DE69933588D1 - Mikrofabrizierte Vorrichtung zur Analyse von Zellen - Google Patents

Mikrofabrizierte Vorrichtung zur Analyse von Zellen

Info

Publication number
DE69933588D1
DE69933588D1 DE1999633588 DE69933588A DE69933588D1 DE 69933588 D1 DE69933588 D1 DE 69933588D1 DE 1999633588 DE1999633588 DE 1999633588 DE 69933588 A DE69933588 A DE 69933588A DE 69933588 D1 DE69933588 D1 DE 69933588D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1999633588
Other languages
English (en)
Other versions
DE69933588T2 (de )
Inventor
Nicholas Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyros Patent AB
Original Assignee
Gyros Patent AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/38Caps; Covers; Plugs; Pouring means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16Particles; Beads; Granular material; Encapsulation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • B01L2300/0806Standardised forms, e.g. compact disc [CD] format
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/10Means to control humidity and/or other gases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
DE1999633588 1998-04-27 1999-03-17 Mikrofabrizierte Vorrichtung zur Analyse von Zellen Active DE69933588D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9808836A GB9808836D0 (en) 1998-04-27 1998-04-27 Microfabricated apparatus for cell based assays

Publications (1)

Publication Number Publication Date
DE69933588D1 true DE69933588D1 (de) 2006-11-23

Family

ID=10830968

Family Applications (4)

Application Number Title Priority Date Filing Date
DE1999609462 Active DE69909462D1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen
DE1999633588 Active DE69933588T2 (de) 1998-04-27 1999-03-17 Mikrofabrizierte Vorrichtung zur Analyse von Zellen
DE1999633588 Active DE69933588D1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte Vorrichtung zur Analyse von Zellen
DE1999609462 Active DE69909462T2 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE1999609462 Active DE69909462D1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen
DE1999633588 Active DE69933588T2 (de) 1998-04-27 1999-03-17 Mikrofabrizierte Vorrichtung zur Analyse von Zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1999609462 Active DE69909462T2 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen

Country Status (9)

Country Link
US (5) US6632656B1 (de)
EP (2) EP1298198B1 (de)
JP (1) JP4064631B2 (de)
CA (1) CA2330034A1 (de)
DE (4) DE69909462D1 (de)
DK (1) DK1073709T3 (de)
ES (1) ES2203098T3 (de)
GB (1) GB9808836D0 (de)
WO (1) WO1999055827A1 (de)

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US6955738B2 (en) 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
WO2003102559A1 (en) 2002-05-31 2003-12-11 Gyros Ab Detector arrangement based on surface plasmon resonance
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグGyros Patent AB 微小流動性デバイスの内部の壁
WO2004083109A1 (en) 2003-03-23 2004-09-30 Gyros Patent Ab A collection of micro scale devices
EP1608587B1 (de) 2003-03-23 2016-11-23 Gyros Patent Ab Vorbefüllte vorrichtungen im mikromassstab
EP1628905A1 (de) 2003-05-23 2006-03-01 Gyros Patent Ab Hydrophile/hydrophobe fläche
US20050042770A1 (en) 2003-05-23 2005-02-24 Gyros Ab Fluidic functions based on non-wettable surfaces
WO2004106926A1 (en) 2003-06-02 2004-12-09 Gyros Patent Ab Microfluidic affinity assays with improved performance
US7776272B2 (en) 2003-10-03 2010-08-17 Gyros Patent Ab Liquid router
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent

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US6632656B1 (en) 2003-10-14 grant
EP1073709A1 (de) 2001-02-07 application
DE69909462D1 (de) 2003-08-14 grant
WO1999055827A1 (en) 1999-11-04 application
EP1073709B1 (de) 2003-07-09 grant
JP4064631B2 (ja) 2008-03-19 grant
ES2203098T3 (es) 2004-04-01 grant
US20060194273A1 (en) 2006-08-31 application
DK1073709T3 (da) 2003-11-03 grant
GB9808836D0 (en) 1998-06-24 grant
DE69909462T2 (de) 2004-04-15 grant
US20090239292A1 (en) 2009-09-24 application
JP2002512783A (ja) 2002-05-08 application
CA2330034A1 (en) 1999-11-04 application
US7935522B2 (en) 2011-05-03 grant
US20040058408A1 (en) 2004-03-25 application
EP1298198A3 (de) 2004-02-11 application
US20120003682A1 (en) 2012-01-05 application
EP1298198A2 (de) 2003-04-02 application
DE69933588T2 (de) 2007-08-16 grant
EP1298198B1 (de) 2006-10-11 grant
US8030062B2 (en) 2011-10-04 grant

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