DE69912271T2 - Verfahren zur Herstellung einer biologisch wirksamen Zusammensetzung - Google Patents
Verfahren zur Herstellung einer biologisch wirksamen Zusammensetzung Download PDFInfo
- Publication number
- DE69912271T2 DE69912271T2 DE69912271T DE69912271T DE69912271T2 DE 69912271 T2 DE69912271 T2 DE 69912271T2 DE 69912271 T DE69912271 T DE 69912271T DE 69912271 T DE69912271 T DE 69912271T DE 69912271 T2 DE69912271 T2 DE 69912271T2
- Authority
- DE
- Germany
- Prior art keywords
- chemical
- carrier
- composition
- procedure according
- biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
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- 229920001651 Cyanoacrylate Polymers 0.000 claims description 2
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- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 2
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- 239000012948 isocyanate Substances 0.000 claims description 2
- 150000002513 isocyanates Chemical class 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 239000007791 liquid phase Substances 0.000 claims description 2
- 210000002752 melanocyte Anatomy 0.000 claims description 2
- 238000006384 oligomerization reaction Methods 0.000 claims description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims description 2
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- 150000004072 triols Chemical class 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
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- 239000003814 drug Substances 0.000 description 52
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- 230000035515 penetration Effects 0.000 description 25
- 239000000243 solution Substances 0.000 description 23
- 230000004888 barrier function Effects 0.000 description 19
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 19
- 229960000282 metronidazole Drugs 0.000 description 18
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- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229940002612 prodrug Drugs 0.000 description 5
- 239000000651 prodrug Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- 239000004721 Polyphenylene oxide Substances 0.000 description 1
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- 125000003158 alcohol group Chemical group 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
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- 150000007514 bases Chemical class 0.000 description 1
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- 239000000969 carrier Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 239000002674 ointment Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9801705 | 1998-05-14 | ||
| SE9801705A SE9801705D0 (sv) | 1998-05-14 | 1998-05-14 | Biologically active composition |
| PCT/SE1999/000824 WO1999058109A1 (en) | 1998-05-14 | 1999-05-12 | Biologically active composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69912271D1 DE69912271D1 (de) | 2003-11-27 |
| DE69912271T2 true DE69912271T2 (de) | 2004-08-26 |
Family
ID=20411319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69912271T Expired - Lifetime DE69912271T2 (de) | 1998-05-14 | 1999-05-12 | Verfahren zur Herstellung einer biologisch wirksamen Zusammensetzung |
| DE1077677T Pending DE1077677T1 (de) | 1998-05-14 | 1999-05-12 | Biologisch aktive zusammensetzung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1077677T Pending DE1077677T1 (de) | 1998-05-14 | 1999-05-12 | Biologisch aktive zusammensetzung |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1077677B1 (https=) |
| JP (1) | JP2002514588A (https=) |
| KR (1) | KR100766998B1 (https=) |
| CN (1) | CN1309554A (https=) |
| AT (1) | ATE252371T1 (https=) |
| AU (1) | AU742921B2 (https=) |
| CA (1) | CA2332110A1 (https=) |
| DE (2) | DE69912271T2 (https=) |
| DK (1) | DK1077677T3 (https=) |
| ES (1) | ES2155049T3 (https=) |
| GR (1) | GR20010300014T1 (https=) |
| HU (1) | HUP0102002A3 (https=) |
