbarkeitsverlust dadurch weitgehend ausschalten kann, wenn man den gemäß dem Verfahren des Hauptpatents 672804 erhältlichen Suspensionen des gonadotropen Hypophysenvorderlappenhormons öllösliche Stoffe zusetzt, die oxydationsverhütend wirken. It has now been found that the loss of shelf life can largely be eliminated by adding oil-soluble substances which prevent oxidation to the suspensions of the gonadotropic anterior pituitary hormone obtainable according to the method of main patent 672804.
Als Zusätze kommen die üblichen oxydationsverhütenden Stoffe, insbesondere solche phenolischer Art, wie Hydrochinon, Resorcin, Phenol und Pyrogallol, in Frage. Der mengenmäßige Zusatz dieser Stoffe kann weitgehend schwanken, Im allgemeinen genügt ein o,2%iger Zusatz an dem oxydationsverhütenden Stoff, berechnet auf die Gesamtmenge der Suspension.The usual anti-oxidation substances, in particular, are used as additives phenolic types such as hydroquinone, resorcinol, phenol and pyrogallol are in question. The amount of these substances added can vary widely, in general an o, 2% addition of the antioxidant substance is sufficient, calculated on the basis of the Total amount of suspension.
Es hat sich gezeigt, daß die nach der Erfindung hergestellten Hypophysenvorderlappenhormonpräparate besonders haltbar sind. Zum Beispiel hat eine Suspension des Hormons in einer Lanolin-Olivenöl-Mischung, der o,2 % Hydrochinon oder Resorcin zugesetzt wurde, nach mehrmonatiger Aufbewahrung bei Zimmertemperatur praktisch nichts an Wirksamkeit verloren.It has been shown that the anterior pituitary hormone preparations prepared according to the invention are particularly durable. For example, a suspension of the hormone in a mixture of lanolin and olive oil, to which o, 2% hydroquinone or resorcinol was added, after several months of storage practically none of its effectiveness lost at room temperature.
Beispiel t In too Gewichtsteilen Sesamöl löst man unter Erwärmen to Gewichtsteile wasserfreies Lanolin und 0,2 Gewichtsteile Hydrochinon. Nach dem Abkühlen wird dieses Gemisch mit einer solchen Menge eines gonadotropen Hypophysenvorderlappenhormonpräparates verrieben, daß i ccm der erhaltenen Suspension i oo Ratteneinheiten enthält. Man benötigt zu diesem Zwecke je nach der Reinheit des angewandten Hypophysenvorderlappenhormons o,2 bis i Gewichtsteil. Die hergestellte Suspension ist haltbar und reizlos.Example t In too parts by weight of sesame oil is dissolved by heating to Part by weight of anhydrous lanolin and 0.2 part by weight of hydroquinone. After cooling down becomes this mixture with such an amount of a gonadotropic anterior pituitary hormone preparation triturated so that 1 cc of the suspension obtained contains 100 rat units. Man required for this purpose depending on the purity of the anterior pituitary lobe hormone used 0.2 to i part by weight. The suspension produced is durable and non-irritating.
Beispiel e Man stellt aus i Gewichtsteil eines hochgereinigten Hypophysenvorderlappenhormonpräparates, das ioo ooo Ratteneinheiten in einem Gewichtsteil enthält, ferner aus o,2 Gewichtsteilen Resorcin, i o Gewichtsteilen Lanolin und t oo Gewichtsteilen Olivenöl eine Suspension her. Diese setzt schwer ab, ist halt bar und reizlos und kann injiziert werden.Example e From i part by weight of a highly purified anterior pituitary hormone preparation, which contains 1,000,000 rat units in one part by weight, and 0.2 parts by weight Resorcinol, 10 parts by weight of lanolin and 10 parts by weight of olive oil are a suspension here. This is difficult to settle, is permanent and irritation-free and can be injected.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1937I0056946 DE701094C (en) | 1937-01-23 | 1937-01-23 | Process for the production of an anterior pituitary hormone preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1937I0056946 DE701094C (en) | 1937-01-23 | 1937-01-23 | Process for the production of an anterior pituitary hormone preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE701094C true DE701094C (en) | 1941-01-08 |
Family
ID=7194474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1937I0056946 Expired DE701094C (en) | 1937-01-23 | 1937-01-23 | Process for the production of an anterior pituitary hormone preparation |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE701094C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE940133C (en) * | 1949-10-18 | 1956-03-08 | Heinrich Schmidt | Process for obtaining highly effective organ extracts |
-
1937
- 1937-01-23 DE DE1937I0056946 patent/DE701094C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE940133C (en) * | 1949-10-18 | 1956-03-08 | Heinrich Schmidt | Process for obtaining highly effective organ extracts |
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