DE69904595D1 - Betacarbolinverbindungen - Google Patents

Betacarbolinverbindungen

Info

Publication number
DE69904595D1
DE69904595D1 DE69904595T DE69904595T DE69904595D1 DE 69904595 D1 DE69904595 D1 DE 69904595D1 DE 69904595 T DE69904595 T DE 69904595T DE 69904595 T DE69904595 T DE 69904595T DE 69904595 D1 DE69904595 D1 DE 69904595D1
Authority
DE
Germany
Prior art keywords
betacarbolinverbindungen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69904595T
Other languages
German (de)
Other versions
DE69904595T2 (en
Inventor
Alain Thurieau
Francine Poitout
Marie-Odile Galcera
Philippe Moinet
D Gordon
A Morgan
C Bigg
Jacques Pommier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOD CONSEILS RECH APPLIC
Ipsen Pharma SAS
Original Assignee
SOD CONSEILS RECH APPLIC
Ipsen Pharma SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US8918098P priority Critical
Priority to US9729798A priority
Application filed by SOD CONSEILS RECH APPLIC, Ipsen Pharma SAS filed Critical SOD CONSEILS RECH APPLIC
Priority to PCT/US1999/012874 priority patent/WO1999064420A1/en
Publication of DE69904595D1 publication Critical patent/DE69904595D1/en
Application granted granted Critical
Publication of DE69904595T2 publication Critical patent/DE69904595T2/en
Application status is Expired - Fee Related legal-status Critical
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
DE1999604595 1998-06-12 1999-06-08 Betacarbolinverbindungen Expired - Fee Related DE69904595T2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US8918098P true 1998-06-12 1998-06-12
US9729798A true 1998-06-12 1998-06-12
PCT/US1999/012874 WO1999064420A1 (en) 1998-06-12 1999-06-08 β-CARBOLINE COMPOUNDS

Publications (2)

Publication Number Publication Date
DE69904595D1 true DE69904595D1 (en) 2003-01-30
DE69904595T2 DE69904595T2 (en) 2003-11-27

Family

ID=26780327

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1999604595 Expired - Fee Related DE69904595T2 (en) 1998-06-12 1999-06-08 Betacarbolinverbindungen

Country Status (21)

Country Link
US (1) US6586445B1 (en)
EP (1) EP1086101B1 (en)
JP (1) JP2002517500A (en)
CN (1) CN1169808C (en)
AR (1) AR019153A1 (en)
AT (1) AT229954T (en)
AU (1) AU761020B2 (en)
CA (1) CA2335339A1 (en)
CZ (1) CZ20004580A3 (en)
DE (1) DE69904595T2 (en)
DK (1) DK1086101T3 (en)
ES (1) ES2188184T3 (en)
HK (1) HK1032049A1 (en)
HU (1) HU0302962A2 (en)
IL (1) IL140197D0 (en)
NO (1) NO319532B1 (en)
NZ (1) NZ508765A (en)
PL (1) PL345589A1 (en)
RU (1) RU2233841C2 (en)
TW (1) TWI236477B (en)
WO (1) WO1999064420A1 (en)

