DE69938296T2 - Methode zur verwendung einer qualitätsmasszahl zur feststellung der qualität von biochemischen auftrennungen - Google Patents

Methode zur verwendung einer qualitätsmasszahl zur feststellung der qualität von biochemischen auftrennungen Download PDF

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Publication number
DE69938296T2
DE69938296T2 DE69938296T DE69938296T DE69938296T2 DE 69938296 T2 DE69938296 T2 DE 69938296T2 DE 69938296 T DE69938296 T DE 69938296T DE 69938296 T DE69938296 T DE 69938296T DE 69938296 T2 DE69938296 T2 DE 69938296T2
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DE
Germany
Prior art keywords
separation
data
sample
run
metric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69938296T
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German (de)
English (en)
Other versions
DE69938296D1 (de
Inventor
Elaine S. Sunnyvale MANSFIELD
Lian-She San Diego ZHAO
Marina Fremont VAINER
Curtis R. San Jose KAUTZER
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Global Life Sciences Solutions USA LLC
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GE Healthcare Bio Sciences Corp
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Publication date
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Publication of DE69938296T2 publication Critical patent/DE69938296T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8665—Signal analysis for calibrating the measuring apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G01N30/8634—Peak quality criteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DE69938296T 1998-03-06 1999-02-25 Methode zur verwendung einer qualitätsmasszahl zur feststellung der qualität von biochemischen auftrennungen Expired - Lifetime DE69938296T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/036,767 US6019896A (en) 1998-03-06 1998-03-06 Method for using a quality metric to assess the quality of biochemical separations
PCT/US1999/004246 WO1999045148A1 (en) 1998-03-06 1999-02-25 Method for using a quality metric to assess the quality of biochemical separations
US36767 2001-12-21

Publications (2)

Publication Number Publication Date
DE69938296D1 DE69938296D1 (de) 2008-04-17
DE69938296T2 true DE69938296T2 (de) 2009-03-19

Family

ID=21890529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69938296T Expired - Lifetime DE69938296T2 (de) 1998-03-06 1999-02-25 Methode zur verwendung einer qualitätsmasszahl zur feststellung der qualität von biochemischen auftrennungen

Country Status (6)

Country Link
US (1) US6019896A (https=)
EP (1) EP1070142B1 (https=)
JP (1) JP4360479B2 (https=)
AT (1) ATE388240T1 (https=)
DE (1) DE69938296T2 (https=)
WO (1) WO1999045148A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US20030170734A1 (en) * 2000-04-28 2003-09-11 Stephen Williams Multiplexed assays using electrophoretically separated molecular tags
JP2004516455A (ja) * 2000-07-21 2004-06-03 アプレラ コーポレイション 生物学的データを評価するための方法、システム、および製品
US20020116135A1 (en) * 2000-07-21 2002-08-22 Pasika Hugh J. Methods, systems, and articles of manufacture for evaluating biological data
GB0119959D0 (en) * 2001-08-16 2001-10-10 Sec Dep Of The Home Department Improvements in and relating to analysis
SE0200949D0 (sv) * 2002-03-27 2002-03-27 Biacore Ab Method and system for curve quality control
WO2003085374A2 (en) * 2002-04-02 2003-10-16 Aclara Biosciences, Inc. Multiplexed assays using electrophoretically separated molecular tags
DE10315581B4 (de) * 2003-04-05 2007-06-28 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Verfahren zur Qualitätsbestimmung von RNA-Proben
WO2006130165A2 (en) 2004-09-02 2006-12-07 Vialogy Corp. Detecting events of interest using quantum resonance interferometry
GB0419482D0 (en) * 2004-09-02 2004-10-06 Sec Dep For The Home Departmen Improvements in and relating to analysis
JP2006230917A (ja) * 2005-02-28 2006-09-07 Kaoru Imaoka 重心動揺計および重心動揺特性評価方法
US7799527B2 (en) * 2005-07-01 2010-09-21 Illumina, Inc. Systems and methods for automated quality control of polymer synthesis
US10488393B2 (en) 2010-09-30 2019-11-26 Robert Bosch Gmbh Device and method for self-referenced confidence test
US20140149050A1 (en) * 2011-07-08 2014-05-29 Shimadzu Corporation Data processing system for chromatograph
WO2013077864A1 (en) * 2011-11-22 2013-05-30 Robert Bosch Gmbh Method for self-referenced confidence test
EP3742159A1 (en) * 2019-05-24 2020-11-25 Sartorius Stedim Biotech GmbH Chromatography method, method of determining the influence of the interdependency of at least two parameters in a chromatography method and method of obtaining at least one chromatography method parameter
EP3742160B1 (en) 2019-05-24 2023-08-09 Sartorius Stedim Biotech GmbH Chromatography method, method of determining the concentration of at least one compound in a chromatography method and method of obtaining at least one chromatography method parameter
US12594557B2 (en) 2019-08-12 2026-04-07 Intabio, Llc Isoelectric focusing devices and fixtures
US11285484B2 (en) 2019-08-12 2022-03-29 Intabio, Llc Multichannel isoelectric focusing devices and high voltage power supplies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0359320A3 (en) * 1988-09-14 1991-10-23 Philips Electronics Uk Limited Chromatography apparatus
US5558998A (en) * 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
US5580728A (en) * 1994-06-17 1996-12-03 Perlin; Mark W. Method and system for genotyping
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6015667A (en) * 1996-06-03 2000-01-18 The Perkin-Emer Corporation Multicomponent analysis method including the determination of a statistical confidence interval

Also Published As

Publication number Publication date
JP2002505442A (ja) 2002-02-19
EP1070142A1 (en) 2001-01-24
JP4360479B2 (ja) 2009-11-11
DE69938296D1 (de) 2008-04-17
WO1999045148A1 (en) 1999-09-10
US6019896A (en) 2000-02-01
EP1070142B1 (en) 2008-03-05
EP1070142A4 (en) 2006-07-19
ATE388240T1 (de) 2008-03-15

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