| IL (2) | IL139577A0 (https=) |
| NO (1) | NO20005725L (https=) |
| NZ (1) | NZ508074A (https=) |
| PL (1) | PL344221A1 (https=) |
| SE (1) | SE9801705D0 (https=) |
| TR (1) | TR200003588T2 (https=) |
| WO (1) | WO1999058109A1 (https=) |
| ZA (1) | ZA200006476B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003524652A (ja) * | 2000-02-29 | 2003-08-19 | ツァン，ツィエ | 改良された経皮薬剤パッチ |
| WO2005013939A1 (en) | 2003-08-06 | 2005-02-17 | Nirmal Mulye | Pharmaceutical composition containing water soluble drug |
| KR20090031726A (ko) | 2006-06-14 | 2009-03-27 | 닥터 레디스 레보러터리즈 리미티드 | 국소용 조성물 |
| WO2012028496A1 (de) * | 2010-08-31 | 2012-03-08 | Basf Se | Verzweigte polyester auf basis von zitronensäure sowie deren herstellung und verwendung |
| KR20140089478A (ko) * | 2011-01-13 | 2014-07-15 | 큐엘티 인코포레이티드 | 감광제의 국소 전달용 약학 조성물 및 그의 이용 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940701A (en) * | 1984-01-25 | 1990-07-10 | Beecham Group P.L.C. | Topical drug release system |
| SE9502244D0 (sv) * | 1995-06-20 | 1995-06-20 | Bioglan Ab | A composition and a process for the preparation thereof |
| US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| GB2306885B (en) * | 1995-11-08 | 1999-07-14 | Reckitt & Colmann Prod Ltd | Supersaturated Pharmaceutical Compositions |
-
1998
- 1998-05-14 SE SE9801705A patent/SE9801705D0/xx unknown
-
1999
- 1999-05-12 IL IL13957799A patent/IL139577A0/xx active IP Right Grant
- 1999-05-12 NZ NZ508074A patent/NZ508074A/xx not_active IP Right Cessation
- 1999-05-12 DE DE69912271T patent/DE69912271T2/de not_active Expired - Lifetime
- 1999-05-12 HU HU0102002A patent/HUP0102002A3/hu unknown
- 1999-05-12 TR TR2000/03588T patent/TR200003588T2/xx unknown
- 1999-05-12 DE DE1077677T patent/DE1077677T1/de active Pending
- 1999-05-12 ES ES99927062T patent/ES2155049T3/es not_active Expired - Lifetime
- 1999-05-12 KR KR1020007012709A patent/KR100766998B1/ko not_active Expired - Fee Related
- 1999-05-12 JP JP2000547961A patent/JP2002514588A/ja active Pending
- 1999-05-12 WO PCT/SE1999/000824 patent/WO1999058109A1/en not_active Ceased
- 1999-05-12 CN CN99808549A patent/CN1309554A/zh active Pending
- 1999-05-12 EP EP99927062A patent/EP1077677B1/en not_active Expired - Lifetime
- 1999-05-12 PL PL99344221A patent/PL344221A1/xx unknown
- 1999-05-12 CA CA002332110A patent/CA2332110A1/en not_active Abandoned
- 1999-05-12 AT AT99927062T patent/ATE252371T1/de active
- 1999-05-12 AU AU44051/99A patent/AU742921B2/en not_active Ceased
- 1999-05-12 DK DK99927062T patent/DK1077677T3/da active
-
2000
- 2000-11-09 IL IL139577A patent/IL139577A/en not_active IP Right Cessation
- 2000-11-09 ZA ZA200006476A patent/ZA200006476B/xx unknown
- 2000-11-13 NO NO20005725A patent/NO20005725L/no not_active Application Discontinuation
-
2001
- 2001-04-30 GR GR20010300014T patent/GR20010300014T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0102002A3 (en) | 2002-12-28 |
| HUP0102002A2 (hu) | 2002-03-28 |
| ATE252371T1 (de) | 2003-11-15 |
| CA2332110A1 (en) | 1999-11-18 |
| DK1077677T3 (da) | 2004-02-16 |
| JP2002514588A (ja) | 2002-05-21 |
| TR200003588T2 (tr) | 2001-06-21 |
| IL139577A0 (en) | 2002-02-10 |
| SE9801705D0 (sv) | 1998-05-14 |
| EP1077677B1 (en) | 2003-10-22 |
| GR20010300014T1 (en) | 2001-04-30 |
| AU742921B2 (en) | 2002-01-17 |
| ZA200006476B (en) | 2001-06-11 |
| WO1999058109A1 (en) | 1999-11-18 |
| ES2155049T1 (es) | 2001-05-01 |
| KR100766998B1 (ko) | 2007-10-15 |
| AU4405199A (en) | 1999-11-29 |
| NZ508074A (en) | 2003-01-31 |
| DE69912271D1 (de) | 2003-11-27 |
| CN1309554A (zh) | 2001-08-22 |
| NO20005725L (no) | 2001-01-11 |
| KR20010052349A (ko) | 2001-06-25 |
| ES2155049T3 (es) | 2004-05-16 |
| EP1077677A1 (en) | 2001-02-28 |
| DE1077677T1 (de) | 2001-09-20 |
| PL344221A1 (en) | 2001-10-08 |
| NO20005725D0 (no) | 2000-11-13 |
| IL139577A (en) | 2007-07-04 |
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| 8364 | No opposition during term of opposition |