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US6696418B1 (en) 1999-09-01 2004-02-24 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
US6495589B2 (en) 2000-04-28 2002-12-17 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
FR2812546B1 (en) * 2000-08-01 2008-11-21 Sod Conseils Rech Applic Heterocycles derivatives of 5-membered ring, their preparation and their application as drugs
US6720330B2 (en) 2000-11-17 2004-04-13 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
FR2818978B1 (en) * 2000-12-28 2003-02-28 Sod Conseils Rech Applic Modulators of sodium channel derived from 2-piperidylimidazoles
GB0108337D0 (en) 2001-04-03 2001-05-23 Novartis Ag Organic compounds
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
WO2003000196A2 (en) * 2001-06-25 2003-01-03 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof
DE10136842A1 (en) * 2001-07-23 2003-02-13 Schering Ag Neuroprotective medicaments useful for treating e.g. multiple sclerosis, comprising gamma-aminobutyric acid-A receptor modulators
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
PA8586801A1 (en) 2002-10-31 2005-02-04 Pfizer Inhibitors of HIV-integrase, pharmaceutical compositions and methods for use
DE10252667A1 (en) * 2002-11-11 2004-05-27 Grünenthal GmbH New spiro-((cyclohexane)-tetrahydropyrano-(3,4-b)-indole) derivatives, are ORL1 receptor ligands useful e.g. for treating anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
MXPA05007563A (en) 2003-01-27 2005-09-21 Pfizer Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use.
JP4996926B2 (en) * 2004-02-05 2012-08-08 プロビオドルグ エージー New inhibitors of glutaminyl cyclase
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101837127A (en) 2003-05-05 2010-09-22 前体生物药物股份公司 Medical use of inhibitors of glutaminyl and glutamate cyclases
EA013790B1 (en) * 2004-02-05 2010-06-30 Пробиодруг Аг Novel inhibitors of glutaminyl cyclase
JP4671123B2 (en) 2003-06-23 2011-04-13 小野薬品工業株式会社 New tri-heterocyclic compounds
EP1675578B9 (en) 2003-10-15 2014-06-25 Probiodrug AG Inhibitors of glutaminyl and glutamate cyclases for the treatment of the neurodegenerative diseases fbd and fdd
DE10360793A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
DE10360792A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
AT374775T (en) 2004-04-26 2007-10-15 Pfizer Inhibitors of the HIV integrase enzyme
BRPI0510319A (en) 2004-04-26 2007-10-16 Pfizer inhibitors of the HIV integrase
DE102004039382A1 (en) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclic cyclohexane derivatives
ES2459742T3 (en) 2004-12-22 2014-05-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
TW200640931A (en) 2005-02-17 2006-12-01 Wyeth Corp Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
JP5035865B2 (en) * 2005-09-26 2012-09-26 国立大学法人高知大学 Proliferation and movement suppression method of Helicobacterpylori strains
US7879859B2 (en) * 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
US20070149557A1 (en) * 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
EP1957486A4 (en) * 2005-11-23 2009-11-11 Painceptor Pharma Corp Compositions and methods for modulating gated ion channels
WO2007115409A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DE102006046745A1 (en) * 2006-09-29 2008-04-03 Grünenthal GmbH Use of spirocyclic cyclohexane-derivative exhibiting an affinity for opioid-receptor and opioid receptor-like-1-receptor, for producing a medicament e.g. for treating diabetic neuropathy, for narcosis or for analgesia during narcosis
WO2009011836A1 (en) * 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
SG10201703086VA (en) * 2008-10-17 2017-05-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their use as therapeutic agents
EP2352373A1 (en) * 2008-10-29 2011-08-10 Merck Sharp & Dohme Corp. Triazole beta carboline derivatives as antidiabetic compounds
TW201028414A (en) * 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
US9107914B2 (en) * 2009-12-28 2015-08-18 Audiocure Pharma Gmbh Beta-carbolines for use in the treatment of hearing loss and vertigo
US8754099B2 (en) 2010-01-15 2014-06-17 Merck Sharp & Dohme Corp Oxadiazole beta carboline derivatives as antidiabetic compounds
ES2635415T3 (en) * 2011-03-28 2017-10-03 Sjt Molecular Research, S.L. Compounds for the treatment of metabolic syndrome
CN105837569B (en) * 2016-04-29 2017-12-26 华南农业大学 Harmaline one kind of oxazoline compounds and preparation method and application
CN106995440A (en) * 2017-05-26 2017-08-01 广西师范大学 Beta-carboline compound and synthesizing method and application thereof
CN107163041A (en) * 2017-05-26 2017-09-15 广西师范大学 Beta-carboline compound as well as synthesis method and application thereof
CN107141285A (en) * 2017-05-26 2017-09-08 广西师范大学 Beta-carboline compound and synthetic method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378803A (en) * 1987-12-11 1995-01-03 Sterling Winthrop Inc. Azole-fused peptides and processes for preparation thereof

Also Published As

Publication number Publication date
EP1086101B1 (en) 2002-12-18
EP1086101A1 (en) 2001-03-28
AU761020B2 (en) 2003-05-29
NO20006268A (en) 2001-01-29
NZ508765A (en) 2003-10-31
ES2188184T3 (en) 2003-06-16
WO1999064420A1 (en) 1999-12-16
NO20006268D0 (en) 2000-12-11
JP2002517500A (en) 2002-06-18
CN1169808C (en) 2004-10-06
AR019153A1 (en) 2001-12-26
TWI236477B (en) 2005-07-21
HU0302962A2 (en) 2003-12-29
CA2335339A1 (en) 1999-12-16
CN1308632A (en) 2001-08-15
IL140197D0 (en) 2002-02-10
CZ20004580A3 (en) 2001-12-12
NO319532B1 (en) 2005-08-29
RU2233841C2 (en) 2004-08-10
DK1086101T3 (en) 2003-03-31
AU4553699A (en) 1999-12-30
DE69904595T2 (en) 2003-11-27
US6586445B1 (en) 2003-07-01
PL345589A1 (en) 2001-12-17
HK1032049A1 (en) 2003-04-17
AT229954T (en) 2003-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee